DSpace at EWHA: 탈력발작을 동반하는 기면증 환자의 국소 뇌혈류에 관한 연구
To investigate the abnormality of cerebral perfusion in narcoleptics with cataplexy, cerebral perfusion was measured by brain single photon emission computed tomography(SPECT). The difference of cerebral perfusion between narcoleptics and normal controls was tested by statistical parametric mapping(SPM) analysis. Twenty-five narcoleptics with cataplexy and 25 normal controls performed 99mTc-ethylcysteinate dimer brain SPECT study. A night polysomnography and multiple sleep latency test (MSLT) in next day were performed in all patients. Brain SPECT was carried out in all patients and normal controls during waking state. The clinical symptoms and the results of MSLT were concordant to the International Classification of Sleep Disorders criteria for narcolepsy in all patients. The MSLT showed short mean sleep latency(1.69±1.0 min) and 2 - 5 sleep onset REM periods per each patient. The SPM analysis of brain SPECT in narcoleptics with cataplexy showed hypoperfusion in bilateral anterior ...http://dspace.ewha.ac.kr/handle/2015.oak/186890
The scintigraphic evaluation of the pulmonary perfusion pattern of dogs hospitalised with babesiosis
ABSTRACT. The possibility of coagulopathy in Babesia canis rossi infections in the canine patient has been suggested in the literature, but minimal work has been done to evaluate the clinicopathological nature of it in further detail. Pulmonary thromboembolism (PTE) has not yet been implicated in canine babesiosis (CB), but may also be one of the causes of the sudden dyspnoea and tachypnoea that are frequently seen in complicated CB patients. The objective of this study was to prospectively evaluate the scintigraphic pulmonary perfusion pattern in hospitalised dogs with babesiosis in an attempt to ascertain whether a scintigraphic pattern consistent with clinically relevant PTE does indeed occur in these patients. The study consisted of a normal control group of 9 mature healthy Beagle dogs (group 1) and a Babesia group with 14 dogs of a variety of breeds that were naturally infected with Babesia (group 2). Pulmonary perfusion scintigraphy was performed after making thoracic radiographs and ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282008000200005&lng=pt&nrm=iso
Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT - IOS...
Background: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. Objective: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acihttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad170281
Increasing myocardial 123I-BMIPP uptake in non-ischemic area in a patient with acute myocardial ischemia. - Semantic Scholar
The subject was a 65-year-old woman with chest pain. An electrocardiogram revealed T-wave-inversion in leads III, aVF, V1-V5. 99mTc-tetrofosmin myocardial SPECT showed mildly reduced uptake in the anteroseptal wall and the apex. These findings suggested acute myocardial ischemia. Coronary angiography did not show any stenotic lesions, but diffuse coronary ectasia was noted in three vessels. Coronary flow velocity was remarkably reduced on coronary angiography. Epicardial coronary spasm was not provoked by ergonovine loading test. Left ventriculography showed diffuse hypokinesis. 123I-BMIPP myocardial SPECT showed mildly reduced uptake in the anteroseptal wall and the apex on the early images. But 4-hour delayed images showed an increase of 8% in myocardial 123I-BMIPP uptake. We treated this patient with ticlopidine and nicorandil. After drug therapy her symptoms and left ventriculography improved. 123I-BMIPP myocardial SPECT findings on the early images improved, whereas delayed images showed a decreasehttps://www.semanticscholar.org/paper/Increasing-myocardial-123I-BMIPP-uptake-in-non-isc-Nishikawa-Ito/9eae1fa7b8f5d6705ec76dae3319425a53233401
iLab Publications - University of Southern California
A. H. Craig, J. L. Cummings, L. A. Fairbanks, L. Itti, B. L. Miller, J. Li, I. Mena, Cerebral blood flow correlates of apathy in Alzheimer disease, Archives of Neurology, Vol. 53, No. 11, pp. 1116-20, Nov 1996. [1998 impact factor: 3.375] (Cited by 231). Abstract: BACKGROUND: Apathy is a pervasive noncognitive neuropsychiatric disturbance in Alzheimer disease, which causes significant caregiver distress. The neuroanatomical substrate of apathy is not well understood. OBJECTIVE: To study the relationship between regional cerebral blood flow and the presence and severity of the personality disturbance, apathy, in individuals with Alzheimer disease. DESIGN: Analysis of the relationship between regional cerebral blood flow as measured by single photon emission computed tomography and severity of apathy as measured by the Neuropsychiatric Inventory using an analysis of variance design. We examined regional cerebral perfusion alterations as measured by xenon 133Xecalibrated technetium Tc 99m ...http://ilab.usc.edu/publications/Craig_etal96.html
Myocardial perfusion defects and associated systemic ventricular dysfunction in congenitally corrected transposition of the...
Myocardial perfusion was assessed with the radiopharmaceutical sestamibi (technetium-99m methoxy isobutyl isonitrile) using a one day stress rest protocol.10-13 Patients were exercised on a Schiller CS100 treadmill to maximum exercise capacity according to a standard or modified Bruce protocol after overnight fasting.14 Approximately one minute before the end of the period of exercise-that is, at peak exercise, 5.29 MBq/kg sestamibi was injected intravenously. The second study was performed four hours later at rest using 15.86 MBq/kg sestamibi. Single photon emission computed tomographic (SPECT) images were acquired one hour after each injection using a Siemens triple detector gamma camera (MULTISPECT 3).. High resolution collimators were used with a non-circular orbit with two detectors undergoing a 120 rotation for 32 frames, at 40 seconds per frame with a 64 × 64 matrix. Reconstruction of the stress images was performed using a Butterworth filter (cut off 0.28 to 0.40 and power factor 10). ...http://heart.bmj.com/content/80/4/322.full
SPECT/CT using 67Ga and 111In-labeled leukocyte scintigraphy for diagnosis of infection. - Semantic Scholar
UNLABELLED The present study evaluated the role of SPECT/CT as an adjunct to (67)Ga (GS) or (111)In-labeled white blood cell (WBC) scintigraphy for diagnosis or localization of infection. METHODS Eighty-two patients (56 male and 26 female; mean age, 62 y) assessed for known or suspected infectious processes underwent 88 SPECT/CT studies. Forty-seven patients underwent GS SPECT/CT (13 with fever of unknown origin, 21 with suspected osteomyelitis, and 13 with suspected soft-tissue infection), and 35 patients underwent WBC SPECT/CT (24 with suspected vascular graft infection, and 11 with suspected osteomyelitis). Ninety-eight suggestive sites were identified (52 on GS and 46 on WBC). Additional information provided by SPECT/CT for diagnosis or localization of infection, as compared with planar and SPECT scintigraphy, was recorded. The SPECT/CT contribution was analyzed on a patient and site basis and was compared for the 2 tracers and clinical indications. RESULTS SPECT/CT provided additionalhttps://www.semanticscholar.org/paper/SPECT-CT-using-67Ga-and-111In-labeled-leukocyte-sc-Bar-Shalom-Yefremov/9ba39b4335642ed14764850f0b4742811fb766a7
Quantification of area at risk during coronary occlusion and degree of myocardial salvage after reperfusion with technetium-99m...
Serial myocardial imaging with technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) has been proposed for evaluating myocardial salvage after reperfusion. To define 99mTc-MIBI uptake before and after reperfusion, 17 open-chest dogs underwent 3 hours of left anterior descending artery occlusion and 3 hours of reperfusion. 99mTc-MIBI was injected during occlusion (group 1) or after 90 minutes of reperfusion (group 2). Myocardial 99mTc-MIBI activity was correlated with microsphere flow during occlusion and reperfusion. Anatomic risk area and infarct area were defined by postmortem vital staining and correlated with the perfusion defects defined by analysis of 99mTc-MIBI macroautoradiographs and gamma camera images of myocardial slices. The left ventricle was divided into 96 segments for gamma well counting. Flow and 99mTc-MIBI activity were normalized to nonischemic values. Myocardial segments were grouped, based on occlusion flow, into zones: severely ischemic (less than or equal to 30% ...http://circ.ahajournals.org/content/82/4/1424
Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes - Full Text View ...
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up ...https://clinicaltrials.gov/ct2/show/NCT00368199
A NEW PHOTON DETECTOR FOR SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY AND POSITRON EMISSION TOMOGRAPHY | SBIR.gov
DEVELOPMENT OF A NOVEL TYPE OF PARTICLE DETECTOR IS PLANNED BASED ON ENERGY-SENSITIVE SUPERCONDUCTING STRUCTURES. IN POSITRON EMISSON TOMOGRAPHY (PET)/SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) APPLICATION IT PROMISES ORDER OF MAGNITUDE IMPROVEMENTS IN IMAGE QUALITY BECAUSE OF (1) SUBMILLIMETER SPATIAL RESOLUTION; (2) VERY FAST, SUBNANOSECOND READOUT; AND (3) VERY HIGH STOPPING POWER FOR HIGH ENERGY PHOTONS. THE POSSIBILITY OF DEVELOPMENT OF A NEW RING DETECTOR THAT FEATURES BOTH SPECT AND PET IMAGING CAPABILITY IS SUGGESTED ...https://www.sbir.gov/sbirsearch/detail/358689
Percutaneous Cholecystostomy in the Management of Acute Chol... : Infectious Diseases in Clinical Practice
Biliary stasis, which is commonly found in hospitalized AC patients with prolonged fasting or receiving total parenteral alimentation, leads to a high rate of false-positive hepatobiliary scintigraphy.8 The number of false-positive scans can be decreased by augmenting the scan with intravenous morphine or cholecystokinin or by performing delayed images.. In summary, each imaging modality-US, CT, and hepatobiliary scintigraphy-has a role in the evaluation of AC. Ultrasound is the most commonly used first-line imaging modality because it is a simple bedside test which provides rapid results. Computed tomography is a more useful diagnostic test if other abdominal pathologies are under consideration. Hepatobiliary scintigraphy is the most sensitive and specific of the imaging modalities for diagnosis of AC in the noncritically ill patient. The diagnostic accuracy of each imaging modality depends on the patient's clinical scenario. Consultation with the radiologist can often clarify which imaging ...http://journals.lww.com/infectdis/Fulltext/2007/03000/Percutaneous_Cholecystostomy_in_the_Management_of.9.aspx
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Carbon Monoxide Poisoning - Full Text View - ClinicalTrials.gov
The study is a retrospective review of the PI's experience using SPECT brain imaging and hyperbaric oxygen therapy in the diagnosis and treatment of non-acute phases of carbon monoxide poisoning. The purpose is to see if the SPECT brain imaging is consistent with the clinical condition and cognitive testing on the patients ...https://clinicaltrials.gov/ct2/show/NCT00596180?recr=Open&cond=%22Carbon+Monoxide+Poisoning%22&rank=1
Our publications</span> </span>
Quantitative liver lesion volume determination by nanoparticle-based SPECT - Mol Imaging Biol. 2014 Apr. Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver - PLoS One 2014 Mar 5.. The role of molecular imaging in modern drug development - Drug Discovery Today 2014 Jan 13.. Preclinical Imaging: an Essential Ally in Modern Biosciences - Molecular Diagnosis & Therapy 2013 Oct 22.. (99m)Tc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities - Journal of Pharmaceutics 2013 Apr 2.. Osteogenic potential of Sr-doped calcium phosphate hollow spheres in vitro and in vivo - J. Biomed Mater Res A 2013 Jan 28.. In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse - Brain Research Bulletin 2013 Jan 11.. Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial ...http://www.cromedresearch.com/events-publications/our-publications/
Evidence of cerebral hypoperfusion in scleroderma patients.
OBJECTIVES: To investigate regional cerebral blood flow by (99m)Tc-hexamethylpropylenamineoxime (HMPAO) single photon emission computed tomography (SPECT) in a series of 40 patients (mean age 58.5+/-11.5 yr) affected by systemic sclerosis (SSc) in cohttp://www.biomedsearch.com/nih/Evidence-cerebral-hypoperfusion-in-scleroderma/11136880.html
Optimisation of quantitative lung SPECT applied to mild COPD : a software phantom simulation study
BACKGROUND: The amount of inhomogeneities in a (99m)Tc Technegas single-photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (COPD), is correlated to disease advancement. A quantitative analysis method, the CVT method, measuring these inhomogeneities was proposed in earlier work. To detect mild COPD, which is a difficult task, optimised parameter values are needed.. METHODS: In this work, the CVT method was optimised with respect to the parameter values of acquisition, reconstruction and analysis. The ordered subset expectation maximisation (OSEM) algorithm was used for reconstructing the lung SPECT images. As a first step towards clinical application of the CVT method in detecting mild COPD, this study was based on simulated SPECT images of an advanced anthropomorphic lung software phantom including respiratory and cardiac motion, where the mild COPD lung had an overall ventilation reduction of ...http://www.diva-portal.org/smash/record.jsf?pid=diva2:811406
A Single Center Study to Establish the Imaging Protocol of 99mTc-EC-DG in Evaluating the Presence and Severity of Coronary...
The study will assess the safety and tolerability of technetium-99m-labeled ethylenedicysteine-deoxyglucose (99mTc-EC-DG).. An outcome will be to develop an imaging protocol for a multicenter trial that will measure the specific imaging parameters required for determination of sensitivity and specificity of 99mTc-EC-DG in a cardiovascular single photon emission computed tomography (SPECT) study compared to an exercise/regadenoson 99mTc- Sestamibi (MIBI) study for detection of the presence and, when available, severity of coronary artery disease (CAD) as documented by coronary angiography when available.. This study will be a single-center, prospective, open-label study of up to 6 patients with positive findings from a MIBI (99mTc-sestamibi) exercise/regadenoson study within 30 days for evaluation of CAD. Patients who meet study eligibility criteria will undergo a 99mTc-EC-DG rest study and a 99mTc-EC-DG exercise/regadenoson study. When possible, patients enrolled will have clinical plans for a ...https://clinicaltrials.gov/ct2/show/NCT01778218?recr=Open&cond=%22Coronary+Artery+Disease%22&rank=11
This study demonstrated that cortical and subcortical atrophy in type 2 diabetes is associated with diminished regional cerebral perfusion and vasoreactivity. Brain atrophy, as indicated by CSF volume, was prominent in the frontal and temporal regions. Hypoperfusion during baseline rest and diminished CBF response to hypercapnia affected all regions. A1C levels and diabetic retinopathy were further associated with CBF reduction, altered vasoreactivity, and atrophy that was most prominent in the temporal region. This study focused on neuroasymptomatic subjects; therefore, those with significant late complications of diabetes and history of cerebrovascular accidents that may further affect CBF were excluded. Cerebromicrovascular disease and endothelial dysfunction affect multiple brain regions and vascular territories and are associated with CBF dysregulation beyond the brain atrophy.. Hyperglycemia is a unifying mechanism for diabetic tissue damage in the brain, as glucose utilization requires ...http://care.diabetesjournals.org/content/30/5/1193
Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2...
In vivo diagnosis with cancer-specific targeting agents that have optimal characteristics for imaging is an important development in treatment planning for cancer patients. Overexpression of the HER2 antigen is high in several types of carcinomas and has predictive and prognostic value, especially for breast cancer. A new type of targeting agent, the Affibody molecule, was described recently. An Affibody dimer, His6-(ZHER2:4)2 (15.4 kDa), binds to HER2 with an affinity of 3 nmol/L and might be used for the imaging of HER2 expression. The use of 99mTc might improve the availability of the labeled conjugate, and Tc(I)-carbonyl chemistry enables the site-specific labeling of the histidine tag on the Affibody molecule. The goals of the present study were to prepare 99mTc-labeled His6-(ZHER2:4)2 and to evaluate its targeting properties compared with the targeting properties of 125I-4-iodobenzoate-His6-(ZHER2:4)2 [125I-His6-(ZHER2:4)2]. METHODS: The labeling of His6-(ZHER2:4)2 with 99mTc was performed ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:219873
Nuclear Medicine/Radiopharmaceutical Market is Poised to Grow at a CAGR of 7.8% & to Reach $5.55 Billion by 2017 - New Report...
(PRWEB) April 11, 2013 -- The Nuclear Medicine / Radiopharmaceuticals Market [SPECT/PET Radioisotopes (Technetium, F-18)], [Beta/Alpha Radiation Therapy (I131,http://www.prweb.com/releases/nuclear-medicine/market/prweb10623311.htm
Pilot 99mTechnetium-MIBI Single Photon Emission Computed Tomography - Computed Tomography (SPECT-CT) in Papillary Carcinoma (CA...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. ...https://clinicaltrials.gov/ct2/show/NCT00984191
Myocardial Perfusion Imaging | Medical City Dallas
Learn more about Myocardial Perfusion Imaging at Medical City Dallas DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...http://medicalcityhospital.com/hl/?/37420/MRI&com.dotmarketing.htmlpage.language=1
Candy Stripe Mesh Cami Top and Bikini Set ( M-L ) ~igemini.net~
Who says it doesn't get hot at the North Pole? This outfit comes complete with a cami top and bikini bottoms. Melt your lover's cold heart wearing thihttp://igemini.ecrater.com/p/6024509/candy-stripe-mesh-cami-top-and
November 2017 - TECHNETIUM TC-99M DISOFENIN KIT generic equivalents, pharmaceutical patent and freedom to operate
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...https://www.drugpatentwatch.com/p/generic-api/technetium+tc-99m+disofenin+kit
December 2017 - TECHNETIUM TC-99M GLUCEPTATE KIT generic equivalents, drug patent expiry and freedom to operate
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...https://www.drugpatentwatch.com/p/generic-api/technetium+tc-99m+gluceptate+kit
Technetium Injection No. 2
I got injected in the morning, and then I returned three hours later to get scanned. Which meant plenty of kick-around time, and so I visited a few tool stores, but strangely felt agitated in each so that I didn't buy anything. Then to a used CD & book store to peruse the stock, and then to another tool store, one of my long term faves. This time, I was allowed to purchase a few items, having a list on hand. Then to an outdoor store and peruse the goods there, buy a few trinkets and then got held up at the cash register as there was an item I was looking for and the stockist went to look for. While waiting they switched the cashier, from female to male, and he did the friendly nattering thing while waiting for the stockist to report back on a certain item's availability. It wasn't to be had as it turned out. I suppose this is a more elaborate exercise in checkout obstruction/delay; wait for a determination from the stockist AND switch cashiers. In the latter instance, the perps have been pulling ...http://tiworld.blogspot.com/2017/03/technetium-injection-no-2.html