Static electric field strengths of 0.001 V/nm and 0.002 V/nm induced conformational changes in the protein but had no ... This study demonstrated that it is necessary to gain insight into protein dynamics under external electric field stress, in ... modeling approach was applied to evaluate the effect of external electric field on gliadin protein structure and surface ... It is known that protein conformation determines the functionality of the protein, any change in its conformation may lead to ...
A distance geometry-based description and validation of protein main-chain conformation ... Protein backbone. (a) Full-atom representation described by the Ramachandran φ and ψ angles (in red); the ω torsion and τ ...
N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding J Mol Biol. ... The m(6)A-modified hairpin has a predisposed conformation that resembles the hairpin conformation in the RNA-HNRNPC complex ... A-dependent regulation of protein binding through a change in RNA structure, termed "m(6)A-switch", affects transcriptome-wide ...
An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1 ... An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1.. Rudolph, M.J., ... A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a ... Carbon catabolite-derepressing protein kinase. A. 271. Saccharomyces cerevisiae. Mutation(s): 0 Gene Names: SNF1, CAT1, CCR1, ...
Keywords: mass spectrometry; protein folding; protein-ligand interactions; protein dynamics; FK506-binding protein; FKBP12; ... Here, we apply well-established chemistry to conformation-sensitive oxidative protein labelling on a timescale of a few seconds ... Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation. In: International Journal of Molecular ... followed by analysis through a routine protein analysis workflow. For a set of model proteins, we show that site selectivity of ...
The pathogenic mutation T182A converts the prion protein into a molten globule-like conformation whose misfolding to oligomers ... The pathogenic mutation T182A converts the prion protein into a molten globule-like conformation whose misfolding to oligomers ... The pathogenic mutation T182A converts the prion protein into a molten globule-like conformation whose misfolding to oligomers ... The pathogenic mutation T182A converts the prion protein into a molten globule-like conformation whose misfolding to oligomers ...
Previous studies have shown that the protein-free U2-U6 snRNA complex adopts two conformations in equilibrium, characterized by ... indicating a specific conformation of the active site stabilized by the protein. These data suggest that although the central ... spliceosomal proteins, to facilitate and stabilize the catalytically active conformation. We showed that incubation with the ... in the form of RNA-protein complexes (U1, U2, U4, U5 and U6) and hundreds of proteins. U2 and U6 small nuclear (sn)RNAs are the ...
Publication: A protein dynamics study of Photosystem II; the effects of protein conformation on reaction center function.. All ... A protein dynamics study of Photosystem II; the effects of protein conformation on reaction center function. ...
All species are found to have a restricting influence on the conformation of a peptide bond. Nonplanar deformations of the ... various hydrogen bonding species that are similar to those typically found in the environment of a peptide within a protein ... Theoretical Studies of Environmental Effects on Protein Conformation: Flexibility of the Peptide Bond S. Scheiner and C. W. ... Theoretical Studies of Environmental Effects on Protein Conformation. 1. Flexibility of the Peptide Bond ...
Conjugation with tetanus toxoid protein however greatly increased the molar mass and polydispersity of the final conjugates. ... Conformation analysis using HYDFIT (which globally combines sedimentation and viscosity data), "Conformation Zoning" and Wales- ... Solution conformation and flexibility of capsular polysaccharides from Neisseria meningitidis and glycoconjugates with the ... protein used for the conjugation. As with the recently published finding for Hib-TT complexes, it is the carbohydrate component ...
Highly motivated candidates with a doctoral degree in related fields (e.g., stem cell biology or electrophysiology) or a strong background in structural biology (e.g., NMR, single molecule analysis), genomics/proteomics or neuroscience are welcomed although the background of applicants is not strictly limited to these research fields. Applicants are also encouraged to apply for JSPS, HFSP or other postdoctoral fellowships such as the RIKEN Foreign Postdoctoral Researcher program.. ...
30/6/2016). Tryptophan fluorescence quenching as a binding assay to monitor protein conformation changes in the membrane of ... Tryptophan fluorescence quenching as a binding assay to monitor protein conformation changes in the membrane of intact ... Tryptophan fluorescence quenching as a binding assay to monitor protein conformation changes in the membrane of intact ... Intrinsic protein fluorescence is due to aromatic amino acids, mainly tryptophan, which can be selectively measured by exciting ...
Influence of glycosylation on protein folding and conformation. N-linked glycans can affect the protein structure in two ... which is a frequently used method to evaluate the quality of the protein backbone conformation (Hooft et al., 1997. ; Lovell et ... Definition of ω6 conformations. The ω6 torsion (O6-C6-C5-O5) mainly occurs in one of the three staggered conformations, which ... such as protein glycosylation or protein-carbohydrate interactions. The Protein Data Bank (PDB) is a valuable resource for ...
List of protein structure prediction software Chou PY, Fasman GD (1974). "Prediction of protein conformation". Biochemistry. 13 ... Chou PY, Fasman GD (1978). "Empirical predictions of protein conformation". Annu Rev Biochem. 47: 251-276. doi:10.1146/annurev. ... doi:10.1093/protein/11.5.345. PMID 9681866. Chen H, Gu F, Huang Z (2006). "Improved Chou-Fasman method for protein secondary ... Kyngas J, Valjakka J (1998). "Unreliability of the Chou-Fasman parameters in predicting protein secondary structure". Protein ...
Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin ... Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin Kurzbach, D., Platzer, G., ... Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin. Biochemistry, 52(31), 5167- ...
Implementing REST to the entire ligand as opposed to solely the perturbed region, and also some important flexible protein ... in terms of both ligand and protein conformations. We have developed our FEP+ modified protocol based on one ligand-protein ... Protein and ligands preparation. Protein structures were downloaded from the Protein Data Bank (pdb; (www.rcsb.org). For the ... A highly accurate metadynamics-based Dissociation Free Energy method to calculate protein-protein and protein-ligand binding ...
Structure and function of locked conformation of the SARS-CoV-2 spike protein identified A new preprint research paper, posted ... The findings suggest the spike protein turns into a locked state to stabilize the spike protein during virus egress. ... Recombinant SARS-CoV-2 protein vaccine less immunogenic but more antigenic than expected Now, a new preprint research paper ... Arf family proteins function to mediate the recruitment of cytosolic effectors to specific subcellular compartments. ...
A New Infectious Agent, Role Of Protein Conformation, Prion Diseases. In 1997 Stanley Prusiner was awarded the Nobel Prize in ... While the latter rely on nucleic acid for survival and replication, the prion is made of a protein and lacks nucleic acid. Both ... His theory, the "prion hypothesis," concerns an unusual protein, the prion, which occurs in the complete absence of DNA and RNA ...
G PROTEIN-BOUND CONFORMATION OF MASTOPARAN-X, NMR, 14 STRUCTURES - 1A13 , canSARS ... Target Protein. Gene. Expression System. Organism. Synonims. Actions. 1A13_A P01515 --. ESCHERICHIA COLI. JAPANESE YELLOW ...
Protein Binding * Protein Conformation * Protein Interaction Domains and Motifs Substances * DNA-Binding Proteins ...
... microstructure and protein conformation. Tan, Jien; Deng, Chunyang; Yao, Yao; Wu, Na; Xu, Mingsheng; Chen, Shuping; Yin, ... microstructure and protein conformation of alkali-induced egg white (EW) gels were investigated. With increasing concentration ... And the protein component was not affected by ion concentration. Due to the difference in charge density, the three anions had ... three copper salts promoted the aggregation of EW proteins while decreasing the ß-sheet content. The three-dimensional gel ...
"Computational prediction of protein aggregation: Advances in proteomics, conformation-specific algorithms and biotechnological ... contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic ... These studies spotted aggregation as a major force driving protein evolution. Actual algorithms work on both protein sequences ... Protein aggregation is behind the onset of neurodegenerative disorders and one of the serious obstacles in the production of ...
2021 - ARC Centre of Excellence for Innovations in Peptide and Protein Science ... Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.. *Post by: CIPPS ...
... a flexible engine to explore backbone conformations and their relationships to covalent geometry. ... Protein Geometry Database: a flexible engine to explore backbone conformations and their relationships to covalent geometry. ...
... protein conformation, protein structure prediction, protein tertiary structure2, recurrent layer, structure quality analysis, ... Equipping Decoy Generation Algorithms for Template-free Protein Structure Prediction with Maps of the Protein Conformation ... AlphaFold2, antimicrobial peptide recognition, conformation sampling, Convolution Layer, Decoy generation, decoy quality, deep ... Analysis of AlphaFold2 for Modeling Structures of Wildtype and Variant Protein Sequences ...
Influence of proline residues on protein conformation. J Mol Biol. 1991;218:397-412. DOIPubMedGoogle Scholar ... Major outer membrane protein variants of Chlamydia trachomatis are associated with severe upper genital tract infections and ... Comparison of the major outer membrane protein variant sequence regions of B/Ba isolates: a molecular epidemiologic approach to ... Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: evidence for serovar Da ...
Walker LC, LeVine H (2000). "The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly". ... protein]; -pathy [suff. disease]; proteinopathies pl.; proteinopathic adj), or proteopathy, protein conformational disorder, or ... proteins that assist protein folding) may antagonize proteotoxicity during aging and in protein misfolding-diseases to maintain ... Some proteins can be induced to form abnormal assemblies by exposure to the same (or similar) protein that has folded into a ...
Understanding the conformational coupling mechanism between a protein and a conjugated fluorophore enables structure-based ... the protein adopts an open conformation (left). Binding of glucose shifts the population to a closed conformation in which ... We demonstrated this effect in glucose-binding proteins that adopt distinct conformations in response to glucose. The apo- and ... The binding reaction provokes a conformational change from an open, apo-protein, conformation in which the interdomain ...