Characterization of an acetylcholine receptor α3 gene promoter and its activation by the POU domain factor SCIP/Tst-1<...
... that the POU domain transcription factor, SCIP/Tst-1, specifically activates α3 in a neural context. Other POU domain factors ... that the POU domain transcription factor, SCIP/Tst-1, specifically activates α3 in a neural context. Other POU domain factors ... that the POU domain transcription factor, SCIP/Tst-1, specifically activates α3 in a neural context. Other POU domain factors ... that the POU domain transcription factor, SCIP/Tst-1, specifically activates α3 in a neural context. Other POU domain factors ...
RCSB PDB - 2XSD: Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA
POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1. C. 164. Mus musculus. Mutation(s): 0 Gene Names: Pou3f1, Oct6, Otf-6, Otf6, Scip. ... Crystal Structure of the Dimeric Oct6 (POU3F1) POU Domain Bound to Palindromic More DNA.. Jauch, R., Choo, S.H., Ng, C.K.L., ... Crystal Structure of the dimeric Oct-6 (Pou3f1) POU domain bound to palindromic MORE DNA. *PDB DOI: https://doi.org/10.2210/ ... POU domain bound to palindromic MORE DNA ...
Brain 4: A novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression - HSC
Dive into the research topics of Brain 4: A novel mammalian POU domain transcription factor exhibiting restricted brain- ... Brain 4: A novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. ...
POU domain - Wikipedia
POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The ... POU (pronounced pow) is a family of eukaryotic transcription factors that have well-conserved homeodomains. The Pou domain is ... Mathis JM, Simmons DM, He X, Swanson LW, Rosenfeld MG (Jul 1992). "Brain 4: a novel mammalian POU domain transcription factor ... Andersen B, Rosenfeld MG (Feb 2001). "POU domain factors in the neuroendocrine system: lessons from developmental biology ...
Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
... is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The ... POU Domain Factors * POU6F2 protein, human * Pou6f2 protein, mouse Grants and funding * P30 EY006360/EY/NEI NIH HHS/United ... Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary ... Using a mouse genetic reference panel, we identified a transcription factor, Pou6f2, that modulates CCT in the mouse. POU6F2 is ...
enQuireBio™ Recombinant Human POU domain class 2-associating factor 1 Protein 10μg enQuireBio™ Recombinant Human POU domain...
POU-er-ful developmental regulators revisited : Current Opinion in Endocrinology, Diabetes and Obesity
The POU domain transcription factors have been proposed to be important regulators of key developmen ... POU domain factors can exert critical functions in cell types in which they exhibit either transient or sustained expression ... The POU domain transcription factors have been proposed to be important regulators of key developmental processes. The ... POU-er-ful developmental regulators revisited : Current Opinion in Endocrinology, Diabetes and Obesity. ...
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
SMART: POU domain annotation
POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The ... The POU-specific (POUs) domain, in association with a POU-type homeodomain, forms the bipartite DNA-binding POU domain. The ... The domain within your query sequence starts at position 241 and ends at position 315; the E-value for the POU domain shown ... The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal ...
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JASPAR -
HNF1A - MA0046.1 - profile summary
JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six ... POU domain factors. Homeo domain factors. MA0046.2. MA0046. 2. HNF1A. Homo sapiens POU domain factors. Homeo domain factors. ... JASPAR is an open-access database of curated, non-redundant transcription factor (TF) binding profiles stored as position ...
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo | Journal of Neuroscience
2003) Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a. Development 130:111-121. doi ... 2002) Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 35:267-282. doi:10.1016/s0896 ... 2010) Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervation. J Comp ... 2007) Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally ...
MMRRC:043257-MU
Guide to the Human Genome
POU Domain. T Box Family. PHD Finger Proteins. Krüppel-related Zinc Finger Proteins. Helix-Loop-Helix Transcription Factors. ... 9. Protein Interaction Domain Families. Domains, Motifs, and Composition. LIM Domain Proteins. PDZ Domain. WD Repeat Proteins. ... Tetratricopeptide Domains. WW Domain. Additional Interaction Domain Families (includes IQ, sterile α, COMM, DEP, Tudor, BTB, EH ... Epidermal Growth Factor. Fibroblast Growth Factors. TGF-β Family. Growth Hormone and Related Hormones. Cadherins and Related ...
SMART: HOX domain annotation
POU domain, class 3, transcription factor 4 (P49335) (SMART). OMIM:300039: Deafness, X-linked 3, conductive, with stapes ... SOLUTION STRUCTURE OF OCT3 POU-HOMEODOMAIN. 1oct. CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA ... HOMEODOMAIN FROM RAT LIVER LFB1/HNF1 TRANSCRIPTION FACTOR, NMR, 20 STRUCTURES. 2lk2. Solution NMR structure of homeobox domain ... TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE ...
The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges | eLife
... another novel RGC should express the Pou-domain containing transcription factor (Brn3c); and (6) a final RGC should not express ... The factors that guide developing arbors to synapse with appropriate targets within a layer are not well understood. An initial ... This is a convincing set of data that they have identified a factor that is critical for the formation of a microcircuit within ... This study represents a significance contribution to our understanding of molecular factors which govern development of neural ...
Medical Science Monitor | Elastic Net-Based Identification of a Multigene Combination Predicting the Survival of Patients with...
CONCLUSIONS:We developed a multigene combination which could be treated as an independent prognostic factor in cervical cancer ... The Octamer-Binding Transcription Factor 4 (OCT4) Pseudogene, POU Domain Class 5 Transcription Factor 1B (POU5F1B), is ... Effects of Intrinsic and Extrinsic Factors on the Level of Hope and Psychological Health Status of Patients with Cervical ... Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ... DOI :10.12659/ ...
Charcot-Marie-Tooth Disease Neuropathies: An Introduction: Overview, Clinical Presentation, Diagnostic Considerations
... which are determined at least in part by transcription factors such as Oct-6 (POU domain family) and EGR2. ... Mutations in the zinc-finger domain containing transcription factor EGR2 were linked to CMT1D and CHN. ... Missense mutations (Gln333Pro, protein rod domain and Pro8Arg, head domain) affecting the self-assembly of neurofilament light ... with MPZ mutations in certain gene domains, while mutations in other domains result in hypomyelination indistinguishable from ...
Charcot-Marie-Tooth Disease Neuropathies: An Introduction: Overview, Clinical Presentation, Diagnostic Considerations
... which are determined at least in part by transcription factors such as Oct-6 (POU domain family) and EGR2. ... Mutations in the zinc-finger domain containing transcription factor EGR2 were linked to CMT1D and CHN. ... Missense mutations (Gln333Pro, protein rod domain and Pro8Arg, head domain) affecting the self-assembly of neurofilament light ... with MPZ mutations in certain gene domains, while mutations in other domains result in hypomyelination indistinguishable from ...
Larry W. Swanson - Publications
A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Annual ... Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. The Embo Journal. ... Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0. ... Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 347: 528-33 ...
Frontiers | Genome-wide association study in patients with posterior urethral valves
Missense mutation of POU domain class 3 transcription factor 3 in Pou3f3L423P mice causes reduced nephron number and impaired ... POU domain family values: flexibility, partnerships, and developmental codes. Genes Dev. (1997) 11:1207-25. doi: 10.1101/gad. ... This variant is located within a transcription factor binding motif which is targeted by 16 members of the POU gene family ( ... 26) showed in mice that a missense mutation in Pou3f , one of the genes predicted to target the transcription factor binding ...
SCOPe 2.08: Domain d1e3oc2: 1e3o C:1-75
PDB Compounds: (C:) octamer-binding transcription factor 1. SCOPe Domain Sequences for d1e3oc2:. Sequence; same for both SEQRES ... PDB Description: crystal structure of oct-1 pou dimer bound to more ... SCOPe Domain Coordinates for d1e3oc2:. Click to download the PDB-style file with coordinates for d1e3oc2.. (The format of our ... Fold a.35: lambda repressor-like DNA-binding domains [47412] (1 superfamily). core: 4 helices; folded leaf, closed. ...
Analysis of two Pit-1 gene polymorphisms: Single nucleotide polymorphisms (SNPs) distribution patterns in Podolica cattle breed...
Type 2 Diabetes: Genetic Advance and Aetiology
... dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor- ... Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta ... Hepatocyte nuclear factor 1 homeobox B; IDE: Insulin degrading enzyme; IGF2BP2: Insulinlike growth factor 2 mRNA binding ... Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. ...
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... using Protein DNA array and found the decrease of POU domain factor. Based on this result, we confirmed Brn2 is decreased in HD ... We further screened transcription factors, which reduced in HD model mouse, ... TLS and transcription factor NF-Y. Although transcriptional dysregulation has been reported in polyQ disease, the precise ...
RatRef 12 v1 11222119 A.sample.csv on Ticket #486 - Attachment - BASE
"Rattus norvegicus POU domain, class 1, transcription factor 1 (Pou1f1), mRNA.","organ morphogenesis [goid 9887] [evidence IEA ... Rattus norvegicus similar to Non-POU-domain-containing, octamer binding protein (LOC499170), mRNA.",, ... transcription factor complex [goid 5667] [evidence IEA]; nucleus [goid 5634] [evidence IEA]",GHF1; Pit1; GHF1A; PIT1Z ... "Rattus norvegicus coagulation factor 2 (F2), mRNA.",blood coagulation [goid 7596] [pmid 1557383] [evidence TAS]; proteolysis ...
Integrative genomic analyses of recepteur d'origine nantais and its prognostic value in cancer
... serum response factor (SRF), POU domain, class 2, transcription factor 1 (POU2F1) regulatory transcription factor binding sites ... Moreover, all identified RON proteins contain the semaphorin (sema) domain, followed by the PSI domain, and four IPT domains. ... domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. Here, we identified RON genes from 14 vertebrate ... domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) ...
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... including non-POU domain-containing octamer-binding protein (NONO) and splicing factor proline and glutamine rich (SFPQ) ... non-POU domain-containing octamer-binding protein. PCR. polymerase chain reaction. PXR. pregnane X receptor. RIP. RNA ... which contain RNA/DNA binding domain, a low-complexity domain, and intrinsically disordered regions, interact with specific DNA ... PXR upregulates the expression of gluconeogenic factors such as glucose-6-phosphatase (G6Pase) and lipogenic factors such as ...
POU 5 类同源框 1（POU5F1）基因 | MCE
Hyposomatotropism (Growth Hormone Deficiency): Practice Essentials, Background, Pathophysiology
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 1990 Oct 11 ... Insulinlike growth factors. Insulinlike growth factors (IGFs) are a family of peptides that partially depend on GH and that ... Mangalam HJ, Albert VR, Ingraham HA, Kapiloff M, Wilson L, Nelson C. A pituitary POU domain protein, Pit-1, activates both ... Insulinlike growth factor binding proteins. Six high-affinity insulinlike growth factor binding proteins (IGFBPs) bind IGFs in ...