Orotic acid, nucleotide-pool imbalance, and liver-tumor promotion: a possible mechanism for the mitoinhibitory effects of...
This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat ... Rats. Rats, Inbred F344. Ribonucleoside Diphosphate Reductase / antagonists & inhibitors. Transforming Growth Factor alpha / ... This study was designed to determine the possible mechanism by which orotic acid exerts its mitoinhibitory effect on rat ... or plasma from rats exposed to various liver cell-proliferative stimuli, such as two-thirds partial hepatectomy, lead nitrate, ...http://www.biomedsearch.com/nih/Orotic-acid-nucleotide-pool-imbalance/1531940.html
Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes.
As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single pe ... Rats. Rats, Inbred F344. Stem Cells / metabolism*. Substrate Specificity. Tumor Suppressor Proteins*. ... As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single ... 3507236 - The effect of storage on rat tissues and human plasma amino acid levels determined by h.... 6295766 - The acute ...http://www.biomedsearch.com/nih/Fat-depot-origin-affects-fatty/11158926.html
Interleukin 15 offers selective protection from irinotecan-induced intestinal toxicity in a preclinical animal model.
Rats. Rats, Inbred F344. Grant Support. ID/Acronym/Agency: CA16056/CA/NCI NIH HHS; R01 CA65761/CA/NCI NIH HHS ... in the modulation of the therapeutic selectivity of CPT-11 in normal rats and rats bearing advanced colorectal cancer. The ... A rat model with dose-limiting toxicity profiles that are similar to those observed in patients treated with CPT-11 was ... Morphological examination of rat intestinal tissues after treatment with LD of CPT-11 revealed dramatic protection of duodenal ...http://www.biomedsearch.com/nih/Interleukin-15-offers-selective-protection/9699654.html
Neurotransmitter alterations associated with feeding and satiety.
Chronically malnourished rats were sacrificed in a food-deprived state, following eating a small amount of food, or following ... Rats. Rats, Inbred F344. Satiation / physiology*. Satiety Response / physiology*. Serotonin / metabolism*. Grant Support. ... Chronically malnourished rats were sacrificed in a food-deprived state, following eating a small amount of food, or following ... 18377969 - Feeding specific glutamate surge in the rat lateral hypothalamus revealed by low-flow p.... 17276349 - Fly foie gras ...http://www.biomedsearch.com/nih/Neurotransmitter-alterations-associated-with-feeding/3620959.html
Acute heat treatment improves insulin-stimulated glucose uptake in aged skeletal muscle.
Rats. Rats, Inbred F344. Grant Support. ID/Acronym/Agency: AG-031575/AG/NIA NIH HHS; HD-002528/HD/NICHD NIH HHS; P20 RR-016475/ ... In the present study, one bout of in vivo heat treatment applied to 24-mo-old Fischer 344 rats improved insulin-stimulated ...http://www.biomedsearch.com/nih/Acute-heat-treatment-improves-insulin/21148343.html
The Ly-49D receptor activates lysis of H-2d-expressin | Open-i
Rats. *Rats, Inbred F344. *Receptors, NK Cell Lectin-Like. *Recombinant Proteins/immunology ... Bottom Line: To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK. ... Bottom Line: To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK. ... To define Ly-49D-ligand interactions, we transfected the mouse Ly-49D receptor into the rat NK line, RNK-16 (RNK.mLy-49D). As ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2192910_JEM981115.f3&req=4
Steady-state distribution of endogenous GPI-anchored pr | Open-i
Rats, Inbred F344. *Recombinant Fusion Proteins/metabolism. *Transfection. *Viral Envelope Proteins/metabolism ... Fischer rat thyroid (FRT) cells constitute an ideal model to test this hypothesis, since they missort both endogenous and ... Fischer rat thyroid (FRT) cells constitute an ideal model to test this hypothesis, since they missort both endogenous and ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2140173_JCB14620.f7&req=4
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours - Publikationsserver der Universität...
Rats, Inbred F344. MESH. Receptors, Androgen/metabolism. MESH. Testosterone/antagonists & inhibitors. MESH. ... In rats bearing Dunning R3327-G prostate carcinomas casodex exerted a strong antitumour effect at the beginning of therapy. ... Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ... Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and ...https://epub.uni-regensburg.de/4758/
The development of HCC in rats exposed to DENA+RS and k | Open-i
The development of HCC in rats exposed to DENA+RS and killed after one year. Panel A: macroscopic appearance, with withish-grey ... Rats were exposed to a protocol for the induction of hepatocellular carcinoma (HCC). Using an orthotopic and syngeneic system ... Rats were exposed to a protocol for the induction of hepatocellular carcinoma (HCC). Using an orthotopic and syngeneic system ... Figure 1: The development of HCC in rats exposed to DENA+RS and killed after one year. Panel A: macroscopic appearance, with ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3927807_aging-06-026-g001&req=4
Generation of the conditional SIRT1 transgenic mice tha | Open-i
Mice, Inbred C57BL. *Models, Biological. *Rats. *Rats, Inbred F344. *Sirtuin 1. *beta Catenin/metabolism ... We observed that rats on a CR diet have ∼2-fold higher levels of SIRT1 in the gut epithelium relative to ad lib-fed controls ( ... We observed that rats on a CR diet have ∼2-fold higher levels of SIRT1 in the gut epithelium relative to ad lib-fed controls ( ... rats. β-actin served as the loading control in all lanes. (B) Schematic representation of the strategy used for the generation ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2289879_pone.0002020.g001&req=4
Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis - Danish National Research...
Rats; Rats, Inbred F344; cdc42 GTP-Binding Protein; rac1 GTP-Binding Protein Main Research Area: Medical science Publication ...http://www.forskningsdatabasen.dk/catalog/235074113
Slc:Wistar Outbred Rats Show Close Genetic Similarity with F344 Inbred Rats.. Exp Anim. 2015 Feb 5;64(1):25-9. ... Efficient collection and cryopreservation of embryos in F344 strain inbred rats.. Cryobiology. 2013 Aug 5. [Epub ahead of print ... NBRP-Rat: The worldwide rat resource center. The XVIIIth International Workshop on Genetic Systems in the Rat（京都市）2010.11.30- ... Stress-reactive rats (high-avoidance female rats) have a shorter lifespan than stress-nonreactive rats (low-avoidance female ...http://www.anim.med.kyoto-u.ac.jp/nbr/publications_jp.aspx
Steven Lindley | Stanford Medicine Profiles
Differences in the behavioral responses of Lewis and Fischer (F344) inbred rat strains to stress and psychoactive drugs have ... Together these findings suggest that the inbred, behaviorally divergent F344 and Lewis rats have selective differences in ... corticosterone levels on multiple dopamine neurochemical estimates were examined in inbred Fischer and Lewis inbred rat strains ... In unstressed control animals, the Lewis strain had lower DA concentrations in the dorsal striatum (ST; 80.3% of F344) and ...https://med.stanford.edu/profiles/steven-lindley
a), (b), and (c)) Neural electrophysiology of group A | Open-i
Rats. *Rats, Inbred F344. *Rats, Sprague-Dawley. *Tissue Engineering. Related in: MedlinePlus ... Rats in group A were repaired by acellular nerve grafts only. Rats in group B were repaired by tissue engineering nerve. In ... Rats in group A were repaired by acellular nerve grafts only. Rats in group B were repaired by tissue engineering nerve. In ... Bottom Line: To investigate the effect of tissue engineering nerve on repair of rat sciatic nerve defect.After six and twelve ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4120921_NP2014-139085.003&req=4
Table of Contents | Disease Models & Mechanisms
Editors' choice: Transferring a Tp53-knockout allele from an outbred rat stock to the F344 inbred rat genetic background alters ... Summary: Feeding with a cafeteria diet (CAF) is a reproducible model of human metabolic syndrome in the rat. By using inbred ... Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet Neus ... A rat model for hepatitis E virus Yannick Debing, Niraj Mishra, Erik Verbeken, Kaat Ramaekers, Kai Dallmeier, Johan Neyts ...http://dmm.biologists.org/content/9/10
Repeated fear-induced diurnal rhythm disruptions predict PTSD-like sensitized physiological acute stress responses in F344 rats...
Rats, Inbred F344. *Stress Disorders, Post-Traumatic/physiopathology*. *Stress, Physiological/physiology*. *Stress, ... Adult male F344 rats implanted with biotelemetry devices were exposed to repeated conditioned fear or control conditions for 22 ... Repeated fear-induced diurnal rhythm disruptions predict PTSD-like sensitized physiological acute stress responses in F344 rats ... Rats exposed to repeated fear had fear-evoked increases in behavioural freezing and HR/CBT during exposure to the fear ...https://www.ncbi.nlm.nih.gov/pubmed/24447583?access_num=24447583&link_type=MED&dopt=Abstract
Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal...
The DA rat strain was used to establish a lung exposure model. Five other inbred rat strains (PVG, PVG.1AV1, LEW, WF and F344) ... All rat strains displayed a biphasic pattern of leukocyte infiltration in the lungs, dominated by neutrophils 2 days after ... The number of macrophages was higher in the DA rat compared with the other strains. The infiltration of lymphocytes in the ... With a novel focus on the immune system this paper investigate whether late phase pulmonary effects developed in rats exposed ...http://onlinelibrary.wiley.com/doi/10.1002/jat.2878/abstract?globalMessage=0
Prednisolone has a positive effect on the kidney but not on the liver of brain dead rats: a potencial role in complement...
Our study aimed to evaluate this disparity by investigating the effect of prednisolone administration on BD rats. METHODS: BD ... mechanisms in the liver may explain the disparity between the effects of prednisolone on the kidney and liver of BD rats. The ... induction was performed in ventilated rats by inflating a Fogarty catheter placed in the epidural space. Prednisolone (22.5 mg/ ... Rats, Inbred F344, Real-Time Polymerase Chain Reaction ... METHODS: BD induction was performed in ventilated rats by ...https://www.situ.ox.ac.uk/publications/466758
Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture | BMC Genomics |...
Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats. Funct Integr Genomics. 2010;10:63-72. ... However, Esd was confirmed by microarray-based qPCR analysis to influence spinal bone mineral density in inbred rats  and ... QTL masking can also be due to genetic drift occurring in inbred population of high generation [31, 32]. To overcome this ... The CC is a panel of recombinant inbred lines of mice descended from eight genetically divergent strains , designed for ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-2213-x
Genetic and Cellular Factors in the Immune Response | The Journal of Immunology
... of reciprocally mated F1 hybrids into both the highly responding ACI strain of inbred rats and the poorly responding F344 ... Limited inbreeding studies with the highly responding backcrosses indicated that they also bred true. Inbreeding of moderately ... Pedigree analyses of the antibody responses to poly(Glu52Lys33Tyr15) in a variety of hybrids of the ACI and F344 strains were ... Such unexpected antibody responses were found in all of the crosses examined: F1 hybrids, F2 hybrids, F1 backcrosses, inbred F1 ...http://www.jimmunol.org/content/106/4/980
Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat. - PubMed - NCBI
Rats, Inbred F344. *Sympatholytics/toxicity. *alpha-Synuclein/genetics. *alpha-Synuclein/metabolism*. Substances. *SNCA protein ... we grafted fetal rat ventral mesencephalon into the dopamine depleted striatum of rats that had previously received 6- ... Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat.. Kordower JH1, Dodiya HB, Kordower AM, Terpstra B ... All rats were sacrificed five weeks after the virus injections. Double label immunohistochemistry combined with confocal ...https://www.ncbi.nlm.nih.gov/pubmed/21600984?dopt=Abstract
Spatial exploration-induced Arc mRNA and protein expression: evidence for selective, network-specific reactivation. - PubMed -...
Rats, Inbred F344. Substances. *Cytoskeletal Proteins. *Nerve Tissue Proteins. *RNA, Messenger. *activity regulated ... the fidelity of Arc mRNA translation and the temporal dynamics of behaviorally induced Arc protein expression after rats ...https://www.ncbi.nlm.nih.gov/pubmed/15716412
Decellularized musculofascial extracellular matrix for tissue engineering. - PubMed - NCBI
Rats, Inbred F344. *Regeneration. *Swine. *Tissue Engineering/methods*. *Tissue Scaffolds/chemistry. *Vascular Endothelial ... A-C) Immunohistochemical staining of D-muscle and D-fascia 30 days after subcutaneous implantation in Fischer 344 rats. (A) H&E ...https://www.ncbi.nlm.nih.gov/pubmed/23347834
Novel neuronal phenotypes from neural progenitor cells. - PubMed - NCBI
Rats. *Rats, Inbred F344. *Rats, Sprague-Dawley. *Reverse Transcriptase Polymerase Chain Reaction ... Confocal photomicrographs in the top row are rat brain sections stained with the antibody to VAS. At left is an atlas graphic ... Confocal photomicrographs in the top row are rat brain sections stained with the antibody to GnRH. At left is an atlas graphic ... Confocal photomicrographs in the top rows are rat brain sections stained with the antibody to CRH and SS, respectively. At left ...https://www.ncbi.nlm.nih.gov/pubmed?term=15044527
FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing...
Inbred strains of male F344 and WKAH rats were purchased from Charles River Japan (Atsugi, Kanagawa, Japan) and Japan SLC ( ... Effects of FTY720 and CsA on rat skin allograft survival (WKAH donor to F344 recipient). F344 rats with transplanted WKAH skin ... Rat allogeneic MLC. Allogeneic MLC was performed using nylon nonadherent spleen cells from F344 rats as responder cells and ... Effects of FTY720 and CsA on numbers of CD3+ T cells in peripheral blood of skin-allografted rats. F344 rats with transplanted ...http://www.jimmunol.org/content/160/11/5493?ijkey=09f234383ebeb64805b095d5920c4fc6336626e2&keytype2=tf_ipsecsha