*  Ganaxolone - Wikipedia
Alfaxalone Alfadolone Hydroxydione Minaxolone P1-185 Pregnanolone Renanolone Carter RB, Wood PL, Wieland S, Hawkinson JE, ...
  https://en.wikipedia.org/wiki/Ganaxolone
*  Pregnanolone - Wikipedia
Pregnanolone, also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone.[1] It is ... During pregnancy, pregnanolone and allopregnanolone are involved in sedation and anesthesia of the fetus.[5][6] ... Pregnanolone, also known as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or as 5β-pregnan-3α-ol-20-one, is a naturally occurring ... the fetus is sedated by the low oxygen tension of the fetal blood and the neurosteroid anesthetics pregnanolone and the sleep- ...
  https://en.wikipedia.org/wiki/Eltanolone
*  Pregnanolone - Wikipedia
During pregnancy, pregnanolone and allopregnanolone are involved in sedation and anesthesia of the fetus. Pregnanolone, also ... Pregnanolone, also known as eltanolone (INN), as well as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or 3α-hydroxy-5β-pregnan-20- ... the fetus is sedated by the low oxygen tension of the fetal blood and the neurosteroid anesthetics pregnanolone and the sleep- ... October 1994). "Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in ...
  https://en.wikipedia.org/wiki/Pregnanolone
*  Pregnanolone (disambiguation) - Wikipedia
Pregnanolone, also known as tetrahydroprogesterone (THP), may refer to: Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α ... Shannon, E. E. (2005). "Characterization of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/ ... Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone) Isopregnanolone (3β-hydoxy-5α-pregnan-20-one or 3β, ... "Serum Profiles of Free and Conjugated Neuroactive Pregnanolone Isomers in Nonpregnant Women of Fertile Age". The Journal of ...
  https://en.wikipedia.org/wiki/Pregnanolone_(disambiguation)
*  Characterization of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred...
Pregnanolone showed a dose-dependent increase in pregnanolone-appropriate responding in all mice (Fig. 1). Pregnanolone doses ... pregnanolone, pregnanolone, saline, saline) with an animal never receiving pregnanolone or saline for more than two consecutive ... Each dose of pregnanolone was given once, regardless of what drug the animal received the day before (pregnanolone or saline). ... This dose of pregnanolone was chosen based on the only study that has tested pregnanolone's discriminative stimulus effects in ...
  http://jpet.aspetjournals.org/content/314/2/675
*  Neuroactive Steroids in Brain and Relevance to Mood | SpringerLink
Allopregnanolone and pregnanolone are produced by the human corpus luteum. Mol Cell Endocrinol 2005; 239:37-44.PubMedCrossRef ... Neuroactive pregnanolone isomers during pregnancy. J Clin Endocrinol Metab 2005; 90:395-403.PubMedCrossRefGoogle Scholar ... Pregnanolone emulsion. A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent. ...
  https://link.springer.com/chapter/10.1007/978-1-4020-6854-6_20
*  CDKL5 Gene - GeneCards | CDKL5 Protein | CDKL5 Antibody
Complete information for CDKL5 gene (Protein Coding), Cyclin Dependent Kinase Like 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDKL5&rf=/home/genecards/current/website/carddisp.pl&go_func=6
*  GABRA1 Gene - GeneCards | GBRA1 Protein | GBRA1 Antibody
Pregnanolone. 128-20-1. rac BHFF. 123557-91-5. Retigabine dihydrochloride. Antiepileptic compound. 150812-13-8. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=GABRA1
*  Human Metabolome Database: Showing metabocard for Allopregnanolone (HMDB0001449)
Pregnanolone, (3beta)-isomer. MeSH. Pregnanolone, (3beta, 5alpha)-isomer. MeSH. Pregnanolone, (3beta, 5beta,14beta)-isomer. ...
  http://www.hmdb.ca/metabolites/HMDB01449
*  Frontiers | Neurosteroid Influences on Sensitivity to Ethanol | Endocrinology
For example, in rats trained to discriminate pregnanolone, high levels of responding on the pregnanolone-appropriate lever ... Shannon, E. E., Purdy, R. H., and Grant, K. A. (2005b). Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and ... In contrast, the direct agonists muscimol and gaboxadol produced low levels of pregnanolone-appropriate responding (Engel et al ... In drug discrimination procedures, zolpidem substituted for the discriminative stimulus effects of pregnanolone in rats (Engel ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00010/full
*  Planetary Formulas 49% OFF Retail
Can Pregnanolone Be Used For Hormone Balance? 09/15/11 (1118) (1) ...
  https://vitanetonline.com/forums/3/
*  Prenatal and Perinatal Medicine and Psychology Towards Integrated Neurosciences: General Remarks and Future Perspectives |...
Circulating levels of pregnanolone isomers during the third trimester of human pregnancy. The Journal of Steroid Biochemistry ...
  https://birthpsychology.com/node/2070
*  Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site
6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. J. Biol. Chem. 278, 13196-13206 [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4375505/
*  Plus it
1997) Behavior in animal models of anxiety after intracranial microinjection of pregnanolone in hippocampus, lateral septum and ... 1993) GABAA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and ...
  http://www.jneurosci.org/content/18/14/5275
*  DailyMed - PROGESTERONE- progesterone capsule
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=849e9f62-7414-3c22-9cb1-934f953400fc
*  Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cε
a) Muscimol-stimulated 36Cl uptake in the presence of 1 nM allopregnanolone (n = 11 of each genotype) or 1 μM pregnanolone (n ... Alphaxaolone, allopregnanolone, pregnanolone, and metyrapone were prepared as 10-mM stock solutions in DMSO. All drugs were ... Mice were given an intraperitoneal injection of pregnanolone (32 mg/kg) and placed on their backs. The time interval between ... Aurora, Ohio, USA), and allopregnanolone, pregnanolone, CRF, and metyrapone were from Sigma-Aldrich. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC151152/?lang=en-ca
*  Human blood metabolite timetable indicates internal body time | PNAS
4C), pregnanolone sulfate-like metabolite (Fig. 4D), and urocoritsol-3-glucronide (Fig. 4E) as well as the amino acids, ... A pregnanolone isomer and its precursor (progesterone) were also found as circadian-oscillating metabolites in the brain and ... Abundance is shown of cortisol (A), cortisone (B), urocortisone-3-glucronide (C), pregnanolone sulfate-like metabolite (D), ( ...
  http://www.pnas.org/content/109/37/15036?ijkey=19ecf661fbd4ddb184170dafe0c9bd8de34f917b&keytype2=tf_ipsecsha
*  One-channel Cell-attached Patch-clamp Recording | Protocol
Kussius, C. L., Kaur, N., Popescu, G. K. Pregnanolone Sulfate Promotes Desensitization of Activated NMDA Receptors. J. Neurosci ... Kussius, C. L., Kaur, N., Popescu, G. K. Pregnanolone Sulfate Promotes Desensitization of Activated NMDA Receptors. The Journal ...
  https://www.jove.com/video/51629/one-channel-cell-attached-patch-clamp-recording
*  Plus it
1). The 5β-isomer of allopregnanolone ("pregnanolone"), like allopregnanolone itself, is a potent positive modulator of GABAA ... Metabolic pathway for conversion of progesterone to allopregnanolone (5α,3α-pregnanolone) and its blockade by finasteride, a 5α ... and pregnanolone (5β-pregnan-3α-ol-20-one) (Atkinson et al., 1965;Conney et al., 1966; Gyermek et al., 1967, 1968). In contrast ... Allopregnanolone and pregnanolone produce a powerful enhancement of GABAA receptor responses in vitro (Majewska et al., 1986; ...
  http://jpet.aspetjournals.org/content/288/2/679
*  Alfadolone - Wikipedia
Ganaxolone Hydroxydione Minaxolone Pregnanolone Renanolone C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of ...
  https://en.wikipedia.org/wiki/Alfadolone
*  Renanolone - Wikipedia
Alfadolone Alfaxolone Ganaxolone Hydroxydione Minaxolone Pregnanolone R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May ...
  https://en.wikipedia.org/wiki/Renanolone
*  Susan S Girdler - Publications - University of North Carolina at Chapel Hill
Gordon, J. L., Girdler, S. S., Meltzer-Brody, S. E., Stika, C. S., Thurston, R. C., Clark, C. T., Prairie, B. A., Moses-Kolko, E., Joffe, H. & Wisner, K. L. Mar 1 2015 In : American Journal of Psychiatry. 172, 3, p. 227-236 10 p.. Research output: Contribution to journal › Review article ...
  https://uncch.pure.elsevier.com/en/persons/susan-s-girdler/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fsystematicreview