Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11] (ab110025)
Mouse monoclonal Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11] validated for WB, ELISA, IHC, Flow Cyt, ICC/IF ... Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the ... Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11]. See all Mitochondrial Pyruvate dehydrogenase kinase 1 ... Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11] images. * Western blot - Anti-Mitochondrial Pyruvate ...http://www.abcam.com/mitochondrial-pyruvate-dehydrogenase-kinase-1-antibody-4a11-ab110025.html
Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and...
... on the activation state of the hepatic pyruvate dehydrogenase complex (PDHa), the activity of mitochondrial PDH kinase, hepatic ... Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and ... Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and ... Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and ...http://www.biochemj.org/content/284/1/129
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells |...
Integrating Bioinformatics and Physiology to Describe Genetic Effects in Complex Polygenic Diseases ... Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells. ... pyruvate dehydrogenase) kinase 1, a negative regulator of PDH, to metabolic coupling in 832/13 clonal beta-cells. Knockdown of ... glucose-stimulated cellular oxygen consumption and pyruvate-stimulated mitochondrial oxygen consumption increased 1.7- (P , ...https://www.ludc.lu.se/peter-spegel-associate-professor/publication/2dc3b368-04b2-4131-b6b1-02888c906fff
... implying that the flux through the pyruvate dehydrogenase complex (PDC) is independent of insulin concentrations (9). Taken ... and the complex study design along with the limited resources did not allow us to include a control group of healthy ...http://care.diabetesjournals.org/content/34/1/220
DLAT - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor -...
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the ... "Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.". Kato M ... Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDH1A ... The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the ...http://www.uniprot.org/uniprot/P10515
dihydrolipoyl dehydrogenase - Creative Enzymes
A component of the multienzyme 2-oxo-acid dehydrogenase complexes. In the pyruvate dehydrogenase complex, it binds to the core ... A flavoprotein (FAD). A component of the multienzyme 2-oxo-acid dehydrogenase complexes. In the pyruvate dehydrogenase complex ... lipoate dehydrogenase; lipoic acid dehydrogenase; lipoyl dehydrogenase; protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase ... dihydrolipoic dehydrogenase; dihydrothioctic dehydrogenase; lipoamide dehydrogenase (NADH); lipoamide oxidoreductase (NADH); ...https://www.creative-enzymes.com/product/Dihydrolipoyl-Dehydrogenase_11818.html
RCSB PDB - 1IYU: LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE Macromolecule...
Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter ... DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX (1IYU:A) * Dihydrolipoyllysine Residue ...http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1IYU
Dlat MGI Mouse Gene Detail - MGI:2385311 - dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. IPR036625 E3-binding ... PR:000006504 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial. (term ... and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in ... pyruvate decarboxylase deficiency DOID:3649. ICD10CM:E74.4. MESH:D015325. NCI:C103968. OMIM:245348. OMIM:245349. OMIM:312170. ...http://www.informatics.jax.org/marker/MGI:2385311
Pyruvate dehydrogenase complex - Wikipedia
Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called ... The reaction catalysed by pyruvate dehydrogenase complex is: Initially, pyruvate and thiamine pyrophosphate (TPP or vitamin B1 ... In eukaryotes PDC is tightly regulated by its own specific pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase ... "pyruvate dehydrogenase reaction" because it also involves the oxidation of pyruvate. This multi-enzyme complex is related ...https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex
pdhC - Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - Mycoplasma mycoides subsp. capri LC str...
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation. ,p>Information which has been ... tr,F4MPG6,F4MPG6_MYCML Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Mycoplasma mycoides ... Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation. ,p>Information which has been generated by the UniProtKB ...http://www.uniprot.org/uniprot/F4MPG6
pdhC - Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex - Leifsonia xyli subsp. xyli ...
... pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). ... The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple ... The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple ... Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexAdd BLAST. 452. Amino acid ...http://www.uniprot.org/uniprot/Q6ABX9
Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly |...
... pyruvate dehydrogenase complex; hPDC, human PDC; PDK, pyruvate dehydrogenase kinase; rhE2/E3BP, recombinant human E2/E3BP; rhE3 ... Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly. ... Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly ... Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine ...http://www.biochemj.org/content/437/3/565
Gentaur Molecular :EIAab \ Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex,Lipoyl-containing...
Lipoyl-containing pyruvate dehydrogenase complex component X,Mouse,Mus musculus,Pdhx,Pyruvate dehydrogenase protein X c \ ... Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, ... Lipoamide dehydrogenase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex E3 component). [Dlst] ... Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex,Lipoyl-containing pyruvate dehydrogenase ...http://www.antibody-antibodies.com/product2880028-search-Dihydrolipoamide_dehydrogenase_binding_protein_of_pyruvate_dehydrogenase_complex,Lipoyl_containing_pyruvate_dehydrogenase_complex_component_X,Mouse,Mus_musculus,Pdhx,Pyruvate_dehydrogenase_protein_X_c.html
Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3...
In E. coli, pyruvate is metabolized by the pyruvate dehydrogenase (PDH) complex and pyruvate oxidase during aerobic growth ... Quail MA, Haydon DJ, Guest JR: The pdhR-aceEF-lpd operon of Escherichia coli expresses the pyruvate dehydrogenase complex. Mol ... Escherichia coli poly(3-hydroxybutyrate)L-serine deaminateEntner-Doudoroff pathwayPyruvate dehydrogenase complex ... Overexpression of the pyruvate dehydrogenase complex for enhanced PHB production. ...https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-014-0172-6
Inactivation and disassembly of the pyruvate dehydrogenase multienzyme complex from bovine kidney by limited proteolysis with...
The lipoamide dehydrogenase and pyruvate dehydrogenase components, however, are not cleaved by the inactivase. ... However, the inactivation of the overall reaction does not affect any of the component activities of the enzyme complex. By ... are unable to catalyze the coordinated reaction sequence of pyruvate oxidation. The dissociation occurs as a consequence of ... Mammalian pyruvate dehydrogenase multienzyme complex is inactivated when treated with a leupeptin-sensitive enzyme (termed ' ...https://www.semanticscholar.org/paper/Inactivation-and-disassembly-of-the-pyruvate-dehyd-Kresze-Steber/032f1775aa844093b1357e47e1f23b228bf45a8e
Journal News section of ASBMB Today
The key enzyme complex bridging these two processes is known as the pyruvate dehydrogenase complex, or PDC, and is the subject ... Pyruvate dehydrogenase complex. Energy generation in prokaryotic and eukaryotic organisms is a highly efficient, multistep and ... To harness the full energy content of glucose, pyruvate undergoes further oxidation in the Krebs cycle, generating large ... Normally, glucose is metabolized initially via the glycolytic pathway, generating pyruvate and small amounts of ATP. ...https://www.asbmb.org/asbmbtoday/201408/JournalNews/
Paper Chase | HMS
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat. Genet. ... SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters. Nat. Genet. ... Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection. Nat. Genet. ...https://hms.harvard.edu/research/paper-chase?pcs=3&pcq=Nature%20Genetics
September 2009 - Volume 67 - Issue 3 : Journal of Trauma and Acute Care Surgery
Potential Dysregulation of the Pyruvate Dehydrogenase Complex by Bacterial Toxins and Insulin. Thomas, Gregory W.; Mains, ...http://journals.lww.com/jtrauma/toc/2009/09000
Structure and Dynamics of Macromolecular Assemblies from Electron Microscopy Maps | IntechOpen
Architecture of an icosahedral pyruvate dehydrogenase complex. The pyruvate dehydrogenase multienzyme complex couples the ... Architecture of an icosahedral pyruvate dehydrogenase complex. Figure 7. (a) The experimental map (at 14 Å resolution) of the ... Their applications are highlighted with four examples: architecture of an icosahedral pyruvate dehydrogenase complex, dynamics ... of the icosahedral complex formed from 60 copies of the E2 catalytic domain of the pyruvate dehydrogenase. (b) The X-ray ...https://www.intechopen.com/books/modern-electron-microscopy-in-physical-and-life-sciences/structure-and-dynamics-of-macromolecular-assemblies-from-electron-microscopy-maps/
Remodeling of intermediate metabolism in the diatom Phaeodactylum tricornutum under nitrogen stress | Proceedings of the...
... the pyruvate dehydrogenase complex, and the TCA cycle (Fig. 3). Genes related to chlorophyll biosynthesis and fucoxanthin ... Dark gray, glutamate dehydrogenase- and aspartate aminotransferase-related fluxes; light gray, GS/GOGAT pathway; black, ... GOGAT, glutamine oxoglutarate aminotransferase; GS, glutamine synthetase; NH4+, ammonium; NO3−, nitrate; PDC, pyruvate ... 4A). In contrast, the central hub involving pyruvate, phosphoenolpyruvate, and oxaloacetate is down-regulated in nitrogen- ...http://www.pnas.org/content/112/2/412.full
Structural Biochemistry/Krebs Cycle (Citric Acid cycle) - Wikibooks, open books for an open world
... the pyruvate dehydrogenase relates to the reactions of the citric acid cycle itself. The pyruvate dehydrogenase complex is ... Pyruvate Dehydrogenase Complex. Although glucose can be formed by pyruvate, the irreversible step of the formation of ... Then, the pyruvate is oxidatively decarboxylated by the pyruvate dehydrogenase complex in order to form the acetyl CoA in the ... The phosphorylation of the of the pyruvate dehydrogenase component (E1) by pyruvate dehydrogenase kinase I (PDK) switches of ...https://en.wikibooks.org/wiki/Structural_Biochemistry/Krebs_Cycle_
Search of: Recruiting, Not yet recruiting, Available Studies | 'Rare Diseases' - List Results - ClinicalTrials.gov
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies. *Pyruvate Dehydrogenase Complex ... Survival outcomes in pyruvate dehydrogenase deficiency disease. *Neurological outcomes in pyruvate dehydrogenase deficiency ...https://clinicaltrials.gov/ct2/results?recr=Open&cond=%22Rare+Diseases%22&show_down=Y
Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria - 1st Edition
Hormonal Regulation of Pyruvate Metabolism in Rat Liver Mitochondria. Pyruvate Dehydrogenase Complex: Structure, Function, and ...https://www.elsevier.com/books/energy-metabolism-and-the-regulation-of-metabolic-processes-in-mitochondria/mehlman/978-0-12-487850-1
Protein (Weighted) Links for PubMed (Select 8102256) - Protein - NCBI
M2 antigen complex 70 kDa subunit; AltName: Full=Pyruvate dehydrogenase complex component E2; Short=PDC-E2; Short=PDCE2; Flags ... PREDICTED: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial isoform X1 ... RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; AltName ... Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; AltName: Full= ...https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein_weighted&from_uid=8102256
Aminoethanesulfonic Acid Manufacturer, Supplier & Exporter from India
Boron trifluoride-acetic acid-complex *Boron trifluoride-dimethyl ether complex *Brilliant green (hydrogen sulfate) (C.I. 42040 ... Aldehyde dehydrogenase *1-Butyl-3-methylimidazolium hydrogensulfate *Butyric acid *Boron hydride-tert-butylamine ... CALCIUM PYRUVATE *CALCIUM PHOSPHATE monobasic *CALCIUM PHOSPHATE *CALCIUM PROPIONATE. *CALCIUM-D-SACCHARATE (tetrahydrate) ...http://www.alphachemikaindia.com/aminoethanesulfonic-acid-570936.html
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