*  Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now? | Clinical Chemistry
Novel Uses for Platelet Function Testing in the Clinical Laboratory: Where Are We Now?. Brad S. Karon, Gilles Montalescot, Neil ... platelet function testing; LTA, light transmission aggregometry; ARCTIC, Double Randomization of a Monitoring Adjusted ... Platelet function testing (PFT),7 usually performed by techniques such as light transmission aggregometry (LTA), has ... Viscoelastic coagulation tests (such as TEG and ROTEM®) that provide information on both platelet function and coagulation ...
  http://clinchem.aaccjnls.org/content/60/3/441
*  Newly Developed System for the Platelet Function Analysis -- MEDICA Trade Fair
... a newly developed system for the platelet function analysis, is presented. This system assesses effects of the anti platelet ... Due to the standardised test protocols and the possibility to adapt test variables by the user the Multiplate system is ... The Multiplate platelet function analyser, a newly developed system for the platelet function analysis, is presented. This ... Newly Developed System for the Platelet Function Analysis ... The instrument allows parallel testing in 5 channels. The ...
  https://www.medica-tradefair.com/cgi-bin/md_medica/lib/pub/tt.cgi/Newly_Developed_System_for_the_Platelet_Function_Analysis.html?oid=16273&lang=2&ticket=g_u_e_s_t
*  Abstract 4538: Poor Response to Aspirin in Patients with Peripheral Arterial Disease Enrolled in the Effect of Lipid...
Methods: PAD patients (n=45), on ASA, with baseline platelet function tests were included. Platelet function was measured by ... the time for a platelet plug to close an aperture in a Platelet Function Analyzer (PFA)-100 with collagen/epinephrine (CEPI) ... Background: Increased platelet aggregation and variable response to aspirin (ASA) have been reported in patients with ... induced platelet aggregation ,30% in patients with PAD enrolled in the ELIMIT. ...
  http://circ.ahajournals.org/content/118/Suppl_18/S_907.2
*  Platelet Function Tests: Why They Fail to Guide Personalized Antithrombotic Medication | Journal of the American Heart...
Care Platelet Function Tests That Use High Shear. Presently, 3 commercially available point‐of‐care PFTs claim to test platelet ... Gorog Thrombosis Test: a global in‐vitro test of platelet function and thrombolysis. Blood Coagul Fibrinolysis. 2003; 14:31-39. ... Point‐of‐care platelet function testing in patients undergoing PCI: between a rock and a hard place. Neth Heart J. 2007; 15:299 ... Platelet Function Tests: Why They Fail to Guide Personalized Antithrombotic Medication. Diana A. Gorog, Young‐Hoon Jeong ...
  http://jaha.ahajournals.org/content/4/5/e002094.full
*  Multiple electrode aggregometry - Wikipedia
... is a test of platelet function in whole blood. The test can be used to diagnose platelet disorders, monitor antiplatelet ... The ASA Reagent is used as a quality control in the platelet function testing with Multiplate, allowing the assessment of ... This reagent is used as a quality control in Multiplate platelet function testing. The GPIIb/IIIa antagonist blocks the binding ... cAMP inhibits platelet aggregation, and decreased amounts of cAMP in platelets lead to platelet aggregation. The PGE1 reagent ...
  https://en.wikipedia.org/wiki/Multiple_electrode_aggregometry
*  ARCTIC Blows A Cold Wind On Platelet Function Tests
The use of platelet-function tests to monitor and guide antiplatelet therapy in PCI patients has sparked heated debate. ... The use of platelet-function tests to monitor and guide antiplatelet therapy in PCI patients has sparked heated debate. ... The use of platelet-function tests to monitor and guide antiplatelet therapy in PCI patients has sparked heated debate. ... In addition, a follow-up study, ANTARCTIC, is evaluating the value of platelet-function testing in an elderly population "with ...
  https://www.forbes.com/sites/larryhusten/2012/11/04/arctic-blows-a-cold-wind-on-platelet-function-tests/
*  Evolving role of platelet function testing in coronary artery interven | VHRM
Evolving role of platelet function testing in coronary artery interventions Rakesh K Sharma1, Donald J Voelker1, Rohit Sharma1 ... Keywords: platelet function testing, platelet function assay, clopidogrel, coronary artery disease, acute coronary syndrome, ... Research use of platelet function testing has been successfully validated in identifying new antiplatelet drugs like prasugrel ... While the importance of routine platelet function testing may be uncertain, it may be useful in high-risk patients such as ...
  https://www.dovepress.com/evolving-role-of-platelet-function-testing-in-coronary-artery-interven-peer-reviewed-article-VHRM
*  Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single...
Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single- ... Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single- ... Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single- ... Dual Antiplatelet Therapy Monitoring for Neurointerventional Procedures Using a Point-of-Care Platelet Function Test: A Single- ...
  http://www.ajnr.org/content/early/2008/05/15/ajnr.A1070
*  The preparation of platelet-rich plasma for platelet counts and tests of platelet function (author's transl)]. - Semantic...
The preparation of platelet-rich plasma for platelet counts and tests of platelet function (author's transl)].' by Volker Paul ... The preparation of platelet-rich plasma for platelet counts and tests of platelet function (author's transl)].. @article{ ... The preparation of platelet-rich plasma for platelet counts and tests of platelet function (author's transl)].}, author={Volker ... Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review.. *Y Zhu, M ...
  https://www.semanticscholar.org/paper/%5BThe-preparation-of-platelet-rich-plasma-for-counts-Schulz-Kochsiek/4be0df2071d6e8748c8473d741cf04e43dc67805
*  Similar papers for Genetic and platelet function testing of antiplatelet therapy for percutaneous coronary intervention: the...
The genetic clopidogrel profile was a good marker of platelet function response on clopidogrel but was not related to clinical ... No significant improvement in clinical outcomes with platelet function monitoring was observed. The purpose of this study is to ... treatment did not differ between slow and rapid metabolizers according to the study algorithm based on platelet function only. ... Slow metabolizers identified as carriers of at least one loss-of-function allele CYP2C19*2 (n = 459) were more likely poor ...
  https://www.semanticscholar.org/paper/Genetic-and-platelet-function-testing-of-antiplate-Collet-Hulot/2826b2407c7ec315623f935a60ae1eb9cdaa168c?tab=relatedPapers
*  A reliable screening test for platelet function is
StudyAlsways.com also provides practice tests which will be helpful to Medical, Engineering, MBA entrance examination or in job ... A reliable screening test for platelet function is ---------. Options :. *Clot retraction time ...
  http://www.studyalways.com/forum/10037-reliable-screening-test-for-platelet-function.aspx
*  Platelet-Function Testing Might Benefit Select PCI Patients, Says Expert Panel | Indonersia Center
Indonersia - A new position paper on the current role of platelet-function testing in patients undergoing PCI highlights the ... Platelet-Function Testing Might Benefit Select PCI Patients, Says Expert Panel Platelet-Function Testing Might Benefit Select ... "The whole field of platelet-function testing is a difficult field. It's not easy to test platelets the right way. It's much ... "platelet-function testing may help the decision-making by providing information on the level of platelet reactivity," according ...
  http://indonersiacenter.blogspot.com/2013/10/platelet-function-testing-might-benefit.html
*  Pharmacodynamics and Pharmacokinetics of Eptifibatide in Patients With Acute Coronary Syndromes | Circulation
Platelet Function Testing. All sites received training to ensure standard performance of assays.14 Platelet aggregation was ... Blood for platelet aggregation and receptor occupancy testing also was collected in tubes containing 0.1 mol/L buffered citrate ... The Wilcoxon signed-rank test was applied to the difference between TRAP- and ADP-induced platelet aggregation values (for ... Inhibition of Platelet Aggregation. Median inhibition of ADP-induced platelet aggregation (Figure 1) exceeded 80% of the ...
  http://circ.ahajournals.org/content/104/4/399
*  News - UMC Utrecht
New platelet function test wins encouragement prize. Tuesday 2 August 2016. The PACT, a promising new diagnostic platelet ... function test, was awarded an incentive award by the Center for Circulatory Health of the University Medical Center Utrecht ...
  http://www.umcutrecht.nl/en/Research/Research-programs/Circulatory-Health/News
*  RMS | Flow Cytometry
Platelet Function Tests - Buffer Induced Problems. Cytometry Published 25 November 2015. * Download PDF Myeloma Cells with ... London where he studied the role of the Src family kinases Lck and Fyn in T cell function. He is currently head of the Flow ...
  https://www.rms.org.uk/network-collaborate/science-sections/flow-cytometry.html
*  Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients With Coronary Artery Disease...
Platelet function testing. Blood sampling for platelet function analyses were collected from an antecubital vein with a 21- ... Distribution of platelet function profiles were analyzed, and high post-treatment platelet reactivity (HPPR) was defined as the ... Platelet function profile analyses. In the overall study population, maximal ADP-induced platelet aggregation was 54 ± 15% and ... 1997) Studies on platelet membrane glycoproteins and platelet function during hemodialysis. J Am Soc Nephrol 8:799-803. ...
  http://www.onlinejacc.org/content/55/11/1139
*  Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in...
Blood Sampling for Platelet Function Testing. Samples for platelet function testing were taken at predosing (0 hour) and after ... Expression of Platelet Receptors. Platelet function, as measured by expression of glycoprotein IIb/IIIa and P-selectin ... Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) ... The patient population had stable CAD, and similar findings may not occur in the analysis of platelet function in patients with ...
  http://circ.ahajournals.org/content/120/25/2577
*  Value of Platelet Reactivity in Predicting Response to Treatment and Clinical Outcome in Patients Undergoing Primary Coronary...
Platelet function testing. Platelet function was measured with Platelet Function Analyzer-100 (PFA-100) (Dade Behring, Miami, ... To test the role of spontaneous and drug-modulated PR, platelet function was related to: 1) angiographic evaluation (TIMI flow ... 2002) Determination of platelet aggregation inhibition during percutaneous coronary intervention with the Platelet Function ... in patients stratified according to PR measured with Platelet Function Analyzer-100. High platelet reactivity = CADP-CT at ...
  http://www.onlinejacc.org/content/48/11/2178
*  Study of the Pathophysiological Mechanisms Involved in Bleeding Events - Full Text View - ClinicalTrials.gov
Platelet Function Tests. Additional relevant MeSH terms: Aniridia. Syndrome. Hemorrhage. Oculocerebrorenal Syndrome. Chromosome ... The platelet function will be evaluated by comparing the intensity of platelet responses obtained in patient and controls [ ... The platelet function will be evaluated by comparing the intensity of platelet responses obtained in patient and controls. ... Thus, modulation of PtdIns(4,5)P2 levels and/or Rho-dependent signalling would be expected to impact platelet function. ...
  https://clinicaltrials.gov/ct2/show/NCT01314560?cond=%22Aniridia%22&rank=7
*  Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel - Full Text...
It thus seems reasonable to test the efficacy of the drug (by platelet function tests) and modify treatment accordingly. ... Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS ... The aim of the study is, therefore, to assess whether a strategy of monitoring platelet function during clopidogrel treatment ... They will be tested for response to clopidogrel by the VerifyNow P2Y12 assay (either on chronic clopidogrel treatment or 12-24 ...
  https://clinicaltrials.gov/ct2/show/NCT01643031?recr=Open&cond=%22Platelet+Aggregation+Inhibitors%22&rank=19
*  Von Willebrand Disease | National Heart, Lung, and Blood Institute (NHLBI)
Platelet function test. This test measures how well your platelets are working. ... No single test can diagnose VWD. Your doctor may recommend one or more blood tests to diagnose the disorder. These tests may ... This test is done if one or more of the first three tests are abnormal. It shows the structure of your von Willebrand factor. ... This test shows how well your von Willebrand factor works.. *Factor VIII clotting activity. This test checks the clotting ...
  https://www.nhlbi.nih.gov/health-topics/von-willebrand-disease
*  9781420080094 - Animal Hematotoxicology: A Practical | eCampus.com
Platelet Function Tests. p. 115. Other Factor Assays. p. 116. Toxic Effects on Platelets and Coagulation. p. 117. ...
  http://www.ecampus.com/animal-hematotoxicology-practical-guide/bk/9781420080094
*  Indmedica - Transfusion Bulletin
Platelet Function Testing to Assess Effectiveness of Platelet Transfusion Therapy. Mohamed E. Salarna, Sundara Raman, Mary Jo ... However improvement in platelet count following transfusion may not necessarily indicate improvement in platelet function or ... In this evaluation platelet function testing using the PFA. 100 provided a better indication of transfusion outcome than did ... results of the platelet function Analyzer (PFA-100) and post-transfusion CCI. Platelet transfusion requests with different ...
  http://www.indmedica.com/journals.php?journalid=2&issueid=2&articleid=25&action=article
*  Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Elvitegravir Versus...
Adequate hematologic function (absolute neutrophil count ≥ 1,000/mm^3; platelets ≥ 50,000/mm^3; hemoglobin ≥ 8.5 g/dL) ... Negative serum pregnancy test (females of childbearing potential only). *Males and females of childbearing potential must agree ... Adequate renal function (estimated glomerular filtration rate according to the Cockcroft-Gault formula ≥ 60 mL/min) ... The background regimen will be constructed by the investigator based on viral resistance testing. The fully active PI will be ...
  https://clinicaltrials.gov/show/NCT00707733?order=21
*  Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer - Full Text...
Adequate bone marrow function as shown by: absolute neutrophil count (ANC) ≥ 1.5 x 10⁹/L, platelets ≥ 100 x 10⁹/L, Hgb , 9 g/dL ... Women of childbearing potential must have a negative serum pregnancy test within 14 days of the administration of the first ... Adequate renal function as shown by serum creatinine ≤ 1.5 x ULN or glomerular filtration rate (GFR) of 60cc/ml using the ... Adequate liver function as shown by: serum bilirubin ≤ 1.5 x upper limit of normal (ULN), and serum transaminases activity ≤ 3 ...
  https://clinicaltrials.gov/ct2/show/NCT01270321?term=sirolimus+cancer&recr=Open&rank=17