*  A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia? | Journal of Neurology, Neurosurgery & Psychiatry
This is the first study to have determined the extent to which99mTc-HMPAO SPECT contributes to the clinical differentiation of dementing conditions. Moreover, it has provided information that is useful to the clinician in the interpretation of individual test results and a guide to the optimal clinical usage of CBF imaging in the diagnosis of dementia.. To facilitate the interpretation of individual patterns of CBF abnormality, it is suggested that table 3 is used as follows: if a demented patient is considered to have either Alzheimer's disease or vascular dementia at initial presentation (table 3a) on the basis of neuropsychological evaluation, neurological examination, and CT, then bilateral posterior CBF abnormality or bilateral posterior plus unilateral anterior CBF abnormality provides support for the diagnosis of Alzheimer's disease. By contrast, bilateral anterior CBF abnormality, bilateral anterior plus unilateral posterior CBF abnormality, or "patchy" CBF changes provide support for ...
  http://jnnp.bmj.com/content/64/3/306
*  Effect of glucose-insulin-potassium infusion on thallium myocardial clearance. | Circulation
Factors influencing the rate of 201Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net 201Tl clearance rates from myocardium with and without initial 201Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous 201Tl was injected and the occlusion released 5 min later. Thirty minutes after 201Tl injection, 30 ml of either GIK (nine dogs) or saline (five dogs) was infused intravenously. The clearance rates of 201Tl from the anterior wall (without initial 201Tl loading) and from the posterior wall (with initial 201Tl loading) were monitored with miniaturized cadmium telluride detectors placed on the myocardium. Calculation of net myocardial clearance rates was performed by linear regression analysis from serial 1 min counts. Compared with saline infusion, GIK increased the net clearance of 201Tl from both ...
  http://circ.ahajournals.org/content/68/1/203
*  A Study to Evaluate the Diagnostic Accuracy of Dipyridamole Stress Technetium-99 M Tetrofosmin, Single-Photon Emission Computed...
This study investigated the diagnostic accuracy of dipyridamole stress technetium-99 m tetrofosmin, single-photon emission computed tomography as a possible
  http://adisinsight.springer.com/trials/700270677
*  Evaluation of myocardial perfusion and function by gated single-photon emission computed tomography technetium-99m...
OBJECTIVES The value of gated single-photon emission computed tomography technetium-99m methoxyisobutylisonitrile (gated SPECT (99m)Tc-MIBI) in children is not yet established probably because gated SPECT (99m)Tc-MIBI has rarely been used in pediatric clinical and research studies. The purpose of this study was to evaluate perfusion abnormalities and left ventricular (LV) function by gated SPECT (99m)Tc-MIBI in children and adolescents with severe congenital heart disease (CHD). METHODS Seventeen children and adolescents with severe CHD (11 boys and six girls, mean age 11+/-4 years) underwent 2-day rest-stress (11 boys) or 1-day rest (six girls) gated SPECT (99m)Tc-MIBI. Myocardial perfusion was evaluated by a 17-segment model with a 5-point score to derive the summed stress score, the summed rest score (SRS), and the summed difference score based on the 4D-MSPECT software results. The extent of myocardial perfusion abnormalities was also expressed as a percentage of the LV size. The 4D-MSPECT
  https://www.semanticscholar.org/paper/Evaluation-of-myocardial-perfusion-and-function-by-Sobic-Saranovic-Pavlovi%C4%87/8912df4be9109f2d24c4100c91f62d7b6c87810c
*  Effect of Asiaticoside on 99mTc-Tetrofosmin and 99mTc-Sestamibi Uptake in MCF-7 Cells.
This study was done to examine the effect of asiaticoside on MCF-7 cell uptake of (99m)Tc-tetrofosmin ((99m)Tc-Tfos) and (99m)Tc-sestamibi ((99m)Tc-MIBI). METHODS: The 3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was use
  http://www.biomedsearch.com/nih/Effect-Asiaticoside-99mTc-Tetrofosmin-Sestamibi/22080437.html
*  Dr Shock MD PhD: August 2007
First they compared healthy controls with depressed patients without medication for at least 2 weeks before undergoing SPECT. Single photon emission computed tomography (SPECT) is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera. However, it is able to provide true 3D information. Usually the gamma-emitting tracer used in functional brain imaging is 99mTc-HMPAO (hexamethylpropylene amine oxime). 99mTc is a metastable nuclear isomer which emits gamma rays which can be detected by a gamma camera. When it is attached to HMPAO, this allows 99mTc to be taken up by brain tissue in a manner proportial to brain blood flow, in turn allowing brain blood flow to be assessed with the nuclear gamma camera. Because blood flow in the brain is tightly coupled to local brain metabolism and energy use, the 99mTc-HMPAO tracer (as well as the similar 99mTc-EC tracer) is used to assess brain metabolism regionally ...
  http://ectweb.blogspot.com/2007/08/
*  "Comparative myocardial extraction of two technetium-labeled BATO deriv" by Jeffrey A. Leppo and Denis J. Meerdink
The transcapillary exchange of a new class of 99mTc-labeled compounds (BATO) were compared to 201Tl in isolated, blood perfused rabbit hearts. During variable blood flow (0.15-2.44 ml/min/g), peak and net extraction (Emax and Enet, respectively), and capillary permeability-surface area product (PScap) were determined with paired indicator-dilution techniques. Serial bolus injections of 201Tl, [111In]albumin, and [99mTc]BATO; chloro[tris(cyclohexanedionedioxime)methyl boronic acid]Tc (SQ30217, n = 8) and a hydroxy-substituted derivative (SQ32014, n = 5) were given to a total of 13 hearts. Mean (+/- s.d.) SQ30217 Emax and Enet were 0.72 +/- 0.09 and 0.55 +/- 0.18, respectively, which were higher than thallium values of 0.57 +/- 0.10 and 0.46 +/- 0.17 (p less than 0.03). Mean SQ30217 PScap was 1.1 +/- 0.4 ml/min/g and was also higher than corresponding thallium determinations (0.7 +/- 0.3; p less than 0.001). SQ32014 Emax, Enet, and PScap were all significantly less than thallium values (p less ...
  http://escholarship.umassmed.edu/oapubs/1219/
*  December 2017 - TECHNETIUM TC-99M TEBOROXIME KIT generic entry, drug patent expiry and freedom to operate
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
  https://www.drugpatentwatch.com/p/generic-api/technetium+tc-99m+teboroxime+kit
*  Is the "Warm-up effect" in angina mediated by improved myocardial perfusion? - Radcliffe Department of Medicine
Introduction. Considerable doubt remains about whether the 'warm-up' effect in angina represents ischaemic preconditioning (IPC), or is simply due to improved myocardial perfusion via acute recruitment of collaterals. We investigated the latter possibility using quantitative tetrofosmin SPECT. Methods. 11 patients (age 63±8 years, 8 male) with coronary disease and preserved left ventricular function underwent symptom-limited treadmill exercise off antianginal medication. On three separate days at weekly intervals, 99m Tc-tetrofosmin 400-450MBq was injected at rest, during a single exercise test (Ex1), and during the second of two exercise tests separated by 30 minutes (Ex2a and Ex2b). Exercise injections were given at equivalent heart rates. SPECT acquisitions were obtained 1-2 hours after each tetrofosmin injection. Quantitative analysis was performed by comparing polar plots derived from radial slices with a normal database. The 'hypoperfusion index' was the product of
  https://www.rdm.ox.ac.uk/publications/245372
*  Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebstein's anomaly through recognition of septal...
Semantic Scholar extracted view of 'Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebstein's anomaly through recognition of septal artifact.' by Gabriel B. Grossman et al.
  https://www.semanticscholar.org/paper/Correct-interpretation-of-a-myocardial-perfusion-S-Grossman-Halkar/773e032bdf059be05205c78e530c80d049208b51
*  Problem with removing fusion protein. MALDI TOF. Tricine SDS PAGE. - Protein and Proteomics - BioForum
Problem with removing fusion protein. MALDI TOF. Tricine SDS PAGE. - posted in Protein and Proteomics: Hello, I have problem with cleave a peptide (3,2 kDa) off a fusion protein.The construct contains protease site between fusion protein and the peptide of interest (actually I have 2 constructs: with enterokinase and with factor Xa site). Both proteases seem to work, but both show some nonspecificity. I use tricine sds gel, that is for visualising small peptides, but I don't get a ba...
  http://www.protocol-online.org/forums/topic/24938-problem-with-removing-fusion-protein-maldi-tof-tricine-sds-page/
*  Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus...
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope p
  http://www.biomedsearch.com/nih/Stress-thallium-technetium-99m-sequential/25381092.html
*  China Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189) - China Rattan Sofa Set, Outdoor Sofa Set
China Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189), Find details about China Rattan Sofa Set, Outdoor Sofa Set from Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189) - Ningbo Meteor Furniture Co., Ltd.
  http://meteorfurniture.en.made-in-china.com/product/TBumxyLvACVF/China-Garden-Sectional-Outdoor-Wicker-Rattan-Sofa-Set-MTC-189-.html
*  Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I...
article{412594, abstract = {Impulsive aggression in dogs has an important impact on human public health. Better insight into the pathophysiology of this phenomenon could lead to more adequate diagnosis and treatment. Indirect in vivo research on peripheral body fluids and post-mortem studies in impulsive animals and humans indicate a deficient serotonergic system in general and disturbances in the serotonin-2A (5-HT2A) receptor in particular. In this study, brain perfusion and the 5-HT2A receptors were examined in impulsive, aggressive dogs, in comparison with a group of normally behaving animals. In order to decide which dogs to include in this study, owners were asked to describe the general behaviour of the dogs, the circumstances in which aggression occurred and their conduct during aggressive acts. Finally, 19 dogs were retained for this study, showing, according to different behavioural specialists, disinhibited dominance aggression. Functional imaging studies were performed on all these ...
  https://biblio.ugent.be/publication/412594
*  Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints. - Free Online...
Free Online Library: Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints.(ORIGINAL ARTICLE) by 'Ear, Nose and Throat Journal'; Health, general CAT scans CT imaging Head injuries Nervous system diseases Analysis Research Radiology Radiology, Medical Single photon emission computed tomography Usage SPECT imaging
  https://www.thefreelibrary.com/Evaluating+the+role+of+single-photon+emission+computed+tomography+in+...-a0368676024
*  Single Photon Emission Computerized Tomography (SPECT)
Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. It scans images for diagnosis of heart disease and abnormalities.
  http://www.medindia.net/patients/patientinfo/single-photon-emission-computerized-tomography.htm
*  SPECT and SPECT/CT - Thieme eBooks
Thieme eBooks, Internationally renowned authorities in the field of hybrid imaging contribute firsthand expertise on the practical application of single-photon emission computed tomography (SPECT) and SPECT/CT. By combining clear anatomic markers from CT with functional knowledge from SPECT, SPECT/CT provides added value for patient evaluation and is becoming increasingly prevalent in routine clinical practic...
  http://ebookstore.thieme.com/product/spect-spectct
*  Technetium - Drugs.com
Technetium is a medicine available in a number of countries worldwide. A list of US medications equivalent to Technetium is available on the Drugs.com website.
  https://www.drugs.com/international/technetium.html
*  Revision history of "Technetium" - Conservapedia
10:55, 20 March 2008‎ Welshman (Talk , contribs)‎ . . (590 bytes) (+590)‎ . . (New page: {{Element , name=Technetium , symbol=Tc , anumber=43 , amass=97 amu , state=Solid , class=Metallic , cstructure=Hexagonal , color=Silvery-gray , date=1937 , discname=Carlo Perrier and Emil...) ...
  http://www.conservapedia.com/index.php?title=Technetium&action=history
*  Interpreting Nuclear Stress Test Results - Heart Disease - MedHelp
I am a 61 year old male. I had triple bypass surgery in January 2007. In October I had a follow-up nuclear stress test (Stress QGS Tetrofosmin). I would like help interpreting the results of the...
  http://www.medhelp.org/posts/Heart-Disease/Interpreting-Nuclear-Stress-Test-Results/show/447725
*  CERETEC 500 MICROGRAMS KIT FOR RADIOPHARMACEUTICAL PREPARATION | Drugs.com
Patient information for CERETEC 500 MICROGRAMS KIT FOR RADIOPHARMACEUTICAL PREPARATION Including dosage instructions and possible side effects.
  https://www.drugs.com/uk/ceretec-500-micrograms-kit-for-radiopharmaceutical-preparation-leaflet.html
*  TEKTROTYD 16 MICROGRAM KIT FOR RADIOPHARMACEUTICAL PREPARATION | Drugs.com
Patient information for TEKTROTYD 16 MICROGRAM KIT FOR RADIOPHARMACEUTICAL PREPARATION Including dosage instructions and possible side effects.
  https://www.drugs.com/uk/tektrotyd-16-microgram-kit-for-radiopharmaceutical-preparation-leaflet.html
*  New technology
Carlat says we shouldn't use SPECT for diagnosis? We shouldn't use SPECT tools that we know work to help discover the many missed diagnoses often found under the large umbrella of ADD/ADHD? This question regarding the use of SPECT is more than a simple ADD diagnostic tool ...
  http://www.corepsych.com/label/new-technology/