*  A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia? | Journal of Neurology, Neurosurgery & Psychiatry
This is the first study to have determined the extent to which99mTc-HMPAO SPECT contributes to the clinical differentiation of dementing conditions. Moreover, it has provided information that is useful to the clinician in the interpretation of individual test results and a guide to the optimal clinical usage of CBF imaging in the diagnosis of dementia.. To facilitate the interpretation of individual patterns of CBF abnormality, it is suggested that table 3 is used as follows: if a demented patient is considered to have either Alzheimer's disease or vascular dementia at initial presentation (table 3a) on the basis of neuropsychological evaluation, neurological examination, and CT, then bilateral posterior CBF abnormality or bilateral posterior plus unilateral anterior CBF abnormality provides support for the diagnosis of Alzheimer's disease. By contrast, bilateral anterior CBF abnormality, bilateral anterior plus unilateral posterior CBF abnormality, or "patchy" CBF changes provide support for ...
  http://jnnp.bmj.com/content/64/3/306
*  Effect of glucose-insulin-potassium infusion on thallium myocardial clearance. | Circulation
Factors influencing the rate of 201Tl clearance from the myocardium have not been clearly defined. This study determined the effect of an intravenous infusion of glucose-insulin-potassium (GIK) on the net 201Tl clearance rates from myocardium with and without initial 201Tl loading. Anesthetized open-chest dogs underwent 5 min of left anterior descending coronary artery occlusion and intravenous 201Tl was injected and the occlusion released 5 min later. Thirty minutes after 201Tl injection, 30 ml of either GIK (nine dogs) or saline (five dogs) was infused intravenously. The clearance rates of 201Tl from the anterior wall (without initial 201Tl loading) and from the posterior wall (with initial 201Tl loading) were monitored with miniaturized cadmium telluride detectors placed on the myocardium. Calculation of net myocardial clearance rates was performed by linear regression analysis from serial 1 min counts. Compared with saline infusion, GIK increased the net clearance of 201Tl from both ...
  http://circ.ahajournals.org/content/68/1/203
*  A Study to Evaluate the Diagnostic Accuracy of Dipyridamole Stress Technetium-99 M Tetrofosmin, Single-Photon Emission Computed...
This study investigated the diagnostic accuracy of dipyridamole stress technetium-99 m tetrofosmin, single-photon emission computed tomography as a possible
  http://adisinsight.springer.com/trials/700270677
*  Effect of Asiaticoside on 99mTc-Tetrofosmin and 99mTc-Sestamibi Uptake in MCF-7 Cells.
This study was done to examine the effect of asiaticoside on MCF-7 cell uptake of (99m)Tc-tetrofosmin ((99m)Tc-Tfos) and (99m)Tc-sestamibi ((99m)Tc-MIBI). METHODS: The 3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was use
  http://www.biomedsearch.com/nih/Effect-Asiaticoside-99mTc-Tetrofosmin-Sestamibi/22080437.html
*  Dr Shock MD PhD: August 2007
First they compared healthy controls with depressed patients without medication for at least 2 weeks before undergoing SPECT. Single photon emission computed tomography (SPECT) is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera. However, it is able to provide true 3D information. Usually the gamma-emitting tracer used in functional brain imaging is 99mTc-HMPAO (hexamethylpropylene amine oxime). 99mTc is a metastable nuclear isomer which emits gamma rays which can be detected by a gamma camera. When it is attached to HMPAO, this allows 99mTc to be taken up by brain tissue in a manner proportial to brain blood flow, in turn allowing brain blood flow to be assessed with the nuclear gamma camera. Because blood flow in the brain is tightly coupled to local brain metabolism and energy use, the 99mTc-HMPAO tracer (as well as the similar 99mTc-EC tracer) is used to assess brain metabolism regionally ...
  http://ectweb.blogspot.com/2007/08/
*  "Comparative myocardial extraction of two technetium-labeled BATO deriv" by Jeffrey A. Leppo and Denis J. Meerdink
The transcapillary exchange of a new class of 99mTc-labeled compounds (BATO) were compared to 201Tl in isolated, blood perfused rabbit hearts. During variable blood flow (0.15-2.44 ml/min/g), peak and net extraction (Emax and Enet, respectively), and capillary permeability-surface area product (PScap) were determined with paired indicator-dilution techniques. Serial bolus injections of 201Tl, [111In]albumin, and [99mTc]BATO; chloro[tris(cyclohexanedionedioxime)methyl boronic acid]Tc (SQ30217, n = 8) and a hydroxy-substituted derivative (SQ32014, n = 5) were given to a total of 13 hearts. Mean (+/- s.d.) SQ30217 Emax and Enet were 0.72 +/- 0.09 and 0.55 +/- 0.18, respectively, which were higher than thallium values of 0.57 +/- 0.10 and 0.46 +/- 0.17 (p less than 0.03). Mean SQ30217 PScap was 1.1 +/- 0.4 ml/min/g and was also higher than corresponding thallium determinations (0.7 +/- 0.3; p less than 0.001). SQ32014 Emax, Enet, and PScap were all significantly less than thallium values (p less ...
  http://escholarship.umassmed.edu/oapubs/1219/
*  December 2017 - TECHNETIUM TC-99M TEBOROXIME KIT generic entry, drug patent expiry and freedom to operate
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
  https://www.drugpatentwatch.com/p/generic-api/technetium+tc-99m+teboroxime+kit
*  Is the "Warm-up effect" in angina mediated by improved myocardial perfusion? - Radcliffe Department of Medicine
Introduction. Considerable doubt remains about whether the 'warm-up' effect in angina represents ischaemic preconditioning (IPC), or is simply due to improved myocardial perfusion via acute recruitment of collaterals. We investigated the latter possibility using quantitative tetrofosmin SPECT. Methods. 11 patients (age 63±8 years, 8 male) with coronary disease and preserved left ventricular function underwent symptom-limited treadmill exercise off antianginal medication. On three separate days at weekly intervals, 99m Tc-tetrofosmin 400-450MBq was injected at rest, during a single exercise test (Ex1), and during the second of two exercise tests separated by 30 minutes (Ex2a and Ex2b). Exercise injections were given at equivalent heart rates. SPECT acquisitions were obtained 1-2 hours after each tetrofosmin injection. Quantitative analysis was performed by comparing polar plots derived from radial slices with a normal database. The 'hypoperfusion index' was the product of
  https://www.rdm.ox.ac.uk/publications/245372
*  Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebstein's anomaly through recognition of septal...
Semantic Scholar extracted view of 'Correct interpretation of a myocardial perfusion SPECT study in a patient with Ebstein's anomaly through recognition of septal artifact.' by Gabriel B. Grossman et al.
  https://www.semanticscholar.org/paper/Correct-interpretation-of-a-myocardial-perfusion-S-Grossman-Halkar/773e032bdf059be05205c78e530c80d049208b51
*  Problem with removing fusion protein. MALDI TOF. Tricine SDS PAGE. - Protein and Proteomics - BioForum
Problem with removing fusion protein. MALDI TOF. Tricine SDS PAGE. - posted in Protein and Proteomics: Hello, I have problem with cleave a peptide (3,2 kDa) off a fusion protein.The construct contains protease site between fusion protein and the peptide of interest (actually I have 2 constructs: with enterokinase and with factor Xa site). Both proteases seem to work, but both show some nonspecificity. I use tricine sds gel, that is for visualising small peptides, but I don't get a ba...
  http://www.protocol-online.org/forums/topic/24938-problem-with-removing-fusion-protein-maldi-tof-tricine-sds-page/
*  Stress thallium-201/rest technetium-99m sequential dual-isotope high-speed myocardial perfusion imaging validation versus...
Recent advances in nuclear myocardial perfusion imaging (MPI) have made it possible to develop a dual-isotope protocol for high-speed acquisition with image quality and radiation delivery comparable to that obtained with conventional single isotope p
  http://www.biomedsearch.com/nih/Stress-thallium-technetium-99m-sequential/25381092.html
*  China Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189) - China Rattan Sofa Set, Outdoor Sofa Set
China Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189), Find details about China Rattan Sofa Set, Outdoor Sofa Set from Garden Sectional Outdoor Wicker/Rattan Sofa Set (MTC-189) - Ningbo Meteor Furniture Co., Ltd.
  http://meteorfurniture.en.made-in-china.com/product/TBumxyLvACVF/China-Garden-Sectional-Outdoor-Wicker-Rattan-Sofa-Set-MTC-189-.html
*  Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints. - Free Online...
Free Online Library: Evaluating the role of single-photon emission computed tomography in the assessment of neurotologic complaints.(ORIGINAL ARTICLE) by 'Ear, Nose and Throat Journal'; Health, general CAT scans CT imaging Head injuries Nervous system diseases Analysis Research Radiology Radiology, Medical Single photon emission computed tomography Usage SPECT imaging
  https://www.thefreelibrary.com/Evaluating+the+role+of+single-photon+emission+computed+tomography+in+...-a0368676024
*  Radiation Dose to Patients From Cardiac Diagnostic Imaging | Circulation
For 99mTc sestamibi rest-stress imaging, good agreement exists between E1 from ICRP (11.3 mSv) and PI (14.6 mSv for 4.8-hour urinary void, 13.5 mSv for 2-hour void) dose coefficients. The higher E1 with the longer void time is primarily due to the higher equivalent dose to the bladder wall (41 versus 21 mSv) and demonstrates the potential dose-reduction benefit of hydration and early micturition after radiopharmaceutical administration. Much of the difference between ICRP- and PI-derived E1 is due to an idiosyncrasy in the methodology of ICRP Publication 60 for determining dose to "remainder" organs, which was later amended.22 For 99mTc tetrofosmin, even closer agreement exists between ICRP- and PI-derived E1 values, which are 9.3 and 9.7 mSv, respectively.. 201Tl dosimetry varies markedly between manufacturers' PIs. E1 for a 3.5-mCi injection determined with dose coefficients from ICRP Publication 53 Addendum 5 and PIs 1, 2, and 3 are 22.0, 28.7, 9.3, and 28.4 mSv, respectively. When we examine ...
  http://circ.ahajournals.org/content/116/11/1290
*  Single Photon Emission Computerized Tomography (SPECT)
Single Photon Emission Computed Tomography, a nuclear imaging diagnostic tool helps in accurate assessment of blood flow to organs. It scans images for diagnosis of heart disease and abnormalities.
  http://www.medindia.net/patients/patientinfo/single-photon-emission-computerized-tomography.htm
*  Technetium 99m-labeled sestamibi imaging reliably identifies retained contractile reserve in dyssynergic myocardial segments.
BACKGROUND: Recently there has been considerable controversy regarding the use of 99mTc-labeled sestamibi as an agent for the detection of viable myocardium. In this study we have used dobutamine-induced left ventricular wall thickening by echocardio
  http://www.biomedsearch.com/nih/Technetium-99m-labeled-sestamibi-imaging/9420803.html
*  SPECT and SPECT/CT - Thieme eBooks
Thieme eBooks, Internationally renowned authorities in the field of hybrid imaging contribute firsthand expertise on the practical application of single-photon emission computed tomography (SPECT) and SPECT/CT. By combining clear anatomic markers from CT with functional knowledge from SPECT, SPECT/CT provides added value for patient evaluation and is becoming increasingly prevalent in routine clinical practic...
  http://ebookstore.thieme.com/product/spect-spectct
*  SPECT scan - Why it's done - Mayo Clinic
SPECT scan - Overview covers definition, risks, results of this imaging test that creates 3-D pictures using a radioactive substance and a special camera.
  https://www.mayoclinic.org/tests-procedures/spect-scan/details/why-its-done/icc-20303156
*  Technetium - Drugs.com
Technetium is a medicine available in a number of countries worldwide. A list of US medications equivalent to Technetium is available on the Drugs.com website.
  https://www.drugs.com/international/technetium.html
*  Revision history of "Technetium" - Conservapedia
10:55, 20 March 2008‎ Welshman (Talk , contribs)‎ . . (590 bytes) (+590)‎ . . (New page: {{Element , name=Technetium , symbol=Tc , anumber=43 , amass=97 amu , state=Solid , class=Metallic , cstructure=Hexagonal , color=Silvery-gray , date=1937 , discname=Carlo Perrier and Emil...) ...
  http://www.conservapedia.com/index.php?title=Technetium&action=history
*  Interpreting Nuclear Stress Test Results - Heart Disease - MedHelp
I am a 61 year old male. I had triple bypass surgery in January 2007. In October I had a follow-up nuclear stress test (Stress QGS Tetrofosmin). I would like help interpreting the results of the...
  http://www.medhelp.org/posts/Heart-Disease/Interpreting-Nuclear-Stress-Test-Results/show/447725
*  CERETEC 500 MICROGRAMS KIT FOR RADIOPHARMACEUTICAL PREPARATION | Drugs.com
Patient information for CERETEC 500 MICROGRAMS KIT FOR RADIOPHARMACEUTICAL PREPARATION Including dosage instructions and possible side effects.
  https://www.drugs.com/uk/ceretec-500-micrograms-kit-for-radiopharmaceutical-preparation-leaflet.html
*  TEKTROTYD 16 MICROGRAM KIT FOR RADIOPHARMACEUTICAL PREPARATION | Drugs.com
Patient information for TEKTROTYD 16 MICROGRAM KIT FOR RADIOPHARMACEUTICAL PREPARATION Including dosage instructions and possible side effects.
  https://www.drugs.com/uk/tektrotyd-16-microgram-kit-for-radiopharmaceutical-preparation-leaflet.html