Estrogen receptor - Wikipedia
Estrogen receptors also occur within the cell nucleus, and both estrogen receptor subtypes have a DNA-binding domain and can ... As hormone receptors for sex steroids (steroid hormone receptors), ERs, androgen receptors (ARs), and progesterone receptors ( ... nuclear estrogen receptors (ERα and ERβ), which are members of the nuclear receptor family of intracellular receptors, and ... "Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts". Proceedings of ...
Estrogen receptor transcription and transactivation
... * Estrogen receptor transcription and transactivation: ErbB family of ... Estrogen receptor transcription and transactivation: Novel morphoregulatory functions for the adhesion receptor Ep-CAM in the ... Estrogen receptor transcription and transactivation: Genetic modifiers of cancer risks conferred by BRCA1 and BRCA2 Authors: P ... Estrogen receptor transcription and transactivation: Antitumor potential of bisphosphonates Authors: JR Green ...
Male Infertility Medication: Estrogen receptor blockers, Dopamine antagonists, Gonadotropins
Estrogen receptor blockers. Class Summary. These agents cause increased hypothalamic secretion of GnRH owing to blockage of ... These agents are ergot derivatives and dopamine receptor agonists. They act on postsynaptic dopamine receptors while causing no ... Semisynthetic ergot alkaloid derivative with strong dopamine D2-receptor agonist and partial dopamine D1-receptor effects. ... Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis. J Clin Endocrinol Metab. ...
Genome-wide analysis of estrogen receptor binding sites | Nature Genetics
We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis ... Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene ... The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular ... regulation, particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of ...
Performance Standards for the Human Recombinant Estrogen Receptor Binding Assay - OECD
Breast Cancer: Unlocking Mechanisms That Silence Estrogen Receptor Gene Alpha | ScienceDaily
The researcher says this study provides a basis for understanding how the complex pattern of estrogen receptor gene alpha ... The mechanisms that silence the estrogen receptor gene alpha, in certain breast cancer cell lines may be closer to being ... They discovered that in estrogen receptor-negative cells - which are able to silence the expression of the estrogen receptor - ... In a previous study, the researchers found that in estrogen receptor-positive and estrogen receptor-negative mammary cell lines ...
Estrogen Receptors Linked to Increased Melanoma Survival
Their research showed that there is a receptor on melanocytes that is activated by estrogen. This may make some sense when you ... In mouse studies, when given a compound now known only as G-1 (a compound that activates those estrogen receptors on the ... Estrogen Receptors Linked to Increased Melanoma Survival. July 11, 2018. Cancer Horizons ... So, when melanoma is present, these same estrogen receptors can activate a pathway that causes differentiation within the tumor ...
Oestrogen receptor gene | The Scientist Magazine®
Accumulating evidence suggests that oestrogen protects against cardiovascular disease, and oestrogen receptors have been ... Kunnas and colleagues studied a dinucleotide repeat of the alpha oestrogen receptor gene in 119 Finnish men who died suddenly. ... Oestrogen receptor gene. NEW YORK, July 31 (Praxis Press) Accumulating evidence suggests that oestrogen protects against ... Accumulating evidence suggests that oestrogen protects against cardiovascular disease, and oestrogen receptors have been ...
Retroperitoneal Fibrosis Medication: Glucocorticoids, Immunosuppressives, Estrogen receptor antagonists, DMARDs, Other
Estrogen receptor antagonists. Class Summary. These agents bind to estrogen receptors, preventing stimulating effects of ... Competitively binds to estrogen receptor, producing nuclear complex that decreases DNA synthesis and inhibits estrogen effects ...
Estrogen Receptor, Progesterone Receptor Tests: MedlinePlus Medical Test
Estrogen receptor/progesterone receptor tests look for receptors that attach to the hormones estrogen and/or progesterone in ... Breast cancers that have these receptors often respond well to some types of treatments. Learn more. ... Receptors are proteins that attach to certain substances. ... What are estrogen receptor/progesterone receptor (ER/PR) tests? ... medlineplus.gov/lab-tests/estrogen-receptor-progesterone-receptor-tests/ Estrogen Receptor, Progesterone Receptor Tests. ...
Selective Estrogen Receptor Modulators: Drug Class, Uses, Side Effects, Drug Names
Selective estrogen receptor modulators (SERM) are a class of medications used to relieve postmenopausal symptoms and to prevent ... Selective estrogen receptor modulators work by modulating the activity of estrogen receptors, proteins in cells that are ... SERMs bind to estrogen receptors and activate estrogen pathways in some tissue while blocking its effects in other types of ... Selective estrogen receptor modulators may also be combined with estrogen for postmenopausal women with an intact uterus, who ...
Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function
Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes ... Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its function J Biol Chem. 2006 Apr 14;281(15 ... Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes ...
RCSB PDB - 1U9E: CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397
CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-397 ... Structure-Based Design Of Estrogen Receptor-beta Selective Ligands. Manas, E.S., Unwalla, R.J., Xu, Z.B., Malamas, M.S., Miller ... We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal ... We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal ...
oestrogen receptor positive (ER+) - Cancer Council Queensland
Estrogen Receptor alpha Antibody (ABIN2812887)
... Validated for FACS. Tested in Human, Mouse. Order online. ... Target Details for Estrogen Receptor alpha (hide) Target Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1)) ... Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1)) Binding Specificity All epitopes for Estrogen Receptor alpha ... estrogen receptor 1 L homeolog antibody, estrogen receptor 1 (alpha) antibody, estrogen receptor 1 antibody, esr1.L antibody, ...
Estrogen Receptor Modulators | Harvard Catalyst Profiles | Harvard Catalyst
"Estrogen Receptor Modulators" by people in Harvard Catalyst Profiles by year, and whether "Estrogen Receptor Modulators" was a ... The novel estrogen receptor modulator STX attenuates Amyloid-ß neurotoxicity in the 5XFAD mouse model of Alzheimers disease. ... "Estrogen Receptor Modulators" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Estrogen Receptor Modulators" by people in Profiles. ...
Osmotic Regulation of Estrogen Receptor-β in Rat Vasopressin and Oxytocin Neurons | Journal of Neuroscience
Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on ... nuclei are regulated by estrogen and exhibit robust expression of estrogen receptor (ER)-β. In contrast, only ∼7.5% of oxytocin ... Osmotic Regulation of Estrogen Receptor-β in Rat Vasopressin and Oxytocin Neurons. Suwit J. Somponpun and Celia D. Sladek ... Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM, Webb P ( 2000) Estrogen receptor pathways to AP-1. J Steroid ...
WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines
... with a critical role in estrogen-induced growth that may also mediate endocrine resistance. WNT4 signaling may represent a ... WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines Breast Cancer Res. ... Keywords: Breast cancer; Endocrine resistance; Endocrine therapy; Estradiol; Estrogen receptor; Lobular carcinoma; Wnt ... of ILC cases express the estrogen receptor (ER). However, a subset of ILC cases may be resistant to endocrine therapies, ...
Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat...
Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ... Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ... Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ... Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat ...
FDA approves new drug to treat estrogen-receptor-positive breast cancer | UCLA Health
The drug, Ibrance (palbociclib), was studied in 165 post-menopausal women with advanced estrogen-receptor positive (ER+) and ... Klein enrolled and was prescribed Ibrance in combination with an anti-estrogen treatment. Nine months later, her scans showed ... a standard anti-estrogen treatment, compared with women who received letrozole alone. ... it is traditionally treated with therapies like tamoxifen or letrozole that target the hormone receptor pathway. ...
Mammographic density changes following discontinuation of tamoxifen in premenopausal women with oestrogen receptor-positive...
To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor- ... et al. Mammographic density changes following discontinuation of tamoxifen in premenopausal women with oestrogen receptor- ... To evaluate the changes in mammographic density after tamoxifen discontinuation in premenopausal women with oestrogen receptor- ... Mammographic density changes following discontinuation of tamoxifen in premenopausal women with oestrogen receptor-positive ...
Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha | bioRxiv
Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha. View ORCID Profile ... Inhibition of top candidate ESRRA (Estrogen Related Receptor Alpha) killed tumors by direct effects on energy metabolism and ... Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha ... Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha ...
Osteoporosis Medication: Calcium Metabolism Modifiers, Parathyroid Hormone Analogs, Selective Estrogen Receptor Modulator,...
Selective Estrogen Receptor Modulator. Class Summary. Selective estrogen receptor modulators (SERMs) affect some of the ... Estrogens can directly affect bone mass through estrogen receptors in bone, reducing bone turnover and bone loss. Estrogens can ... Like estrogen, these are antiresorptive agents. However, because of their selective receptor-modulating property, they provide ... Estrogen Derivatives. Class Summary. Estrogen derivatives are approved for the prevention of osteoporosis and relief of ...
Peptide profiling: Correlating estrogen receptor conformation with biological response
Both estradiol and xenoestrogens can bind two estrogen receptors (ERs), ER alpha and ER beta, to elicit biological responses. ... This dual ligand quality characterizes what is now known as a selective estrogen receptor modulator (SERM). Peptide profiling, ... The receptors are ligand inducible transcription factors that exhibit unique biological actions. While estradiol binds both ... Chemicals found in the environment have been found to behave like the bodys natural estrogen, estradiol. These exogenous ...
Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder -...
OBJECTIVE: To assess the expression of the androgen receptor (AR) and oestrogen receptors (ERs) in bladder tumours because ... The expression of androgen and/or oestrogen receptors has been assessed in bladder cancer, leading to conflicting data of ... Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder - ... We simultaneously analyze three receptors in non-neoplastic bladder tissues as well as in primary and metastatic bladder tumour ...
Oestrogen receptor β immunohistochemistry: time to get it right? | Journal of Clinical Pathology
... the authors aimed to investigate the impact of oestrogen receptor β (ERβ) expression on breast cancer outcome using a cohort of ...
Estrogen receptor beta predicts tamoxifen sensitivity for estrogen receptor alpha negative breast cancer
Social behavior of male mice needs estrogen receptor activation in brain region at puberty
Sonoko Ogawa at Tsukuba University revealed that expression of an estrogen receptor (ERα) in the medial amygdala (MeA) of the ... Pubertal activation of estrogen receptor α in the medial amygdala is essential for the full expression of male social behavior ... Sonoko Ogawa at the University of Tsukuba showed that activation of an estrogen receptor in a region of the limbic system ... Polymorphism in estrogen receptor alpha linked to back pain. Apr 11, 2013 ...
Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. | NCBS
Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor ... Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer.. Title. ... Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer.. ... Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer.. ...
Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic...
Selective estrogen receptor modulators (SERMs, Fig. 1), such as tamoxifen, act as agonists or antagonists of estrogen receptors ... 2018) Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment. ... selective estrogen receptor modulator. SULT. sulfotransferase. TLCA. glycolithocholic acid. TLCA-S. taurolithocholic acid ... 2006) Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chem Res Toxicol 19:1125-1137. ...