B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta
... consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. Studies of Ig alpha or Ig beta have shown ... The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) ... B-cell antigen receptor-induced apoptosis requires both Ig alpha and Ig beta Blood. 1997 Mar 1;89(5):1513-20. ... The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) ...
Receptors, Antigen, T-Cell, alpha-beta | Profiles RNS
Receptors, Antigen, T-Cell, alpha-beta*Receptors, Antigen, T-Cell, alpha-beta ... Antigen, T-Cell, alpha-beta" by people in UAMS Profiles by year, and whether "Receptors, Antigen, T-Cell, alpha-beta" was a ... Receptors, Antigen, T-Cell [D12.776.543.750.705.816.824]. *Receptors, Antigen, T-Cell, alpha-beta [D12.776.543.750.705.816. ... Antigen T Cell Receptor, beta Chain*Antigen T Cell Receptor, beta Chain ...
OR6C4 - Wikipedia
1992). "Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity". J. Immunol. 148 (11 ... Olfactory receptor 6C4 is a protein that in humans is encoded by the OR6C4 gene. Olfactory receptors interact with odorant ... The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding- ... The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and ...
Sjogren Syndrome: Practice Essentials, Etiology, Epidemiology
Expressed antigens include SSA/Ro, SSB/La, alpha-fodrin and beta-fodrin, and cholinergic muscarinic receptors. [13] Dendritic ... These cells are primarily CD4 T cells (75%) and memory cells, with 10% B cells and immunoglobulin-secreting plasma cells. ... Damage and/or cell death due to viral infection or other causes may provide triggering antigens to Toll-like receptors in or on ... Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, Phi Beta ...
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases |...
Thus, administration of flagellin, and perhaps other pathobiont antigens, may confer some protection against chronic ... Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360, 225-231 ... CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 ... Chassaing, B., Ley, R. E. & Gewirtz, A. T. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota ...
Frontiers | Gut Microbiome Contributes to Liver Fibrosis Impact on T Cell Receptor Immune Repertoire
This study investigated the link between GM and the intrahepatic T cell receptor (TCR) immune repertoire (IR), and whether GM ... Furthermore, GM modulated hepatic stellate cell (HSC) activation via TCR IR-mediated intrahepatic immune milieu. Our study ... Furthermore, GM modulated hepatic stellate cell (HSC) activation via TCR IR-mediated intrahepatic immune milieu. Our study ... This study investigated the link between GM and the intrahepatic T cell receptor (TCR) immune repertoire (IR), and whether GM ...
Current DRC investigators
T-lymphocytes receptors, antigen, T-cell, alpha-beta, histocompatibility antigens class II. Dr. Kappler has spent the last 10 ... Diabetes mellitus Type 1, insulin, autoantigens, antigen T-cell receptors, programmed cell death 1 receptor. Dr. Michels ... T-lymphocytes, antigen-presenting cells, myeloid cells, cell communication, cell movement, autoantigens, in vivo imaging. The ... B-lymphocytes receptors, antigen, B-cell, clonal anergy, signal transduction receptors, IgC. The primary goals of Dr. Cambiers ...
NIOSHTIC-2 Search Results - Full View
These HDI-responsive T cells expressed unique oligoclonal gamma/delta rather than alpha/beta T-cell receptors, with ... DNA sequence analysis of T-cell receptors was used to further define clonal populations of HDI-responsive T cells. HDI antigen ... control antigens lead to increased proliferation of specific cell types, CD3+CD4-CD8(dim) and/or CD3+CD4-CD8- cells, from HDI- ... including the cell types involved and the form of the chemical that acts as an antigen. The purpose of this investigation was ...
BUV395 Rat Anti-Mouse Ly-49A
Killer cell lectin-like receptor, subfamily A member 1) which belongs to the C-type lectin superfamily. Ly-49A is comprised of ... Killer cell lectin-like receptor, subfamily A member 1) which belongs to the C-type lectin superfamily. Ly-49A is comprised of ... MHC Class I ligand-bound Ly-49A can negatively regulate NK-cell cytolytic activity via tyrosine phosphorylation of its ITIM.,/ ... MHC Class I ligand-bound Ly-49A can negatively regulate NK-cell cytolytic activity via tyrosine phosphorylation of its ITIM.,/ ...
5til.2 | SWISS-MODEL Template Library
Murine class I major histocompatibility complex H-2 Db in complex with LCMV-derived GP33 altered peptide V3P and T-cell ... H-2 class I histocompatibility antigen, D-B alpha chain: A. Beta-2-microglobulin: B. Alpha chain of murine P14 T cell receptor ... class I major histocompatibility complex H-2 Db in complex with LCMV-derived GP33 altered peptide V3P and T-cell receptor P14 ...
Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor
... encodes for a 397-amino acid receptor that has an amino terminus with no significant homology to the already reported alpha- ... which we have termed the CRF2gamma receptor. The CRF2gamma cDNA ... We report the discovery of a new CRF2 receptor splice isoform ... and beta-termini. When expressed in 293-EBNA (Epstein-Barr nuclear antigen) cells, the CRF2gamma receptor responds in a dose- ... We report the discovery of a new CRF2 receptor splice isoform found in human brain, which we have termed the CRF2gamma receptor ...
Metagenomi to Present Preclinical In Vivo and Ex Vivo Gene-Editing Data at the 63rd American Society of Hematology (ASH) Annual...
... novel gene editing systems were used to disrupt the T cell receptor alpha-chain constant region and the T cell receptor beta- ... Beta-2 microglobulin was edited in 95 percent of T cells. A chimeric antigen receptor (CAR) construct was also shown to be ... Novel gene editing systems are shown to enable efficient and specific edits in T cells, NK cells, and B cells- ... B cell editing occurred in approximately 80% of target cells with successful transgene integration. Whats more, as these gene ...
Anti-CD79 Antibody Offers Novel Approach to Therapy in Autoimmune Disease, Transplantation and Lymphoma
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity. 1999 Feb ... B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol. 1997 Jul 1; ... subunits of the B cell antigen receptor (BCR) become dissociated rendering the receptor incompetent to transduce activating ... is a transmembrane protein found exclusively in B cells that is the transducer component of B-cell receptor (BCR), generating a ...
SMART: MHC II alpha domain annotation
HISTOCOMPATIBILITY ANTIGEN. 1j8h. Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen ... CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, ... MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and ... MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and ...
Frontiers | Long Non-coding RNAs and mRNAs Expression Profiles of Monocyte-Derived Dendritic Cells From PBMCs in AR
... expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). DCs are ... obtained from peripheral blood mononuclear cells (PBMCs). DCs are known to play a major role in the regulating function of ... cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. Conclusions: Our research ... expression profiles of monocyte-derived dendritic cells (DCs) ... Dendritic cells (DCs), which are the most important antigen- ...
2p5w.1 | SWISS-MODEL Template Library
Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry ... HLA class I histocompatibility antigen, A-2 alpha chain: A. Beta-2-microglobulin: B. T-CELL RECEPTOR, ALPHA CHAIN: C. ... 1 x SER- LEU- LEU- MET- TRP- ILE- THR- GLN- CYS: Cancer/testis antigen 1B(Non-covalent). SER-LEU-LEU-MET-TRP-ILE-THR-GLN-CYS.1 ... Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry Coordinates. ...
SMART: IG domain annotation
CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, ... Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, ... AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY. ... Structure of New Antigen Receptor variable domain from sharks. 1ves. Structure of New Antigen Receptor variable domain from ...
Clinical Significance | Nanopia IL-2R | SEKISUI MEDICAL CO., LTD.
Interleukin-2-Receptor (IL-2R) is a protein that is expressed on the cell surface of T and B cells upon activation of by ... antigen stimulation. IL-2R is composed of 3 chains, alpha, beta, and gamma. ... sIL-2R are alpha chains of the IL-2R which have been cleaved by protease and released into blood. ... Measuring soluble Interleukin-2 Receptor (sIL-2R) can be useful in the aid-in-diagnosis of Non-Hodgkin lymphoma and ATL (adult ...
SMART: IG domain annotation
CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE, ... Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, ... AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY. ... Structure of New Antigen Receptor variable domain from sharks. 1ves. Structure of New Antigen Receptor variable domain from ...
Human HLA-DR Alexa Fluor® 700-conjugated Antibody FAB4869N-100: R&D Systems
DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC Class II DR; MLRW ... It presents these peptides on the cell surface for recognition by the T cell receptor on CD4+ T cells. This interaction is ... beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from ... FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLADR; HLA-DR; HLA- ...
Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an...
U937 Cells. *T-Lymphocyte Subsets. *Receptors, Antigen, T-Cell, alpha-beta. *Peptides ... Testing of T cell-based cancer therapeutics often involves measuring cancer antigen-specific T-cell populations with the ... Using tetramer-based, single-cell sorting and T-cell receptor β (TCRβ) sequencing, we identified recurrent UNC-CDK4-1 tetramer- ... Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an ...
Reactome | MyrG2-BLK [plasma membrane]
Anti-TCR V delta 1 antibody [TS8.2] (GTX79232) | GeneTex
In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both ... T cell receptor delta variable 1 , hDV101S1 Background T cell receptors recognize foreign antigens which have been processed as ... molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one ... the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor ...
anti-TCR Vβ3 (Pur/PF) - Ancell Corporation
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCRs recognize ... antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4). ... Human HA1.7 TCR beta chain expressed on transgenic mouse cells. Specificity: Antibody JOVI-3 is specific for the human V beta 3 ... Functional Application: Antibody JOVI-3 is mitogenic for T cells expressing TCR V beta 3. ...
Anti-Rt TCR alpha/beta FITC - EXBIO Antibodies
Antigen description The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta ... The mouse monoclonal R73 recognizes an extracellular epitope TCR alpha/beta, the dominant subtype of T cell receptor expressed ... A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential ... Exbio - Research products - Antibodies - CD and related antigens - Anti-Rt TCR alpha/beta FITC ...
A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires.
Receptors, Antigen, T-Cell, alpha-beta. Receptors, Antigen, T-Cell, gamma-delta ... The process of V(D)J recombination assembles T cell receptor (TCR) genes (α,β,γ,δ) from variable (V), ... and is essential for the formation of diverse antigen receptor repertoires on αβ and γδ T lymphocytes. ... The locus encoding the T cell antigen receptor (TCR) α-chain and δ-chain (Tcra-Tcrd) undergoes recombination of its variable- ...
WikiGenes - Fluorescent Antibody Technique
Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor. Almeida, E.A., Huovila, A.P., Sutherland, A.E., Stephens, L.E ... The detection by the immunofluorescence assay of 10 to 20 times more antigen-positive cells in n-butyrate-treated BC-1 cells ... Immunofluorescence revealed alpha 6 beta 1 and alpha v beta 3 on the plasma membrane [23]. ... Characterization of cross-reacting antigens on the Epstein-Barr virus envelope and plasma membranes of producer cells. Thorley- ...
CD247 Protein Human Recombinant | CD3Z Antigen | ProSpec
CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3- ... T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD3Z, T3Z, TCRZ, CD3H, CD3Q, CD3-ZETA. ... gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen ... T-cell surface glycoprotein CD3 zeta chain (CD247) is a member of the CD3Z/FCER1G family. ...
CD8A - wikidoc
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen ... or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to ... "The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions". Cell. 40 (3 ... The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell ...