Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif ... "Entrez Gene: PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4)". Lasagni L, Francalanci M, Annunziato F, Lazzeri E, ... Platelet+factor+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif ... Platelet-derived growth factor. References. *↑ 1.0 1.1 Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M (July 1990). " ... 1987). "Human platelet factor 4 gene is mapped to 4q12----q21". Cytogenet. Cell Genet. 45 (2): 67-69. doi:10.1159/000132431. ... Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with ...

ELISA Based Anti-Platelet Factor 4 Polyspecific and IgG-Specific Antibody Detection Assays Compared to the Unfractionated ... Heparin-Induced Thrombocytopenia Testing: ELISA Based Anti-Platelet Factor 4 Polyspecific and IgG-Specific Antibody Detection ... Heparin-Induced Thrombocytopenia Testing: ELISA Based Anti-Platelet Factor 4 Polyspecific and IgG-Specific Antibody Detection ... Heparin-Induced Thrombocytopenia Testing: ELISA Based Anti-Platelet Factor 4 Polyspecific and IgG-Specific Antibody Detection ...

Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor ... Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor ... Binding of anti-platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor ... The chemokine platelet factor 4 (PF4) undergoes conformational changes when complexing with polyanions. This can induce the ...

B chain and the plasma platelet factor 4 (PF4) levels were measured in 17 healthy controls and 55 brain tumour patients. In the ... The plasma concentration of the platelet-derived growth factor (PDGF)- ... The plasma concentration of the platelet-derived growth factor (PDGF)-B chain and the plasma platelet factor 4 (PF4) levels ... Plasma platelet-derived growth factor-B chain is elevated in patients with extensively large brain tumour Acta Neurochir (Wien) ...

Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C. ... "Platelet Factor 4" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and ... Park KS, Rifat S, Eck H, Adachi K, Surrey S, Poncz M. Biologic and biochemic properties of recombinant platelet factor 4 ...

... fibroblast growth factors basic (FGF basic), hepatocyte growth factor (HGF), interleukin-8, platelet-derived growth factor, ... ELISA for angiogenic factors, chemokine platelet factor 4 (PF4) and serotonin. The concentrations of angiogenic factors were ... 12 Platelets are also the main physiological transporters of proangiogenic and antiangiogenic factors.13 Proangiogenic factors ... hepatocyte growth factor; IL-8, interleukin 8; PDGFR, platelet-derived growth factor; TIMP-1, metalloproteinase inhibitor 1; ...

... coagulation factors, and the endothelial cells lining the blood vessels. The platelets arise from the fragmentation of the ... The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). On resting platelets, GP ... Overview of Platelet Disorders Overview of Platelet Disorders. The hemostatic system consists of platelets, coagulation factors ... Platelet adhesion to vWF via platelet GP Ib platelet activation. *Platelet aggregation mediated by the interaction of GP IIb/ ...

... and platelet counts started to recover on the fifth day after ECC. With the extension of ECC time, the drop in platelet counts ... We concluded that thrombocytopenia was common after ECC, maximum drop of the platelet counts after ECC was usually seen on the ... with different time on platelet count in patients undergoing cardiac surgery. A total of 427 patients who underwent elective ... and the recovery level and speed of platelet counts is lower. ... Platelets derived growth factor and fibroblast growth factor-2 ...

... coagulation factors, and the endothelial cells lining the blood vessels. The platelets arise from the fragmentation of the ... The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). On resting platelets, GP ... Overview of Platelet Disorders Overview of Platelet Disorders. The hemostatic system consists of platelets, coagulation factors ... Platelet adhesion to vWF via platelet GP Ib platelet activation. *Platelet aggregation mediated by the interaction of GP IIb/ ...

Pro-inflammatory platelet factor 4 (CXCL4/PF4) signaling in rheumatoid arthritis To, Jeffrey Abstract. Background: Rheumatoid ... Of particular interest is platelet factor 4 (PF4), a major constituent of platelet alpha-granules. Methods: Cultured SW982 ... Of particular interest is platelet factor 4 (PF4), a major constituent of platelet alpha-granules. Methods: Cultured SW982 ... Platelets also function as immune cells that contain and secrete pro-inflammatory molecules but their role in RA is not ...

The high mortality associated with VITT was highest among patients with a low platelet count and intracranial hemorrhage. ... by a factor of 1.7 (95% CI, 1.3 to 2.3) for every 50% decrease in the baseline platelet count, by a factor of 1.2 (95% CI, 1.0 ... Overall mortality was 22%. The odds of death increased by a factor of 2.7 (95% confidence interval [CI], 1.4 to 5.2) among ... Conclusions: The high mortality associated with VITT was highest among patients with a low platelet count and intracranial ...

Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior ... An immune-mediated response associated with platelet factor 4/heparin antibodies has been proposed as the underlying ... To determine the frequencies of admission thrombocytopenia, heparin-induced thrombocytopenia, and presence of platelet factor 4 ... and platelet factor 4/heparin IgG antibodies (optical density ,0.4, in a subset of patients with previously collected plasma ...

Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities and platelet activation. ... Dive into the research topics of Platelet factor 4 binds to vascular proteoglycans and controls both growth factor activities ...

Scully et al.: Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination; 22 patients presented with acute ... Scully et al.: Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination; 22 patients presented with acute ... Scully et al.: Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination; 22 patients presented with acute ... Scully et al.: Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination; 22 patients presented with acute ...

H. M. McGowan, R. Vandongen, L. D. Kelly, K. J. Hill; Increased levels of platelet-activating factor (1-O-alkyl-2- ... Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip ... hypertensive rats for the presence of platelet-activating factor (PAF), a potent vasodilator and a putative mediator of the ... The extract was analysed for PAF by a bioassay using 5-hydroxy-[14C]tryptamine-labelled platelets. ...

Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination.external icon Scully et al. NEJM (April 16, 2021). ... Triggering and predisposing factors are unknown. The formation of antibodies against PF4 may cause platelet consumption with ... Antibodies to platelet factor 4 (PF4) were positive in 22 patients and negative in 1 patient. ... Possible contributing factors include disruptions to opioid use disorder treatment services, social patterns in drug usage, and ...

The protein is called platelet factor 4 (PF4). We know that in the course of infection, many people make antibodies that stick ... Billions of platelets get used up in these clots, leading to low numbers of platelets in the blood. In some patients, this led ... In our lab, we work on how platelets get activated in VITT. In 2021, our team showed the main mechanism for platelet activation ... These complexes bind to and activate small cells called platelets that are vital for blood clotting. Normally, platelets float ...

PF4V1; platelet factor 4 variant 1 [KO:K05407]. 9547 CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]. ... GRB2; growth factor receptor bound protein 2 [KO:K04364]. 6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO: ... CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell ... CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467] [EC:2.7.11.10]. ...

platelet factor 4. ISO. protein:increased expression:plasma. RGD. PMID:26283469. RGD:401794584. NCBI chr14:17,298,304... ... complement factor B. ISO. RGD. PMID:6900632. RGD:7411737. NCBI chr20:3,970,643...3,976,510 Ensembl chr20:3,951,474...3,976,505 ... transforming growth factor, beta 1. ISO. DNA:polymorphism:promoter:exon (human). RGD. PMID:21640045. RGD:5147902. NCBI chr 1: ... coagulation factor V. no_association. ISO. DNA:mutation: :1691G>A (human). RGD. PMID:15077257. RGD:7394769. NCBI chr13: ...

platelet factor 4. involved_in. ISS. ISO. GO_REF:0000024. (PMID:2140694). UniProt. RGD. PMID:2140694. GO_REF:0000024. NCBI ... MAF bZIP transcription factor B. involved_in. ISO. (PMID:8620536). RGD. PMID:8620536. NCBI chr 3:148,998,111...149,000,031 ... KLF transcription factor 13. involved_in. ISO. (MGI:3796470,PMID:18285334). RGD. PMID:18285334. MGI:3796470. NCBI chr 1: ... RUNX family transcription factor 1. involved_in. ISO. (PMID:9199349). RGD. PMID:9199349. NCBI chr11:31,839,880...32,074,427 ...

Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. 10.1056/NEJMoa2105385. ... CBC with platelet count and peripheral smear. Median initial platelet count in largest series was 47 x 109/L with a wide range ... The platelet count at presentation is often 10 x 109/L, somewhat lower than in VITT (median, 20 x 109/L), and thromboses have ... A patient who presents with thrombosis and a normal platelet count post-vaccination might be in an early stage of VITT. ...

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination. N. Engl. J. Med. 2021, 384, 2202-2211. [Google ... may result in very rare events of producing autoantibodies against platelet-factor 4, potentially causing catastrophic ... SARS-CoV-2 infection is associated with a pro-thrombotic platelet phenotype. Cell Death Dis. 2021, 12, 50. [Google Scholar] [ ... Gallie, D.R. Cap-independent translation conferred by the 5′ leader of tobacco etch virus is eukaryotic initiation factor 4G ...

Migration of THP-1 monocytes in response to complete or fractionated platelet releasate was assessed and located to just one of ... The presence of PEDF and involucrin, two proteins not previously reported in platelet releasate, was confirmed by western ... Here, we describe an experimental approach that fractionates proteins released from human platelets, linking bioassay activity ... in particular platelet activation, adhesion, and wound healing. ... platelet factor 4, platelet basic protein, and actin binding ...

Aqueous Gel Formation of a Synthetic Peptide Derived from the β-Sheet Domain of Platelet Factor-4. Biomacromolecules 2002, 3 (6 ... Cite this: Nano Letters 2002, 2, 4, 295-299. Publication Date (Web):February 21, 2002. Publication History. *Received10 ... Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2002, 2, 4, 295-299 ... The Journal of Physical Chemistry B 2023, 127 (4) , 912-920. https://doi.org/10.1021/acs.jpcb.2c06404. ...

Laghrissi-Thode, F., et al., Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ... Ford, D.E., et al., Depression is a risk factor for coronary artery disease in men: the precursors study. Arch Intern Med, 1998 ... Williams, R.B. and A.B. Littman, Psychosocial factors: role in cardiac risk and treatment strategies. Cardiol Clin, 1996. 14(1 ... Kop, W.J., et al., Inflammation and coagulation factors in persons , 65 years of age with symptoms of depression but without ...

... we observed no evidence of platelet recombination, using platelet factor 4 (Pf4)-Cre; Rosa26Ai14 mice (well known to recombine ... 2015) Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage Journal of Thrombosis ... Although we saw robust labeling of platelets in PF4-Cre; Ai14 mice, we saw no recombination of platelets in P2ry12-CreER mice ( ... 1977) Amino acid sequence of human platelet factor 4 PNAS 74:2256-2258. ...

Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS Authors: CC Huang, CH Chou, SU Chen, HN Ho, ... Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells ... Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent ... B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling ...

Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux ... Oral, direct Factor Xa inhibition with BAY 59-7939 for the prevention of venous thromboembolism after total hip replacement ... A dose-finding study with TAK-442, an oral factor Xa inhibitor, in patients undergoing elective total knee replacement surgery ... Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study ...

4-Methoxytrityl chloride; p-Anisylchlorodiphenylmethane; p-Monomethoxytrityl chloride; MMT; Linear Formula: CH3OC6H4C(C6H5)2Cl ... Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. ... A series of aryl phosphoglyceride (3, 19-61) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) ... CH3OC6H4C(C6H5)2Cl ...