*  Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets. |...
Our results are consistent with the concept that anaplerosis via pyruvate carboxylase determines pyruvate cycling, which has ... Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.. ... The anaplerotic enzyme pyruvate carboxylase is highly expressed in beta cells, and anaplerosis influences insulin secretion in ... By inhibiting pyruvate carboxylase in rat islets, we aimed to clarify the hitherto unknown metabolic events underlying ...
  https://www.ludc.lu.se/erik-renstrom/publication/8f12a027-a3f5-4dc4-b142-007cb81d9f6a
*  KEGG BRITE: KEGG Orthology (KO) - Hydrogenovibrio crunogenus
... ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] K01601 rbcL; ribulose-bisphosphate carboxylase large chain [EC:4.1. ... 00620 Pyruvate metabolism [PATH:tcx00620] 00630 Glyoxylate and dicarboxylate metabolism [PATH:tcx00630] ... ribulose-bisphosphate carboxylase small chain [EC:4.1.1.39] K01602 rbcS; ribulose-bisphosphate carboxylase small chain [EC:4.1. ... 1.39] K01601 rbcL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39] K01602 rbcS; ...
  http://www.genome.jp/kegg-bin/get_htext?tcx00001+Tcr_0428
*  Ligand-induced conformational transitions and secondary-structure composition of chicken liver pyruvate carboxylase |...
Secondary-structure composition of chicken liver pyruvate carboxylase estimated from the far-u.v. c.d. spectrum of the enzyme ... Ligand-induced conformational transitions and secondary-structure composition of chicken liver pyruvate carboxylase. Karen S. ... Apparent conformational transitions induced in chicken liver pyruvate carboxylase by substrates, KHCO3 and MgATP, and the ... Ligand-induced conformational transitions and secondary-structure composition of chicken liver pyruvate carboxylase ...
  http://www.biochemj.org/content/177/2/697
*  Human Metabolome Database: Showing metabocard for Oxalacetic acid (HMDB0000223)
2. Pyruvate carboxylase, mitochondrial. General function:. Involved in catalytic activity. Specific function:. Pyruvate ... Dworzak E, Grunicke H, Berger H, Jarosch E, Haas H, Hopfel I: [Pyruvate dehydrogenase deficiency in a child with persistent ... Sperl W, Maurer H, Dworschak E, Hopfel I, Hammerer I: [Lactic acid acidosis with mitochondrial myopathy due to a pyruvate ... pyruvate carboxylase deficiency. Pediatr Res. 1986 Mar;20(3):274-9. [PubMed:3085060 ] ...
  http://www.hmdb.ca/metabolites/HMDB0000223
*  RCSB PDB - 4HNV: Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase Structure Summary Page
Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis. ... Pyruvate carboxylase A, B, C, D 1173 Staphylococcus aureus EC#: 6.4.1.1 IUBMB Mutation: R54E Gene Name(s): pycA SAV1114 ... Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase. *DOI: 10.2210/pdb4hnv/pdb ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=4HNV
*  Pyruvate carboxylase - Wikipedia
Pyruvate Carboxylase Symmetry Comparison Pyruvate carboxylase uses a covalently attached biotin cofactor which is used to ... During gluconeogenesis, pyruvate carboxylase is involved in the synthesis of phosphoenolpyruvate (PEP) from pyruvate. Pyruvate ... deficiency of pyruvate carboxylase can also lead to hypoglycemia. Pyruvate carboxylase deficiency PDB: 2QF7​; Jitrapakdee S, St ... A deficiency of pyruvate carboxylase can cause lactic acidosis as a result of lactate build up. Normally, excess pyruvate is ...
  https://en.wikipedia.org/wiki/Pyruvate_carboxylase
*  Pyruvate carboxylase deficiency - Wikipedia
Children with pyruvate carboxylase deficiency type A typically survive only into early childhood. Pyruvate carboxylase ... GeneReview/NCBI/NIH/UW entry on Pyruvate Carboxylase Deficiency Pyruvate carboxylase deficiency at NLM Genetics Home Reference ... Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid and to accumulate in the blood. High levels of ... Pyruvate carboxylase also plays a role in the formation of the protective sheath that surrounds certain nerve cells (myelin) ...
  https://en.wikipedia.org/wiki/Pyruvate_carboxylase_deficiency
*  The conversion of alanine into glutamine in guinea-pig renal cortex. Essential role of pyruvate carboxylase | Biochemical...
Essential role of pyruvate carboxylase. M Forissier, G Baverel. Biochemical Journal Oct 15, 1981, 200 (1) 27-33; DOI: 10.1042/ ... 7. In this pathway, the central role of pyruvate carboxylase, which explains the discrepancy between our results and those of ... pyruvate carboxylase and enzymes of the tricarboxylic acid cycle is proposed for the conversion of alanine into glutamine. 6. ... 3. At neither concentration of alanine was there accumulation of glucose, glycogen, pyruvate, lactate, aspartate or ...
  http://www.biochemj.org/content/200/1/27
*  Native Bovine Pyruvate Carboxylase - Creative Enzymes
Pyruvate carboxylase is a mitochondrial protein that has a biotin prosthetic group that requ ... Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate. ... Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate. Pyruvate carboxylase is a mitochondrial protein ... The enzyme from Creative Enzymes has been used as a positive control during the assay of pyruvate carboxylase activity in cell- ...
  https://www.creative-enzymes.com/product/Native-Bovine-Pyruvate-Carboxylase_1428.html
*  mcb100ExamIIISolutions - GAP dehydrogenase - NADH b pyruvate carboxylase c biotin d carbon dioxide or bicarbonate 5 a phosphate...
GAP dehydrogenase - NADH b) pyruvate carboxylase c) biotin d) carbon dioxide or bicarbonate 5. a) phosphate + glycogen(n) ÅÆ ... Unformatted text preview: GAP dehydrogenase - NADH b) pyruvate carboxylase c) biotin d) carbon dioxide or bicarbonate 5. a) ... pyruvate carboxylase - ATP PEP carboxykinase - GTP 3-phosphoglcerate kinase - ATP ...
  https://www.coursehero.com/file/106786/mcb100ExamIIISolutions/
*  Fall 08 Exam 2 - e Phosphopentose isomerase a Pyruvate carboxylase b Pyruvate kinase c PEP carboxykinase d Glucose 6...
e. Phosphopentose isomerase a. Pyruvate carboxylase b. Pyruvate kinase c. PEP carboxykinase d. Glucose 6-phosphatase e. ... Unformatted text preview: e. Phosphopentose isomerase a. Pyruvate carboxylase b. Pyruvate kinase c. PEP carboxykinase d. ... Fall 08 Exam 2 - e Phosphopentose isomerase a Pyruvate.... This preview shows document pages 1 - 9. Sign up to view the full ...
  https://www.coursehero.com/file/5691303/Fall-08-Exam-2/
*  Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene.
In addition to phosphoenolpyruvate carboxylase (PEPCx), pyruvate carboxylase (PCx) has recently been found as an anaplerotic ... Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene.. Peters- ... Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene. ... Peters-Wendisch, P., Kreutzer, C., Kalinowski, J., Pátek, M., Sahm, H., and Eikmanns, B. J. (1998). Pyruvate carboxylase from ...
  https://pub.uni-bielefeld.de/publication/1904807
*  Cold Inactivation of Phosphoenolpyruvate Carboxylase and Pyruvate Orthophosphate Dikinase from the C4 Perennial Plant Atriplex...
"Cold Inactivation of Phosphoenolpyruvate Carboxylase and Pyruvate Orthophosphate Dikinase from the C4 Perennial Plant Atriplex ... Studies on Dilution Inactivation of Sheep Liver Pyruvate Carboxylase. Khew-Goodal, Y.S.; Johannssen, W.; Attwood, P.V.; Wallace ... Assaying for Pyruvate Orthophosphate Dikinase Activity: Necessary Precautions with Phosphoenolpyruvate Carboxylase as Coupling ... Cold Inactivation of Phosphoenolpyruvate Carboxylase and Pyruvate Orthophosphate Dikinase from... Salahas, G.; Cormas, E.; ...
  https://www.deepdyve.com/lp/springer_journal/cold-inactivation-of-phosphoenolpyruvate-carboxylase-and-pyruvate-ikl8ywE3b4
*  pyruvate carboxylase deficiency | The Colleen Giblin Research Laboratories for Pediatric Neurology
Tag Archives: pyruvate carboxylase deficiency. Research. LABORATORY & CLINICAL RESEARCH:. Laboratory Research. a. Molecular ... pyruvate dehydrogenase deficiency and pyruvate carboxylase deficiency, among other mitochondrial disorders, were first ... The molecular genetics, pathogenesis and clinical forms of Pyruvate carboxylase deficiency.. *The natural history and therapy ... Pyruvate dehydrogenase function, regulation, and deficiency. The identification of modulatory genes involved in the function of ...
  http://giblinlab.org/tag/pyruvate-carboxylase-deficiency/
*  Manganese in the structure of Crystal Structure of S. Aureus Pyruvate Carboxylase A610T Mutant (pdb 3hb9)
The binding sites of Manganese atom in the structure of Crystal Structure of S. Aureus Pyruvate Carboxylase A610T Mutant (pdb ... Manganese in the structure of Crystal Structure of S. Aureus Pyruvate Carboxylase A610T Mutant (pdb 3hb9). ...
  http://manganese.atomistry.com/pdb3hb9.html
*  In vivo hyperpolarized carbon13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an...
... a combined mellitus on the turnover of rat liver pyruvate carboxylase and pyruvate magnetic resonance imaging and ... pathways of pyruvate can be monitored with hyperpolar- [1-13C]pyruvate and [4-13C]OAA, kpyr-,oaa, showed a more than 3-fold ... 6. Demand for intermediate metabolite OAA drives higher anaplerotic pyruvate carboxylase flux. Anaplerotic flux through PC is ... Flux ready exists within the cellular environment and in the through hepatic pyruvate carboxylase and phosphoenolpyruvate ...
  http://medicinelakex1.com/o/oar.a-star.edu.sg1.html
*  Manganese in the structure of Crystal Structure of Human Pyruvate Carboxylase (Missing The Biotin Carboxylase Domain At the N...
Missing The Biotin Carboxylase Domain At the N-Terminus) ... structure of Crystal Structure of Human Pyruvate Carboxylase ( ... The binding sites of Manganese atom in the structure of Crystal Structure of Human Pyruvate Carboxylase (Missing The Biotin ... Carboxylase Domain At the N-Terminus) (pdb code 3bg3). This binding sites where shown with 5.0 Angstroms radius around ...
  http://manganese.atomistry.com/pdb3bg3.html
*  Structural Biochemistry/Chemistry of important organic molecules in Biochemistry/Vitamins and Cofactors - Wikibooks, open books...
Acetyl COA carboxylase. Biotin. Pyruvate carboxylase. 5'-Deoxyadenosyl cobalamin. Methylmalonyl mutase. Tetrahydrofolate. ... Because thiamine can be converted to thiamine pyrophosphate, a coenzyme that is part of the pyruvate dehydrogenase complex, the ... insufficiency of thiamine leads to the formation of an altered pyruvate dehydrogenase complex that causes neurological defects. ...
  https://en.wikibooks.org/wiki/Structural_Biochemistry/Chemistry_of_important_organic_molecules_in_Biochemistry/Vitamins_and_Cofactors
*  Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism - Full Text View - ClinicalTrials.gov
This study is also open to patients with any type of glycogen storage disease, pyruvate carboxylase deficiency, type B, or ... Pyruvate Carboxylase Deficiency Disease. Pathologic Processes. Malnutrition. Nutrition Disorders. Heart Defects, Congenital. ... Diagnosis of disorder in long chain fatty acid oxidation, glycogen storage disease, pyruvate carboxylase deficiency, type B, or ... Genetics Home Reference related topics: Barth syndrome Mitochondrial trifunctional protein deficiency Pyruvate carboxylase ...
  https://clinicaltrials.gov/ct2/show/NCT01461304?cond=%22mitochondrial+trifunctional+protein+deficiency%22&rank=3
*  Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism - Full Text View - ClinicalTrials.gov
This study is also open to patients with any type of glycogen storage disease, pyruvate carboxylase deficiency, type B, or ... Pyruvate Carboxylase Deficiency Disease. Acidosis. Amino Acid Metabolism, Inborn Errors. Cardiomyopathy, Hypertrophic. Muscle ... Diagnosis of disorder in long chain fatty acid oxidation, glycogen storage disease, pyruvate carboxylase deficiency, type B, or ... Genetics Home Reference related topics: Barth syndrome Mitochondrial trifunctional protein deficiency Pyruvate carboxylase ...
  https://clinicaltrials.gov/ct2/show/NCT01461304?term=%22Expanded+Access%22+%5BSTUDY-TYPES%5D&recr=Open&rank=4
*  RCSB PDB for 3BG9
Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer ... Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus) F1077A Mutant. *DOI: ... Pyruvate carboxylase, mitochondrial A, B, C, D 718 Homo sapiens EC#: 6.4.1.1 IUBMB Fragment: CT+PT+BCCP Domain Mutation: F1077A ...
  http://www.rcsb.org/pdb/explore/geometryDisplay.do?structureId=3BG9
*  Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women | Diabetes
... and pyruvate kinase, which increased with increased BMI, and carbonic anyhydrase 3 decreased with increasing BMI. ... we plan to investigate the role of AMPK in regulating downstream metabolic targets such as acetyl-CoA carboxylase and the ...
  http://diabetes.diabetesjournals.org/content/54/5/1283.full
*  Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications | Genetics
... pyruvate/glyceraldehyde-3-phosphate pathway (Eisenreichet al. 1998; Lichtenthaler 1999), by which the monoterpenes (C10), ... such as the small subunit of ribulose-bisphosphate carboxylase/oxygenase and alcohol dehydrogenase (Clegget al. 1997). Very few ... The plastidial pool of IPP is derived from the glycolytic intermediates pyruvate and glyceraldehyde-3-phosphate and provides ...
  http://www.genetics.org/content/158/2/811