*  KEGG ENZYME: 1.1.1.239
Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1. ...
  http://www.genome.jp/dbget-bin/www_bget?ec:1.1.1.239
*  pregnane steroids
The structures of acetoxy progestins(pregnane steroids). C. Matthew Peterson, M.D. Progestogens, Progesterone antagonists, ...
  https://library.med.utah.edu/kw/human_reprod/mml/hrcontra_fig08.html
*  pregnane X receptor ELISA Kits | Biocompare.com
Compare pregnane X receptor ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... Your search returned 66 pregnane X receptor ELISA ELISA Kit across 7 suppliers. ...
  http://www.biocompare.com/pfu/110627/soids/2-26154/Assay_Kit/ELISA_pregnane_X_receptor
*  Pregnane Based Steroids Also Inhibit Myostatin - Mind And Muscle
PREGNANE STEROIDS. There are currently three main Pregnane skeleton steroids on the market in addition to the grey market YK11 ... Pregnane Steroids Build Muscle. YK11 is a pregnane based SARM that shows great muscle growth and reduced side effects. ... This shows that a pregnane based skeleton is capable of activating the androgen receptor and also having other mass building ... It also legitimizes the current crop of Pregnane based prohormones that are being sold by LG Sciences and other manufacturers. ...
  http://mindandmuscle.net/articles/pregnane-based-sarm-also-inhibits-myostatin/
*  Pregnane - Wikipedia
... and 5β-pregnane (17β-ethyletiocholane). It has a gonane core. 5β-Pregnane is the parent of the progesterones, pregnane alcohols ... Pregnanes are steroid derivatives with carbons present at positions 1 through 21. Most biologically significant pregnane ... Pregnane is a C21 steroid and, indirectly, a parent of progesterone. It is a parent hydrocarbon for two series of steroids ... Pregnanes at the US National Library of Medicine Medical Subject Headings (MeSH) PubChem Diagram at qmul.ac.uk Definition of ...
  https://en.wikipedia.org/wiki/Pregnane
*  IJMS | Free Full-Text | Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β- ... Keywords: soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4 soft coral; pregnane; Scleronephthya flexilis; ... Kuo C-Y, Juan Y-S, Lu M-C, Chiang MY-N, Dai C-F, Wu Y-C, Sung P-J. Pregnane-Type Steroids from the Formosan Soft Coral ... Kuo, C.-Y.; Juan, Y.-S.; Lu, M.-C.; Chiang, M.Y.-N.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. Pregnane-Type Steroids from the ...
  http://mdpi.com/1422-0067/15/6/10136
*  pregnane-3,17-diol-11,20-dione Summary Report | CureHunter
pregnane-3,17-diol-11,20-dione: induces delta-aminolevulinic acid synthetase in chick embryo & rat liver; RN given refers to ... 5 beta-pregnane-3 alpha,17 alpha-diol-11,20-dione; 5alpha-pregnane-3alpha,17alpha-diol-20-one; pregnane-3,17-diol-11,20-dione ... pregnane-3,17-diol-11,20-dione. Subscribe to New Research on pregnane-3,17-diol-11,20-dione ... 3alpha,5alpha)-isomer; pregnane-3,17-diol-11,20-dione, (3alpha,5beta)-isomer; pregnane-3,17-diol-11,20-dione, (3beta,5alpha)- ...
  http://www.curehunter.com/public/keywordSummaryC009026-pregnane-3-17-diol-11-20-dione.do
*  Abstract T P225: Loss of Pregnane X Receptor Impairs Stroke Recovery | Stroke
Abstract T P225: Loss of Pregnane X Receptor Impairs Stroke Recovery. Jeremy Grenier, Edward Koellhoffer, Courtney Townshend, ... Pregnane X Receptor (PXR) is a nuclear receptor which binds many xenobiotic targets including many commonly prescribed ... Abstract T P225: Loss of Pregnane X Receptor Impairs Stroke Recovery. Jeremy Grenier, Edward Koellhoffer, Courtney Townshend, ... Abstract T P225: Loss of Pregnane X Receptor Impairs Stroke Recovery. Jeremy Grenier, Edward Koellhoffer, Courtney Townshend, ...
  http://stroke.ahajournals.org/content/46/Suppl_1/ATP225
*  Pregnane X receptor - Wikipedia
pregnane X receptor at the US National Library of Medicine Medical Subject Headings (MeSH) Nuclear Receptor Resource Page This ... 2001). "The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic ... In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear ... Kliewer S, Goodwin B, Willson T (2002). "The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism". Endocr. ...
  https://en.wikipedia.org/wiki/Pregnane_X_receptor
*  Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. | Sigma...
Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.. [Jian ... but did not affect expression of human pregnane X receptor (hPXR). In reporter assays, byakangelicin activated CYP3A4 promoter ...
  https://www.sigmaaldrich.com/catalog/papers/20942813
*  Decrease in serum concentration of 5α-pregnane-3,20-dione prior to spontaneous labor
5α-pregnane-3α-ol-20-one (3αOH-DHP): No major effects of 3αOH-DHP were seen in the in vitro model. Thus unlikely that it ... 5α-pregnane-3α-ol-20-one (3αOH-DHP), a potent CNS depressant progesterone metabolite, was included in the in vitro study. ... 5α-pregnane-3,20-dione (5αDHP): Mean serum 5αDHP concentrations declined significantly during the last week of pregnancy (p, ... Decrease in serum concentration of 5α-pregnane-3,20-dione prior to spontaneous labor. Löfgren, Mats Umeå University, Faculty of ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:441635
*  Plus it
Pregnane X receptor as a master regulator of chemotherapy resistance in prostate cancer cells. Yakun Chen, Yong Tang, Man-Tzu ... Pregnane X receptor (PXR), an orphan nuclear receptor known for its activation by many important clinical drugs, is a major ... Pregnane X receptor as a master regulator of chemotherapy resistance in prostate cancer cells ... Pregnane X receptor as a master regulator of chemotherapy resistance in prostate cancer cells ...
  http://mct.aacrjournals.org/content/6/11_Supplement/A196
*  Plus it
Activation status of the Pregnane X Receptor (PXR) influences Vemurafenib availability in humanized mouse models. A. Kenneth ... Activation status of the Pregnane X Receptor (PXR) influences Vemurafenib availability in humanized mouse models ... Activation status of the Pregnane X Receptor (PXR) influences Vemurafenib availability in humanized mouse models. ... Activation status of the Pregnane X Receptor (PXR) influences Vemurafenib availability in humanized mouse models ...
  http://cancerres.aacrjournals.org/content/early/2015/09/11/0008-5472.CAN-15-1454
*  Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats | Drug...
pregnane X receptor. P450. cytochrome P450. TCPOBOP. 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene. WT. wild type. ZFN. zinc- ... 2012) Pregnane X receptor as a target for treatment of inflammatory bowel disorders. Trends Pharmacol Sci 33:323-330. ... 2016) Pregnane X receptor (PXR)-mediated gene repression and cross-talk of PXR with other nuclear receptors via coactivator ... The pregnane X receptor [(PXR); official gene name NR1I2 in human and Nr1i2 in rodents] and constitutive androstane receptor [( ...
  http://dmd.aspetjournals.org/content/45/10/1068.full
*  Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor | Journal...
We introduce a novel method to screen herbal remedies for their ability to activate pregnane X receptor. Pregnane X receptor ... John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci USA 97: 7500-7502 ... Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, and Moore JT (2002) Pregnane X receptor (PXR), ... Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor. Dan E. ...
  http://jpet.aspetjournals.org/content/310/2/528.long
*  Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor...
pregnane X receptor. RIF. rifampicin. XREM. xenobiotic-responsive enhancer module. SNP. single nucleotide polymorphism. kb. ... 2004) The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin ... 2001) Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol Pharmacol 60:427-431. ... 2003) A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the ...
  http://molpharm.aspetjournals.org/content/78/4/704.long
*  Plus it
pregnane X receptor. ET-743. trabectedin. A-792611. methyl 1-(5-(2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-4- ... In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. ... In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. ... In Vivo and In Vitro Characterization of a First-in-Class Novel Azole Analog That Targets Pregnane X Receptor Activation. ...
  http://molpharm.aspetjournals.org/content/80/1/124
*  Plus it
The pregnane X receptor (PXR, NR1I2) is a member of the nuclear receptor superfamily that is activated by a myriad of ... Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, and Gonzalez FJ (2007) The pregnane X receptor gene-humanized ... ABBREVIATIONS: PXR, pregnane X receptor; h, human; m, mouse; TTR, transthyretin; PCR, polymerase chain reaction; PXR KO, PXR ... Ding X and Staudinger JL (2005a) Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein ...
  http://dmd.aspetjournals.org/content/36/8/1538
*  Plus it
Pregnane X receptor (PXR) is a member of the nuclear receptor (NR) family of ligand-activated transcription factors and is ... Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, and Miller DS (2006) In vivo activation of human pregnane ... Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, and Ory DS (2006) Pregnane X ... Chen Y, Tang Y, Wang MT, Zeng S, and Nie D (2007) Human pregnane X receptor and resistance to chemotherapy in prostate cancer. ...
  http://dmd.aspetjournals.org/content/37/4/719
*  The effect of the neuroactive steroid 5β-pregnane-3β, 20(R)-diol on the time course of GABA evoked currents is different to...
The effect of the neuroactive steroid 5β-pregnane-3β, 20(R)-diol on the time course of GABA evoked currents is different to ... We have therefore tried to clarify this issue by comparing the effect of pregnenolone sulphate and 5beta-pregnane-3beta, 20(R)- ... In conclusion, the effect of 5beta-pregnane-3beta, 20(R)-diol on GABA-evoked currents is different to that of pregnenolone ... The actions of pregnenolone sulphate and 5beta-pregnane-3beta, 20(R)-diol were not altered in the presence of allopregnanolone ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:356400
*  Phase-Trafficking Methods in Natural Products, Modulators of Organic Anion Transporting Polypeptides from Rollinia emarginata,...
The isolates showed a wide variety of structures including pregnane and cardiac glycosides, pentacyclic triterpenes, ... and Pregnane and Cardiac Glycosides from Asclepias spp.. ...
  https://kuscholarworks.ku.edu/handle/1808/9993
*  Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor...
Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor ... Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor ...
  http://dmd.aspetjournals.org/content/45/2/118/tab-figures-data
*  A pharmacogenetic study of pregnane X receptor (NR112) in Han Chinese | ScholarBank@NUS
A pharmacogenetic study of pregnane X receptor (NR112) in Han Chinese. Authors: Wang, X.-D.. Li, J.-L.. Su, Q.-B.. Deng, X.-Y. ... The pregnane X receptor (PXR/NR1I2) gene is a critical transcriptional regulator of a number of important drug metabolizing ... A pharmacogenetic study of pregnane X receptor (NR112) in Han Chinese. Current Drug Metabolism 8 (8) : 778-786. ScholarBank@NUS ...
  http://scholarbank.nus.edu.sg/handle/10635/106603
*  Pregnane X Receptors - Nuclear Receptors
SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively), which ... Meclizine dihydrochloride is a Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Learn More ...
  https://www.emmx.com/pregnane-x-receptors.html