Multiple pathways underlying endothelium-dependent relaxation in the rabbit isolated femoral artery. - Department of...
The hyperpolarization but not the relaxation to nitric oxide was abolished by either glibenclamide or 25 mM potassium.8. These ... In artery segments stimulated with potassium chloride (25 mM), the maximal change in tension and membrane potential evoked by ... The potassium channel blocker, glibenclamide (10 microM; 10 min) also abolished the change in membrane potential to ... The potassium channel blocker, glibenclamide (10 microM; 10 min) also abolished the change in membrane potential to ...
Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. - Department of...
... on total delayed rectifier potassium current, iK, in rabbit sino-atrial (SA) node pacemaker cells; total iK is composed of the ... Potassium Channels, Potassium Channels, Voltage-Gated, Rabbits, Sinoatrial Node, Stimulation, Chemical, Sulfonamides ... Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. ... Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. ...
Keeping the heart going: a new role for KATP channels. - Department of Pharmacology
Adaptation, Physiological, Adenosine Triphosphate, Animals, Heart, Heart Failure, Humans, Potassium Channels, Pressure, ...
A crucial influence of precontraction on potassium-induced relaxation in the rat isolated mesenteric artery - Department of...
A crucial influence of precontraction on potassium-induced relaxation in the rat isolated mesenteric artery ... A crucial influence of precontraction on potassium-induced relaxation in the rat isolated mesenteric artery ...
p-Chloroamphetamine (PCA), 3,4-methylenedioxy-methamphetamine (MDMA) and d-fenfluramine pretreatment attenuates d-fenfluramine...
PCA pretreatment reduced d-fenfluramine-evoked 5-HT release by 90.9% while potassium-evoked release was reduced by only 66.8%. ... PCA pretreatment reduced d-fenfluramine-evoked 5-HT release by 90.9% while potassium-evoked release was reduced by only 66.8%. ... Potassium, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Serotonin, p-Chloroamphetamine ...
Depolarization block of neurons during maintenance of electrographic seizures. - Department of Pharmacology
The duration of the extracellular potassium transients associated with each ictal burst was not affected by disruptions in ... Potassium Channel Blockers, Potassium Channels, Rats, Rats, Sprague-Dawley, Seizures ... The duration of the extracellular potassium transients associated with each ictal burst was not affected by disruptions in ...
Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated...
Potassium Channels, Rats, Rats, Wistar ...
Involvement of cyclic GMP and potassium channels in relaxation evoked by the nitric oxide donor, diethylamine NONOate, in the...
... while the contribution through potassium channels was assessed with different sub-type-selective potassium channel blockers. ... The inhibitory action of ChTX suggests part of the cGMP-insensitive component involves the activation of potassium channels, a ... However, the contribution made to relaxation by potassium channels appears to be unmasked following pharmacological attenuation ... calcium-activated potassium channels (BK(Ca)). The inhibitory effects of ODQ and ChTX were additive (pEC50=5.1+/-0.4; n=9). The ...
Medical Research Revealed | Crossing the boundaries between art and science - Department of Pharmacology
Small positively charged sodium ions (Na+ represented by orange) are pumped out of the cells in exchange for potassium ions (K+ ...
Coordination of vasomotor responses by the endothelium. - Department of Pharmacology
Intermediate-Conductance Calcium-Activated Potassium Channels, Membrane Potentials, Muscle, Smooth, Vascular, Potassium, ...
Ca(2+) entry through L-type Ca(2+) channels helps terminate epileptiform activity by activation of a Ca(2+) dependent...
Potassium Channel Blockers, Potassium Channels, Potassium Channels, Calcium-Activated, Rats, Rats, Wistar, Receptors, N-Methyl- ...
Apamin | Anatomical Neuropharmacology Unit
Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain ... Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in ...
Ion Channel Gating | Anatomical Neuropharmacology Unit
Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in ...