HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance...HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance...
... while the fold change derived by cell-based assays refers to the concentrations of extracellular pro-drug (AZT) added to the ... Nucleoside analogs are typically formulated as pro-drugs, which require intracellular phosphorylation to form an analog of ( ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002359