*  A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human...
There is evidence of a multimeric protein complex containing the products of the Polycomb group genes, Polycomb and ... The function of LID could be to counteract the repressive activity that histone deacetylation has on chromatin. Two ... Polycomb is the archetypal Polycomb group gene (Puro and Nygren 1975). An amorphic Polycomb mutation (Pc3) showed no intergenic ... Polycomb and Polyhomeotic. As expected for components of a multimeric complex, the products of Polycomb, PC, and Polyhomeotic, ...
  http://www.genetics.org/content/156/2/645
*  Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell...
... participating in one of two distinct multimeric protein complexes, the Polycomb repressive complexes 1 (PRC1) and 2 (PRC2). ... Collectively, these results indicate that Ring1A/B-mediated Polycomb silencing functions downstream of the core transcriptional ... The Polycomb group (PcG) proteins mediate heritable silencing of developmental regulators in metazoans, ... participating in one of two distinct multimeric protein complexes, the Polycomb repressive complexes 1 (PRC1) and 2 (PRC2). ...
  https://www.neuroscience.ox.ac.uk/publications/100083
*  SMART: Secondary literature for PHD domain
... complexes or a subunit of a separate complex that interacts with ESC.E(Z) complexes. ... The products of Polycomb group (PcG) genes are required for the epigenetic repression of a number of important developmental ... whereas its carboxyl-terminal region has transcriptional repressive activity. Co-localization and association of Mi-2, RFP, and ... We discuss the implications of PCL association with ESC.E(Z) complexes and the possibility that PCL may either be a subunit of ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=PHD
*  Polycomb repressive complex 1 - Wikipedia
Polycomb group proteins play a major role in transcriptional regulation during development. Polycomb Repressive Complexes PRC1 ... Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. ... "Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes". Journal of Biological Chemistry. ... in development as well as the inactive X chromosome.PRC1 inhibits the activated form of RNA polymerase II preinitiation complex ...
  https://en.wikipedia.org/wiki/Polycomb_repressive_complex_1
*  Suz12 polycomb repressive complex 2 subunit pseudogene 1 - Wikipedia
SUZ12 polycomb repressive complex 2 subunit pseudogene 1 is a protein that in humans is encoded by the SUZ12P1 gene. "Human ... SUZ12 polycomb repressive complex 2 subunit pseudogene 1". Retrieved 2016-04-06. Visser R, Koelma N, Vijfhuizen L, van der ...
  https://en.wikipedia.org/wiki/Suz12_polycomb_repressive_complex_2_subunit_pseudogene_1
*  Frontiers | Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells | Cell and Developmental Biology
To induce and stabilize the pluripotent state, complex circuitries involving signaling pathways, transcription regulators and ... To induce and stabilize the pluripotent state, complex circuitries involving signaling pathways, transcription regulators and ... the polycomb module comprises targets of the polycomb repressive complex 1 (PRC1) and PRC2, which include differentiation- and ... polycomb group proteins; PD03, PD0325901; PRC1, polycomb repressive complex 1; PRC2, polycomb repressive complex 2; PRMT7, ...
  https://www.frontiersin.org/articles/10.3389/fcell.2017.00007/full
*  Browsing by Subject "Caenorhabditis elegans"
Discovery and Characterization of the Polycomb Repressive Complex 1 of C. Elegans  Karakuzu, Ozgur (2009-06-17) ... Much of early embryogenesis is controlled through complex networks comprised of maternally provided factors. Oocytes are packed ... The Study of Wnt Signaling Effector POP-1/TCF in C. Elegans Early Embryos  Lo, Miao-Chia (2005-04-29) ... Study of Oocyte-To-Embryo Transition Regulators, OMA-1 and OMA-2 in C. Elegans  Nishi, Yuichi (2007-05-22) ...
  http://repositories.tdl.org/utswmed-ir/browse?value=Caenorhabditis+elegans&type=subject
*  Hyperosmotic priming of Arabidopsis seedlings establishes a long-term somatic memory accompanied by specific changes of the...
Polycomb repressive complex 1. REF6: Relative of early flowering 6. RpII: RNA polymerase II ... Role of the polycomb protein EED in the propagation of repressive histone marks. Nature. 2009, 461: 762-767. 10.1038/ ... established and maintained by Polycomb complexes and SUVH histone methyltransferases, respectively [30]. Both marks have been ... Angel A, Song J, Dean C, Howard M: A Polycomb-based switch underlying quantitative epigenetic memory. Nature. 2011, 476: 105- ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-6-r59
*  Ji F[au] - PubMed - NCBI
Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. ... 1.. Effect of Tenax addition amount and desorption time on desorption behaviour for bioavailability prediction of polycyclic ... Author Correction: Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric ... 2018 Dec 1;190:9-14. doi: 10.1016/j.talanta.2018.07.063. Epub 2018 Jul 20. ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Ji+F%5Bau%5D&dispmax=50
*  IJMS | Free Full-Text | Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases | HTML
... the polycomb repressive complex member EZH2 (PRC2) and the polycomb repressive complex member Bmi1 (PRC1) [26], decrease with ... Notes: PRC1, polycomb-group repressive complex 1; PRC2, polycomb-group repressive complex 2; SIRT1, sirtuin 1; H3K36me3, tri- ... through the recruitment of chromatin modification complexes, including the polycomb group complex [21]. ... This is achieved by recruiting methyl-CpG-binding-domain protein complexes that also contain HDACs. These complexes remove ...
  http://mdpi.com/1422-0067/14/9/17643/htm
*  PRC2 - Wikipedia
Play media PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other ... Polycomb Repressive Complex 1). This complex has histone methyltransferase activity and primarily trimethylates histone H3 on ... Geisler, Sarah J.; Paro, Renato (2015-09-01). "Trithorax and Polycomb group-dependent regulation: a tale of opposing activities ... Koehler, Claudia; Hennig, Lars (2010). "Regulation of cell identity by plant Polycomb and trithorax group proteins". Current ...
  https://en.wikipedia.org/wiki/PRC2
*  Roles of repressive epigenetic machinery in lineage decision of T cells - Naito - 2013 - Immunology - Wiley Online Library
Polycomb repressive complex 2 is another Polycomb complex, which catalyses H3K27 di-methylation (H3K27 me2) and tri-methylation ... Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell 2012; 45:330- ... Polycomb complexes. Polycomb group genes were initially identified as genes that caused homeotic transformation in Drosophila. ... namely Polycomb repressive complex (PRC) 1 and PRC2. The core components of Drosophila PRC1 are Polycomb, Posterior sex comb, ...
  http://onlinelibrary.wiley.com/doi/10.1111/imm.12058/full
*  Similar articles for PubMed (Select 18836456) - PubMed - NCBI
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis. ... 2015 Mar 1;136(5):E272-81. doi: 10.1002/ijc.29240. Epub 2014 Oct 10. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=18836456
*  IJMS | Free Full-Text | ANRIL: Molecular Mechanisms and Implications in Human Health | HTML
Polycomb proteins work in multi-protein complexes, the Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC2 is involved in ... Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol. Cell 2010 ... initiation of long term repression of CDKN2B locus by complexing SUZ12 in the polycomb repressive complex 2 (PRC2) [25], ... Polycomb repressive complexes are critical in the epigenetic regulation of the CDKN2A/B locus (reviewed in reference [45]). ...
  http://www.mdpi.com/1422-0067/14/1/1278/htm
*  Scientists Identify Key Regulator of Male Fertility | EPICOS
The mechanism is a protein complex called Polycomb Repressive Complex 1 (PRC1). Researchers were surprised when they found that ... True to the "repressive" in its name, PRC1 also tamps down specific genes and the activation of fertile sperm production until ... Researchers show in their current study that when mice reach reproductive age, the PRC1 protein complex changes. It sheds ...
  https://www.epicos.com/article/167002/scientists-identify-key-regulator-male-fertility
*  The Emerging Epigenetic Landscape in Melanoma | IntechOpen
RNF2, an E3 ubiquitin ligase, is a core component of the polycomb repressive complex 1 (PRC1). In the context of PRC1, RNF2 ... A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double‐strand breaks. The ... Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell. 2002;111(2):197-208. ... Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. ...
  https://www.intechopen.com/books/human-skin-cancer-potential-biomarkers-and-therapeutic-targets/the-emerging-epigenetic-landscape-in-melanoma/
*  Protocols and Video Articles Authored by Bradley M. Dickson
Polycomb CBX proteins regulate gene expression by targeting Polycomb repressive complex 1 (PRC1) to sites of H3K27me3 via their ... A Cellular Chemical Probe Targeting the Chromodomains of Polycomb Repressive Complex 1 Nature Chemical Biology. Mar, 2016 , ... The aim of this study was to determine the structure of the dominant negative Gαi1β1γ2 G203A/A326S complex (Gi-DN) and to ... Aug, 2009 , Pubmed ID: 19708733 The mechanism of rare events in complex systems can be found by sampling dynamical paths that ...
  https://www.jove.com/author/Bradley++M._Dickson
*  Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in...
There are two major multimeric PcG protein complexes that have been widely studied: Polycomb repressive complex (PRC) 1 and 2. ... Pcl2 interacts with core components of the histone H3K27 methyltransferase complex Polycomb repressive complex 2 (PRC2), to ... 2010). JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464,306-310 ... 2001). Reconstitution of a functional core polycomb repressive complex. Mol. Cell 8,545-556 ...
  http://dev.biologists.org/content/138/8/1471
*  About - Dykhuizen Lab
... chromatin remodeling complex and the Polycomb repressive complex 1. More specifically, the focus of our lab is to decipher the ... While many of the same chromatin modifying complexes present in humans are also present in lower organisms such as drosophila, ... As a corollary, many of the subunits of these chromatin modifying complexes have recently been found to be mutated or ... We study two diverse protein complexes with cell type specific expression of subunits, the BAF (human SWI/SNF) ...
  http://www.dykhuizenlab.com/about.html
*  IJMS | Free Full-Text | Epidermal Stem Cells and Their Epigenetic Regulation | HTML
There are two main complexes, the Polycomb Repressive Complexes-2 (PRC2) and the Polycomb Repressive Complexes-1 (PRC1). The ... Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol. ... Polycomb repressive complex 2 impedes intestinal cell terminal differentiation. J. Cell Sci 2012, 125, 3454-3463. [Google ... RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3. Cell 2012, 148, 664 ...
  http://www.mdpi.com/1422-0067/14/9/17861/htm
*  Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review)
Polycomb proteins can form two major complexes: polycomb repressive complex 1 and 2 (PRC1 and PRC2). BMI1, a subunit of PRC1, ... β-catenin is a key component in the pathway and is inhibited by a protein complex that includes GSK-3, axin and APC (60,61). ... Polycomb-group gene products play a pivotal role in HCC formation and maintenance by modulating the Wnt pathway. ... Chiba T, Miyagi S, Saraya A, et al: The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side ...
  https://spandidos-publications.com/or/29/1/3
*  BMI1, ATM and DDR
The polycomb group protein BMI1 is a component of the polycomb repressive complex 1 (PRC1). Although lacking enzymatic activity ... DSB-elicited ATM activation requires binding of the MRN (MRE11-RAD50-NBS1) complex via a direct association with NBS1 [5]. BMI1 ... This possibility is supported by precipitation of the BMI1- NBS1-ATM complex in 293T cells co-transfected with BMI1 and ATM ( ... It was found that ΔHT and ΔPS elevated γH2AX (Figure ​(Figure1),1), which can be attributable to their competition with ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4580051/
*  Genome-wide identification of Polycomb-associated RNAs by RIP-seq
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2. Mol Cell. 2010 ... all four RNAs bind and regulate Polycomb Repressive Complex 2 (PRC2), the complex that catalyzes trimethylation of histone H3- ... Recent studies of HOX genes and X-inactivation have provided evidence for RNA cofactors in Polycomb repressive complex 2 (PRC2 ... Reconstitution of a functional core polycomb repressive complex. Mol Cell. 2001;8:545-556. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3021903/?lang=en-ca
*  Plus it
BMI1, a member of the polycomb-repressive complex 1 (35, 36) is frequently overexpressed in cancers (37-39). Overexpression of ... When tumors reached an average volume of 100 to 150 mm3, 6.25 μg of synthetic miRNA (miR-708/miR-CON) complexed with 1.6 μL ... The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular ... Also, miR-708 inhibited the expression of polycomb repressor, BMI1. We investigated whether the 3′-UTR of ZEB2 and BMI1 are ...
  http://cancerres.aacrjournals.org/content/71/19/6208
*  IJMS | Free Full-Text | Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players | HTML
This lncRNA binds the Xi in cis to induce chromosome X silencing by recruiting the polycomb repressive complex 2 (PRC2) that ... a component of the polycomb repressive complex 1. This interaction contributes to the role of CBX in promoting EZH2-mediated H3 ... which also associate with the PRC2 and other chromatin repressive complexes [121,122]. One of these lncRNAs is HOX Antisense ... Zhao, J.; Sun, B.K.; Erwin, J.A.; Song, J.J.; Lee, J.T. Polycomb proteins targeted by a short repeat RNA to the mouse X ...
  http://mdpi.com/1422-0067/14/9/18319/htm