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*  MED8 - Mediator of RNA polymerase II transcription subunit 8 - Homo sapiens (Human) - MED8 gene & protein
Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II ... a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. ... interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA ... br>,/br>These range from a single component such as Viral genomes to several components as in the case of eukaryotic ...
  http://www.uniprot.org/uniprot/Q96G25
*  Long non-coding RNA - Wikipedia
... increases during cellular stress such as viral infection in some cancer cells where they may similarly regulate global changes ... short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs. However ... an ncRNA repressor of RNA polymerase II transcription". RNA. 13 (4): 583-96. doi:10.1261/rna.310307. PMC 1831867 . PMID ... June 2007). "RNA maps reveal new RNA classes and a possible function for pervasive transcription". Science. 316 (5830): 1484-8 ...
  https://en.wikipedia.org/wiki/Long_non-coding_RNA
*  Negative-sense single-stranded RNA virus - Wikipedia
The negative viral RNA is complementary to the mRNA and must be converted to a positive RNA by RNA polymerase before ... Negative sense ssRNA viruses need RNA polymerase to form a positive sense RNA. The positive-sense RNA acts as a viral mRNA, ... The virus uses its own RNA replicase, also known as RNA-dependent RNA polymerase (RdRp), to form positive RNA template strands ... The negative RNA strands combine with capsids and viral RdRp to form new negative RNA virions. After assembly and maturation of ...
  https://en.wikipedia.org/wiki/Negative-sense_single-stranded_RNA_virus
*  Antisense RNA - Wikipedia
... and Stephenson found an antisense oligoneucleotides to the viral RNA of Rous scarcoma virus was capable of inhibiting viral ... RNA I and RNA II forms a duplex which introduces a conformational change of RNA II. Consequently, RNA II cannot hybridize with ... RNA-RNA interactions either in nucleus or cytoplasm and RNA-protein interactions (epigenetic). Antisense RNAs can be ... The replication of ColE1 relies on the transcription of a primer RNA named RNA II. Once RNA II is transcribed, it hybridizes to ...
  https://en.wikipedia.org/wiki/Antisense_RNA
*  Vaccines | Free Full-Text | Replicon RNA Viral Vectors as Vaccines
Replicon RNA vectors have also been subjected to clinical trials. Overall, immunization with self-replicating RNA viruses ... Immunization of mice, chicken, pigs and primates with virus-like particles, naked RNA or layered DNA/RNA plasmids has provided ... Administration of replicon RNA vectors has resulted in strong immune responses and generation of neutralizing antibodies in ... Moreover, recombinant particles and replicon RNAs have been encapsulated by liposomes to improve delivery and targeting. ...
  http://www.mdpi.com/2076-393X/4/4/39
*  Viral RNA Replication Modes: Evolutionary and Dynamical Implications | SpringerLink
Sardanyés J. (2014) Viral RNA Replication Modes: Evolutionary and Dynamical Implications. In: Corral Á., Deluca A., Font-Clos F ... J. Sardanyés, F. Martínez, J.A. Daròs, S.F. Elena, Dynamics of alternative modes of RNA replication for positive-sense RNA ... L. Chao, C.U. Rang, L.E. Wong, Distribution of spontaneous mutants and inferences about the replication mode of the RNA ... F. Martínez, J. Sardanyés, J.A. Daròs, S.F. Elena, Dynamics of a plant RNA virus intracellular accumulation: stamping machine ...
  https://link.springer.com/chapter/10.1007/978-3-319-08138-0_21
*  quantitative viral RNA assay - Molecular Biology
quantitative viral RNA assay - (Jun/08/2001 ). I'd like to determine viral RNA level changes in virus producing cell culture ...
  http://www.protocol-online.org/biology-forums/posts/955.html
*  The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients - Full Text View -...
The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients. This study has been ... A Randomized Controlled Clinical Study to Determine If the Addition of HIV RNA Viral Load Is an Effective Tool in Determining ... RNA Virus Infections. Virus Diseases. Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immunologic ... whether an antiretroviral treatment regimen based upon clinical evaluation and CD4 counts plus HIV RNA viral load is more ...
  https://clinicaltrials.gov/show/NCT00002376?order=323
*  Zika virus infection alters human and viral RNA | EurekAlert! Science News
These modifications -- chemical tags known as methyl groups -- influence viral replication and the human immune response. ... of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and ... the researchers removed the human enzymes responsible for adding methyl groups to viral RNA. Without m6A, the viral RNA was ... the cell modifies viral RNA with m6A as a means to get rid of the infection. RNA tagged with m6A is a beacon for human enzymes ...
  https://www.eurekalert.org/pub_releases/2016-10/uoc--zvi101816.php
*  Link uncovered between viral RNA and human immune response
Bevilacqua »HIV-1 genome »Molecular Biology »PKR »RNA »RNA dimers »TAR »double-stranded RNAs »genetic material »human cells » ... Further reports about: , Bevilacqua , HIV-1 genome , Molecular Biology , PKR , RNA , RNA dimers , TAR , double-stranded RNAs , ... One way for this to happen is for the viral RNA to first form linked pairs called dimers. These RNA dimers then allow separate ... Link uncovered between viral RNA and human immune response. 06.08.2009. In its fight against an intruding virus, an enzyme in ...
  http://www.innovations-report.com/html/reports/life-sciences/link-uncovered-viral-rna-human-immune-response-137329.html
*  Microbial Transcriptomics | Bacterial and viral RNA-Seq
RNA-Seq) offers an unbiased approach for analyzing and quantifying bacterial, viral, and other microbial transcripts. ... RNA-Seq for Microbial Transcript Analysis. Bacterial, viral, and other microbial RNA-Seq experiments enable annotation and ... Note: If using the TruSeq RNA library prep kit, you will NOT need to extract RNA and transcribe to cDNA. If you use an RNA ... Streamlined, cost-efficient, and scalable solution for total RNA analysis.. Note: If you use a TruSeq RNA library prep kit, you ...
  https://www.illumina.com/areas-of-interest/microbiology/microbial-sequencing-methods/microbial-transcriptomics.html
*  Viral RNA/DNA Purification | Thermo Fisher Scientific - US
Viral RNA and DNA capture, purification and qRT-PCR and qPCR analyses; featuring PureLink™, RNA UltraSense™, & Dynabeads® ... Specific Capture of Viral RNA/DNA Target a specific viral RNA or DNA sequence and capture only that specific nucleic acid ... Dynabeads® SILANE Viral RNA/DNA Sensitive and highly consistent isolation of viral RNA and DNA from cell-free samples. These ... Viral RNA/DNA purification Both spin-column and 96-well plate kits are designed for fast and easy isolation of viral RNA or DNA ...
  https://www.thermofisher.com/us/en/home/life-science/dna-rna-purification-analysis/viral-rna-dna-purification.html
*  Application # 2007/0265222. Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection -...
These compounds are precursors to inhibitors of RNA-dependent ... which are precursors to inhibitors of RNA-dependent RNA viral ... inhibiting RNA-dependent RNA viral replication, and/or a method for treating RNA-dependent RNA viral infection in a mammal in ... RNA-dependent RNA viral polymerase is a positive-sense single-stranded RNA-dependent RNA viral polymerase. In a class of this ... RNA-dependent RNA viral replication is a positive-sense single-stranded RNA-dependent RNA viral replication. In a class of this ...
  http://patents.com/us-20070265222.html
*  Clinical Prognostic Value of RNA Viral Load and CD4 Cell Counts during Untreated HIV-1 Infection-A Quantitative Review
Comparing a patient with RNA at upper 75th centile with a patient at median RNA, 5-year relative risks were 1.4 (95% CI 1.2-1.7 ... Median within-population interquartile ranges were 74,000 copies/mL for RNA with no significant change during the course of ... without pre-treatment RNA monitoring - while not precluding earlier treatment based on clinical, socio-demographic or public ... of population-level variation in RNA, and 25% of variation in CD4, were due to within-patient fluctuations. ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005950
*  A Viral RNA Structural Element Alters Host Recognition of Nonself RNA | Science
A Viral RNA Structural Element Alters Host Recognition of Nonself RNA Message Subject. (Your Name) has forwarded a page to you ... A Viral RNA Structural Element Alters Host Recognition of Nonself RNA. By Jennifer L. Hyde, Christina L. Gardner, Taishi Kimura ... A Viral RNA Structural Element Alters Host Recognition of Nonself RNA. By Jennifer L. Hyde, Christina L. Gardner, Taishi Kimura ... As an example, 2'-O methylation of the 5′ cap of viral RNA subverts mammalian antiviral responses by evading restriction of ...
  http://science.sciencemag.org/content/early/2014/01/29/science.1248465
*  Nuclear Export of Viral RNAs by Joachim Hauber, P. K. Vogt | Waterstones
Buy Nuclear Export of Viral RNAs by Joachim Hauber, P. K. Vogt from Waterstones today! Click and Collect from your local ... Nuclear Export of Viral RNAs - Current Topics in Microbiology and Immunology 259 (Paperback). Joachim Hauber (editor), P. K. ... CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that ...
  https://www.waterstones.com/book/nuclear-export-of-viral-rnas/joachim-hauber/p-k-vogt/9783642625220
*  DIGITAL.CSIC: A comparison of viral RNA-dependent RNA polymerases
A comparison of viral RNA-dependent RNA polymerases. Autor : Ferrer-Orta, Cristina ; Arias, Armando; Escarmís, Cristina; ... Comparing these data with results from previous structural analyses of viral RNA-dependent RNA polymerases that catalyze de ... Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. These viruses ... The recent explosion of structural information on picornaviral 3D polymerases has provided insights into the initiation of RNA ...
  https://digital.csic.es/handle/10261/110069
*  PureLink® Pro 96 Viral RNA/DNA Kit | Thermo Fisher Scientific - SA
96 Viral RNA/DNA Kits the most flexible and sensitive viral extraction kits available anywhere. ... PureLink™ 96 viral RNA or DNA extraction can be performed manually using centrifugation or vacuum manifold processing, or on ... Obtain the ultimate in viral sensitivity with the PureLink™ enhanced lysis/binding buffer formulation that provides the highest ... sensitivity in viral recovery using silica spin columns or 96 plates. ...
  https://www.thermofisher.com/sa/en/home/life-science/dna-rna-purification-analysis/viral-rna-dna-purification/purelink-96-viral-rna-dna-kit-and-mini-kit.html
*  PureLink® Viral RNA/DNA Mini Kit | Thermo Fisher Scientific - CA
Benefits: Yields highly concentrated viral nucleic acids for greater sensitivity in detection - start with 500 µl of sample and ... Viral RNA/DNA Mini Kit. Pure. Sensitive. Concentrated. ... Viral RNA/DNA Purification › * PureLink® Viral RNA/DNA Mini Kit ... Viral Extraction with the PureLink® Viral RNA/DNA Mini Kit One of the most difficult viruses to extract is HBV due to the rigid ... The PureLink® Viral RNA/DNA Mini Kit accommodates starting volumes of up to 500 µL, and elution volumes as low as 10 µL ...
  https://www.thermofisher.com/ca/en/home/life-science/dna-rna-purification-analysis/viral-rna-dna-purification/purelink-viral-rnadna-mini-kit.html
*  Plasma RNA viral load is not associated with intrapatient quasispecies heterogeneity in HIV-1 infection, Archives of Virology |...
"Plasma RNA viral load is not associated with intrapatient quasispecies heterogeneity in HIV-1 infection, Archives of Virology" ... Plasma RNA viral load is not associated with intrapatient quasispecies heterogeneity in HIV-1 infection. Plasma RNA viral load ... In this study, we analyzed the association between intrapatient viral diversity and RNA viral load in 16 antiretroviral therapy ... In this study, we analyzed the association between intrapatient viral diversity and RNA viral load in 16 antiretroviral therapy ...
  https://www.deepdyve.com/lp/springer_journal/plasma-rna-viral-load-is-not-associated-with-intrapatient-quasispecies-s6tjZh0vCP
*  Structure Cluster - 1L2X: Atomic Resolution Crystal Structure of a Viral RNA Pseudoknot 3D Similarity Report Page
Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution. ... Description: RNA pseudoknot rna , Length: 28 This entity is NOT a polypeptide entity and therefore cannot be considered for the ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1L2X
*  IDEALS @ Illinois: Single molecule pull-down of viral RNA-protein complexes
viral RNA total internal reflection fluorescence microscopy Ribonucleic acid (RNA). Abstract:. Protein and RNA molecules ... The viral DI RNA associates with multiple viral proteins during replication, and is therefore expected to form heterogeneous ... Using the RNA sequence information of DI RNA, we designed several short complementary DNA probes to capture single DI RNA ... Utilizing a biological system of virally infected mammalian cells, the substrate targeted in the study are viral RNA-protein ...
  https://www.ideals.illinois.edu/handle/2142/31924
*  The ESCRT-I Subunit TSG101 Controls Endosome-to-Cytosol Release of Viral RNA
... is dispensable for viral envelope fusion with endosomal membranes and viral RNA transport to late endosomes but is necessary ... The ESCRT-I Subunit TSG101 Controls Endosome-to-Cytosol Release of Viral RNA. ... There, the viral envelope undergoes fusion with endosomal membranes, thereby releasing the nucleocapsid into the cytoplasm and ... Previously, we reported that the viral envelope fuses preferentially with the membrane of vesicles present within ...
  https://insights.ovid.com/traff/200812000/00128667-200812000-00022
*  Automated Workflow for High Quality, High Throughput Viral RNA | Thermo Fisher Scientific - JP
The ability to perform high throughput viral RNA isolation from diverse samples also increases laboratory efficiency, reduces ... labor cost, and improves viral detection. This article describes how the Ambion® MagMAX™ magnetic bead-based technology has ... High quality viral RNA for veterinary assays is essential for rapid viral identification. ... The Ambion MagMAX-96 Viral RNA Isolation Kit is designed for viral RNA/DNA purification from a variety of sample types, such as ...
  https://www.thermofisher.com/jp/en/home/references/ambion-tech-support/rna-isolation/tech-notes/automated-workflow-for-high-quality-high-throughput-viral-rna.html
*  Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing | PNAS
We conclude that viral replicating RNA constitutes the majority of the viral immunostimulatory RNA associated with RIG-I. In ... purified SeV-C RNA, total RNA from SeV-C-infected cells, and poly(I:C) were used in various experiments. Viral RNA was isolated ... or trailer RNA. Comparison of relative abundances of DI RNA and genome RNA/L mRNA between total RNA from infected cells, RIG-I ... Analysis of RIG-I-Associated RNA at Early Times of SeV Infection.. We next determined whether the same or different viral RNA ...
  http://www.pnas.org/content/107/37/16303