*  Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats | Hypertension
Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice. Mol Biol Cell. 2007; 18: 943-952. ... Hornstein I, Alcover A, Katzav S. Vav proteins, masters of the world of cytoskeleton organization. Cell Signal. 2004; 16: 1-11. ... Immunohistochemical Analysis of Vav Expression in Rat Glomeruli. By immunohistochemical analysis, we found that, among the Vav ... Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell. 2007; 129: 865- ...
*  Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats | Hypertension
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*  Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity | Science...
Natural killer (NK) cells discriminate between healthy cells and virally infected or transformed self-cells by tuning activating and inhibitory signals received through cell surface receptors. Inhibitory receptors inhibit NK cell function by recruiting and activating the tyrosine phosphatase Src homology 2 (SH2) domain-containing protein tyrosine phosphatase-1 (SHP-1) to the plasma membrane. However, to date, the guanine nucleotide exchange factor VAV1 is the only direct SHP-1 substrate identified in NK cells. We reveal that the adaptor protein linker for activation of T cells (LAT) as well as phospholipase C-γ1 (PLC-γ1) and PLC-γ2 are SHP-1 substrates. Dephosphorylation of Tyr132 in LAT by SHP-1 in NK cells abrogated the recruitment of PLC-γ1 and PLC-γ2 to the immunological synapse between the NK cell and a cancer cell target, which reduced NK cell degranulation and target cell killing. Furthermore, the ubiquitylation of LAT by the E3 ubiquitin ligases c-Cbl and Cbl-b, which was induced by ...
*  Requirement of Tyrosine-phosphorylated Vav for Morphological Differentiation of All-trans-Retinoic Acid-treated HL-60 Cells --...
Our previous data demonstrated that cellular and nuclear tyrosine-phosphorylated Vav associate with phosphoinositide 3-kinase during all-trans-retinoic acid-dependent granulocytic differentiation of HL-60 cells. In this study, aimed to analyze the mechanism by which Vav is recruited and activated, we report that the Src homology 2 domain of Vav interacts with tyrosine-phosphorylated proteins in a differentiation-dependent manner. Two adaptor proteins, Cbl and SLP-76, were identified, showing a discrete distribution inside the cells, with Cbl absent from the nuclei and SLP-76 particularly abundant in the nuclear compartment. Of note, Vav interacts with the tyrosine kinase Syk, which is also present in the nuclear compartment and may phosphorylate Vav in vitro when cells differentiate. Inhibition of Syk activity by piceatannol prevents both in vitro and in vivo Vav tyrosine ...
*  Occlusion of DH Domain Inhibits Vav | Science Signaling
The Dbl homology (DH)-containing protein Vav acts as a guanine nucleotide exchange factor (GEF) for the Rho family of guanine triphosphatases (GTPases), and, in vitro, Vav exhibits specific GEF activity toward Rac protein. Phosphorylation of Vav in response to B cell receptor or T cell receptor stimulation precedes Rac activation. Expression of NH2-terminal deletion (residues 1-182) mutants of Vav leads to chronically activated Vav and increased Rac activity. Phosphorylation of Tyr174 is important for activation of Vav, but until now, the mechanism by which Vav is activated has remained elusive. Aghazadeh et al. have used nuclear magnetic resonance (NMR) to solve the structure of the Vav DH domain in solution. By comparing the structure of the DH domain in the presence or absence of phosphate at Tyr174, the authors identified that, in the inactive state, Tyr174 resides in ...
*  anti-ARHGEF18 antibody | GeneTex
ARHGEF18 antibody (Rho/Rac guanine nucleotide exchange factor (GEF) 18) for ICC/IF, WB. Anti-ARHGEF18 pAb (GTX102223) is tested in Human samples. 100% Ab-Assurance.
*  Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation | Science Signaling
The guanine nucleotide exchange factor (GEF) Vav1 is essential for transducing T cell antigen receptor (TCR) signals and therefore plays a critical role in the development and activation of T cells. It has been presumed that the GEF activity of Vav1 is important for its function; however, there has been no direct demonstration of this. Here, we generated mice expressing enzymatically inactive, but normally folded, Vav1 protein. Analysis of these mice showed that the GEF activity of Vav1 was necessary for the selection of thymocytes and for the optimal activation of T cells, including signal transduction to Rac1, Akt, and integrins. In contrast, the GEF activity of Vav1 was not required for TCR-induced calcium flux, activation of extracellular signal-regulated kinase and protein kinase D1, and cell polarization. Thus, in T cells, the GEF activity of Vav1 is essential for some, but not all, of its functions.. ...
*  British Library EThOS: The role of p110δ and Vav proteins in BCR signalling
B-lymphocytes participate in the generation of effective immune responses capable of specifically recognising and selectively eliminating foreign microorganisms and molecules. The binding of an antigen to receptors on B cells activates signalling cascades that induce B cell proliferation, differentiation into memory and antibody secreting plasma cells that facilitate elimination of the antigen. PI3K and Vav are activated downstream of B cell receptor (BCR) and the CD19 co-receptor, p110δ isoform of catalytic subunit of PI3Kinase was chosen as a candidate for immunological assessment as its expression pattern is limited to leukocytes unlike ubiquitously expressed α, β and γ isoforms. We determined the structure of p110δ gene and its deletion was achieved by Cre/LoxP recombination system. We have shown that p110δ function is required for BCR-mediated calcium flux, activation of PLCγ2 and Bruton's tyrosine kinase (Btk). p110δ-/- cells fail to activate protein kinase B (PKB) or upregulate ...
*  Presentation History
10/28/08 - Bing Yao presented Rauch, S. et al. (2008) Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity. Journal of Virology 82, 2918-2929. ...
*  ADAP-ting TCR Signaling to Integrins | Science Signaling
Adaptor proteins are essential components of T cell receptor (TCR) signaling cascades regulating gene transcription and cytoskeletal reorganization. The molecular adaptor adhesion- and degranulation-promoting adaptor protein (ADAP), also known as Fyn binding protein (FYB) or Slp-76-associated protein of 130 kilodaltons (SLAP-130), interacts with a number of signaling intermediates including Slp-76, the Src family tyrosine kinase Fyn, vasodilator-stimulated phosphoprotein (VASP), and the actin-nucleating protein WASP. Recently ADAP was shown genetically to positively regulate T cell activation, TCR-induced integrin clustering, and T cell adhesion. The mechanism by which ADAP couples TCR stimulation to integrin clustering remains unclear; however, studies of ADAP, the exchange factor Vav1, and WASP suggest that TCR and integrin clustering may be controlled by distinct signaling pathways.. ...
*  Plus it
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of human cancer, due in large part to a high incidence of metastasis and resistance to conventional chemotherapies. As such, new therapies are needed to halt the metastatic process. The proto-oncogene Vav1 is ectopically expressed in over half of human pancreatic cancers, and its expression correlates with a poor prognosis in humans and promotes survival and transformation in isolated tumor cells. We have found that Vav1, through its GEF activity towards Rac1, also potently induces migration by pancreatic tumor cells. In addition, Vav1 also signals through Cdc42 to drive the formation of invadopodia and matrix degradation, which also promotes tumor cell invasion. Importantly, the activation of Vav1 circumvents the requirement for active Src in this process. Because Vav1 is ectopically expressed in pancreatic cancers and ...
*  VAV3 - Wikipedia
Vav 3 oncogene, também conhecido como VAV3, é uma proteína que em humanos é codificado pelo gene VAV3. VAV3 mostrou interação com a Grb2. «Entrez Gene: VAV3 vav 3 oncogene» Blagoev, Blagoy; Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (2003). «A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling». United States. Nat. Biotechnol. 21 (3): 315-8. ISSN 1087-0156. PMID 12577067. doi:10.1038/nbt790 A referência emprega parâmetros obsoletos ,coautor= (ajuda); Parâmetro desconhecido ,quotes= ignorado (,titulolivro=) sugerido (ajuda) Zeng, L; Sachdev P, Yan L, Chan J L, Trenkle T, McClelland M, Welsh J, Wang L H (2000). «Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation». UNITED STATES. Mol. ...
*  Rabgef1 MGI Mouse Gene Detail - MGI:1929459 - RAB guanine nucleotide exchange factor (GEF) 1
View mouse Rabgef1 Chr5:130171798-130214342 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
*  Table of Contents - December 15, 2009, 2 (101) | Science Signaling
Online Cover This week's issue features a Research Article that defines a role for the catalytic activity of the Vav1 guanine nucleotide exchange factor (GEF) in T cell biology. The image shows a complex between the catalytic core of Vav1 in gray and its substrate, the Rac1 GTPase, in gold. The locations of Leu334 and Lys335 in the Dbl homology (DH) domain of Vav1 are indicated in red. These two amino acid residues make key contacts with Rac1 and are essential for the exchange reaction. Experiments with mice that have a knock-in mutation in these residues showed that Vav1 has both GEF-dependent and GEF-independent activities that are necessary for T cell development and activation. [Image: Steve Smerdon, MRC National Institute for Medical Research, London, UK] ...
*  OriGene - Vav1 (NM 011691) cDNA Clone
Vav1 - Vav1 (untagged) - Mouse vav 1 oncogene (Vav1), transcript variant 1, (10ug) available for purchase from OriGene - Your Gene Company.
*  Vav - Connection - Kabbalah, Chassidism and Jewish Mysticism
Design. The sixth letter of the alef-beis is the vav.. The design of the letter vav is a hook.2 The form of the vav can also represent a chute which connects a higher level to a lower level.. Gematria. The numerical equivalent of the vav is six. Six represents con-nection, exemplified by the angels in Ezekiel's vision, whose six wings enabled them to soar to unite and connect with G‑d. Six also represents the six books of the Mishnah. Through learning Torah, one connects with G‑d.. Six also represents completion, because something that is surrounded on all six sides-north, south, east, west, above and below-is complete. Similarly we find that when the Jewish people left the land of Egypt, G‑d surrounded them with six Clouds of Glory.3 The cloud above them protected them from the sun. The cloud below shielded them from the hot desert sand.The four clouds around them-back and front, left and right-served as a protective shield. Arrows and ...
*  X-Ray & Vav: Series Info
X-Ray and Vav is an animated series by Rooster Teeth. The series revolves around the heroes X-Ray and Vav, based on the team formed by Ray Narvaez, Jr. and Gavin Free, and is directed by Jordan Cwierz and Lindsay Jones, with Patrick Rodriguez as the art director. X-Ray and Vav want to be the greatest super heroes ever, but they're the last people you'd want to be saved by. Despite their lack of superhero prowess, the duo is ready to take on any thug, robber or villain who stands in the way of justice. And they'll do it in true X-Ray and Vav fashion; crotch touching and creating chaos to save the day (for the most part ...
*  RCSB PDB - Protein Feature View - Rab5 GDP/GTP exchange factor - Q9UJ41 (RABX5 HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
*  Vav1 interacts with β-catenin in lung epithelial cance | Open-i
Vav1 interacts with β-catenin in lung epithelial cancer cell linesa. Vav1 protein expression in pulmonary and lymphoid cell lines. Total cell extracts were ana
*  OriGene - VAV1 (NM 001258206) shRNA
VAV1 - VAV1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector shRNA available for purchase from OriGene - Your Gene Company.
*  X-Ray and Vav
... want to be the greatest super heroes ever, but they're the last people you'd want to be saved by. Despite their lack of superhero prowess, the duo is ready to take on any thug, robber or villain who stands in the way of justice. And they'll do it in true X-Ray and Vav fashion; crotch touching and creating chaos to save the day (for the most part)!. ...
*  WikiGenes - VAV3-AS1 - VAV3 antisense RNA 1
The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
*  EZH2 - 维基百科,自由的百科全书
该基因编码的蛋白属于多梳家族(PcG)成员。PcG家族成员相互结合形成多聚蛋白复合物,这种复合物涉及到在细胞世代间维持基因的转录抑制状态。EZH2主要通过将三个甲基基团加到组蛋白3的27号赖氨酸(H3K27)上行使基因沉默者的角色,三甲基化H3K27是维持染色质凝聚的一种重要修饰[4]。. 该蛋白与胚胎外胚层发育蛋白(EED)、癌蛋白VAV1和X连锁核蛋白(XNP)之间关系密切。EZH2蛋白可能在造血系统和中枢神经系统中起到重要作用[3]。. ...
*  Wasted Potential | Adventure Log | Obsidian Portal
Obsidian Portal allows you to create campaign websites for tabletop roleplaying games. Better manage your group and your campaign, and have a better game.
*  U.S. adds jobs, despite Hurricane Sandy impact | NJBIZ
Though economists expected Hurricane Sandy to devastate November employment, the private sector held its hiring pace steady last month, adding 147,000 jobs to the U.S. economy and edging down the unemployment rate to 7.7 percent, from 7.9 percent in October, the U.S. Department of Labor's Bureau of Labor Statistics reported today.