*  The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.
The aim of this study was to determine if the neutral cannabinoid CB₁ receptor antagonist, AM4113, regulates body weight in the ... 0/AM4113; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1 Comments/Corrections. From MEDLINE®/PubMed®, a database of the U.S. ... The aim of this study was to determine if the neutral cannabinoid CB₁ receptor antagonist, AM4113, regulates body weight in the ... We confirmed that the AM4113-induced reduction in food intake is mediated by CB₁ receptors using CB₁ receptor knockout mice. In ...
  http://www.biomedsearch.com/nih/neutral-cannabinoid-CB1-receptor-antagonist/21056053.html
*  "Cannabinoid Modulation of Reinforcement Maintained by Stimulation of t" by Jason Wiebelhaus
PF-3845 also reduced ICSS, but did so independent of CB1 and CB2 receptors, and only with one dose (30.0 mg/kg) that has not ... THC, JZL184, and SA-57 all produced time-dependent reductions in ICSS that were mediated through CB1 receptors, as they were ... contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to ... Thus, cannabinoids do not facilitate ICSS in C57BL/6 mice over a range of doses and pre-treatment times, similar to most ...
  https://scholarscompass.vcu.edu/etd/555/
*  Frontiers | Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and...
Previously, we showed that cannabinoid type 1 (CB1) receptor mRNA and protein are localized in serotonergic neurons of the ... In order to substantiate the physiological role of the CB1 receptor in serotonergic neurons of the raphe nuclei, we generated ... In order to substantiate the physiological role of the CB1 receptor in serotonergic neurons of the raphe nuclei, we generated ... Thus, we were able to show that functional CB1 receptor signaling in central serotonergic neurons modulates distinct behaviors ...
  https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00235/full
*  Cannabinoids | Panaxia - Medical Cannabis Division
The Cannabinoid Receptors - CB1 and CB2 have been identified. While CB1 is mostly expressed in the central nervous system it ... Cannabinoids bind the cannabinoid receptors CB1 and CB2, expressed both in the central nervous system as well as in the ... The affinity to the receptors varies between the cannabinoid and while some may bind CB1 or CB2, others have the affinity to ... However, it has been shown that cannabinoids exert some of their effects via a non CB receptor dependent mechanism. ...
  http://www.panaxia.co.il/cannabis/scientific-and-clinical-data/scientific-literature/
*  Association between cannabinoid CB1 receptor expression and Akt signalling in prostate cancer
... Cipriano, Mariateresa Umeå ... Background: In prostate cancer, tumour expression of cannabinoid CB1 receptors is associated with a poor prognosis. One ... CB1 receptor immunoreactivity (CB1IR) was rescored from previously published data using the same scale as pAkt-IR. There was a ... In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well- ...
  http://www.diva-portal.org/smash/record.jsf?pid=diva2:645296
*  Cannabinoid receptor type 2 - Wikipedia
Cannabinoid receptor Cannabinoid receptor type 1 (CB1) GRCh38: Ensembl release 89: ENSG00000188822 - Ensembl, May 2017 GRCm38: ... The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that ... though not as densely as the CB1 receptor and located on different cells. Unlike the CB1 receptor, in the brain, CB2 receptors ... The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1 ...
  https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2
*  Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats | SpringerLink
... a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse ... Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats. ... SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has ... Involvement of the spinal cannabinoid receptor in nociception. Abstracts, 1995 Symposium on Cannabis and the Cannabinoids, p 44 ...
  https://link.springer.com/article/10.1007%2FBF02247436
*  Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1 | Biochemical Journal
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. M Bouaboula, C Poinot- ... The G-protein-coupled central cannabinoid receptor (CB1) has been shown to be functionally associated with several biological ... Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1 ... Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1 ...
  http://www.biochemj.org/content/312/2/637
*  Cannabinoid CB1 Receptor in Dorsal Telencephalic Glutamatergic Neurons: Distinctive Sufficiency for Hippocampus-Dependent and...
Stop-CB1 mice (n = 4), and conventional CB1 receptor KO mice (CB1-KO, n = 2). CB1 receptor transcript levels in Stop-CB1 was ... Stop-CB1 mice and their Glu-CB1 receptor rescue (Glu-CB1-RS) littermates, and mice from the complete CB1 receptor rescue (CB1- ... Quantification of CB1 receptor protein in hippocampal extracts revealed 28% of CB1 receptor in Glu-CB1-RS relative to CB1-RS ... Stop-CB1, CB1-RS, and Glu-CB1-RS. Black triangles, loxP sites; white box (stop), stop cassette; white box (CB1), CB1 receptor ...
  http://www.jneurosci.org/content/33/25/10264
*  Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK...
Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK ... Mathieu Verdurand, Vu Nguyen, Daniela Stark, et al., "Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult ...
  https://www.hindawi.com/journals/ijmi/2011/548123/cta/
*  Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1...
A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded ... soluble cannabinoid CB1 receptor. agonists. Julia M. Adam,*a Jim Cairns,a Wilson Caulfield,a Phillip Cowley,a Iain Cumming,a ... soluble cannabinoid CB1 receptor. agonists. J. M. Adam, J. Cairns, W. Caulfield, P. Cowley, I. Cumming, M. Easson, D. Edwards, ... A novel CB1 receptor agonist. lead series was identified using a high-throughput screening approach. The initial screen ...
  http://pubs.rsc.org/en/Content/ArticleLanding/2010/MD/c0md00022a
*  CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a | Molecular Pharmacology
CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a ... CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a. Jason L. Niehaus, ... CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a. Jason L. Niehaus, ... CB1 Cannabinoid Receptor Activity Is Modulated by the Cannabinoid Receptor Interacting Protein CRIP 1a. Jason L. Niehaus, ...
  http://molpharm.aspetjournals.org/content/72/6/1557/tab-article-info
*  Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells...
Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells ... is mediated by the cannabinoid CB1 receptors and requires the elevation of intracellular Ca(2+) and the activation of specific ... CB1 receptor, DAGLα, MAGL, and FAAH) and the CaBPs calbindin D28k, calretinin, and parvalbumin in the rat hippocampus. CB1, ... substrates that expressed 2-AG/CB1 signaling system and selective CaBPs should be considered when analyzing the cannabinoid ...
  https://www.sigmaaldrich.com/catalog/papers/25018703
*  AID 464688 - Displacement of [3H]CP-55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cells after 3 hrs by...
CP-55940 from human recombinant cannabinoid CB1 receptor expressed in CHO cells after 3 hrs by liquid scintillation counting. ...
  https://pubchem.ncbi.nlm.nih.gov/bioassay/464688
*  ACEA (a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with...
... a highly selective cannabinoid CB1 receptor agonist) stimulates hippocampal neurogenesis in mice treated with antiepileptic ... Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis ... Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Jin, K.; Xie, L.; Kim, S.H.; Parmentier-Batteur, S.; ... Effect of ACEA--a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the ...
  https://www.deepdyve.com/lp/elsevier/acea-a-highly-selective-cannabinoid-cb1-receptor-agonist-stimulates-DJjyDHvejw
*  Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide...
cannabinoid CB1 receptor. sEPSC. spontaneous excitatory postsynaptic current. EPM. elevated plus maze. FAAH. fatty acid amide ... 2001) CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. J Neurophysiol 85:468-471. ... Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide ... Preservation of Striatal Cannabinoid CB1 Receptor Function Correlates with the Antianxiety Effects of Fatty Acid Amide ...
  http://molpharm.aspetjournals.org/content/78/2/260
*  Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis |...
These cannabinoids bind to 2 different cell surface G-protein-coupled receptors (GPCR), CB1 and CB2. CB1 receptor is ... Cannabinoid receptors are expressed in human lung cancers. Cannabinoid receptors have been shown to be overexpressed in ... and CB1/CB2 agonist Win55,212-2. Furthermore, to characterize the role of cannabinoid receptors in this growth inhibition, CB1 ... Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis. Anju ...
  http://cancerpreventionresearch.aacrjournals.org/content/4/1/65.full
*  Endocannabinoids Modulate N-Type Calcium Channels and G-Protein-Coupled Inwardly Rectifying Potassium Channels via CB1...
The CB1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors. J Neurosci 19: ... that bind to and activate cannabinoid receptors. Thus far, at least three putative endogenous ligands for cannabinoid receptors ... Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, and Kano M (2002) The cannabinoid CB1 receptor mediates retrograde ... ABBREVIATIONS: CB1R, CB1 cannabinoid receptor; DSI, depolarization-induced suppression of inhibition; DSE, depolarization- ...
  http://molpharm.aspetjournals.org/content/65/3/665
*  Cannabinoid CB1 receptor antagonists
Cannabinoids and the zebra finch. Cannabinoid CB1 receptor and emotion. CB1 cannabinoid receptor knockout mice. CB1 cannabinoid ... Cannabinoid CB1 receptors are expressed in this brain reward circuit and modulate the dopamine-releasing effects of Delta(9)- ... This review examines the development of cannabinoid CB1 receptor antagonists as a new class of therapeutic agents for drug ... CANNABINOID CB1 ANTAGONISTS AS PROMISING NEW MEDICATIONS FOR DRUG DEPENDENCE by. Le Foll B, Goldberg SR. NIDA. J Pharmacol Exp ...
  https://www.cannabis-marijuana.com/cb1/antagonists.html
*  Cannabinoid CB1 receptor and emotion
Cannabinoids and the zebra finch. CB1 cannabinoid receptor agonism isn't rewarding 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 ... RATIONALE: Endogenous and exogenous cannabinoids acting through the CB1 cannabinoid receptors are implicated in the control of ... Involvement of CB1 cannabinoid. receptors in emotional behaviour by. Martin M, Ledent C, Parmentier M, Maldonado R, Valverde O. ... Recently, knockout mice deficient in the CB1 cannabinoid receptor have been generated, and these animals result in an excellent ...
  https://www.cannabis-marijuana.com/cb1/emotion.html
*  A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in...
The pharmacological actions of THC result from its activity at the cannabinoid CB1 receptor, located mainly in the central ... After the discovery of endogenous ligands of CB1 and CB2 receptors and of nonclassical cannabinoids a multitude of structure- ... A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in ... hCB2 Receptor Binding Results. Table 7 indicates that the order of importance of the variables is , , . Table 8 shows that no ...
  https://www.hindawi.com/journals/jqc/2014/431432/
*  A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in...
A Theoretical Study of the Relationships between Electronic Structure and CB1 and CB2 Cannabinoid Receptor Binding Affinity in ... LXXIX: cannabinoid receptors and their ligands: beyond CB1 and CB2," Pharmacological Reviews, vol. 62, no. 4, pp. 588-631, 2010 ... L. Console-Bram, J. Marcu, and M. E. Abood, "Cannabinoid receptors: nomenclature and pharmacological principles," Progress in ... R. Silvestri, A. Ligresti, G. L. Regina et al., "Synthesis, cannabinoid receptor affinity, molecular modeling studies and in ...
  https://www.hindawi.com/journals/jqc/2014/431432/ref/
*  Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. | Molecular Pharmacology
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.. C C Felder, K E Joyce, ... HU 210 had a higher affinity for the CB1 receptor. Anandamide, a recently identified endogenous cannabinoid agonist, was ...
  http://molpharm.aspetjournals.org/content/48/3/443.short
*  Noladin Ether Acts on Trabecular Meshwork Cannabinoid (CB1) Receptors to Enhance Aqueous Humor Outflow Facility | IOVS | ARVO...
The major targets of cannabinoid ligands are cannabinoid (CB)1 and CB2 receptors. 1 2 CB1 receptors are located in the central ... the involvement of cannabinoid receptors in controlling IOP has been explored. 8 9 10 11 It has been shown that CB1 receptors ... Expression of CB1 receptors on porcine trabecular meshwork cells. (A) CB1 receptor immunofluorescence observed with a primary ... Expression of CB1 receptors on porcine trabecular meshwork cells. (A) CB1 receptor immunofluorescence observed with a primary ...
  http://iovs.arvojournals.org/article.aspx?articleid=2124902
*  Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
We show here that the type 1 cannabinoid receptor (CB1) interacts physically with G-protein-associated sorting protein 1 (GASP1 ... We conclude that the contribution of CB1-type receptors expressed on the peripheral terminals of nociceptors to cannabinoid- ... We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in the peripheral nervous system ... Cannabinoids Mediate Analgesia Largely Via Peripheral Type 1 Cannabinoid Receptors in Nociceptors Nature Neuroscience. Jul, ...
  https://www.jove.com/author/Rohini_Kuner?language=Italian