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*  Serum Elastase Activity, Serum Elastase Inhibitors, and Occurrence of Carotid Atherosclerotic Plaques | Circulation
Low values of serum elastase activity and high values of serum elastase inhibitors were strongly and independently associated with increased carotid plaque occurrence in this 4-year longitudinal study performed in a large sample of relatively aged subjects. The magnitude of the associations and the consistency of the results are noteworthy, and this is the first investigation that reports the relations between serum elastase parameters and subsequent development of atherosclerosis.. In our study, no association was observed between serum elastase activity and serum elastase inhibitors. The elastase-type activity measured in this study was derived, up to 90%, from metallo-endopeptidases5 such as MMP-2 and MMP-9.15 Their specific inhibitors, TIMPs (tissue inhibitors of metalloproteinases),16 were not measured. The major source of the elastase inhibitors determined in this investigation was ...
  http://circ.ahajournals.org/content/105/22/2638
*  Pancreatic elastase - Wikipedia
Pancreatic elastase is a form of elastase that is produced in the acinar cells of the pancreas, initially produced as an inactive zymogen and later activated in the duodenum by trypsin. Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. Pancreatic elastase 1 is a serine endopeptidase, a specific type of protease that has the amino acid serine at its active site. Although the recommended name is pancreatic elastase, it can also be referred to as elastase-1, pancreatopeptidase, PE, or serine elastase. The first isozyme, pancreatic elastase 1, was initially thought to be ...
  https://en.wikipedia.org/wiki/Pancreatic_elastase
*  Pulmonary function in normal and elastase-treated hamsters exposed to a complex mixture of olefin-ozone-sulfur dioxide reaction...
An elastase-induced emphysema model was utilized to determine if hamsters with preexisting lung disease were more susceptible to lung damage from air-pollutant exposure. Male golden hamsters, divided into two treatment groups, were given a single intratracheal injection of either 6 units of porcine pancreatic elastase (EMP) or buffer (CNT). After a 4-week recovery period, equal numbers of each group were exposed 23 hr/day x 28 day to filtered air (AIR) or to the complex by-products from a dark-phase-reaction mixture of trans-2-butene, ozone, and sulfur dioxide (MIX). Lung-function measurements on the elastase-treated groups showed changes consistent with mild emphysema. There were no significant differences in lung volumes or lung compliance between the AIR- and MIX-exposed animals. However, the nitrogen washout slope decreased and the diffusing capacity for carbon monoxide increased in both the CNT and EMP hamsters exposed to the MIX. The ...
  https://www.osti.gov/scitech/biblio/7090877
*  Best Pancreatic Elastase Doctor in Thane, Pancreatic Elastase Doctors | Credihealth
Find the best pancreatic elastase doctors in Thane. Get guidance from medical experts to select pancreatic elastase specialist in Thane from trusted hospitals - credihealth.com
  https://www.credihealth.com/doctors/thane/pancreatic-elastase
*  Pancreatic Elastase ELISA | Eldan
Eldan offers r-Biopharm's Pancreatic Elastase ELISA for the quantitative determination of pancreatic elastase in feces. The test enables to obtain a quick and
  http://eldan.biz/pancreatic-elastase-elisa/
*  CELA1 - Wikipedia
Chymotrypsin-like elastase family member 1 (CELA1) also known as elastase-1 (ELA1) is an enzyme that in humans is encoded by the CELA1 gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Elastase-1 was formerly designated pancreatic elastase 1. However unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. Hence this enzyme has been renamed as elastase-1. To date, elastase 1 expression has only been detected in skin keratinocytes. Literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase ...
  https://en.wikipedia.org/wiki/CELA1
*  CELA3B - Wikipedia
Chymotrypsin-like elastase family member 3B also known as elastase-3B, protease E, or fecal elastase is an enzyme that in humans is encoded by the CELA3B gene. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B (this protein). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function ...
  https://en.wikipedia.org/wiki/CELA3B
*  carbenicillin: Topics by WorldWideScience.org
Generation of a Pseudomonas aeruginosa elastase gene targeted deletion mutant by Red recombination system%采用Red重组系统敲除铜绿假单胞菌弹性蛋白酶基因. Institute of Scientific and Technical Information of China (English). 余华; 熊浚智; 何晓梅; 盛哈蕾; 蔡文强; 谢玮; 张克斌. 2013-01-01. The aim of this study is to obtain the elastase activity negative strain by knocking out the elastase gene in Pseudomonas aeruginosa PAO1. Three genes of Red recombination system from λ phage were amplified and cloned into Esche-richia-Pseudomonas shuttle vector pUCP, and the pUCP-Red vector was transformed into PAO1 competent cells by electropo-ration. Then the recombinant DNA fragment which contains gentamycin antibiotic cassette flanked by two 80-bp homology sequences of elastase gene upstream and downstream locuses respectively was obtained by conventional cloning methods. And the fragment was electroporated into PAOl/pUCP-Red competent cells and screened on LB plate ...
  https://worldwidescience.org/topicpages/c/carbenicillin.html
*  Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2922053/
*  RCSB PDB - 1FLE: CRYSTAL STRUCTURE OF ELAFIN COMPLEXED WITH PORCINE PANCREATIC ELASTASE Structure Summary Page
1FLE: Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
  http://www.rcsb.org/pdb/explore/explore.do?structureId=1fle
*  Acute mechanical effects of elastase on the infrarenal mouse aorta: implications for models of aneurysms.
Intraluminal exposure of the infrarenal aorta to porcine pancreatic elastase represents one of the most commonly used experimental models of the development and progression of abdominal aortic aneurysms. Morphological and histological effects of elas
  http://www.biomedsearch.com/nih/Acute-mechanical-effects-elastase-infrarenal/22236532.html
*  CELA2B - Wikipedia
Chymotrypsin-like elastase family member 2B is and enzyme that in humans is encoded by the CELA2B gene. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. GRCh38: Ensembl release 89: ENSG00000215704 - Ensembl, May 2017 "Human PubMed Reference:". Kawashima I, Tani T, Shimoda K, Takiguchi Y (April 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163-72. doi:10.1089/dna.1987.6.163. PMID ...
  https://en.wikipedia.org/wiki/CELA2B
*  Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase
Addresses: OXFORD CTR MOL SCI, OXFORD OX1 3QY, ENGLAND. DYSON PERRINS LAB, OXFORD OX1 3QY, ENGLAND. UNIV OXFORD, MOL BIOPHYS LAB, OXFORD OX1 3QU, ENGLAND. UNIV UPPSALA, DEPT BIOCHEM, S-75123 UPPSALA, SWEDEN.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-15 ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:106832
*  Immobilized porcine pancreatic elastase - Molecular Innovations, Inc.
Cleaves PAI-1 between the P3 and P4 residues to create a loop-inserted species that is non-inhibitory towards the target enzymes uPA and tPA. Gene ID: 396766 ...
  http://mol-innov.com/products/immobilized-porcine-pancreatic-elastase/
*  Human monocyte elastolytic activity, the propeptides of types I and III procollagen, proteoglycans and interleukin 6 in...
article{f561b706-a69b-42d5-989e-e889493c3cc6, author = {Slot-Jensen, Hanne and Jensen, LT and Saxne, Tore and Diamant, M and Bendtzen, Klaus}, issn = {1593-098X}, language = {eng}, number = {4}, pages = {391--394}, publisher = {Pacini}, series = {Clinical and Experimental Rheumatology}, title = {Human monocyte elastolytic activity, the propeptides of types I and III procollagen, proteoglycans and interleukin 6 in synovial fluid from patients with arthritis}, volume = {9}, year = {1991 ...
  https://lup.lub.lu.se/search/publication/f561b706-a69b-42d5-989e-e889493c3cc6
*  RCPA - Trypsin faeces
Spectrophotometry.. Some laboratories may assay chymotrypsin which requires a different substrate.. These tests are now replaced by specific assays for human pancreatic elastase. See Pancreatic elastase faeces.. ...
  http://www.rcpa.edu.au/Library/Practising-Pathology/RCPA-Manual/Items/Pathology-Tests/T/Trypsin-faeces
*  Proteases - Enzymes
SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM), which displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and , 100 nM for human, mouse, rat, rabbit and porcine elastase respectively) and inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active. Learn More ...
  https://www.emmx.com/proteases.html
*  Elastase activity of endocervical mucus in normal pregnancy.
Elastase activity of 294 samples of endocervical mucus taken from 125 normal pregnant women during the visits to antenatal clinic were measured. Activity of the enzyme increased gradually with the advance of gestational age. Steep rising of the enzym
  http://www.biomedsearch.com/nih/Elastase-activity-endocervical-mucus-in/1503539.html
*  Structure Cluster - 1FZZ: THE CRYSTAL STRUCTURE OF THE COMPLEX OF NON-PEPTIDIC INHIBITOR ONO-6818 AND PORCINE...
1FZZ: The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1FZZ
*  Enzyme Explorer Product Application Index for Elastase | Sigma-Aldrich
Enzyme Explorer Product Application Index for Elastase at Sigma-Adlrich online. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.
  https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/cell-signaling-enzymes/elastase.html
*  RCSB PDB - 4GVU: Lyngbyastatin 7-Porcine Pancreatic Elastase Co-crystal Structure Methods Report Page
4GVU: Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.
  http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=4GVU
*  3R Research Foundation Switzerland / 3R Info Bulletins / Non-Invasive Methods: Investigation of Airways Diseases by MRI in Rats
To study specific aspects of human respiratory diseases and its treatment it is necessary to measure the induced symptoms and the impairment of lung function in living animals. For example, key features of asthmatic inflammation (airway hyperresponsiveness, eosinophilic inflammation together with an increase in activated T cells in the airways) are induced in actively sensitized Brown Norway (BN) rats exposed to allergen (ovalbumin, OVA). Alternatively, an inflammation similar to that observed in chronic obstructive pulmonary disease (COPD) patients (neutrophilia and mucus cell metaplasia) can be elicited in rodents by the administration of endotoxin (lipopolysaccharide; LPS). Emphysema, one of the most critical components of COPD, which results in the destruction of lung parenchymal tissue by a number of proteases (neutrophil elastase or matrix metalloproteinases), is induced in rats by the application of a single dose of porcine pancreatic elastase. In all ...
  http://www.forschung3r.ch/en/publications/bu32_print.html
*  CELA2B Full-Length MS Protein Standard - Creative Proteomics
CELA2B Full-Length MS Protein Standard (NP_056933), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues.
  https://www.creative-proteomics.com/product/detail-cpfl310126_4183.htm
*  In the title complex, [CdCl2(C3H4N2S)4],the CdII atom has an (2006 ?); - Aurora Kinases as Druggable Targets in Cancer Therapy
In the title complex, [CdCl2(C3H4N2S)4],the CdII atom has an (2006 ?); Davarski (1996 ?); Mac pc?ek & Davarski (1993 ?); Maniukiewicz (2004 ?); Raper (1981 ?); Suh (2005 ?, 2007 ?, 2009 ?). ??3 Data collection: (Bruker, 2001 ?); cell refinement: (Bruker, 2001 ?); data reduction: (Sheldrick, 2008 ?); system(s) used to refine structure: (Sheldrick, 2008 ?); molecular graphics: (Sheldrick, 2008 ?); software Elastase Inhibitor, SPCK supplier used to prepare Elastase Inhibitor, SPCK supplier material for publication: positions. The amino organizations participate in intra- and inter-molecular NHN and NHCl hydrogen bonds (Table 1). In the crystal structure molecules Elastase Inhibitor, SPCK supplier are interconnected by these relationships into a three-dimensional hydrogen relationship network (Fig. 2). Experimental A waterCethanol (1:1) remedy (40 ml) of 2-aminothiazole (5 mmol) was added dropwise to a waterCethanol (1:1) remedy (40 ml) of CdCl2.2.5H2O (2 mmol) ...
  http://www.exposed-skin-care.net/2017/08/16/in-the-title-complex-cdcl2c3h4n2s4the-cdii-atom-has-an-2006/
*  BIOETYMOLOGY : ORIGIN IN BIOMEDICAL TERMS: elastase
1.Gertler A, Hofmann T The involvement of the amino-terminal amino acid in the activity of pancreatic proteases. I. The effects of nitrous acid on elastase, J Biol Chem, 1967 ...
  http://bioetymology.blogspot.com/2012/02/elastase.html