Plectin - Wikipedia
Studies employing a plectin knockout mouse have shed light on the functions of plectin. Pups died 2-3 days after birth, and ... Plectin is expressed in nearly all mammalian tissues. In cardiac muscle and skeletal muscle, plectin is localized to ... Plectin has been proposed as a biomarker for pancreatic cancer. Although normally a cytoplasmic protein, plectin is expressed ... "Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate ...
SCOPe 2.08: Protein: Actin binding domain of plectin
Timeline for Protein Actin binding domain of plectin from a.40.1.1: Calponin-homology domain, CH-domain: *Protein Actin binding ... Protein Actin binding domain of plectin [89056] (1 species). duplication: consists of tandem repeat of two CH domains. ... Lineage for Protein: Actin binding domain of plectin. *Root: SCOPe 2.08 *. Class a: All alpha proteins [46456] (290 folds). ... More info for Protein Actin binding domain of plectin from a.40.1.1: Calponin-homology domain, CH-domain. ...
LGMDR17 - Plectin (PLEC) related (formerly LGMD2Q) | cmdir.org
Plectin Protein - ACROBiosystems
Various species and tags of Plectin proteins. Minimal Batch-to-Batch Variation. Bulks in stock. ... Plectin. Brief Information. Name:Plectin Target Synonym:PLTN,Hemidesmosomal protein 1 Number of Launched Drugs:0 Number of ... Plectin,PLTN,PCN,HD1,Hemidesmosomal protein 1,PLEC1. Background. Interlinks intermediate filaments with microtubules and ...
The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes : LSBU Open Research
The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes. Journal article. Almeida, FV, Walko, G, McMillan ... Taken together, our data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and ... In this study, we examine how crosstalk between the cytolinker plectin and F-actin controls keratin network organisation and ... Disruption of the keratin cytoskeleton through loss of plectin facilitated greater nuclear deformation, which depended on acto- ...
MedlinePlus: Genes: P
Congenital Muscular Dystrophy: Background, Pathophysiology, Epidemiology
Rezniczek GA, Walko G, Wiche G. Plectin gene defects lead to various forms of epidermolysis bullosa simplex. Dermatol Clin. ... Mutation in exon 1f of PLEC, leading to disruption of plectin isoform 1f, causes autosomal-recessive limb-girdle muscular ... Epidermolysis bullosa with late-onset muscular dystrophy and plectin deficiency. Muscle Nerve. 2011 Jul. 44(1):135-41. [QxMD ... Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late- ...
Multifaceted peptide assisted one-pot synthesis of gold nanoparticles for plectin-1 targeted gemcitabine delivery in pancreatic...
Plectin-1 is known to be aberrantly expressed in the surface of pancreatic ductal adenocarcinoma (PDAC) cells while showing ... Plectin-1 is known to be aberrantly expressed in the surface of pancreatic ductal adenocarcinoma (PDAC) cells while showing ... Plectin-1 is known to be aberrantly expressed in the surface of pancreatic ductal adenocarcinoma (PDAC) cells while showing ... Plectin-1 is known to be aberrantly expressed in the surface of pancreatic ductal adenocarcinoma (PDAC) cells while showing ...
Human Genome Variation Society
Recombinant Human NAT9 GST (N-Term) Protein (H00026151-P01): Novus Biologicals
SCOPe 2.08: Domain d1sh6a2: 1sh6 A:128-237
PDB Description: Crystal structure of actin-binding domain of mouse plectin. PDB Compounds: (A:) Plectin 1. SCOPe Domain ... Protein Actin binding domain of plectin [89056] (1 species). duplication: consists of tandem repeat of two CH domains. ... d1sh6a2 a.40.1.1 (A:128-237) Actin binding domain of plectin {Human (Homo sapiens) [TaxId: 9606]} ...
Molecular Vision: Sun, Mol Vis 2015; 21:428-442. Figure 9
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Guide to the Human Genome
Epidermolysis bullosa with pyloric atresia: MedlinePlus Genetics
This gene provides instructions for making a protein called plectin. Like α6β4 integrin, plectin helps attach the epidermis to ... When plectin is altered or missing, the skin is less resistant to friction and minor trauma and blisters easily. ... Some PLEC gene mutations prevent the cell from making any functional plectin, while other mutations result in an abnormal form ... Pfendner E, Uitto J. Plectin gene mutations can cause epidermolysis bullosa with pyloric atresia. J Invest Dermatol. 2005 Jan; ...
SMART: PLEC domain annotation
Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III ... Plectin may have a role in cross-linking intermediate filaments, in inter-linking intermediate filaments with microtubules and ... The plectin repeat is also seen in the cell adhesion junction plaque proteins, desmoplakin, envoplakin, and bullous pemphigoid ... Plectin is recruited into hemidesmosomes, multiprotein complexes that facilitate adhesion of epithelia to the basement membrane ...
Ahmed Basim Abduljabar - Research - Aarhus University
Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content...
Equine laminitis: congenital, hemidesmosomal plectin deficiency in a Quarter Horse foal. Equine Vet J 2004; 36:299-303. ... Equine laminitis: congenital, hemidesmosomal plectin deficiency in a Quarter Horse foal. Equine Vet J 2004; 36:299-303. ... Equine laminitis: congenital, hemidesmosomal plectin deficiency in a Quarter Horse foal. . Equine Vet J. 2004. ; 36. :. 299. - ... Equine laminitis: congenital, hemidesmosomal plectin deficiency in a Quarter Horse foal. . Equine Vet J. 2004. ; 36. :. 299. - ...
Limb-Girdle Muscular Dystrophy: Practice Essentials, Background, Pathophysiology
Publications from CCI Users and Staff | University of Gothenburg
WikiGenes - VIM - vimentin
Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. Brown, M.J., Hallam, J.A., Liu, Y., ... Overexpression of the plectin IF-binding domain in the T cell line Jurkat induces the perinuclear aggregation of vimentin IFs [ ...
Pharmaceuticals | October 2022 - Browse Articles
SMART: CH domain annotation
Crystal Structure of the actin binding domain of plectin. 1p2x. CRYSTAL STRUCTURE OF THE CALPONIN-HOMOLOGY DOMAIN OF RNG2 FROM ... Crystal structure of actin-binding domain of mouse plectin. 1sjj. Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha- ... Crystal structure of a complex between integrin beta4 and plectin. 3fer. Crystal structure of n-terminal actin-binding domain ... Crystal structure of actin-binding domain of mouse plectin. 1sh6. ...
CBC-Attributed Research Publications 2013 - Chicago Biomedical Consortium (CBC)
Publikationen
Recruitment of vimentin to the cell surface by β3 integrin and plectin mediates adhesion strength.. Ramona Bhattacharya, ...
Expression of N471D strumpellin leads to defects in the endolysosomal system | Disease Models & Mechanisms | The Company of...
Department of Neurobiology, University of Osnabrück
Plectin. link between MTs and intermediate filaments (?). clip170. links endosomes to MTs Pierre P94. STOP. calmodulin- ...
Adgrg4 Mouse Gene Details | adhesion G protein-coupled receptor G4 | International Mouse Phenotyping Consortium
Clinical Manifestations of Congenital Myasthenic Syndromes Duygu Selcen, md