Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first ... Thus, phorbol ester exposure can show a wide range of results. The main results of phorbol exposure are tumor promotion and ... While phorbol itself does not have irritant activity, nearly all phorbol esters are highly irritant, with a wide range of half- ... TPA and other phorbol esters can also be used to induce tumor formation and elucidate its mechanism. Some phorbol esters such ...

ProTGF-alpha cleavage is activated in response to tumor-promoting phorbol ester or to calcium … ... Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzyme J Biol ... The enzyme activity was about 5-6-fold increased by exposure of the cells with phorbol ester or with calcium ionophore. The ... The enzyme was partially purified from membranes of phorbol ester-treated CHO cells. The molecular mass of the enzyme was ...

... channel by 4α-phorbol esters was investigated by combining information from chemical modification of 4α-phorbol-d... ... channel by 4α-phorbol esters was investigated by combining information from chemical modification of 4α-phorbol-didecanoate (4α ... Binding of 4α-phorbol esters occurs in a loop in the TM3−TM4 domain of TRPV4 that is analogous to the capsaicin binding site of ... Modulation of the Transient Receptor Potential Vanilloid Channel TRPV4 by 4α-Phorbol Esters: A Structure−Activity Study. * ...

Macrolides Attenuate Phorbol Ester-Induced Tumor Necrosis Factor-α and Mucin Production from Human Airway Epithelial Cells ... Orapan Poachanukoon, Sittichai Koontongkaew, Paopanga Monthanapisut, Napaporn Pattanacharoenchai; Macrolides Attenuate Phorbol ... mucoepidermoid airways epithelial cells were pretreated with AZM or MDM for 2 h and then stimulated with 200 nmol/l phorbol 12- ...

Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen- ... Noh H, Sung E, Kim J, Lee T and Song I: Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin ... Noh, H., Sung, E., Kim, J., Lee, T., Song, I.Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by ... Noh, H., Sung, E., Kim, J., Lee, T., Song, I.Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by ...

A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary ... A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary ... A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary ... A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary ...

Pyne, N J and Murphy, G J and Milligan, G and Houslay, M D (1989) Treatment of intact hepatocytes with either the phorbol ester ... Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional ... Challenge of hepatocytes with the tumour promoting phorbol ester TPA, however, elicited a marked enhancement of the ...

Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester. B G Wallace B G Wallace ... B G Wallace; Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester.. J Cell Biol 1 July 1988 ... Agrin-induced receptor aggregation also was inhibited by phorbol 12-myristate 13-acetate, an activator of protein kinase C, and ...

The structure of the phorbol, first determined by Dr. Heck in 1967, was a congested tetracyclic skeleton with both cyclopropane ... Phorbol, a Tigliane natural product first isolated in 1934 by Dr.Flaschenträger and Dr. Wolffersdorff, drove 17 research groups ... from the first synthesis of the phorbol skeleton and the first synthesis of the racemic phorbol by Dr. Wender to the first ... Phorbol, a Tigliane natural product first isolated in 1934 by Dr.Flaschenträger and Dr. Wolffersdorff, drove 17 research groups ...

A phorbol-12-myristate-13-acetate (TPA) is a synthetic analogue of phorbol ester (PE), a natural toxic compound of ... Microbubbles enhanced synthetic phorbol ester degradation by ozonolysis Kuvshinov, Dmitriy; Siswanto, Anggun; Zimmerman, ... Kuvshinov, D., Siswanto, A., & Zimmerman, W. (2014). Microbubbles enhanced synthetic phorbol ester degradation by ozonolysis. ...

In the presence of phorbol myristate acetate (PMA), an activator of PKC and analog of diacylglycerol, IGF-II receptor number ... Modulation of the insulin growth factor II/mannose 6-phosphate receptor of microvascular endothelial cells by phorbol ester via ... Modulation of the insulin growth factor II/mannose 6-phosphate receptor of microvascular endothelial cells by phorbol ester via ... Modulation of the insulin growth factor II/mannose 6-phosphate receptor of microvascular endothelial cells by phorbol ester via ...

Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha ... Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha ... Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha ... Development of a sensitive in vitro assay to quantify the biological activity of pro-inflammatory phorbol esters in Jatropha ...

... whereas 4α-phorbol (4α-PHR), a biologically inactive phorbol, has no effect. These data suggest that phorbol ester receptor- ... whereas 4α-phorbol (4α-PHR), a biologically inactive phorbol, has no effect. These data suggest that phorbol ester receptor- ... whereas 4α-phorbol (4α-PHR), a biologically inactive phorbol, has no effect. These data suggest that phorbol ester receptor- ... whereas 4α-phorbol (4α-PHR), a biologically inactive phorbol, has no effect. These data suggest that phorbol ester receptor- ...

Down-regulation of mannose receptor activity in macrophages after treatment with lipopolysaccharide and phorbol esters. V L ... Down-regulation of mannose receptor activity in macrophages after treatment with lipopolysaccharide and phorbol esters.. J ...

The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO ... Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13- ... dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. The synthetic diacylglycerol analogues oleolyl- ... The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO ...

Phorbol Rearrangements. Zimmermann, T., Franzyk, Henrik & Christensen, Søren Brøgger, 28 Sep 2018, In: Journal of Natural ...

... ... MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells.. ... 2022). MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia ... activator phorbol myristate acetate (PMA). PMA-triggered differentiation of HL-60 cells into macrophage-like cells was ...

Time course of phorbol esters in reaction products in acid catalyzed transesterification. ...

Dive into the research topics of Intracellular Reactions in Single Human Granulocytes upon Phorbol Myristate Acetate ... title = "Intracellular Reactions in Single Human Granulocytes upon Phorbol Myristate Acetate Activation using Confocal Raman ... T1 - Intracellular Reactions in Single Human Granulocytes upon Phorbol Myristate Acetate Activation using Confocal Raman ... Intracellular Reactions in Single Human Granulocytes upon Phorbol Myristate Acetate Activation using Confocal Raman ...

Dive into the research topics of Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of ... Interestingly, PKCα, PKCβII, and PKCε translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12 ... Interestingly, PKCα, PKCβII, and PKCε translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12 ... Interestingly, PKCα, PKCβII, and PKCε translocation to the plasma membrane was more pronounced and more prolonged in phorbol-12 ...

Jung, SH, Woo, MS, Kim, SY, Kim, WK, Hyun, JW, Kim, EJ, Kim, DH & Kim, HS 2006, Ginseng saponin metabolite suppresses phorbol ... Dive into the research topics of Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 ... T1 - Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of ... Ginseng saponin metabolite suppresses phorbol ester-induced matrix metalloproteinase-9 expression through inhibition of ...

Phorbol esters produce a delay in the expression of melanogenesis by b-16 melanoma cells. Abstr. ...

Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in ...

We previously showed that phorbol-12-myristate-13-acetate (PMA) transactivates MMP-9 expression in HCC cells in an AP-1 and NF- ... We previously showed that phorbol-12-myristate-13-acetate (PMA) transactivates MMP-9 expression in HCC cells in an AP-1 and NF- ... expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol ... expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol ...

Dive into the research topics of Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 ... title = "Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in ... T1 - Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in ... Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in capillary ...

Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many ... Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts ... Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts ... N2 - Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in ...

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain). RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03 The ...

Inactive phorbol ester, 4α-phorbol 12,13-didecanoate at 1 μM, did not inhibit these responses. Prior treatment of TECs with ... Inactive phorbol ester, 4α-phorbol 12,13-didecanoate at 1 μM, did not inhibit these responses. Prior treatment of TECs with ... Inactive phorbol ester, 4α-phorbol 12,13-didecanoate at 1 μM, did not inhibit these responses. Prior treatment of TECs with ... Inactive phorbol ester, 4α-phorbol 12,13-didecanoate at 1 μM, did not inhibit these responses. Prior treatment of TECs with ...

... and the phorbol ester 4 α-phorbol 12,12-didecanoate (4 α-PDD, Sigma) were made in 10% DMSO. Stock solutions of the integrin ... phorbol esters (Watanabe et al., 2002a; F. Xu et al., 2003), low pH and citrate (Suzuki et al., 2003a), endocannabinoids, and ... activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J ...