*  HSPA1 - Heat shock 70 kDa protein 1 - Pongo abelii (Sumatran orangutan) - HSPA1 gene & protein
... ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for ... Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its ... folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and ... In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a ...
  http://www.uniprot.org/uniprot/Q5R7D3
*  Protein Folding Activity of the Ribosome (PFAR) : A Target for Antiprion Compounds
Protein Folding Activity of the Ribosome (PFAR): A Target for Antiprion Compounds. Banerjee, Debapriya Uppsala University, ... Thus, prions originate as protein folding problems. The discovery of yeast prion(s) and the development of a red-/white-colony ... and inhibit specifically the protein folding activity of the ribosome (PFAR). The domain V of the 23S/25S/28S rRNA of the large ... 6AP and GA inhibit PFAR by competition with the protein substrates for the common binding sites on the domain V rRNA. PFAR ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:775067
*  Different conformations of nascent polypeptides during translocation across the ER membrane
It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest ... In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. ... that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the ribosome. ...
  http://su.diva-portal.org/smash/record.jsf?pid=diva2:187952
*  JCI - Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis
... preventing the proper folding of the protein and ultimately leading to impaired trafficking and ER retention (28). It is likely ... To study this further, we transiently expressed a transgenic LC3B fusion protein tagged with both red fluorescent protein (RFP ... protein transport (Atg10, Atg16l2); and protein ubiquitination (Atg3) (56, 57). Genes associated with transmitting an ... which disrupts disulfide bridging at critical nodes of protein folding. The majority of reported mutations reside within the ...
  https://haochuduo.net.insight.mobile.jci.org/articles/view/93817
*  Circular permutation in proteins - Wikipedia
"Circular permuted proteins in the universe of protein folds". Proteins: Structure, Function, and Bioinformatics. 78 (7): 1618- ... Circularly permuted versions of proteins will often fold in a different order, providing information about the folding of the ... Regardless of which protein comes first, this fusion protein may show similar function. Thus, if a fusion between two proteins ... Find insertion sites for other proteins. Inserting one protein as a domain into another protein can be useful. For instance, ...
  https://en.wikipedia.org/wiki/Circular_permutation_in_proteins
*  Table of Contents - March 15, 1996, 271 (5255) | Science
Protein Folding Triggered by Electron Transfer. By Torbjörn Pascher, John P. Chesick, Jay R. Winkler, Harry B. Gray ... Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein. By Theresa M. Klauck, Maree C. Faux, Kirstin ... See 1526, the special section on Protein Kinesis beginning on 1513, and the News story on 1493. [R. Schekman and L. Orci] ... immunolabeled to reveal the sites of the nuclear envelope that are associated with the coat protein coatomer. Antibodies to ...
  http://science.sciencemag.org/content/271/5255
*  Stanford researchers make first direct observation of 3-D molecule folding in... ( All the crucial proteins in our bodi...)
... folding,in,real,time,biological,biology news articles,biology news today,latest biology news,current biology news,biology ... The researchers are the first to study the energy and folding behavior...,Stanford,researchers,make,first,direct,observation,of ... All the crucial proteins in our bodies must fold into complex shapes t...Recently scientists have discovered that RNA-the ... All the crucial proteins in our bodies must fold into complex shapes to do their jobs. These snarled molecules grip other ...
  http://www.bio-medicine.org/biology-news-1/Stanford-researchers-make-first-direct-observation-of-3-D-molecule-folding-in-real-time-2208-1/
*  JBC Special Section | Meet Lila Gierasch, JBC editor-in-chief
If they don't fold properly, many of them are degraded. Chaperones are decision points - if a protein hasn't folded properly, ... We are exploring how chaperones facilitate protein folding and protein quality control in two ways. One is to burrow into the ... They get released as folded proteins, but along the way, the partially folded states that are newly synthesized are being ... An expert in protein folding, Gierasch says the Journal of Biological Chemistry welcomes all research that gets to the heart of ...
  http://www.asbmb.org/asbmbtoday/201706/JBCSpecialIssue/GIERASCH/
*  In Silico Archive | In the Pipeline
Protein Folding: Complexity to Make More Complexity?. September 25, 2008. Want a hard problem? Something to really keep you ... Try protein folding. That'll eat up all those spare computational cycles you have lounging a… Read More ... The Motions of a Protein. March 26, 2009. So, people like me spend their time trying to make small molecules that will bind to ... some target protein. So what happens, anyway, when a small molecule binds t… Read More ...
  http://blogs.sciencemag.org/pipeline/archives/category/in-silico/page/12
*  Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes....
Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes. ... Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes. ... Finally, we established that the G protein of the folding mutant of the Vesicular Stomatitis virus, ts045, is blocked at a ... These monomers are properly folded, judging by their binding of conformation-specific mAbs. When the G protein is translated in ...
  http://jcb.rupress.org/content/120/3/647
*  Developing a Spectroscopic Toolkit for Probing Protein Structure and Folding - Carlos Baiz
Understanding protein folding from a molecular perspective is one of the central challenges in modern biophysics. Current ... Developing a Spectroscopic Toolkit for Probing Protein Structure and Folding Baiz, Carlos Raul University of Chicago, Chicago, ... Understanding protein folding from a molecular perspective is one of the central challenges in modern biophysics. Current ... Baiz, Carlos R; Tokmakoff, Andrei (2015) Structural disorder of folded proteins: isotope-edited 2D IR spectroscopy and Markov ...
  http://grantome.com/grant/NIH/F32-GM105104-02
*  SELECTBIO - Systems Biology Europe Speaker Biography
... folding will be discussed, including the structure and dynamics of fluid lipid bilayers, physical principles of protein folding ... Membrane Protein Folding and Assembly. Wednesday, 17 October 2012 at 10:00 ...
  https://selectbiosciences.com/conferences/biographies.aspx?speaker=50002&conf=SBE2012
*  A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G | Science
A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G ... A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G ... A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G ... A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G ...
  http://science.sciencemag.org/content/253/5020/657
*  All Categories: Antibodies, ELISA Kits, Lysates | Cell Signaling
Protein Folding / Stability (90). Protein Folding (22). Unfolded Protein Response (68). Protein Translation (140). RNA ... G Proteins (126). Growth / Development (1034). Immunity / Inflammation (2361). Membrane Trafficking (287). Metabolism (459). ...
  https://www.cellsignal.com/browse/protein-folding-stability-protein-folding?N=4294960016+4294956287
*  2010 Michigan Tech Research Magazine | Michigan Technological University
Ulrich Hansmann Honored for Research on Protein Folding. by Jennifer Donovan. Ulrich Hansmann, professor of physics and leader ... Hansmann is renowned for his computational modeling of protein folding, a molecular process that, when it goes awry, can give ... "Uli's achievements in the protein-folding problem-one of the most significant challenges in science today-have been astonishing ... His work could help uncover the underlying processes causing proteins to misfold, potentially leading to effective therapies. ...
  https://www.mtu.edu/magazine/research/2010/
*  Journal of Integrative Bioinformatics
A Hierarchical Approach to Protein Fold Prediction. Mohammad, Tabrez Anwar Shamim / Nagarajaram, Hampapathalu Adimurthy ... Protein-Protein Interaction Article Classification Using a Convolutional Recurrent Neural Network with Pre-trained Word ...
  https://www.degruyter.com/view/j/jib.2011.8.issue-1/issue-files/jib.2011.8.issue-1.xml
*  Antibody Conjugates : Conjugated Monoclonal Antibodies | Cell Signaling
Protein Folding / Stability (14). Protein Folding (9). Unfolded Protein Response (5). Protein Translation (34). RNA Processing ... G Proteins (1). Growth / Development (184). Immunity / Inflammation (398). Membrane Trafficking (54). Metabolism (61). ...
  https://www.cellsignal.com/browse/antibody-conjugates/protein-folding-stability-protein-folding?N=102260+4294960016+4294956287&No=%7Boffset%7D&Nrpp=200
*  Progress in Nucleic Acid Research and Molecular Biology: Volume 79 : Kivie Moldave : 9780125400800
Molecular Biology of Protein Folding, Part B: Volume 84 Dr. P. Michael Conn ... Molecular Biology of Protein Folding, Part A: Volume 83 Dr. P. Michael Conn ... G Protein-Coupled Receptors in Health and Disease, Part B: Volume 89 Ya-Xiong Tao ... Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein: Critical Role in Reverse Transcription and Molecular Mechanism. ...
  https://www.bookdepository.com/Progress-Nucleic-Acid-Research-Molecular-Biology-79-Kivie-Moldave/9780125400800?ref=bd_ser_1_1
*  Computational Physics Class - Projects
Protein Folding - Erez Dekel This project presents a simple model for protein folding that enables the user to select different ... amino acids and bond angles and then anneal the protein into its folded state. The programs are a combination of matlab and c ...
  http://phycomp.technion.ac.il/~comphy/projects_class.html
*  FX Claim PFol
Claim PFol - Protein folding solved by 2010. Category: Science & Technology:Medicine, Biochemistry. JUDGED at 0 ... In the past, these meetings have centered around a large-scale contest of protein folding prediction techniques. ... Proteins used to satisfy this claim must meet the following criteria:. *Must be nontrivial in size: greater than 50 amino acids ... This claim will be judged YES if by 1 Jan 2010 knowledge of a protein's amino acid sequence is sufficient to determine its ...
  http://www.ideosphere.com/fx-bin/Claim?claim=PFol&uid=73
*  SCOP2 - fold: Lambda cro protein-like (2000131)
... the three helices retain similar arrangement to the first three helices of the p22 cro protein-like fold, including HTH motif ... protein Regulatory protein cro of the lambda fold-type (5000952). adopt an alpha+beta fold different from the common fold of ... Globular proteinsFold into compact units. Soluble in aqueous solutions Events. *Fold change in the lambda C1 repressor DNA- ... Fold. fold Lambda cro protein-like (2000131). beta-alpha(3)-beta(2); 2 layers: a/b; antiparallel beta-sheet, order 123; the ...
  http://scop2.mrc-lmb.cam.ac.uk/2000131
*  New headway in battle against neurodegenerative diseases
As the term suggests, protein misfolding diseases stem from the fact that proteins, which need to fold into a particular shape ... Monster mash: Protein folding gone wrong. November 1, 2013 Imagine a 1950s horror movie monster-a creeping, gelatinous, gluey ... Proteins are the workhorses of the cell, and their correctly folded three-dimensional structures are critical to cellular ... a loose classification for proteins which assist in the folding of others, thereby preventing them from causing damage when ...
  https://medicalxpress.com/news/2014-05-headway-neurodegenerative-diseases.html
*  Table of Contents - November 27, 2015, 350 (6264) | Science
Cotranslational protein folding on the ribosome monitored in real time. By Wolf Holtkamp, Goran Kokic, Marcus Jäger, Joerg ... A small protein folds into a non-native form as it is synthesized on the ribosome before adopting its native shape. ...
  http://science.sciencemag.org/content/350/6264/