Pentylenetetrazol, also known as pentylenetetrazole, leptazol, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, ... The mechanism of pentylenetetrazol is not well understood, and it may have multiple mechanisms of action. In 1984, Squires et ... Pentylenetetrazol is also a prototypical anxiogenic drug and has been extensively used in animal models of anxiety. ... In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method ...

... ip administered 30 min followed by pentylenetetrazole induction measured for 30 min relative to control. ... Anticonvulsant activity in pentylenetetrazole-induced Mus musculus albino (mouse) seizure model assessed as survival at 220 mg/ ...

... assessed as protection against pentylenetetrazol-induced seizures administered 30 min prior to seizure induction measured for ...

Antiepileptic potential of Anisomeles indica (Linn.) Kuntze aerial parts in pentylenetetrazole-induced experimental convulsions ... model and pentylenetetrazole (PTZ) models at doses of 200, 400 mg/kg, po once. Phenytoin and diazepam (25 and 2 mg/kg, ip) were ...

Activation of the GABA(A)-receptor δ-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. In ... Activation of the GABA(A)-receptor δ-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. / ... Dive into the research topics of Activation of the GABA(A)-receptor δ-subunit gene promoter following pentylenetetrazole- ... Activation of the GABA(A)-receptor δ-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. ...

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We investigate the expression of Kir channels in epileptic cardiac tissue by using pentylenetetrazole (PTZ)-kindling model in ... Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats. ... We investigate the expression of Kir channels in epileptic cardiac tissue by using pentylenetetrazole (PTZ)-kindling model in ... Expression of cardiac inwardly rectifying potassium channels in pentylenetetrazole kindling model of epilepsy in rats-, ...

Electrode implantation and detection of pentylenetetrazol (PTZ)-induced seizure susceptibility in cohort 5. To monitor the ...

Dive into the research topics of Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal. ...

Pentylenetetrazole Grants and funding * R21 MH106919/MH/NIMH NIH HHS/United States ...

... lacosamide and topiramate on epileptogenesis and related cognitive dysfunction in an experimental model of pentylenetetrazole ( ...

pentylenetetrazol-induced convulsions. positive modulation of GABAAR and antioxidant properties. Silva et al., 2009 [84]. ... 20] reported that pre-inhalation of the EO of Acorus gramineus markedly delayed the appearance of pentylenetetrazole-induced ... pentylenetetrazole-induced convulsion; sedative effect; CNS inhibitory effects. increased GABA level; decreased GABA ... Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and ...

Investigation of Compositional, Structural, and Dynamical Changes of Pentylenetetrazol-Induced Seizures on a Rat Brain by FT-IR ... Therefore, the current study determined molecular consequences of seizures induced by pentylenetetrazol (PTZ), which is a ... and Dynamical Changes of Pentylenetetrazol-Induced Seizures on a Rat Brain by FT-IR Spectroscopy," ANALYTICAL CHEMISTRY, pp. ...

Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: ins Anticonvulsant potential of Grewia ... Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute ... tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ...

The Effects of Cichorium intybus Extract on Cerebellar Apoptosis and Oxidative Stress in Pentylenetetrazole-induced Kindling ...

Therefore, this study was designed to examine the effects of chronic administration of vitamin D3 on pentylenetetrazole (PTZ)- ... Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice ... pentylenetetrazole-induced seizure; priority journal; seizure threshold; tonic clonic seizure; vitamin supplementation; animal ... Inhibitory effects of chronic administration of vitamin D3 on pentylenetetrazole-induced seizures in mice. Epilepsy Research, ...

AGAINST SEIZURES INDUCED BY PENTYLENETETRAZOLE AND ELECTROCONVULSIVE SHOCK IN MICE EVALUATION OF ANTICONVULSANT ACTIVITY OF THE ... AGAINST SEIZURES INDUCED BY PENTYLENETETRAZOLE AND ELECTROCONVULSIVE SHOCK IN MICE. Abstract Nyctanthes arbortristis Linn. ( ... arbortristis protected mice against tonic convulsions induced by maximal electroshock and especially by pentylenetetrazole. ...

in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. In: Brain Injury. 2013 ; Vol. 27, No. 13-14. pp ... in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy, Brain Injury, vol. 27, no. 13-14, pp. 1707-1714 ... in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. Brain Injury. 2013 Jan 1;27(13-14):1707-1714. ... in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. Adhikari Snehunsu, N. Mukunda, M. C. Satish ...

Effect of pentylenetetrazol-induced epileptic seizure on thiol redox state in the mouse cerebral cortex. Epilepsy Res. 2004;62( ... Gupta Y, Kumar MV, Srivastava A. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative ... Feng Y, LeBlanc MH, Regunathan S. Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat ... and learning in pentylenetetrazole-induced kindling rats Running title: Biarum carduchrum effects on seizure, oxidative stress ...

Results: Our results showed that the pentylenetetrazole-induced seizure threshold was 33.4 0.42 mg/kg in control group. In ... Comparison of the Effect of Verapamil, Nifedipine and Diltiazem on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice ... nifedipine and diltiazem on pentylenetetrazole-induced seizure threshold and to compare these effects in mice ... before intravenously the determination of the pentylenetetrazole-induced seizure threshold. ...

In contrast to studies where repeated pentylenetetrazole (PTZ) stimulation resulted in an increase in migrating neurons in ... Kindling status in Sprague-Dawley rats induced by pentylenetetrazole: involvement of a critical development period. Am J Pathol ...

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling. مجله علوم اعصاب پایه و ... Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling ... Tavassoli M, Ardjmand A. Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling. ... Several studies have reported that Pentylenetetrazole (PTZ) impairs memory in experimental animal models. Due to certain ...

We sought to determine whether tolerance occurs to the anticonvulsant activity of ganaxolone in the pentylenetetrazol seizure ...

pentylenetetrazole. QTAP. quantitative targeted absolute proteomics. SRM/MRM. selected/multiple reaction monitoring. ... Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and ... Pentylenetetrazole (PTZ)-kindled mouse is a well-established chemically induced epilepsy model, but it is difficult to ... 1999) Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects. Int J Antimicrob Agents 12:239-244. ...

Pentylenetetrazole (Metrazol) 7. Dopamine (Intropin) 8. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP) ...

Pentylenetetrazole (Metrazol) Related Therapies and Procedures. 1. Intraperitoneal Injections 2. Injections 3. Aftercare (After ...

... inhibits pentylenetetrazole-induced epileptiform seizures. An electrophysiological study: Special issue related to kynurenine. ...

2017). P38 MAPK pathway mediates cognitive damage in pentylenetetrazole-induced epilepsy via apoptosis cascade. Epilepsy Res. ... The MAPK pathway also was reported to contributed to cognitive damage in pentylenetetrazole-induced epilepsy by downregulated ... It was demonstrated that the cognitive deficits in pentylenetetrazole (PTZ)-induced epilepsy was associated with the abnormal ... Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled ...

... did not prevent seizure induced by strychnine or pentylenetetrazol. ...

Idemudia SO, Bhadra S, Lal H (June 1989). "The pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal is ...