*  Chrm4 - Muscarinic acetylcholine receptor M4 - Rattus norvegicus (Rat) - Chrm4 gene & protein
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown ... Cluster: Muscarinic acetylcholine receptor M2. 391. Full view. ,p>This section is used to point to information related to ... Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.PROSITE- ... Muscarinic acetylcholine receptor M4Add BLAST. 478. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
  http://www.uniprot.org/uniprot/P08485
*  Regulator of G-protein signaling 7
Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/ ... Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 ... the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater ... Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G ...
  https://pharos.nih.gov/idg/targets/P49802
*  The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder | Journal of Pharmacology...
The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder. Frederick J. Ehlert, ... The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder. Frederick J. Ehlert, ... The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder. Frederick J. Ehlert, ... The M2 Muscarinic Receptor Mediates Contraction through Indirect Mechanisms in Mouse Urinary Bladder ...
  http://jpet.aspetjournals.org/content/early/2004/12/17/jpet.104.077909
*  Muscarinic acetylcholine receptor M2 - Wikipedia
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine ... "Acetylcholine receptors (muscarinic): M2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... M2 muscarinic receptors act via a Gi type receptor, which causes a decrease in cAMP in the cell, generally leading to ... "Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor. Analysis of the role of N-glycosylation in receptor ...
  https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2
*  Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose...
M2 and M3 muscarinic receptor-dependent transduction pathways. Duodenum myocytes express both M2 and M3 muscarinic receptors ( ... Ca2+ oscillations were selectively inhibited by methoctramine (a M2 muscarinic receptor antagonist). The M2 muscarinic receptor ... suggest that M3 and M2 muscarinic receptor subtypes activate two different pathways and that only the M2 muscarinic receptor- ... the first one involves the M3 muscarinic receptor subtype and InsP3Rs and the second one involves the M2 muscarinic receptor ...
  http://jcs.biologists.org/content/118/10/2261
*  Beta-Adrenoceptor-medicated down-regulation of M2 muscarinic receptors: role of cyclic adenosine 5'-monophosphate-dependent...
Chronic (24 hr) treatment with 8-bromo-cAMP also had no effect on m2 muscarinic receptor mRNA, whereas forskolin caused a 50% ... Furthermore, a role is suggested for cAMP-dependent kinase and PKC in M2 muscarinic receptor down-regulation and their ... Collectively, these results suggest that transregulation of M2 muscarinic receptors by beta2-adrenoceptor stimulation can be ... Beta-Adrenoceptor-medicated down-regulation of M2 muscarinic receptors: role of cyclic adenosine 5'-monophosphate-dependent ...
  http://molpharm.aspetjournals.org/content/49/4/629
*  Muscarinic Acetylcholine Receptor M2 (CHRM2) - Pipeline Review, H1 2018
Muscarinic Acetylcholine Receptor M2 (CHRM2) pipeline Target constitutes close to 8 molecules. The latest report Muscarinic ... Muscarinic Acetylcholine Receptor M2 (CHRM2) - Pipeline Review, H1 2018 ... Muscarinic Acetylcholine Receptor M2 (CHRM2) - Pipeline Review, H1 2018. Summary. Muscarinic Acetylcholine Receptor M2 (CHRM2) ... Muscarinic Acetylcholine Receptor M2 (CHRM2) - Muscarinic cholinergic receptor 2 is an acetylcholine receptor. It is expressed ...
  https://www.jsbmarketresearch.com/pharmaceuticals/muscarinic-acetylcholine-receptor-m2-chrm2-pipeline-review-h1-2018
*  Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung. - Semantic Scholar
m2-Muscarinic receptor predominated in tracheal muscle (372 +/- 85 fmol/mg protein) with fewer m3 receptors (48 +/- 5 fmol/mg ... coupling of muscarinic receptors to the inhibition of adenylyl cyclase was related to the presence of m2-muscarinic receptors ... regions of the lung and relate the ability to measure muscarinic inhibition of adenylyl cyclase to the presence of m2 receptors ... Immunoprecipitation identified more total muscarinic receptors in trachealis muscle than in bronchi or lung. ...
  https://www.semanticscholar.org/paper/Expression-of-muscarinic-receptor-subtypes-and-of-Emala-Aryana/bb7c8db531797790c417d80a1f3cc44a9a03e785
*  Association of autoantibodies against the M2-muscarinic receptor with perinatal outcomes
M2-AAB: autoantibodies against M2-muscarinic receptors; SPE: severe preeclampsia; NP: normal pregnant; NC: non-pregnant control ... The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor (M2-AAB) are ... Previous studies have described the role of autoantibodies against M2-muscarinic receptors (M2-AAB) in © 2013 Li et al.; ... doi:10.1186/1479-5876-11-285 Cite this article as: Li et al.: Association of autoantibodies against the M2-muscarinic receptor ...
  http://spotidoc.com/doc/10888/association-of-autoantibodies-against-the-m2-muscarinic-r..
*  Muscarinic (M2) Receptors - Fatty Acid Synthase Inhibitors Induce Apoptosis
Category: Muscarinic (M2) Receptors. Posted on June 8, 2017. The capability to generate a particular and long-lived antibody ... and interaction with various Fc receptors or the polyimmunoglubilin receptor. Following diversification of the repertoire, ... Figure 1 Diversity in the antigen-combining site of the B cell receptor repertoire (and thus also in the corresponding secreted ...
  http://aksumuniversity.org/category/muscarinic-m2-receptors/
*  Gentaur Molecular :Neuromi \ Muscarinic Acetylcholine Receptor M2, monoclonal antibody, mouse, 100 ul. \ MO19009-100
Muscarinic Acetylcholine Receptor M2, monoclonal antibody, mouse, 100 ul. \ MO19009-100 for more molecular products just ... Muscarinic acetylcholine receptor M5. [CHRM2] Muscarinic acetylcholine receptor M2. [CHRM1] Muscarinic acetylcholine receptor ... Muscarinic acetylcholine receptor M2. [CHRM3] Muscarinic acetylcholine receptor M3. [Chrm5] Muscarinic acetylcholine receptor ... Muscarinic acetylcholine receptor M3. [CHRM2] Muscarinic acetylcholine receptor M2. [CHRM4] Muscarinic acetylcholine receptor ...
  http://www.antibody-antibodies.com/product_det.php?id=1780684&supplier=search&name=Muscarinic%20Acetylcholine%20Receptor%20M2,%20monoclonal%20antibody,%20mouse,%20100%20ul
*  M2, M3 and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons |...
M2, M3 and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons. Hong- ... M2, M3 and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons. Hong- ... M2, M3 and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons. Hong- ... M2, M3 and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons ...
  http://jpet.aspetjournals.org/content/early/2005/01/07/jpet.104.079939
*  Leicester Research Archive: COUPLING OF MUSCARINIC M1, M2 AND M3 ACETYLCHOLINE-RECEPTORS, EXPRESSED IN CHINESE-HAMSTER OVARY...
COUPLING OF MUSCARINIC M1, M2 AND M3 ACETYLCHOLINE-RECEPTORS, EXPRESSED IN CHINESE-HAMSTER OVARY CELLS, TO PERTUSSIS-TOXIN- ...
  https://lra.le.ac.uk/handle/2381/22451
*  M2 subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: effect of chemical homo-dimerization on orthosteric ...
M4 and M5 with respect to receptor subtype selectivity. The side chain of the known M2 preferring muscarinic receptor ... exhibited the highest M2 receptor affinities (pIC50 = 9.0 and 9.2, resp.). At the M2 receptor a steep curve slope of -2 was ... M2 subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: effect of chemical homo-dimerization on orthosteric ... at the muscarinic receptor subtype M2, and seven selected compounds were additionally investigated at M1, M3, M4 and M5 with ...
  https://epub.uni-regensburg.de/30900/
*  Physiology Flashcards by Rebecca Thomas | Brainscape
what muscarinic receptors in the heart are acted on by the parasympathetic system? ... M2 muscarinic receptors. (ACh) 40 why is atropine used in extreme bradycardia to speed up the heart? ...
  https://www.brainscape.com/flashcards/physiology-3679262/packs/5482599
*  Chapter 5 - Regulation Of The Heart Flashcards by Tanaka Makamure | Brainscape
Muscarinic, M2 Receptor. Short latency because no need for 2nd messenger, Ach opens K+ channels. Rapid decay because nodes are ... B1 receptor - Nodes, myocardium. B2 receptor - Blood vessels. Both receptors are Gs, GPCRs.. Longer latency since cAMP build up ... Binds to M2 receptors>deactivates adenyl cyclase>decreases cAMP>Inactivates Protein kinase A.. Also released Ach suppresses ... Pressure receptors. Both atria have receptors that influence heart rate. They are located principally in the venoatrial ...
  https://www.brainscape.com/flashcards/chapter-5-regulation-of-the-heart-6145395/packs/9460358
*  Anti-Muscarinic Acetylcholine Receptor 2 antibody [EPR4568] (ab109226)
Rabbit recombinant monoclonal Muscarinic Acetylcholine Receptor 2 antibody [EPR4568] validated for WB, IP, IHC and tested in ... Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models. ... Anti-Muscarinic Acetylcholine Receptor 2 antibody [EPR4568]. See all Muscarinic Acetylcholine Receptor 2 primary antibodies. ... Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. ...
  http://www.abcam.com/muscarinic-acetylcholine-receptor-2-antibody-epr4568-ab109226.html
*  Compound Report Card
Muscarinic acetylcholine receptor M2 Homo sapiens 0.216 Show More. 10uM. ChEMBL_ID. Target Name. Organism. Score. ...
  https://www.ebi.ac.uk/chembldb/compound/inspect/CHEMBL278020
*  Compound Report Card
Muscarinic acetylcholine receptor M2 Rattus norvegicus 1.000 CHEMBL320 Muscarinic acetylcholine receptor M3 Rattus norvegicus ... Muscarinic acetylcholine receptor M2 Rattus norvegicus 1.000 CHEMBL320 Muscarinic acetylcholine receptor M3 Rattus norvegicus ... Muscarinic acetylcholine receptor M1 Rattus norvegicus 1.000 CHEMBL317 Muscarinic acetylcholine receptor M4 Rattus norvegicus ... Muscarinic acetylcholine receptor M1 Rattus norvegicus 1.000 CHEMBL317 Muscarinic acetylcholine receptor M4 Rattus norvegicus ...
  https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL9967
*  CHEMBL34833 Compound Report Card
Muscarinic acetylcholine receptor M2 Sus scrofa 0.967 CHEMBL1741179 Probable DNA dC->dU-editing enzyme APOBEC-3A Homo sapiens ... Orphan nuclear receptor LRH-1 Homo sapiens 0.970 CHEMBL4781 ... Adenosine A3 receptor Homo sapiens 0.795 CHEMBL3691 Autotaxin ... Lysophosphatidic acid receptor Edg-4 Homo sapiens 0.803 CHEMBL256 ... Lysophosphatidic acid receptor Edg-7 Homo sapiens 0.893 CHEMBL3724 ...
  https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL34833
*  Search of: 'Sudden infant death syndrome' - List Results - ClinicalTrials.gov
Muscarinic M2 receptor mRNA expression in blood. *Acetylcholinesterase mRNA expression in blood ... Apparent Life Threatening Events, Sudden Infant Death Syndrome and Muscarinic Receptors. *Apparent Life-Threatening Event in ...
  https://clinicaltrials.gov/ct2/results?cond=%22Sudden+infant+death+syndrome%22&show_rss=Y&sel_rss=new14
*  Compound Report Card
Muscarinic acetylcholine receptor M2 Homo sapiens 0.300 Show More. Calculated Compound Parent Properties. Mol. Weight. Mol. ... Muscarinic acetylcholine receptor M1 antagonist Muscarinic acetylcholine receptor M1 DailyMed ISBN Indications MESH Heading. ... Alpha-1b adrenergic receptor Rattus norvegicus 0.358 CHEMBL211 ... Sigma opioid receptor Homo sapiens 0.853 CHEMBL320 Muscarinic ... Muscarinic acetylcholine receptor M1 Homo sapiens 0.974 CHEMBL287 ...
  https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1101
*  Plus it
8A). In ICSMCs from control rats, western blot analysis confirmed the basal expression of both muscarinic M2 and M3 receptors. ... Western blot analysis of muscarinic M2 and M3 receptors in the colonic neuromuscular layer (A) and ICSMCs (B) from control rats ... Western Blot Analysis of Muscarinic M2 and M3 Receptors in Colonic Tissues and ICSMCs.. Colonic specimens were dissected to ... To address this issue, we examined the expression of muscarinic M2 and M3 receptors in specimens of the colonic neuromuscular ...
  http://jpet.aspetjournals.org/content/356/2/434
*  Ch. 7 Pharmacology & Therapeutics Flashcards - ACAAI Review 3rd Edition | Brainscape
Ipratropium blocks M2 and M3 receptors with equal affinity, blocking of M2 receptors can lead to? ... Which muscarinic receptor is the primary mediator of smooth muscle contraction in human airways? ... bronchoconstriction (blocking M2 receptors leads to increase Ach release, thus why you can see paradoxical bronchoconstriction ... binds to B2 receptor (GPCR), activates adenylate cyclase, increases cAMP, activating PKA, leading to phosphorylation and muscle ...
  https://www.brainscape.com/flashcards/ch-7-pharmacology-amp-therapeutics-6139580/packs/9442599
*  Elevated Intraocular Pressure - DrugBank
Muscarinic acetylcholine receptor M1. target. DB01085. Pilocarpine. Muscarinic acetylcholine receptor M2. target. ... A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of ...
  https://www.drugbank.ca/indications/DBCOND0034700