Effects of lysine-containing mercaptoacetyl-based chelators on the biodistribution of 99mTc-labeled anti-HER2 Affibody...
Organotechnetium Compounds / chemistry, metabolism*. Peptides / chemical synthesis, chemistry, pharmacology. Radionuclide ... 0/Antibodies; 0/Chelating Agents; 0/Organotechnetium Compounds; 0/Peptides; 0/Recombinant Fusion Proteins; 0/Thioglycolates; 56 ...http://www.biomedsearch.com/nih/Effects-lysine-containing-mercaptoacetyl-based/19035668.html
The scintigraphic evaluation of the pulmonary perfusion pattern of dogs hospitalised with babesiosis
ABSTRACT. The possibility of coagulopathy in Babesia canis rossi infections in the canine patient has been suggested in the literature, but minimal work has been done to evaluate the clinicopathological nature of it in further detail. Pulmonary thromboembolism (PTE) has not yet been implicated in canine babesiosis (CB), but may also be one of the causes of the sudden dyspnoea and tachypnoea that are frequently seen in complicated CB patients. The objective of this study was to prospectively evaluate the scintigraphic pulmonary perfusion pattern in hospitalised dogs with babesiosis in an attempt to ascertain whether a scintigraphic pattern consistent with clinically relevant PTE does indeed occur in these patients. The study consisted of a normal control group of 9 mature healthy Beagle dogs (group 1) and a Babesia group with 14 dogs of a variety of breeds that were naturally infected with Babesia (group 2). Pulmonary perfusion scintigraphy was performed after making thoracic radiographs and ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1019-91282008000200005&lng=pt&nrm=iso
Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT - IOS...
Background: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. Objective: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acihttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad170281
Increasing myocardial 123I-BMIPP uptake in non-ischemic area in a patient with acute myocardial ischemia. - Semantic Scholar
The subject was a 65-year-old woman with chest pain. An electrocardiogram revealed T-wave-inversion in leads III, aVF, V1-V5. 99mTc-tetrofosmin myocardial SPECT showed mildly reduced uptake in the anteroseptal wall and the apex. These findings suggested acute myocardial ischemia. Coronary angiography did not show any stenotic lesions, but diffuse coronary ectasia was noted in three vessels. Coronary flow velocity was remarkably reduced on coronary angiography. Epicardial coronary spasm was not provoked by ergonovine loading test. Left ventriculography showed diffuse hypokinesis. 123I-BMIPP myocardial SPECT showed mildly reduced uptake in the anteroseptal wall and the apex on the early images. But 4-hour delayed images showed an increase of 8% in myocardial 123I-BMIPP uptake. We treated this patient with ticlopidine and nicorandil. After drug therapy her symptoms and left ventriculography improved. 123I-BMIPP myocardial SPECT findings on the early images improved, whereas delayed images showed a decreasehttps://www.semanticscholar.org/paper/Increasing-myocardial-123I-BMIPP-uptake-in-non-isc-Nishikawa-Ito/9eae1fa7b8f5d6705ec76dae3319425a53233401
14 Increased heterogeneity of brain perfusion is an early marker of central nervous system involvement in antiphospholipid...
Methods Patients with a history of positive antiphospholipid antibodies and neuropsychiatric symptoms but without thromboembolism composed the case group; patients without antiphospholipid antibody served as the control group. Subjects with autoantibodies to extractable nuclear antigens were excluded from this study. All patients underwent Tc-99m ECD SPECT and were classified by the number of positive antiphospholipid antibodies they carried. The heterogeneity of brain perfusion was defined as the coefficient of variation. Analysis of variance (ANOVA) was used to evaluate the differences between groups. ...http://lupus.bmj.com/content/4/Suppl_1/A8.3
China Mtc-035 Modern Luxury Rattan/Wicker Sofa Set for Outdoor Furniture - China Outdoor Sofa, Garden Furniture
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China Mtc-133 Wicker Patio Furniture Rattan Sofa Set Kd - China Outdoor Furniture, Home Furniture
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Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: a [I-123]FP-CIT SPECT study. -...
To unveil cognitive-nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug-naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I-123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys-executive (NPS-EX), a visuospatial (NPS-VS), a verbal memory (NPS-VM), and a 'mixed' (NPD-MIX) factor. In PD group, there were inverse correlations between UPDRS-III score and both NPS-VS (P | 0.01) and mSPECT (P | 0.05), and a direct correlation between mSPECT and NPS-EX (P | 0.05). Posthttps://www.semanticscholar.org/paper/Cognitive-nigrostriatal-relationships-in-de-novo-d-Nobili-Campus/4cc56b91c12e10a937cac1aa0c10dc790e611cdb
Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes - Full Text View ...
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease (PD) or Atypical Parkinson Syndromes (APS) with as golden standard the clinical diagnosis after 2-year follow-up ...https://clinicaltrials.gov/ct2/show/NCT00368199
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Carbon Monoxide Poisoning - Full Text View - ClinicalTrials.gov
The study is a retrospective review of the PI's experience using SPECT brain imaging and hyperbaric oxygen therapy in the diagnosis and treatment of non-acute phases of carbon monoxide poisoning. The purpose is to see if the SPECT brain imaging is consistent with the clinical condition and cognitive testing on the patients ...https://clinicaltrials.gov/ct2/show/NCT00596180?recr=Open&cond=%22Carbon+Monoxide+Poisoning%22&rank=1
OSA | Method for reducing background artifacts from images in single-photon emission computed tomography with a uniformly...
Uniformly redundant array coded apertures have proven to be useful in the design of collimators for x-ray astronomy. They were initially expected to be equally successful in single-photon emission computed tomography (SPECT). Unfortunately, the SPECT images produced by this collimator contain artifacts, which mask the true picture and can lead to false diagnosis. Monte Carlo simulation has shown that the formation of a composite image will significantly reduce these artifacts. A simulation of a tumor in a compressed breast phantom has produced a composite image, which clearly indicates the presence of a 5 mm × 5 mm × 5 mm tumor with a 6:1 intensity ratio relative to the background tissue.. © 2002 Optical Society of America. Full Article , PDF Article ...https://www.osapublishing.org/ao/abstract.cfm?URI=ao-41-7-1454
Our publications</span> </span>
Quantitative liver lesion volume determination by nanoparticle-based SPECT - Mol Imaging Biol. 2014 Apr. Demonstration of Metabolic and Cellular Effects of Portal Vein Ligation Using Multi-Modal PET/MRI Measurements in Healthy Rat Liver - PLoS One 2014 Mar 5.. The role of molecular imaging in modern drug development - Drug Discovery Today 2014 Jan 13.. Preclinical Imaging: an Essential Ally in Modern Biosciences - Molecular Diagnosis & Therapy 2013 Oct 22.. (99m)Tc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities - Journal of Pharmaceutics 2013 Apr 2.. Osteogenic potential of Sr-doped calcium phosphate hollow spheres in vitro and in vivo - J. Biomed Mater Res A 2013 Jan 28.. In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [125I]SD7015 in CB1 knock-out and wildtype mouse - Brain Research Bulletin 2013 Jan 11.. Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial ...http://www.cromedresearch.com/events-publications/our-publications/
Chest Pain Can Be Identified By New Tracer Chemical 30 Hours After Pain Relief ( Nuclear medicine combines computers de...)
Health,Nuclear medicine combines computers detectors and radioactive substan...Ever since the introduction of nuclear medicine in diagnosis it has...It has now been demonstrated for the first time that an experiment...The heart normally uses fatty acid as its primary fuel source for ...The new tracer test keys in on this metabolic disturbance and seemin...,Chest,Pain,Can,Be,Identified,By,New,Tracer,Chemical,30,Hours,After,Pain,Relief,,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine newshttp://www.bio-medicine.org/medicine-news/Chest-Pain-Can-Be-Identified-By-New-Tracer-Chemical-30-Hours-After-Pain-Relief--5031-1/
Evidence of cerebral hypoperfusion in scleroderma patients.
OBJECTIVES: To investigate regional cerebral blood flow by (99m)Tc-hexamethylpropylenamineoxime (HMPAO) single photon emission computed tomography (SPECT) in a series of 40 patients (mean age 58.5+/-11.5 yr) affected by systemic sclerosis (SSc) in cohttp://www.biomedsearch.com/nih/Evidence-cerebral-hypoperfusion-in-scleroderma/11136880.html
Optimisation of quantitative lung SPECT applied to mild COPD : a software phantom simulation study
BACKGROUND: The amount of inhomogeneities in a (99m)Tc Technegas single-photon emission computed tomography (SPECT) lung image, caused by reduced ventilation in lung regions affected by chronic obstructive pulmonary disease (COPD), is correlated to disease advancement. A quantitative analysis method, the CVT method, measuring these inhomogeneities was proposed in earlier work. To detect mild COPD, which is a difficult task, optimised parameter values are needed.. METHODS: In this work, the CVT method was optimised with respect to the parameter values of acquisition, reconstruction and analysis. The ordered subset expectation maximisation (OSEM) algorithm was used for reconstructing the lung SPECT images. As a first step towards clinical application of the CVT method in detecting mild COPD, this study was based on simulated SPECT images of an advanced anthropomorphic lung software phantom including respiratory and cardiac motion, where the mild COPD lung had an overall ventilation reduction of ...http://www.diva-portal.org/smash/record.jsf?pid=diva2:811406
Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2...
In vivo diagnosis with cancer-specific targeting agents that have optimal characteristics for imaging is an important development in treatment planning for cancer patients. Overexpression of the HER2 antigen is high in several types of carcinomas and has predictive and prognostic value, especially for breast cancer. A new type of targeting agent, the Affibody molecule, was described recently. An Affibody dimer, His6-(ZHER2:4)2 (15.4 kDa), binds to HER2 with an affinity of 3 nmol/L and might be used for the imaging of HER2 expression. The use of 99mTc might improve the availability of the labeled conjugate, and Tc(I)-carbonyl chemistry enables the site-specific labeling of the histidine tag on the Affibody molecule. The goals of the present study were to prepare 99mTc-labeled His6-(ZHER2:4)2 and to evaluate its targeting properties compared with the targeting properties of 125I-4-iodobenzoate-His6-(ZHER2:4)2 [125I-His6-(ZHER2:4)2]. METHODS: The labeling of His6-(ZHER2:4)2 with 99mTc was performed ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:219873
Search of: stress testing OR exercise echocardiogram OR myocardial perfusion imaging | Recruiting, Not yet recruiting,...
stress testing OR exercise echocardiogram OR myocardial perfusion imaging , Recruiting, Not yet recruiting, Available Studies , NIH, U.S. Fed (98 records ...https://clinicaltrials.gov/ct2/results?term=stress+testing+OR+exercise+echocardiogram+OR+myocardial+perfusion+imaging&recr=Open&fund=01&show_rss=Y&sel_rss=mod14
Myocardial Perfusion Imaging | Doctors Hospital
Learn more about Myocardial Perfusion Imaging at Doctors Hospital of Augusta DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...https://doctors-hospital.net/hl/?/37420/MRI&com.dotmarketing.htmlpage.language=1
Clinical Study of A Single-Center Clinical Study to Evaluate the Safety and Biodistribution of Technetium Tc 99m Ec20 in Normal...
The purpose of this single-center, single-treatment group, baseline-controlled (for safety) study is to evaluate the safety, pharmacokinetics, dosimetry andhttp://adisinsight.springer.com/trials/700256279
S.E.L.F. Enrichment and Enhancement Career Prep Program | Dynamic Images 4 You
S.E.L.F. Enrichment and Enhancement Career Prep Program©Success Etiquette Leadership Facilitation The Program: The S.E.L.F Enrichment and Enhancementhttps://dynamicimages4you.com/self-enrichment-and-enhancement-career-prep-program/
Technetium - Wiktionary
What's New in Version 2.5
OhNo! is a program designed for radiopharmaceutical production laboratories.. Earlier versions of OhNo! were designed for laboratories that manufacture [F18]- fluorodeoxyglucose (FDG) because that was the most common radiopharmaceutical used in PET imaging.. ...http://2sslab.com/News.html
KLUEDO | Suchen
Abstract: We show that it is possible to 'store' quantum states of single-photon fields by mapping them onto collective meta-stable states of an optically dense, coherently driven medium inside an optical resonator. An adiabatic technique is suggested which allows to transfer non-classical correlations from traveling-wave single-photon wave-packets into atomic states and vise versa with nearly 100% efficiency. In contrast to previous approaches involving single atoms, the present technique does not require the strong coupling regime corresponding to high-Q micro-cavities. Instead, intracavity Electromagnetically Induced Transparency is used to achieve a strong coupling between the cavity mode and the atoms ...https://kluedo.ub.uni-kl.de/solrsearch/index/search/searchtype/authorsearch/author/M.+D.+Lukin/start/0/rows/10/sortfield/year/sortorder/asc
Decreased contralateral putamen [I]FP-CIT SPECT uptake in hyperglycemic hemichorea-hemiballismus.
The science of medical imaging: SPECT and PET
Our new series, the Science of Medical Imaging, examines the technology behind non-invasive methods of creating images of the human body. In this first instalment, we look at two types of emission imaging…http://theconversation.com/the-science-of-medical-imaging-spect-and-pet-14086