*  CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids | PNAS
... a CB2 cannabinoid receptor-selective antagonist and was not observed in skin from CB2 cannabinoid receptor-deficient mice. ... Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain ... Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3 ... CB2 cannabinoid receptors have not been found in the CNS or on peripheral neurons, suggesting that activation of CB2 receptors ...
  http://www.pnas.org/content/102/8/3093
*  A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in...
After the discovery of endogenous ligands of CB1 and CB2 receptors and of nonclassical cannabinoids a multitude of structure- ... A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in ... hCB2 Receptor Binding Results. Table 7 indicates that the order of importance of the variables is , , . Table 8 shows that no ... cannabinoids [20]. From this last work it was concluded that CB1 and CB2 receptor affinities are regulated by different ...
  https://www.hindawi.com/journals/jqc/2014/431432/
*  A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in...
A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in ... LXXIX: cannabinoid receptors and their ligands: beyond CB1 and CB2," Pharmacological Reviews, vol. 62, no. 4, pp. 588-631, 2010 ... L. Console-Bram, J. Marcu, and M. E. Abood, "Cannabinoid receptors: nomenclature and pharmacological principles," Progress in ... R. Silvestri, A. Ligresti, G. L. Regina et al., "Synthesis, cannabinoid receptor affinity, molecular modeling studies and in ...
  https://www.hindawi.com/journals/jqc/2014/431432/ref/
*  The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained...
The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained ... The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained ... The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained ... The slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained ...
  http://molpharm.aspetjournals.org/content/early/2017/11/30/mol.117.109355/tab-article-info
*  Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90...
First, CB2 receptor complex was pulled down from HEK293 cells stably expressing FLAG-CB2 with an anti-CB2 antibody and ... Hsp90 may function as a scaffold orienting Gαi2 to interact with the CB2 receptor or stabilizing CB2 receptor on the cell ... Verification of the Interaction between Hsp90 and CB2 Receptor. The association of Hsp90 with CB2 receptor was confirmed by ... Furthermore, we demonstrate that Hsp90 is involved in the CB2 receptor signaling and CB2 receptor-mediated cell migration. ...
  http://molpharm.aspetjournals.org/content/72/5/1289
*  CB2 - Cannabinoid - GPCR - Receptors - Products
Cannabinoid receptor subtypes listed: CB1, CB2, GPR55, GPR119. [1] P. Joost, A. Methner. Phylogenetic analysis of 277 human G- ... CB2. Based on phylogenetic analysis, the family of cannabinoid receptors is separated into two different classes of the ... While CB1 and CB2 receptors share a group together with lysophospholipid (LPL) and melanocortin receptors (GPCR-A13), the newly ... and other LPL receptors[1]. Two orphan GPCRs have recently been implicated as novel cannabinoid receptors; these are GPR119, ...
  https://www.axonmedchem.com/products/receptors/gpcr/cannabinoid/cb2
*  Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor | BenthamScience
Keywords:Cannabinoid receptors, CB2, GPCRs, selective ligand, structure-activity relationship.. Abstract:Cannabinoid receptors ... Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor. Author(s): Shuang Han, Jiong ... Cannabinoid CB2 receptor, which mainly locates in peripheral tissues, represents as a promising drug target for the treatment ... Cannabinoid CB2 receptor, which mainly locates in peripheral tissues, represents as a promising drug target for the treatment ...
  http://www.eurekaselect.com/121839/article
*  Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. | Molecular Pharmacology
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... The recently cloned CB2 cannabinoid receptor subtype was stably transfected into AtT-20 and Chinese hamster ovary cells to ...
  http://molpharm.aspetjournals.org/content/48/3/443.short
*  "Molecular characterization of cannabinoid CB2 receptor-ligand interact" by Jenine Kay Sanzari
The cannabinoid CB2 receptor, a G-protein coupled receptor, is an important target for therapeutics involving inflammation, ... Studying receptor-ligand interactions of the CB2 receptor is the main focus of this dissertation. First, human embryonic kidney ... In conclusion, transmembrane helix 2 of the CB2 receptor demonstrates a role in CB2 species-selectivity. The molecular ... more than a 10-fold higher binding affinity at the mouse CB2 receptor compared to human CB2, resulting in species-selectivity. ...
  https://opencommons.uconn.edu/dissertations/AAI3239572/
*  Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis |...
212-2 acts through both CB1 and CB2 receptors whereas JWH-133 being a CB2 specific ligand acts only through CB2 receptors. A ... Cannabinoid receptors are expressed in human lung cancers. Cannabinoid receptors have been shown to be overexpressed in ... These cannabinoids bind to 2 different cell surface G-protein-coupled receptors (GPCR), CB1 and CB2. CB1 receptor is ... CB1 and CB2. Synthetic cannabinoids, especially JWH, has been shown to specifically bind to CB2 receptor whereas ...
  http://cancerpreventionresearch.aacrjournals.org/content/4/1/65.full
*  Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis | DIAL.pr -...
Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis. In: ACS ... The CB2 cannabinoid receptor has been implicated in the regulation of intestinal inflammation. Following on from the promising ... Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis Primary tabs. ... Home» Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:157082
*  Frontiers | Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms | Pharmacology
... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... it has become clear that not all effects of cannabinoid drugs are attributable to their interaction with CB1 and CB2 receptors ... Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 ... Cannabinoids produce many of their cellular and organ system effects by interacting with the well-characterized CB1 and CB2 ...
  https://www.frontiersin.org/articles/10.3389/fphar.2017.00720/full
*  A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB2 receptor | RTI
... the hypothesis that an amide carbonyl may serve as a hydrogen bond acceptor in interactions with the CB1 cannabinoid receptor. ... of the potent bicyclic cannabinoid CP 47,497 (6) has been synthesized as a model for one conformational isomer of anandamide ... 2001). A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB2 receptor. Bioorganic and ... A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB2 receptor. ...
  https://www.rti.org/publication/pyridone-analogue-traditional-cannabinoids-new-class-selective-ligands-cb2-receptor
*  CANNABINOID CB2 AND μ-OPIOID RECEPTORS SIGNALLING IN MICROGLIAL CELLS: POTENTIAL TARGETS TO INCREASE CLINICAL EFFICACY OF...
2015) CANNABINOID CB2 AND μ-OPIOID RECEPTORS SIGNALLING IN MICROGLIAL CELLS: POTENTIAL TARGETS TO INCREASE CLINICAL EFFICACY OF ... CANNABINOID CB2 AND μ-OPIOID RECEPTORS SIGNALLING IN MICROGLIAL CELLS: POTENTIAL TARGETS TO INCREASE CLINICAL EFFICACY OF ... Two subtypes of the mammalian cannabinoid receptors, CB1 and CB2, have been identified. Opioids produce their pharmacological ... Interestingly, receptors for opioids and cannabinoids are coupled to similar intracellular signalling mechanisms leading to a ...
  http://eprints.unife.it/1065/
*  NOVEL CANNABINOID RECEPTOR 2 (CB2) INVERSE AGONISTS AND THERAPEUTIC POTENTIAL FOR MULTIPLE MYELOMA AND OSTEOPOROSIS BONE...
0066] "CBI" is an abbreviation for "cannabinoid receptor subtype-1." [0067] "CB2" is an abbreviation for "cannabinoid receptor ... Also provided is a method for modulating the activity of a cannabinoid receptor-2 (CB2) by contacting a CB2 receptor with a ... cannabinoid receptor-2 (CB2) in a subject, includes contacting the CB-2 receptor with a compound of Formula IV: ##STR00087## In ... class of compounds to selectively modulate the CB2 receptor. [0008] The cannabinoid receptor subtypes CB 1 (brain) and CB2 ( ...
  http://www.patentsencyclopedia.com/app/20130172388
*  Cannabinoid Inhibition of the Processing of Intact Lysozyme by Macrophages: Evidence for CB2 Receptor Participation | Journal...
cannabinoid. CB1. cannabinoid receptor 1. CB2 cannabinoid receptor 2. HEL, hen egg lysozyme. IL-2. interleukin-2. MHC. major ... Two receptor subtypes have been described and are called cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Both ... whereas the CB2 receptor primarily occurs in the peripheral immune tissues. The CB2 receptor is expressed on B cells, natural ... Cannabinoid Inhibition of the Processing of Intact Lysozyme by Macrophages: Evidence for CB2 Receptor Participation. Kathleen L ...
  http://jpet.aspetjournals.org/content/289/3/1620
*  Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of...
GW405833, widely accepted as a cannabinoid receptor 2 (CB2) agonist, suppresses pathologic pain in preclinical models without ... Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of ... CB2 Receptors in Mice Message Subject (Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental ... Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB ...
  http://jpet.aspetjournals.org/content/362/2/296
*  Compound Report Card
Cannabinoid CB2 receptor Homo sapiens 1.000 CHEMBL5373 Cannabinoid CB2 receptor Mus musculus 1.000 ... Cannabinoid CB1 receptor agonist Cannabinoid CB1 receptor DailyMed PubMed Indications MESH Heading. MESH ID. EFO ID. EFO Term. ... Cannabinoid CB1 receptor Homo sapiens 1.000 CHEMBL5160 Transient receptor potential cation channel subfamily A member 1 Rattus ... Cannabinoid CB1 receptor Rattus norvegicus 1.000 CHEMBL5160 Transient receptor potential cation channel subfamily A member 1 ...
  https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL465
*  Association of British Neurologists' Spring Meeting, Church House Conference Centre, Westminster, London, 14-16 April 2004. |...
069 CANNABINOID RECEPTOR CB-2 EXPRESSION IN ACTIVATED MICROGLIA OF MULTIPLE SCLEROSIS AND AMYOTROPHIC LATERAL SCLEROSIS SPINAL ... receptors as it could be blocked by co-ejection of isoproterenol (SSS: P = 0.02; L-glutamate: P = 0.006). 5HT receptor ... and CB2 thus represents a novel therapeutic target for disease modification, without the side-effects of CB1 agonists. CB-2 ... nicotinic receptors, 125I 5IA85380 and muscarinic M1 receptors, 3H pirenzepine) numbers in the striatum and pallidum of ...
  http://jnnp.bmj.com/content/75/8/1213
*  Curcumin - Hepatitis C - MedHelp
REGRESSION OF FIBROSIS AFTER CHRONIC STIMULATION OF CANNABINOID CB2 RECEPTOR IN CIRRHOTIC RATS. J Pharmacol Exp Ther. 2007 Nov ... Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. 2005 Mar;128(3):742-55. PMID: 15765409 I've ... REGRESSION OF FIBROSIS AFTER CHRONIC STIMULATION OF CANNABINOID CB2 RECEPTOR IN CIRRHOTIC RATS. J Pharmacol Exp Ther. 2007 Nov ... Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. 2005 Mar;128(3):742-55. PMID: 15765409 I've ...
  http://www.medhelp.org/posts/Hepatitis-C/Curcumin/show/388608
*  NMI :: Publikationen
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. ... Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic ...
  http://www.nmi.de/aktuell/aktuell/publikationen/browse/5/
*  Chronic unpredictable stress enhances cocaine-conditioned place preference in type 1 cannabinoid receptor knockout mice. -...
This study examined the effects of exposure to chronic unpredictable stress (CUS) in CB1 receptor knockout (CB1 KO) mice and ... Taken together, these findings support earlier evidence suggesting a role for the CB1 receptor in the response to stress as ... receptor modulates the effects of drugs of abuse and the response to exposure to stressors. In addition, exposure to stressors ... Decreased Cocaine Motor Sensitization and Self-Administration in Mice Overexpressing Cannabinoid CB2 Receptors. *Auxiliadora ...
  https://www.semanticscholar.org/paper/Chronic-unpredictable-stress-enhances-cocaine-cond-Miller-Ward/19e8a24ae458981f79263e1b440c805fbf8ac15e
*  Endocannabinoids Modulate N-Type Calcium Channels and G-Protein-Coupled Inwardly Rectifying Potassium Channels via CB1...
CB2 cannabinoid receptor; 2-AG, 2-arachidonoylglycerol; PTX, pertussis toxin; GIRK, G-protein-coupled inwardly rectifying ... that bind to and activate cannabinoid receptors. Thus far, at least three putative endogenous ligands for cannabinoid receptors ... The CB1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors. J Neurosci 19: ... Two types of cannabinoid receptors, CB1R and CB2R, have been identified, and both couple to G-proteins of the Gi/o class. ...
  http://molpharm.aspetjournals.org/content/65/3/665
*  Similar articles for PubMed (Select 23029555) - PubMed - NCBI
Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice.. Ortega-Alvaro A, Aracil-Fernández A, ... Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. ... gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter. ...
  https://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed&from_uid=23029555