*  Duke Physics
Large proteins frequently fold cotranslationally and/or require chaperones. Firefly (Photinus pyralis) luciferase (Luciferase, ... Over the last 50 years, significant progress has been made toward understanding how small single-domain proteins fold. However ... very little is known about folding mechanisms of medium and large multidomain proteins that predominate the proteomes of all ... has been a model of a cotranslationally folding protein whose extremely slow refolding (approximately days) is catalyzed by ...
  http://fds.duke.edu/db/aas/Physics/faculty/weitao.yang/publications/234860
*  Hspa14 - Heat shock 70 kDa protein 14 - Rattus norvegicus (Rat) - Hspa14 gene & protein
... a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to ... a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q6AYB4. Q0VDF9. B4DYI5. UPI000BB817FA. ...
  http://www.uniprot.org/uniprot/Q6AYB4
*  eScienceCommons: How protein misfolding may kickstart chemical evolution
The origami of disease, and of life: Research into the abnormal folding of proteins related to neurodegenerative conditions is ... "These protein polymers can fold into a seemingly endless array of forms, and sometimes behave like origami," Lynn explains. " ... "The folding events, or phase changes, drive the chemistry and the chemistry drives the replication of the protein molecules," ... Alzheimer's disease, and other neurodegenerative conditions involving abnormal folding of proteins, may help explain the ...
  http://esciencecommons.blogspot.com/2017/02/how-protein-misfolding-may-kickstart.html
*  Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated Protein Degradation? | BenthamScience
2) Expression of proteins involved in polypeptide folding is strongly enhanced by a process called the Unfolded Protein ... 2) Expression of proteins involved in polypeptide folding is strongly enhanced by a process called the Unfolded Protein ... Current Protein & Peptide Science. Title: Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated ... Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated Protein Degradation?. Author(s): Theo van ...
  http://www.eurekaselect.com/81690/article
*  KEGG PATHWAY: Protein processing in endoplasmic reticulum - Homo sapiens (human)
Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are ... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly ... Protein processing in endoplasmic reticulum - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download ... Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein ...
  http://www.genome.jp/kegg-bin/show_pathway?133752177630086/hsa04141.args
*  Folding and misfolding in a naturally occurring circularly permuted PDZ domain
Data reveal that the folding of the permuted protein is characterized by the presence of a low energy off-pathway kinetic trap ... Here we report the first description of the folding mechanism of a naturally occurring circularly permuted protein, a PDZ ... Folding and misfolding in a naturally occurring circularly permuted PDZ domain. Ivarsson, Ylva University of Rome, La Sapienza. ... This study provides a straightforward example of the divergent demands of folding and function. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:636249
*  Protein Conformational Disease: Visit the Facts at a Glance
... and failure to fold into the native structure has profound deleterious effects, frequently causing diseases ... Proteins perform their function for adopting a particular 3D structure, referred as native structure, ... Folding and Design 1 (6): 441-450.. Onuchic JN and Wolynes PG (2004) Theory of protein folding. Current Opinion in Structural ... Mutational Mechanisms of Genetic Disease , Protein Structure , Protein Folding, Evolution and Degradation , Basic Cell Biology ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0021868.html
*  Berkeley Structural Genomics Center: Job Opportunities
Sequence-based detection of distantly related proteins with the same fold. Protein Eng 14:455-8. [PubMed] *Kim VN, Kataoka N, ... Electrophoresis of proteins and protein-protein complexes in a native agarose gel. Anal Biochem 282:147-9. [PubMed] *Kim SH. ... A conserved hypothetical protein from Mycoplasma genitalium shows structural homology to nusb proteins. Proteins 55:1082-6. [ ... A global representation of the protein fold space. Proc Natl Acad Sci U S A 100:2386-90. [PubMed],[abstract] *Kim SH, Shin DH, ...
  http://strgen.org/pubs/
*  ERLEC1 - Endoplasmic reticulum lectin 1 precursor - Homo sapiens (Human) - ERLEC1 gene & protein
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality ... control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. ... Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q96DZ1. V9HWD3. Homo sapiens (Human). 483. ...
  http://www.uniprot.org/uniprot/Q96DZ1
*  Sarkosyl Preparation of Antigens from Bacterial Inclusion Bodies
In many cases, solubility and proper folding of fusion proteins expressed in bacteria pose a major challenge in protein ... Protocol 5: Protein A Purification of Antibodies *Protocol 6: Protein G Purification of Antibodies *Protocol 7: Isolation of ... Protocol 16: Preparing GST-Fusion Proteins from Bacteria *Protocol 17: Preparing His-Fusion Proteins from Bacteria *Protocol 18 ... Enzyme-Linked Detection When Immunogen Is an Immunoglobulin Fusion Protein (Indirect ELISA to Detect Ig Fusion Proteins) * ...
  http://antibodiesmanual.org/index.php?prt=19
*  Two-state trajectory - Wikipedia
Schuler, Benjamin; Lipman, Everett A.; Eaton, William A. (2002). "Probing the free-energy surface for protein folding with ... Rhoades, Elizabeth; Gussakovsky, Eugene; Haran, Gilad (2003). "Watching proteins fold one molecule at a time". Proceedings of ... Schmidt, Ulrich; Weiss, Matthias (2011). "Anomalous diffusion of oligomerized transmembrane proteins". The Journal of Chemical ... measurements of protein dynamics and DNA and RNA dynamics, activity of ion channels, enzyme activity, quantum dots). From these ...
  https://en.wikipedia.org/wiki/Two-state_trajectory
*  Folding Forum • View topic - Protein-Folding Simulations Sped Up
... have been successful overall at modeling biological molecules like proteins. To determine how proteins fold, the simulation ... Protein-Folding Simulations Sped Up. Please confine these topics to things that would be of general interest to those who are ... Protein-folding simulations sped up. By modeling biological molecules over longer timescales, a new algorithm can help better ... Proteins are huge molecules whose function depends on how they fold into intricate structures. To understand how these ...
  https://foldingforum.org/viewtopic.php?f=15&p=299506
*  Protein folding
The split-second folding of gangly protein chains into tight three-dimensional shapes has broad implications for the growing ... number of disorders believed to result from misfolded proteins or parts of proteins, most notably ... ... Protein folding. by dignan » Mon Nov 13, 2006 10:12 am No mention of MS, and they say that, "The split-second folding of gangly ... how the resulting protein will fold -- the first computer model to fully replicate folding of a protein as happens in nature. ...
  http://www.thisisms.com/forum/general-discussion-f1/topic3222.html
*  A protein fold switch joins the circadian oscillator to clock output in cyanobacteria | Science
A protein fold switch joins the circadian oscillator to clock output in cyanobacteria ... A protein fold switch joins the circadian oscillator to clock output in cyanobacteria ... A protein fold switch joins the circadian oscillator to clock output in cyanobacteria ... A protein fold switch joins the circadian oscillator to clock output in cyanobacteria ...
  http://science.sciencemag.org/content/349/6245/324
*  Forschungszentrum Jülich - Protein Folding and Protein Biosynthesis - Incorporation of membrane proteins into lipid bilayers
Functional Protein Dynamics *Protein Folding and Protein Biosynthesis : *Native and unfolded states of phosphoglycerate kinase ... Currently we focus on membrane protein folding in situ using cell-free expression systems and nanodiscs to monitor synthesis ... offer a valuable approach to probe membrane proteins in situ. To express a protein by a cell-free system, purified and ... Incorporation of membrane proteins into lipid bilayers. Nanodisc with cell-free expressed bacteriorhodopsin (bR, purple), an α- ...
  http://www.fz-juelich.de/ics/ics-5/DE/Forschung/Themen/Protein_Folding_and_Protein_Biosynthesis/Incorporation/artikel.html?nn=1517612
*  Analysis of Protein Folding and Oxidation in the Endoplasmic Reticulum - Current Protocols
... translational folding and oxidation steps that lead to correct conformation of the final protein ... Proteins that travel through the secretory pathway undergo post‐ ... protein folding by proteolytic sensitivity (see protocol 3. ), chaperone binding (see protocol 5. ), or protein folding with ... protein folding by proteolytic sensitivity (see protocol 3. ), chaperone binding (see protocol 5. ), or protein folding with ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb1506.html
*  Protein Folding Activity of the Ribosome (PFAR) : A Target for Antiprion Compounds
Protein Folding Activity of the Ribosome (PFAR): A Target for Antiprion Compounds. Banerjee, Debapriya Uppsala University, ... Thus, prions originate as protein folding problems. The discovery of yeast prion(s) and the development of a red-/white-colony ... and inhibit specifically the protein folding activity of the ribosome (PFAR). The domain V of the 23S/25S/28S rRNA of the large ... 6AP and GA inhibit PFAR by competition with the protein substrates for the common binding sites on the domain V rRNA. PFAR ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:775067
*  Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
Circular permutation, when peripheral to the major folding nucleus, may have little effect on folding pathways and could ... it is frequently tolerated by different protein folds. ... We solved the crystal structure and investigated the folding ... This observation contrasts with previous data on the circularly permuted PDZ2 domain from PTP-BL, for which the folding pathway ... The different effects of this circular permutation in two homologous proteins show the strong influence of sequence as compared ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050055
*  New technique allows study of protein folding, dynamics in li... ( CHAMPAIGN Ill. A new technique to s...)
... protein,folding,,dynamics,in,living,cells,biological,biology news articles,biology news today,latest biology news,current ... A new technique to study protein dynamics in living c...Martin Gruebele the James R. Eiszner Professor of Chemistry at Illino ... New technique allows study of protein folding, dynamics in living cells. ...CHAMPAIGN Ill. A new technique to study protein ... "This is the first experiment that allows us to observe the dynamics of a protein folding in a live cell," Gruebele said. "Now ...
  http://www.bio-medicine.org/biology-news-1/New-technique-allows-study-of-protein-folding--dynamics-in-living-cells-12080-1/
*  FOLD4 - Bifunctional protein FolD 4, chloroplastic precursor - Arabidopsis thaliana (Mouse-ear cress) - FOLD4 gene & protein
Bifunctional protein FolD 4, chloroplasticAdd BLAST. 309. Amino acid modifications. Feature key. Position(s). Description ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. O65271. A0A178V455. D7M5L8. UPI00053AE5F2. R0FFA5 ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. O65271. A0A178V455. Arabidopsis thaliana (Mouse- ...
  http://www.uniprot.org/uniprot/O65271
*  I disagree on protein folding- It seems to me that AlphaGo Zero is a great analo... | Hacker News
I disagree on protein folding- It seems to me that AlphaGo Zero is a great analogy to the protein folding problem: If you have ... those rules don't exist as such for protein folding. In other words if I generate 1000 protein folds, I don't know which ones ... I think AlphaGo is a fundamentally different problem than is the protein folding problem. I can generate a Go board and a ... DeepMind has already begun using AlphaGo Zero to study protein folding and has promised it will soon publish new findings.. ...
  https://news.ycombinator.com/item?id=15700141
*  Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives eBook by Laishram Rajendrakumar Singh Kobo...
Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives. byLaishram Rajendrakumar Singh, Tanveer Ali Dar ... Title:Cellular Osmolytes: From Chaperoning Protein Folding to Clinical PerspectivesFormat:Kobo ebookPublished:May 16, 2017 ... The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones ... This book provides essential information on improving protein folding/stability, which is a result of the balance between the ...
  https://www.chapters.indigo.ca/en-ca/books/cellular-osmolytes-from-chaperoning-protein/9789811037078-item.html
*  Use Of Homology Information In Replica Exchange Methods For De-novo Protein Fold Prediction | 9393
The performance of ab-initio methods for protein fold prediction strongly depends on two components: an energy function that is ... The performance of ab-initio methods for protein fold prediction strongly depends on two components: an energy function that is ... Use of homology information in replica exchange methods for de-novo protein fold prediction. ... It is accepted that homologous proteins have similar native structures, thus their energy landscapes and therefore their ...
  https://www.omicsonline.org/proceedings/use-of-homology-information-in-replica-exchange-methods-for-denovo-protein-fold-prediction-9393.html
*  A Two-Layer Learning Architecture for Multi-Class Protein Folds Classification: Medicine & Healthcare Book Chapter | IGI Global
Classification of protein folds plays a very important role in the protein structure discovery process, especially when ... A Two-Layer Learning Architecture for Multi-Class Protein Folds Classification: 10.4018/978-1-4666-3604-0.ch041: ... the protein fold recognition problem can be viewed as a fold classification problem, where a query protein can be classified ... plays a critical role in protein folds recognition. This approach assumes that the number of protein folds is limited according ...
  https://www.igi-global.com/chapter/two-layer-learning-architecture-multi/76094