Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase ... HIF prolyl-hydroxylase) which is responsible for breaking down the hypoxia-inducible factor (HIF) under conditions of normal ... "Safety of HIF Prolyl-Hydroxylase Inhibitors for Anemia in Dialysis Patients: A Systematic Review and Network Meta-Analysis". ... "Cardiac and Kidney Adverse Effects of HIF Prolyl-Hydroxylase Inhibitors for Anemia in Patients With CKD Not Receiving Dialysis ...

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Here, we identified prolyl 3-hydroxylase 2 (P3H2) as a regulator of the GBM in an a cohort of patients with albuminuria. P3H2 ... Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy. Hande Aypek,1 Christoph ... The enzyme prolyl 3-hydroxylase 2 (P3H2) is a posttranslational modifier and catalyzes 3′ hydroxylation (3Hyp) of proline ... Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney ...

Structural enzymology studies of human collagen prolyl 4-hydroxylase (C-P4H-P4H-I, -II, -III) ... Collagen prolyl 4-hydroxylase In this project we try to unravel the reaction mechanism of collagen prolyl 4-hydroxylase (C-P4H ...

Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor ... Crystal structure of HIF prolyl hydroxylase in complex with a biologically active inhibitor. Evdokimov, A.G., Walter, R.L., ... Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor. *PDB DOI: https://doi.org/ ...

Prolyl hydroxylase enzymes (PHDs) feeling cellular air upstream of hypoxia-inducible aspect. Prolyl hydroxylase enzymes (PHDs) ... The oxygen-sensitive sign event that regulates HIF is certainly mediated by hydroxylase enzymes that regulate the proteins ... PHDs hydroxylate conserved prolyl residues from the HIF-1 and HIF-2 subunits, hence marketing their binding towards the von ... balance and consequent transcriptional activity of HIF (20). HIFCprolyl hydroxylases (PHDs; in any other case referred to as ...

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The effect of prolyl hydroxylase domain 2 on the pathogenesis of liver cancer has never been studied. Methods: A ... Several parameters of prolyl hydroxylase domain 2-haplodeficient mice were compared to those of wild type mice, thereby ... Several reports have been published describing the role of prolyl hydroxylase domains - the key oxygen sensor responsible for ... Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice ...

The levels of HIF-α isoforms are regulated in an oxygen-dependent manner by the activity of the HIF prolyl-hydroxylases (PHD or ... The levels of HIF-α isoforms are regulated in an oxygen-dependent manner by the activity of the HIF prolyl-hydroxylases (PHD or ... Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ... Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ...

Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases ... Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases ...

The use of dioxygen by HIF prolyl hydroxylase (PHD1) McNeill LA., Hewitson KS., Gleadle JM., Horsfall LE., Oldham NJ., Maxwell ...

Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase −1(PHD-1) Deficient Mice Share Share Share ... Hyperplasia of Pulmonary Neuroepithelial Bodies (NEB) in Lungs of Prolyl Hydroxylase −1(PHD-1) Deficient Mice ...

Hypoxic preconditioning was mimicked by treatment with two types of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase ... Prolyl Hydroxylases, Prolyl-Hydroxylase Inhibitors, RNA, Messenger, Rats, Sprague-Dawley, Spheroids, Cellular, Stem Cells ... Hypoxic preconditioning was mimicked by treatment with two types of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase ... Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases ...

Eriksson, J., Le Joncour, V., Jahkola, T., Juteau, S., Laakkonen, P., Saksela, O., & Hölttä, E. (2020). Prolyl 4-hydroxylase ... Eriksson, J, Le Joncour, V, Jahkola, T, Juteau, S, Laakkonen, P, Saksela, O & Hölttä, E 2020, Prolyl 4-hydroxylase subunit ... Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas and its depletion inhibits ... Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas and its depletion inhibits ...

Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes ... Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. ...

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels ... HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels ...

Hif Prolyl Hydroxylase Inhibitors: New Treatment Potential against Parkinsons Disease. 2008 Read More ...

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases ... Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases ...

Role of the Hydrogen Bonding Interactions in the O2 Sensitivity of HIF Prolyl Hydroxylase PHD2 ...

Prolyl hydroxylases and therapeutics. Smith TG, Talbot NP. Smith TG, et al. Among authors: talbot np. Antioxid Redox Signal. ... Therapeutic manipulation of the HIF hydroxylases. Nagel S, Talbot NP, Mecinović J, Smith TG, Buchan AM, Schofield CJ. Nagel S, ...

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the respons to hypoxia, and their roles as ... Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the respons to hypoxia, and their roles as ... Prolyl 4-hydroxylases (P4Hs) have central roles in the synthesis of collagens and the regulation of oxygen homeostasis. The 4- ... Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. Author(s): Pornprasertsuk S, Duarte WR, Mochida ...

... prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice were ... HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice ... HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice ... prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice were ...

Endoplasmic Reticulum Stress Alters the Localization of the Prolyl Hydroxylase Ogfod1 in Adult Mouse Cardiomyocytes Share Share ... Endoplasmic Reticulum Stress Alters the Localization of the Prolyl Hydroxylase Ogfod1 in Adult Mouse Cardiomyocytes ...

... and prolyl hydroxylases are the best-studied type of O2-sensing proteins. In general, prolyl hydroxylases trigger cellular ... A Toxoplasma Prolyl Hydroxylase Mediates Oxygen Stress Responses by Regulating Translation Elongation Donna Huber on March 26, ... Thus, oxygen-sensing proteins are important, and among these, 2-oxoglutarate-dependent prolyl hydroxylases are highly conserved ... we discovered a prolyl hydroxylase that allows the parasite to grow at elevated oxygen levels and does so by regulating protein ...

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues. RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10 The following ... lysine hydroxylase 3. lysyl hydroxlase 3. lysyl hydroxylase 3. NP_001075.1. *EC 1.14.11.4 ... Title: Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV ... Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen ...

Prolyl hydroxylation of RIPK1 mediated by EGLN1 promotes the binding of RIPK1 with pVHL to suppress its activation under ... The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN-pVHL pathway represents a classic ... Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure 17, 981-989 (2009 ... Duan, L. J., Takeda, K. & Fong, G. H. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase ...

Expression of PHD (prolyl hydroxylase)-1, PHD-2 and PHD3 is upregulated in the nucleus and cytoplasm in neoplastic breast ... Expression of PHD (prolyl hydroxylase)-1, PHD-2 and PHD3 is upregulated in the nucleus and cytoplasm in neoplastic breast ...

Prolyl hydroxylase 2: A novel regulator of β 2-adrenoceptor internalization. Biao Yan, Zhaoxia Huo, Ying Liu, Xiaoping Lin, Jun ... Dive into the research topics of Prolyl hydroxylase 2: A novel regulator of β 2-adrenoceptor internalization. Together they ...

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of medications for managing renal anemia in ... Profiles Induced by Switching from an Erythropoiesis-Stimulating Agent to a Hypoxia-Inducible Factor Prolyl Hydroxylase ...