*  Disorders of the calcium-sensing receptor: Familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
... was caused by inactivating mutations in the gene for the calcium-sensing receptor (CaSR, sometimes referred to as CaR) had two ... FUNCTIONS OF THE CALCIUM-SENSING RECEPTOR. The calcium-sensing receptor (CaSR) is expressed in multiple tissues, including the ... Cell Calcium 2004; 35:239.. *Geibel J, Sritharan K, Geibel R, et al. Calcium-sensing receptor abrogates secretagogue- induced ... Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor ...
  https://www.uptodate.com/contents/disorders-of-the-calcium-sensing-receptor-familial-hypocalciuric-hypercalcemia-and-autosomal-dominant-hypocalcemia
*  New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium-Sensing Receptor | Science Signaling
Experiments performed in mice in which expression of the extracellular calcium-sensing receptor (CaSR) was completely nullified ... Embryonic and postnatal development of the skeleton requires the functions of the extracellular calcium-sensing receptor (CaSR ... Embryonic and postnatal development of the skeleton requires the functions of the extracellular calcium-sensing receptor (CaSR ... New Insights in Bone Biology: Unmasking Skeletal Effects of the Extracellular Calcium-Sensing Receptor ...
  http://stke.sciencemag.org/content/1/35/pe40
*  Suggestive linkage of the parathyroid receptor type 1 to osteoporosis - The Arthritis Research UK Centre for Osteoarthritis...
... calcium-sensing receptor, epidermal growth factor (EGF), estrogen receptor 1 (ESR1), fibrillin type 1, insulin-like growth ... The candidate genes studied were the androgen receptor, type I collagen A1 (COLIA1), COLIA2, COLIIA1, vitamin D receptor (VDR ... PTH receptor type 1 (PTHR1), transforming growth factor-beta 1, and tumor necrosis factors alpha and beta. Sixty-four ... calcium-sensing receptor, epidermal growth factor (EGF), estrogen receptor 1 (ESR1), fibrillin type 1, insulin-like growth ...
  https://oacentre.kennedy.ox.ac.uk/publications/103970
*  Suggestive linkage of the parathyroid receptor type 1 to osteoporosis | Garvan Institute of Medical Research
... calcium-sensing receptor, epidermal growth factor (EGF), estrogen receptor 1 (ESR1), fibrillin type 1, insulin-like growth ... calcium-sensing receptor, epidermal growth factor (EGF), estrogen receptor 1 (ESR1), fibrillin type 1, insulin-like growth ... The candidate genes studied were the androgen receptor, type I collagen A1 (COLIA1), COLIA2, COLIIA1, vitamin D receptor (VDR ... PTH receptor type 1 (PTHR1), transforming growth factor-beta 1, and tumor necrosis factors alpha and beta. Sixty-four ...
  https://www.garvan.org.au/research/publications/1265
*  NCIRE Researcher Directory
Shoback's laboratory is working on how extracellular calcium-sensing receptors (CaSRs) sense changes in the extracellular ... Role of Calcium-Sensing Receptors in Bone and Mineral Metabolism Dr. ... calcium in the serum and in the bone microenvironment to alter cellular functions. These receptors play critical roles in ... Our work is based on the idea that calcium is released from bone mineral during resorption and remodeling and acts as a ligand ...
  http://ncire.org/research/researcher_directory/Dolores-Shoback-MD/
*  Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. -...
... sensing receptor (CaR) was visualized in single CaR-expressing human embryonic kidney (HEK) 293 cells using ratiometric ... Receptors, Calcium-Sensing, Sensitivity and Specificity, Signal Transduction ... Termination of cyclic adenosine monophosphate (cAMP) signaling via the extracellular Ca(2+)-sensing receptor (CaR) was ... Acetylcysteine, Biosensing Techniques, Calcium, Calcium Signaling, Cell Line, Cell Membrane, Cyclic AMP, Cyclic AMP-Dependent ...
  https://www.dpag.ox.ac.uk/publications/237651
*  PLOS Genetics: The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the...
To determine effects of CaR deficiency on skeletal development and interactions between CaR and 1,25(OH)2D3 or PTH on calcium ... Author Summary Mice with homozygous deletion of the calcium-sensing receptor (CaR) mimic the syndrome of neonatal severe ... We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area ...
  http://journals.plos.org/plosgenetics/article/comments?id=10.1371/journal.pgen.1002294
*  Bronchoconstriction | Colorado PROFILES
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. ... Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway ...
  https://profiles.ucdenver.edu/display/210907
*  Allosteric modulation of Class C GPCRs for CNS and metabolic disorders - Faculty of Pharmacy and Pharmaceutical Sciences
... metabotropic glutamate receptor subtype 5 (mGlu5) and the calcium-sensing receptor (CaSR). mGlu5 is an exciting new target for ... Our lab is interested in the biology and therapeutic potential of targeting Class C G protein-coupled receptors (GPCRs). We are ... We are pursuing a novel class of therapeutics, called allosteric modulators, to selectively target these receptors. To ... calcium handling disorders, asthma and idiopathic pulmonary arterial hypertension. ...
  https://www.monash.edu/pharm/future/courses/pharmaceutical-science-honours/honours-projects/honours-projects/drug-discovery-biology/allosteric-modulation-of-class-c-gpcrs-for-cns-and-metabolic-disorders
*  Etelcalcetide - Wikipedia
Etelcalcetide functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an ... Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland. Parsabiv is ... a novel peptide agonist of the calcium-sensing receptor, reduces serum parathyroid hormone and FGF23 levels in healthy male ... too low blood calcium levels). In clinical studies, the latter side effect was usually mild to moderate and without symptoms. ...
  https://en.wikipedia.org/wiki/Etelcalcetide
*  DailyMed - Search Results for Calcium-sensing Receptor Agonist
SEARCH RESULTS for: Calcium-sensing Receptor Agonist [Drug Class] (8 results) * Share : JavaScript needed for Sharing tools. ...
  https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Calcium-sensing%20Receptor%20Agonist&searchdb=class
*  anti-Calcium-Sensing Receptor Primary Antibodies
... sensing receptor 1 , parathyroid cell calcium-sensing receptor , PCaR1 , parathyroid Cell calcium-sensing receptor , Calcium- ... parathyroid gland calcium-sensing receptor , extracellular calcium-sensing receptor-like , extracellular calcium-sensing ... calcium-sensing receptor , vomeronasal receptor F-1 , calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal ... anti-Calcium-Sensing Receptor (CASR) Antikörper. Bezeichnung:. anti-Calcium-Sensing Receptor Antikörper (CASR). Auf www. ...
  https://www.antikoerper-online.de/positive-regulation-of-peptide-hormone-secretion-pathway-33/casr-antibody-2780/
*  Anti-Calcium Sensing Receptor antibody [5C10, ADD] (ab19347)
Mouse monoclonal Calcium Sensing Receptor antibody [5C10, ADD] validated for WB, ELISA, IHC, Flow Cyt and tested in Human, ... Anti-Calcium Sensing Receptor antibody [5C10, ADD]. See all Calcium Sensing Receptor primary antibodies. ... The Expression of Calcium Sensing Receptor in Normal and Diabetic Rat Eyes.. Med Sci Monit 24:706-710 (2018). Read more (PubMed ... Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein ...
  http://www.abcam.com/calcium-sensing-receptor-antibody-5c10-add-ab19347.html
*  Calcium Sensing Receptor Antibody (Monoclonal, HL 1499)
Calcium Sensing Receptor Monoclonal Antibody from Invitrogen for Western Blot, Immunofluorescence, Immunocytochemistry, ... sensing receptor 1; Parathyroid cell calcium-sensing receptor; Parathyroid cell calcium-sensing receptor 1; Parathyroid Cell ... calcium-sensing receptor; Calcium-sensing receptor (hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism); Calcium ... View (8) other Calcium Sensing Receptor antibodies Invitrogen Calcium Sensing Receptor Monoclonal Antibody (HL 1499). 1 ...
  https://www.thermofisher.com/antibody/product/Calcium-Sensing-Receptor-Antibody-HL-1499-Monoclonal/MA1-16940
*  Calcium-sensing receptor - Wikipedia
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. ... CASRdb - Calcium Sensing Receptor Database, McGill University Receptors, Calcium-Sensing at the US National Library of Medicine ... "Calcium-Sensing Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid ...
  https://en.wikipedia.org/wiki/Calcium-sensing_receptor
*  Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma | Science...
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma ... Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma ... Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma ... Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma ...
  http://stm.sciencemag.org/content/7/284/284ra60.full?ijkey=XKL7zfAv6mOfs&keytype=ref&siteid=scitransmed
*  Frontiers | Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated...
To understand a role for the extracellular calcium-sensing receptor (CaSR) and its noncanonical Wnt mediators, Wnt5a/Ror2, we ... To understand a role for the extracellular calcium-sensing receptor (CaSR) and its noncanonical Wnt mediators, Wnt5a/Ror2, we ... and its receptor TNFR1 play a central role in the development of colitis associated colon cancer. ... and its receptor TNFR1 play a central role in the development of colitis associated colon cancer. ...
  https://www.frontiersin.org/articles/10.3389/fphys.2011.00017/full
*  Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel | Cancer Research
Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel. Rui Xie, Jingyu Xu, ... Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel ... Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel ... Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel ...
  http://cancerres.aacrjournals.org/content/early/2017/09/26/0008-5472.CAN-17-0360
*  A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased...
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gq/11 and Gi/o to stimulate ... The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that plays an important role in extracellular ... A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased ... A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased ...
  http://stke.sciencemag.org/content/11/518/eaan3714
*  Systemic Activation of the Calcium Sensing Receptor Produces Acute Effects on Vascular Tone and Circulatory Function in Uremic...
ABBREVIATIONS: iCa2+, ionized calcium; CaR, calcium-sensing receptor; PTH, parathyroid hormone; R-568, N-(3-[2-chlorophenyl] ... Calcium-sensing receptor (CaR) activation decreases serum parathyroid hormone (PTH) and Ca2+ and, despite long-term reductions ... Ruat M, Molliver ME, Snowman AM, and Snyder SH (1995) Calcium sensing receptor: molecular cloning in rat and localization to ... Ziegelstein RC, Xiong Y, He C, and Hu Q (2006) Expression of a functional extracellular calcium-sensing receptor in human ...
  http://jpet.aspetjournals.org/content/323/1/217
*  Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma...
The calcium-sensing receptor (CaSR) is a class III G-protein-coupled receptor (GPCR) that responds to changes in extracellular ... Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma ... Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma ... Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma ...
  http://jcs.biologists.org/content/118/20/4709
*  CASR elisa kit | Human Extracellular calcium sensing receptor (CASR) ELISA Kit-NP 000379.2
Human Extracellular calcium sensing receptor (CASR) ELISA Kit-NP_000379.2 (MBS7243649) product datasheet at MyBioSource, ELISA ... extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor 1 ... Extracellular calcium sensing receptor (CASR), ELISA Kit. Also Known As Human Extracellular calcium sensing receptor (CASR) ... CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium ...
  https://www.mybiosource.com/prods/ELISA-Kit/Human/Extracellular-calcium-sensing-receptor-CASR/CASR/datasheet.php?products_id=7243649
*  Scholar Spotlight: Rachel Miller is Taking an Interdisciplinary Approach to Understanding Knee Pain | Siebel Scholars
"A lot of top neuroscience labs are trying to figure out the receptors for stimuli such as touch and itch. There are plenty of ... Her time at MIT was especially enjoyable because of the sense of innovation and an environment full of smart people. "Pretty ... Siebel Scholar Rachel Miller using calcium imaging to examine a dorsal root ganglion, a cluster of nerve cell bodies that ...
  http://www.siebelscholars.com/news/scholar-spotlight-rachel-miller-taking-interdisciplinary-approach-understanding-knee-pain
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... sense the environment via functional cell adhesion molecules and inflammatory cytokine and chemokine receptors; (ii) cross the ... In essence, a "calcium roadmap" is provided for how to measure plasticity of astrocytic Gq GPCRs. Applications of the technique ... Receptor tyrosine kinases have been implicated in the development and progression of many cancers, including both leukemia and ... These events include the rapid transport of organelles in axons, calcium responses to injury, and time-lapse studies of the ...
  https://www.jove.com/visualize/abstract/23300962/long-term-in-vivo-imaging-of-multiple-organs-at-the-single-cell-level