... and binding to a proline-rich motif to regulate actin dynamics. ... A scientific resource for the EVH1 protein domain containing ... domains are divided into two classes based on association with proline-rich ligands. Class I EVH1. domains include Ena/Vasp ... Domain Binding and Function. The Ena/Vasp Homology domain 1 (. EVH1. ) is a protein module of ~115 amino acids found in a ... Examples of Domain Proteins. Binding Examples. EVH1 Containing Proteins. Binding Partners. Motif. ...

SH3 domains bind to proline-rich motif containing proteins. The amino acid sequences of the SH3 domains are 70% identical among ... among other proteins. The PTP-PEST proline-rich sequence 332PPKPPR337 has been shown to interact directly with the SH3 domain ... making this the most highly conserved domain for the whole protein family. Notably, the murine and human EFS SH3 domains are ... which then hyper-phosphorylates the substrate domain, allowing the CAS protein to function as a scaffold for other proteins ...

Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM ... For example, a region of WASP known as the proline-rich domain can bind to proteins that contain an "SH3" domain. WASP and WIP ... The Las17 PRD (proline-rich domain) contains 20 SH3-binding PRMs (proline-rich motifs) (Feliciano and Di Pietro, 2012). Vrp1 is ... "A WASP-end3C chimeric protein restores normal growth when SH3 and proline rich domains of multivalent endocytic linker proteins ...

Nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing protein (NALP3, Cryopyrin, PYPAF1) ... and pyrin domain containing protein (NALP3, Cryopyrin, PYPAF1). Proline serine threonine phosphatase-interacting protein ( ... Cryopyrin (also called NALP3, PYPAF1, or NACHT, leucine-rich repeat [LRR], and PYD domains-containing protein 3) is a member of ... PAPA is caused by mutations in the proline serine threonine phosphatase-interacting protein (PSTPIP1, or CD2 binding protein 1 ...

DTX proteins have a basic N terminus; a central proline-rich region; and a C-terminal RING finger domain, a motif often found ... DTX proteins have a basic N terminus; a central proline-rich region; and a C-terminal RING finger domain, a motif often found ... The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity J Biol Chem ... we have now identified a novel protein termed BBAP (B-lymphoma- and BAL-associated protein). Although BBAP has a unique N ...

... and ASTRAL compendium for protein structure and sequence analysis ... Keywords: sh3 domain, cell migration, proline rich peptide, ... Description: The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin. Class: signaling protein ... Compound: Sorbin and SH3 domain-containing protein 1. Species: Homo sapiens [TaxId:9606]. Gene: KIAA0894, KIAA1296, SH3D5, ... Uniprot Q9BX66 (0-60) Domains in SCOPe 2.08: d4lnpa_*Chain B:. Compound: vinculin. Species: Homo sapiens [TaxId:9606]. Gene: ...

The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green ... A bioinformatic search for functional domains has allowed identifying the PAC domain (Proline-rich, Arabinogalactan proteins, ... A bioinformatic search for functional domains has allowed identifying the PAC domain (Proline-rich, Arabinogalactan proteins, ... PAC domains are associated with other types of domains: Histidine-rich, extensin, Proline-rich, or yet uncharacterized. The ...

... heptad repeat domain; TM: transmembrane domain; PR: proline-rich domain; MIS: mitochondrial import sequence; GED: GTPase ... MFN2 also includes a proline-rich domain involved in protein-protein interactions. ... the first coiled-coil domain, which is involved in protein-protein interactions; a GTPase domain crucial for protein activity; ... and a second coiled-coil domain in the C-terminus (the GTPase effector domain, also called the assembly domain) that mediates ...

FNR is recruited to thylakoid membranes via integral membrane thylakoid rhodanase-like protein TROL. We address the fate of ... TROL consists of the centrally positioned rhodanase homology domain which is connected by proline and valine rich swivel with ... The MRM of TROL shares high amino acid similarity with a similar domains of the inner envelope translocon protein component ... probably by the transmembrane signalling involving rhodanase and proline-rich domains. Released FNR can act as efficient ROS ...

E) SF1 protein domains, including 2 zinc finger motifs, Ftz-F1 box (black box), proline-rich domain, hinge domain, and ligand- ... 26) based on the solution structure of SF1 (7), showing the DNA-binding domain bound to its target sequence in the inhibin α ... The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein. EMBO J. 1991;10( ... Ueda H, Sun GC, Murata T, Hirose S. A novel DNA-binding motif abuts the zinc finger domain of insect nuclear hormone receptor ...

67-amino-acid functional domain within the proline-rich region of SLP-76, which we have termed the P-1 domain [21]. ... Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. Singer, A.L., Bunnell, S.C., Obstfeld ... Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the ... Synonyms: Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76, SLP-76 tyrosine ...

Large proline-rich protein BAG6. B [auth A],. D [auth G],. F [auth C],. H [auth E]. 53. Homo sapiens. Mutation(s): 0 Gene Names ... Ubiquitin-like protein 4A. A [auth B],. C [auth H],. E [auth D],. G [auth F]. 47. Homo sapiens. Mutation(s): 0 Gene Names: ... Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.. Mock, J.Y., Chartron, J.W., Zaslaver, M., ... A crystal structure of the Bag6-Ubl4A dimer demonstrates that Bag6-BAG is not a canonical BAG domain, and this finding is ...

Proline rich domain of a fusion protein comprising amino acids 1156-1286 of rat synaptojanin 1. View immunogen .st0{fill:# ... The MA3-936 immunogen is proline rich domain of a fusion protein comprising aa 1156-1286 of rat synaptojanin 1. ... protein binding protein C-terminus binding SH3 domain binding protein complex binding phosphoric ester hydrolase activity ... Proteins were transferred to a PVDF membrane and blocked at 4°C overnight. The membrane was probed with a Synaptojanin 1 ...

A deletion of the p53 protein proline rich domain, in which the Arg/Pro polymorphism resides, reduces the efficiency of ... The BRCA1 and BRCA2 proteins appear to be scaffolding proteins that assemble DNA repair complexes of proteins at double-strand ... This SNP at codon 72 in the p53 protein (out of 393 amino acids) either encodes an arginine (Arg) or a proline (Pro) residue. ... The MDM2 protein is a ubiquitin ligase which negatively regulates p53 levels in a cell by polyubiquitination of the p53 protein ...

The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains.. Kay ... SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite ... SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several ... This motif is involved in protein-protein interaction mediated by SH3 domains. ...

It has been proposed that the GYF domain found in these proteins could also be involved in proline-rich sequence recognition ... Hence, a proline-binding module distinct from SH3 and WW domains regulates protein-protein interactions. ... The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. ... Proline-binding domain in CD2-binding protein. Contains conserved Gly-Tyr-Phe residues. ...

Helton TD, Kojetin DJ, Cavanagh J, Horne WA (2002) Alternative splicing of a β4 subunit proline-rich motif regulates voltage- ... B domain; Linker, sequence connecting SH3 and GK domains, C domain; GK, guanylate kinase, D domain; AID, Ca2+ channel α1 ... The β4a A domain is involved in protein-protein interactions. Results thus far suggest that the β4a-A is highly conserved and ... as a binding site in protein-protein interactions with synaptotagmin I and the LC2 domain of microtubule-associated protein 1A ...

In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. ... Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena- ... Valosin Containing Protein ELISA Kits * V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related, GTP Binding Protein) ELISA ... Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin ...

Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also ... and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. Based on a database ... Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity ... HID homeoprotein-interacting domain, PEST proline, glutamate, serine, threonine-rich region, SQA serine, glutamine, alanine- ...

... functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low ... protein salvador homolog 1. Names. 45 kDa WW domain protein. WW domain-containing protein 3. WW domain-containing protein 4. ... Conserved Domains (1) summary. cd00201. Location:203 → 233. WW; Two conserved tryptophans domain; also known as the WWP or rsp5 ... Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022 ...

The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate ... This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This ... This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an ... This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell ...

Protein-Protein Interactions as New Drug Targets - Author: Klussmann, Enno - Price: 339,90€ ... Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies. S. Costa, G. Cesareni. 17. Proline-Rich Sequence ... 8. Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug ... Protein-Protein Interactions as New Drug Targets. 339,90€. Add to cart. Ebook, PDF with Adobe DRM. ISBN: 9783540728436. DRM ...

The WW domain is a new protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro. It ... we identified binding partners for the FE65 WW domain. Proline-rich sequences sharing a proline-proline-leucine-proline core ... The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. ... WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the ...

... domain is a novel protein module containing aconserved proline-rich motif. We have shown that the PX domain isolatedfrom the ... The PX-domain is also a protein-protein interaction domain [ (PUBMED:15263065) ]. ... Click on the protein counts, or double click on taxonomic names to display all proteins containing PX domain in the selected ... The yeast PX domain-only proteins Grd19p (YOR357C) and Ypt35p (YHR105W), as well as the isolated PX domains from Mvp1p (YMR004W ...

It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also ... This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. ... IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human WBP11 (NP_057396.1). ... This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing ...

... including non-POU domain-containing octamer-binding protein (NONO) and splicing factor proline and glutamine rich (SFPQ) ... Proteins, which contain RNA/DNA binding domain, a low-complexity domain, and intrinsically disordered regions, interact with ... non-POU domain-containing octamer-binding protein. PCR. polymerase chain reaction. PXR. pregnane X receptor. RIP. RNA ... The protein concentration was determined using Bradford protein assay reagent (Bio-Rad, Hercules, CA) with γ-globulin as a ...

All NSP proteins contain an NH2-terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH- ... Secreted protein rich in cysteine (SPARC) is a matricellular protein whose elimination results in lens opacity at one month of ... Richard I. Near,1 Richard S. Smith,3 Paul A. Toselli,4 Thomas F. Freddo,5 Alexander B. Bloom,1 Pierre Vanden Borre,1 David C. ... As NSP family members contain a GEF-like domain, several studies have examined whether NSP proteins activate Ras subfamily ...

The SH3 domain binds to proline-rich motifs, such as PXXP, and the SH2 domain binds to specific phosphotyrosine motifs. In ... The RpS3 protein is highly basic and contains two domains: the KH domain and the S3-C terminal domain. We tested which region ... The SH3 domain of Lyn contains a module that can bind to the proline-rich motif (PxxP) (25-27). Although three putative proline ... 2, lane 9) contains three putative proline-rich motifs, such as PxxP, that can bind to the SH3 domain of Lyn, which raises the ...

The protein contains an ULM motif, a coiled-coil and KH-QUA2 domains, followed by a zinc knuckle and a proline rich region. SF1 ... Functional analysis of 14 RNA binding proteins (RBPs) in two bladder urothelial ca... ... this project is to identify the splicing and transcriptional targets of SF1 in lymphoid cell line overexpressing this protein ...

We show here, that the proline-rich tyrosine kinase 2 (Pyk2) interacts with both mGluR1 and mGluR5 and is precipitated with ... interacts with GST-fusion proteins corresponding to the second intracellular loop and the distal carboxyl-terminal tail domains ... This results in the release of Ca2+ from intracellular stores and the activation of protein kinase C. The activation of Group I ... Our data reveal that Pyk2 couples the activation mGluRs to the mitogen-activated protein kinase pathway even though it ...