*  Abstract C114: The role of LKB1 and TP53 mutation status in determining sensitivity of non-small cell lung cancer cells to the...
There was a wide range of sensitivity [IC50 values: metformin 1.22 mM-34.37 mM; phenformin 0.01-1.39 mM; 2-DG 1.86-15.18 mM] to ... phenformin and 2-DG. Fiona F. Cahill, Sivan Bokobza, Aoife Devery, Neele Drobnitzky, Yanyan Jiang, Luiza Madia Lourenco, ... Loss of TP53 function increased resistance in both A549-wtLKB1 (metformin IC50: 5.42 versus 1.92 mM, p , 0.001; phenformin IC50 ... It has been reported that LKB1 mutated cells are more sensitive to the metabolic inhibitor phenformin (2). We aimed to further ...
  http://mct.aacrjournals.org/content/14/12_Supplement_2/C114
*  Diabetes drug could hold promise for lung cancer patients - Salk Institute for Biological Studies
Metformin and phenformin both inhibit mitochondria; however, phenformin is nearly 50 times as potent as metformin. In the study ... If we can organize enough clinicians who believe in investigating phenformin-and many do-then phenformin as an anti-cancer ... The next step is to determine if phenformin alone would be a sufficient therapy for certain subsets of NSCLC or if the drug ... The Food and Drug Administration took phenformin off the market in 1978 due to a high risk of lactic acid buildup in patients ...
  http://www.salk.edu/news-release/diabetes-drug-could-hold-promise-for-lung-cancer-patients/
*  Phenylalaninylargininylarginine: a novel tripeptide exerting Zn2+-dependent, insulin-mimetic inhibitory action on myocardial...
In the presence of background levels of perfusate Zn2+ the infusion of Phe-Arg-Arg (10 microM), insulin (5 nM), or phenformin ( ... phenformin (phenylethylbiguanide), which has previously been found to exert a Zn(2+)-dependent inhibitory action on lysosomal ...
  http://www.biochemj.org/content/293/3/801
*  Common Diabetes Drug Shows Promise As Lung Cancer Treatment - Redorbit
While two of these drugs, known as metformin and phenformin, both inhibit mitochondrial activity, phenformin is about 50 times ... Although the phenformin treatment looks promising, the FDA actually took the drug off the market in 1978 due to a high risk of ... The early-stage phenformin treatments resulted in increased survival rates and slower tumor progression in only those tumors ... According to the study, the diabetes drug phenformin may effectively treat 30 percent of patients with non-small cell lung ...
  http://www.redorbit.com/news/health/1112773857/diabetes-drug-cures-lung-cancer-013013/
*  Phenformin | CTD
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290 ...
  http://ctdbase.org/detail.go?type=chem&acc=D010629
*  Phenformin and lactic acidosis. | The BMJ
Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients ... Advanced age and cardiovascular and renal disease are absolute contraindications to the use of phenformin in diabetics. ... Phenformin and lactic acidosis.. Br Med J 1976; 1 doi: https://doi.org/10.1136/bmj.1.6001.70 (Published 10 January 1976) Cite ...
  http://www.bmj.com/content/1/6001/70
*  Phenformin as a cause of primary pulmonary hypertension. | The BMJ
Phenformin as a cause of primary pulmonary hypertension. Br Med J 1976; 2 :1450 ... Phenformin as a cause of primary pulmonary hypertension.. Br Med J 1976; 2 doi: https://doi.org/10.1136/bmj.2.6049.1450-c ( ...
  http://www.bmj.com/content/2/6049/1450.3
*  Phenformin decreases size of lung tumors and increases survival in mice
Metformin and phenformin both inhibit mitochondria; however, phenformin is nearly 50 times as potent as metformin. In the study ... If we can organize enough clinicians who believe in investigating phenformin-and many do-then phenformin as an anti-cancer ... Phenformin decreases size of lung tumors and increases survival in mice. *Download PDF Copy ... The next step is to determine if phenformin alone would be a sufficient therapy for certain subsets of NSCLC or if the drug ...
  https://www.news-medical.net/news/20130130/Phenformin-decreases-size-of-lung-tumors-and-increases-survival-in-mice.aspx
*  Phenformin - Wikipedia
Plasma half-life of phenformin is 10 to 15 h. Phenformin protein binding in plasma is about 12 to 20%.[citation needed] ... In Hong Kong, where phenformin is banned, cases of phenformin-induced lactic acidosis occurred after taking Chinese proprietary ... phenformin was still legally available in Italy, Brazil, Uruguay, China, Poland, Greece and Portugal and cases of phenformin- ... Phenformin hydrochloride is a white crystalline powder, with a melting point of 175 to 178 °C; it is soluble at 1 in 8 parts of ...
  https://en.wikipedia.org/wiki/Phenformin
*  Effects of Tolbutamide, Mesoxalate and Phenformin in Vitro on the Liberation of Nitrogen by Rat Liver Slices | Diabetes
Effects of Tolbutamide, Mesoxalate and Phenformin in Vitro on the Liberation of Nitrogen by Rat Liver Slices. ... Effects of Tolbutamide, Mesoxalate and Phenformin in Vitro on the Liberation of Nitrogen by Rat Liver Slices ... Effects of Tolbutamide, Mesoxalate and Phenformin in Vitro on the Liberation of Nitrogen by Rat Liver Slices ... Effects of Tolbutamide, Mesoxalate and Phenformin in Vitro on the Liberation of Nitrogen by Rat Liver Slices ...
  http://diabetes.diabetesjournals.org/content/10/1/52
*  Gentaur Molecular :Biovis \ Phenformin hydrochloride; Appearance White solid \ 1889-1000
Phenformin hydrochloride; Appearance White solid \ 1889-1000 for more molecular products just contact us ... We have also other products like : Phenformin hydrochloride; Appearance White solid. Related products : Phenformin ... Index / Biovis / Phenformin hydrochloride; Appearance White solid / Product Detail : 1889-1000 Phenformin hydrochloride; ...
  http://www.antibody-antibodies.com/product_det.php?id=1989110&supplier=search&name=Phenformin%20hydrochloride%3B%20Appearance%20White%20solid
*  Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in...
Although phenformin is the more potent biguanide in both systems, the metabolic profiles of these drugs are remarkably similar ... Here, we use LC/MS/MS metabolomics (,200 metabolites) to assess metabolic changes induced by metformin and phenformin in an Src ... Although a few metabolic effects of metformin and the related biguanide phenformin have been investigated in established cancer ... Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in ...
  https://www.semanticscholar.org/paper/Metformin-and-phenformin-deplete-tricarboxylic-acid-Janzer-German/b95d988890d7c812e31e3393b6cb918212d9223d
*  Pharmaceutical Ingredients, China Pharmaceutical Ingredients Manufacturers & Suppliers - HiSupplier.com
Phenformin Hydrochloride Active Pharmaceutical Ingredients Phenformine HCl Unit Price: 90.0 USD. Min.Order: 1 Gram. Phenformin ...
  http://www.hisupplier.com/a-pharmaceutical-ingredients/
*  Hereditary Coproporphyria Treatment & Management: Approach Considerations, Diet
Phenformin Phenoperidine Phentolamine mesylate Pipotiazine Palmitate Piracetam Pirbuterol Pirenzepine Pizotifen [Prazosin] [ ...
  https://emedicine.medscape.com/article/205374-treatment
*  Acute Intermittent Porphyria: Practice Essentials, Pathophysiology, Epidemiology
Acute intermittent porphyria (AIP) is one of the porphyrias, a group of diseases involving defects in heme metabolism and that results in excessive secretion of porphyrins and porphyrin precursors. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.
  https://emedicine.medscape.com/article/205220-overview
*  KEGG PATHWAY: hsa04140
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components ...
  http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04140
*  The impact of a community trial on the pharmacological treatment in the individuals with the metabolic syndrome: findings from...
Metformin/phenformin. 4 (4.0%). 28 (32.2%). , 0.0001. 2 (3.1%). 12 (19.7%). 0.003. 6 (3.7%). 40 (27.0%). , 0.0001. ... Metformin, phenformin. 2 (2.5%). 21 (25.6%). , 0.001. 2 (4.4%). 11 (22.9%). 0.010. 4 (3.2%). 32 (24.6%). , 0.001. ...
  http://www.biomedsearch.com/nih/impact-community-trial-pharmacological-treatment/23319975.html
*  Leuprolide - DrugBank
Phenformin. The therapeutic efficacy of Phenformin can be decreased when used in combination with Leuprolide.. Approved, ...
  https://www.drugbank.ca/drugs/DB00007
*  Solute carrier family 22 member 1 - DrugBank
Phenformin. approved, investigational, withdrawn. unknown. substrateinhibitor. Details. DB00331. Metformin. approved. unknown. ...
  https://www.drugbank.ca/biodb/bio_entities/BE0003648