*  ADRB3 - SNPedia
ADRB3, the β3-adrenergic receptor, has been connected to obesity and metabolic conditions. ... adrenergic, beta-3-, receptor. EntrezGene. 155. PheGenI. 155. VariationViewer. 155. ClinVar. ADRB3. ...
  https://snpedia.com/index.php/ADRB3
*  Beta-3 adrenergic receptor - Wikipedia
Other adrenergic receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic ... "Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 ... is a beta-adrenergic receptor, and also denotes the human gene encoding it. Actions of the β3 receptor include Enhancement of ... Beta adrenergic receptors are involved in the epinephrine- and norepinephrine-induced activation of adenylate cyclase through ...
  https://en.wikipedia.org/wiki/Beta-3_adrenergic_receptor
*  Developing Functional Monoclonal Antibodies for Beta-3 Adrenergic Receptor
Our preliminary data showed that several mAb clones speci cally bound to the receptor while increasing the receptor function by ... Developing Functional Monoclonal Antibodies for Beta-3 Adrenergic Receptor Poster Sep 10, 2014 ... G protein-coupled receptors (GPCRs), one of the most commonly used and successful targets for drugs, are a large family of ... These cell surface receptors are acted on by a wide variety of ligands, including small molecules and soluble proteins. ...
  https://www.technologynetworks.com/tn/posters/developing-functional-monoclonal-antibodies-for-beta3-adrenergic-receptor-229675
*  W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample - UCL Discovery
ADRENERGIC RECEPTOR, INSULIN-RESISTANCE, TRP64ARG MUTATION, OBESITY, POLYMORPHISM, ASSOCIATION, GAIN, FAT. UCL classification: ... W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. INT J OBESITY , 22 (4) 377 - 379. ... W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample ... W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. ...
  http://discovery.ucl.ac.uk/97255/
*  AID 310238 - Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP level relative to...
Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP level relative to isoproterenol. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/310238
*  A Study to Investigate the Effect of Mirabegron (YM178) on Subjects With Mild or Moderate Hepatic Impairment Compared to...
Adrenergic beta-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ...
  https://clinicaltrials.gov/show/NCT01579461
*  Patent US5164190 - Subsaturated transdermal drug delivery device exhibiting enhanced drug flux - Google Patents
60/22.5/10/2.5/2.5/2.5 25 3 5.52 1.38 EtOH/H.sub.2 O/Gly/GDO/ML/OA4. 60/22.5/10/2.5/2.5/2.5 75 8 3.35 2.18 EtOH/H.sub.2 O/Gly/ ... 60/28/10/1/1 30 3 13.03 3.35 EtOH/H.sub.2 O/Gly/GMO/ML3. 60/28/10/1/1 25 3 12.98 2.06 EtOH/H.sub.2 O/Gly/GMO/ML4. 60/28/10/1/1 ... 40/54/5/1 40 5 38.8 18.9 EtOH/H.sub.2 O/Gly/GMO 20 12 17.5 5.1 10 6 10.1 3.3 5 3 8.0 1.43. 30/63/5/2 40 6 23.9 10.0 EtOH/H.sub. ... 50/49/1 80 75 3 96.5 9.2 EtOH/H.sub.2 O/GMO 40 75 9 37.4 11.0 20 75 3 25.1 1.93. 50/44/5/1 80 75 6 78.4 36.5 EtOH/H.sub.2 O/Gly ...
  http://www.google.com.au/patents/US5164190
*  Annotation score: 3 out of 5
beta3-adrenergic receptor activity Source: Ensembl. *epinephrine binding Source: Ensembl. *norepinephrine binding Source: ... G-protein coupled receptorUniRule annotation. ,p>Information which has been generated by the UniProtKB automatic annotation ... Belongs to the G-protein coupled receptor 1 family.UniRule annotation. ,p>Information which has been generated by the UniProtKB ... It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel ...
  http://www.uniprot.org/uniprot/Q3UP63
*  KAKEN - Research Projects | treatment using adenovirus vector (KAKENHI-PROJECT-09357009)
This gene, designated WFS1, must have an important role in survival of pancreatic beta cells and neuronal cells. We also found ... Nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.'Diabetes. 49 ... Publications] Ueda K, et al.: 'Prevalence of the Trp64Arg missense mutation of the beta 3-adrenergic receptor gene in Japanese ... Nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.'Diabetes. 49 ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09357009/
*  Dr. Robert Hart
Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.. Source: J Med Chem ... adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.. ... Synthesis and evaluation of potent and selective beta(3) ... 3)-Al(2)O(3) glasses.. Source: J Phys Condens Matter ... Comparative utility of Barona Formulae, Wtar demographic algorithms, and WRAT-3 reading for estimating premorbid ability in a ...
  http://www.phri.ca/people/dr-robert-hart/
*  Interleukin Genetics Receives Notice of Allowance for US Patent for PerioPredict Genetic Risk Test - Bay City Capital
... adrenergic receptor beta 2 (ADRB2 - two SNPs); adrenergic receptor beta 3 (ADRB3); and peroxisome proliferator-activated ... receptor gamma (PPAR-γ). These markers are involved in certain physiological pathways relating to body weight. Certain patterns ...
  http://baycitycapital.com/portfolio-news/interleukin-genetics-receives-notice-of-allowance-for-us-patent-for-periopredict-genetic-risk-test/
*  Maturity-Onset Diabetes of the Young, Type 10 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Adrenergic Agonists. Phase 4. 18. Adrenergic beta-3 Receptor Agonists. Phase 4. ... Selective Estrogen Receptor Modulators. Phase 2. 38. Testosterone 17 beta-cypionate. Phase 2. ... 17-Hydroxy-(17-beta)-androst-4-en-3-one. 17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- ... 3. INS p.Arg46Gln. VAR_063729 rs121908260 ClinVar genetic disease variations for Maturity-Onset Diabetes of the Young, Type 10: ...
  http://www.malacards.org/card/maturity_onset_diabetes_of_the_young_type_10
*  US8110591B2 - 2-aminoaryloxazole compounds as tyrosine kinase inhibitors - Google Patents
More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors. ... Beta3 adrenergic receptor agonists and uses thereof US20070021447A1 (en) 2007-01-25. 2-Imino-4-(thio)oxo-5-poly ... Among tyrosine kinase receptors, c-kit is of special interest. Indeed, c-kit is a key receptor activating mast cells, which ... Tyrosine kinases are receptor type or non-receptor type proteins, which transfer the terminal phosphate of ATP to tyrosine ...
  https://patents.google.com/patent/US8110591?oq=inassignee%3Adoubleclick
*  Isoprenaline - DrugBank
... beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as ... Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. [ ... Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. [ ... Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. [ ...
  https://www.drugbank.ca/drugs/DB01064
*  ICI-118,551 - Wikipedia
"Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic ... Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed ... ICI-118,551 is a selective β2 adrenergic receptor (adrenoreceptor) antagonist. ICI binds to the β2 subtype with at least 100 ... therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, ...
  https://en.wikipedia.org/wiki/ICI-118,551
*  DailyMed - MYRBETRIQ- mirabegron tablet, film coated, extended release
Although mirabegron showed very low intrinsic activity for cloned human beta-1 AR and beta-2 AR, results in humans indicate ... Mirabegron is a beta-3 adrenergic agonist. The chemical name is 2-(2-aminothiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl] ... MYRBETRIQ® is a beta-3 adrenergic agonist indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary ... MYRBETRIQ® is a beta-3 adrenergic agonist indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ba9e9e15-e666-4c56-9271-2e24739cfa2d
*  Frontiers | TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue | Endocrinology
We recently described an important role played by the TGF-beta/Smad3 signaling pathway in modulating the appearance of brown ... We recently described an important role played by the TGF-beta/Smad3 signaling pathway in modulating the appearance of brown ... Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure ... beta3-adrenergic receptors mediate CL 316,243 agonist-induced effects on energy expenditure, insulin secretion, and food intake ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00035/full
*  Table of Contents | Diabetes
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell ... Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes. M P Hermans, J C Levy, R ... A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor. B D Mitchell, S A Cole, A G ... Human insulin receptor substrate-2: gene organization and promoter characterization. L Vassen, W Wegrzyn and L Klein-Hitpass ...
  http://diabetes.diabetesjournals.org/content/48/9
*  Adrb3 (mouse, intracellular) Antibody (internal region, near C-Term) - Peptide-affinity purified goat antibody E - Buy Now! ...
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. ... Autophagy Receptor Motif Plotter. The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in ... Beta-3 is involved in the regulation of lipolysis and thermogenesis.. Cellular Location Cell membrane; Multi-pass membrane ... Beta-3 adrenergic receptor, Beta-3 adrenoreceptor, Beta-3 adrenoceptor, ADRB3, ADRB3R, B3AR. ...
  http://www.abgent.com/products/AF3680a-Adrb3-mouse-intracellular-Antibody-internal-region-near-C-Term
*  Urinary Incontinence Treatment & Management: Approach Considerations, Absorbent Products, Urethral Occlusion
Beta-adrenergic agonists. These agents relax beta-adrenergic receptors that are contained in smooth muscle, such as the bladder ... Alpha-adrenergic agonists. Alpha agonists, such as midodrine (Pro-Amatine) or pseudoephedrine (Sudafed), may improve symptoms ... Mirabegron (Myrbetriq), a beta-3 adrenergic receptor agonist, causes relaxation of the detrusor miuscle and increases bladder ... It has an alpha-adrenergic effect on the bladder neck, an antispasmodic effect on the detrusor muscle, and a local anesthetic ...
  https://emedicine.medscape.com/article/452289-treatment
*  Adrenergic Receptors
... surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, ... adrenergic receptor. Science 245: 1118-1121. Hadcock JR and Malbon CC (1988) Down‐regulation of betaadrenergic receptors: ... 1996) The betaadrenergic receptor is a substrate for the insulin receptor tyrosine kinase. Journal of Biological Chemistry 271 ... Lefkowitz RJ (1998) G protein‐coupled receptors. III. New roles for receptor kinases and beta‐arrestins in receptor signalling ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0000005.html
*  Patents filed at Nov 14 2017 | Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug...
A novel combination comprising a .beta.-hairpin peptidomimetic of the formula cyclo(-Thr-Trp-Ile-Dab-Orn-.sup.DDab-Dab-Trp-Dab- ... Methods and compositions comprising desmopressin in combination with a beta-3-adrenergic receptor agonist. The invention ... in combination with a beta-3-adrenergic receptor agonist. The methods and compositions... ... Use of 2-methylene-19-nor-(20S)-1.alpha.,25-dihydroxyvitamin D.sub.3 and calcimimetics to treat secondary.... Disclosed are ...
  http://www.patents.com/isd-20171114-p112.html
*  Mechanisms Involved in alpha(1B)-Adrenoceptor Desensitization
alpha(1B)-Adrenergic receptors mediate many of the actions of the natural catecholamines, adrenaline and noradrenaline. They ... TGF-beta, and estrogens. Key protein kinases for these effects are G protein coupled receptor kinases and protein kinase C. The ... Many hormones and neurotransmitters are capable of inducing alpha(1B)-adrenergic receptor phosphorylation and desensitization; ... The complex regulation of these receptors unlocks opportunities for therapeutic intervention. (C) 2011 IUBMB IUBMB Life, 63(10 ...
  http://www.ifc.unam.mx/publications/mechanisms-involved-in-alpha1b-adrenoceptor-desensitization