Frontiers | The Potential Use of DNA Methylation Biomarkers to Identify Risk and Progression of Type 2 Diabetes | Endocrinology
The DNA methylation levels and plasticity of CpG sites in the promoter region of the metabolic regulator PPARGC1A have been ... Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. J Clin ... the Septin9 test is simply a detection of DNA methylation levels in the v2 region of the SEPT9 promoter in blood plasma which ... Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes. Acta Obstet Gynecol Scand ...https://www.frontiersin.org/articles/10.3389/fendo.2015.00043/full
DNA methylation signatures for breast cancer classification and prognosis | Genome Medicine | Full Text
It has been known for more than three decades that DNA methylation in regulatory regions such as promoters and enhancers can ... The genetic information is inherited and copied by the DNA replication enzymatic complex, while the DNA methylation pattern is ... The extent of the bias varies from region to region, confounding interpretation of the data. Although altering the temperature ... and that the same regions are differentially methylated between tissues, suggesting a role for these regions in defining tissue ...https://genomemedicine.biomedcentral.com/articles/10.1186/gm325
PTEN hypermethylation profiles of Chinese Kazakh patients with esophageal squamous cell carcinoma - UQ eSpace
Aberrant DNA methylation of promoter region CpG islands may serve as an alternative mechanism to genetic defects in the ... The methylation status of the PTEN promoter region was determined in patients with ESCC (n = 95) and healthy individuals (n = ... The aim of this study was to examine the promoter methylation status of the PTENTSG and its association with esophageal ... this is the first report to show the presence of PTEN promoter CpG hypermethylation in ESCC and its association with tumor ...https://espace.library.uq.edu.au/view/UQ:330501
Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation | Biology Open
While methylation of the entire CGI at the CDKN2A promoter repressed gene expression, inducing DNA methylation of a region 100- ... 2011). DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 12, R10 ... three CpG dinucleotides at the ARF promoter, and the CpG island within the Cdkn1a promoter to decrease expression of the target ... However, no regions with high homology were found as these sgRNAs were designed based on their minimal off-target binding and ...http://bio.biologists.org/content/5/6/866?utm_source=Sub&utm_medium=BiO_DMM&utm_campaign=BiOHomeBox&utm_content=5-866
MAGE-1 and p15. To measure methylation of the MAGE-1 and p15 promoters, a 25 μL PCR was carried out in 10 μL Eppendorf ... A 135-bp region was amplified on human genomic DNA with the PCR primers 5′-GGTCTCACCGCCTGGATC-3′ and 5′-biotin- ... Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic ... In our study, p15 promoter methylation in exposed individuals was nearly twice as high as that observed in the referent ...http://cancerres.aacrjournals.org/content/67/3/876
Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its...
In this study, we have established pyrosequencing assays for the analysis of DNA methylation levels in the promoter region of ... In addition to genetic factors such as mutations and susceptibility differences in the form of rare high-penetrance genes and ... We have established pyrosequencing assays for quantitative measurement of DNA methylation levels in the promoter region of five ... CpG dinucleotides in the promoter region of the cyclin-dependent kinase inhibitor 2A (CDKN2A, p16INK4A), E-cadherin (CDH1), ...http://cancerres.aacrjournals.org/content/69/1/243.full
Promoter Regions, Genetic | Colorado PROFILES
"Promoter Regions, Genetic" by people in this website by year, and whether "Promoter Regions, Genetic" was a major or minor ... "Promoter Regions, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ... Promoter Regions, Genetic*Promoter Regions, Genetic. *Genetic Promoter Region. *Genetic Promoter Regions ... Below are the most recent publications written about "Promoter Regions, Genetic" by people in Profiles. ...https://profiles.ucdenver.edu/display/219535
Association of Genetic Variation in the Promoter Region of OXTR with Differences in Social Affective Neural Processing
... we investigated the effect of variation in the common functional rs2268498 T/C polymorphism in the promoter region of OXTR on ... These results indicate the impact of this OXTR genetic variant on individual differences in social affective neural processing. ... "Association of Genetic Variation in the Promoter Region of OXTR with Differences in Social Affective Neural Processing," ... we investigated the effect of variation in the common functional rs2268498 T/C polymorphism in the promoter region of OXTR on ...http://www.scirp.org/journal/PaperInformation.aspx?paperID=17727
Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples. - PubMed - NCBI
Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.. Szalai R1, ...https://www.ncbi.nlm.nih.gov/pubmed/25461540
Association of Genetic Variation in the Promoter Region of OXTR with Differences in Social Affective Neural Processing
... and genetic variation in OXTR  on emotion processing in the amygdala and connected social brain regions . ... we investigated the effect of variation in the common functional rs2268498 T/C polymorphism in the promoter region of OXTR on ... parietal cortex and occipital regions (Pcorr < 0.01). For fear versus neutral activated regions were restricted to the right ... Effect of OXTR genetic variation at SNP rs- 2268498 during the emotion processing task. The T/T group (n = 14) had bilaterally ...http://file.scirp.org/Html/7-3900070_17727.htm
Re-sequencing of the APOAI promoter region and the genetic association of the -75G | A polymorphism with increased cholesterol...
The aim of this study was to determine the genetic association of polymorphisms in the APOAI promoter region with plasma lipid ... A 435 bp region of the APOAI promoter was analyzed by re-sequencing in 549 Kuwaiti samples. DNA was extracted from blood taken ... The target sequence included a partial segment of the promoter region, 5'UTR and exon 1 located between nucleotides −141 to + ... This study is the first to report sequence analysis of the APOAI promoter in an Arab population. The unexpected positive ...https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-14-90
Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic...
Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic ... at the promoter region of the CYBA and GCLC genes modulate the risk for decreased GFR in type 1 diabetes patients even after ... in the promoter region of three genes related to cellular redox balance: (1) -675 T → A in CYBA (unregistered), where the T ... Biochemical and genetic characterization of Italian subpopulation. Am Heart J. 2007, 154: 1123-1129. 10.1016/j.ahj.2007.07.029. ...https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2350-12-129
WUSCHEL is a primary target for t... preview & related info | Mendeley
... important role in ensuring proper development in higher eukaryotes by controlling accessibility of cis-regulatory DNA regions ... Promoter Regions, Genetic/genetics. *Reverse Transcriptase Polymerase Chain Reaction. *Sequence Analysis, DNA ... Using genetic and molecular analyses we have identified WUSCHEL (WUS) as a biologically important target of the SNF2-class ... We present evidence that SYD is recruited to the WUS promoter and that it is involved in regulation of the stem cell pool ...https://www.mendeley.com/research-papers/wuschel-primary-target-transcriptional-regulation-splayed-dynamic-control-stem-cell-fate-arabidopsis/
Masculine epigenetic sex marks of the CYP19A1/aromatase promoter in genetically male chicken embryonic gonads are resistant to...
... the genetic sex is experimentally reversible by in ovo exposure to exo ... Genetic Markers. Male. Ovary / drug effects, embryology. Phenotype. Promoter Regions, Genetic. RNA, Messenger / genetics, ... In this study, we show that a 170-nt region in the promoter of CYP19A1/aromatase, a key gene required for ovarian estrogen ... Epigenesis, Genetic / drug effects. Ethinyl Estradiol / administration & dosage. Female. Feminization / chemically induced, ...http://www.biomedsearch.com/nih/Masculine-Epigenetic-Sex-Marks-Promoter/22539680.html
A polymorphism in the serotonin transporter gene moderates cardiovascular reactivity to psychosocial stress.
... in the promoter of the serotonin transporter gene (SLC6A4) moderates cardiovascular reactivity to social threat. ... Polymorphism, Genetic / genetics. Promoter Regions, Genetic. Psychological Tests. Serotonin / genetics*, physiology. Serotonin ... OBJECTIVE: To examine whether a polymorphism (5-HTTLPR: serotonin transporter linked polymorphic region) in the promoter of the ...http://www.biomedsearch.com/nih/Polymorphism-in-Serotonin-Transporter-Gene/21364196.html
Transcription of the extended hyp-operon in Nostoc sp. strain PCC 7120.
Promoter Regions, Genetic. Tandem Repeat Sequences. Transcription Initiation Site. Transcription, Genetic*. Chemical. ... The promoter region upstream hypF contains an extended -10 box (TGNTAN3T) which belongs to a subclass of E. coli promoters ... Schematic presentation of the regulatory promoter regions of (A) asr0689, (B) hypF and (C) hypC. Putative NtcA, -35, -10, ... strain PCC 7120, is transcribed together with the hyp-genes with a defined TSP and a promoter region putatively controlled by ...http://www.biomedsearch.com/nih/Transcription-extended-hyp-operon-in/18442387.html
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.
The c-myb promoter contains multiple GGA repeats beginning 17 bp downstream of the transcription initiation site. GGA repeats ... Promoter Regions, Genetic*. Repressor Proteins / metabolism*. Transcription Factors / metabolism*. Trinucleotide Repeats. Grant ... Several G-quadruplex regions have been identified in promoters and shown to be critical for regulation of promoter activity. ... Deletion of GGA repeat region 1 or both regions 1 and 2 in the c-myb promoter increased relative luciferase activities by 3- to ...http://www.biomedsearch.com/nih/novel-G-quadruplex-forming-GGA/18252774.html
beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.
Promoter Regions, Genetic. RNA, Messenger / metabolism. Rats. Regeneration* / drug effects, genetics. Respiratory Mucosa / drug ... Repair of the naphthalene-injured airway proceeded with establishment of focal regions of beta-catenin-null epithelium. The ...http://www.biomedsearch.com/nih/beta-Catenin-Not-Necessary-Maintenance/19213872.html
The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand factor gene promoter and risk of myocardial infarction.
Recently, four linked dimorphisms in the VWF gene promoter were demonstrated to influence plasma VWF l ... Polymorphism, Genetic*. Promoter Regions, Genetic*. Risk. Smoking / adverse effects. von Willebrand Factor / genetics*. ... Recently, four linked dimorphisms in the VWF gene promoter were demonstrated to influence plasma VWF level. We conducted a case ...http://www.biomedsearch.com/nih/1185-1051-dimorphisms-in-von/11736957.html
Site-specific chromatin immunoprecipitation: a selective method to individually analyze neighboring transcription factor...
Promoter Regions, Genetic. Protein Binding. Receptor, Epidermal Growth Factor / chemistry, genetics, metabolism*. Sp1 ... Site-specific ChIP on cell culture extracts: Individual detection of Sp1 TFBSs within the egfr promoter region. PCR-based ... In the center of the image, the egfr promoter region with all investigated Sp1 TFBSs and enzyme cleavage sites is shown. Dashed ... Sp1 TFBSs within egfr promoter region are represented by grey oval disks, indicating their positions in relation to the ...http://www.biomedsearch.com/nih/Site-specific-chromatin-immunoprecipitation-selective/22348285.html
Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ... Promoter Regions, Genetic. Recombinant Fusion Proteins / genetics. Chemical. Reg. No./Substance: 0/Octamer Transcription Factor ... Enhancer Elements, Genetic. Female. Gene Expression Regulation. Genome. Green Fluorescent Proteins / genetics. Hybrid Cells / ... In the current study, we show that activation of an Oct4-GFP transgene that contains the PE region occurs within 22 hours of ...http://www.biomedsearch.com/nih/Pluripotential-reprogramming-somatic-genome-in/18065396.html
Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior.
Promoter Regions, Genetic. Rats. Rats, Sprague-Dawley. Sex Characteristics. Sex Differentiation*. Sexual Behavior, Animal* / ... Consistent with these findings, binding of histone deacetylase (HDAC) 2 and 4 to the promoters was higher in males than in ... It was found that during the critical period for sexual differentiation, histones associated with promoters of essential genes ...http://www.biomedsearch.com/nih/Histone-Deacetylation-during-Brain-Development/21586557.html
Growth hormone signal transduction.
Promoter Regions, Genetic / genetics. Protein-Tyrosine Kinases / physiology. Proto-Oncogene Proteins*. Receptor, Insulin / ...http://www.biomedsearch.com/nih/Growth-hormone-signal-transduction/12099386.html
Impact of sodium/proton exchanger 3 gene variants on sudden infant death syndrome.
Variations in the exons and promoter of the NHE3 gene were analyzed with direct sequencing analy ... Genetic Variation*. Humans. Infant. Male. Medulla Oblongata. Molecular Sequence Data. Promoter Regions, Genetic / genetics. ... CONCLUSIONS: Our findings suggest the involvement of polymorphisms in the NHE3 gene and promoter in cases of SIDS, which may ... RESULTS: The C2405T variant (exon 16) and 2 polymorphisms in the promoter (G1131A and C1197T) were encountered significantly ...http://www.biomedsearch.com/nih/Impact-Exchanger-3-Gene-Variants/19772970.html
In vivo expression profile of an endothelial nitric oxide synthase promoter-reporter transgene.
Promoter Regions, Genetic / genetics*. RNA, Messenger / analysis. Renal Circulation / physiology. Transgenes / genetics*. ... promoter-reporter insertional transgenic murine lines were created containing 5,200 bp of the native murine eNOS promoter ... These transgenic eNOS promoter-reporter lines will be a valuable resource for ongoing studies addressing the regulated ... Only in the brain was the reporter expressed in non-endothelial cell types, such as the CA1 region of the hippocampus. ...http://www.biomedsearch.com/nih/In-vivo-expression-profile-endothelial/10749733.html