Reperfusion after thrombolytic therapy in ischemic stroke measured by single-photon emission computed tomography. | Stroke
We used 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT) to study cerebral perfusion in patients treated with streptokinase for acute ischemic stroke in an open and prospective study. Our primary aims were (1) to compare the extent of reperfusion between patients who had received thrombolytic therapy and a control group studied during the same period who were ineligible to receive such therapy and (2) to determine if, among all patients, reperfusion led to improved outcome.. Fifty-seven patients (22 treated with streptokinase) had two SPECT studies performed, the first before streptokinase administration and the second 24 hours later.. On the first SPECT study hyperfusion was present in the middle cerebral artery or anterior cerebral artery territories in 40 patients (17 treated with streptokinase). Patients in the treatment and control groups with initial hypoperfusion on SPECT were well matched for the volume of the perfusion defect and the severity of ...http://stroke.ahajournals.org/content/25/1/79
Assessment of coronary ischaemia by myocardial perfusion dipyridamole stress technetium-99 m tetrofosmin, single-photon...
Background: Coronary artery lesions in Kawasaki disease invasively assessed by coronary angiography. Evaluation of myocardial perfusion by single-photon emission computed tomography may identify the haemodynamic significance of coronary lesions. Objehttp://www.biomedsearch.com/nih/Assessment-coronary-ischaemia-by-myocardial/25090305.html
14 Increased heterogeneity of brain perfusion is an early marker of central nervous system involvement in antiphospholipid...
Methods Patients with a history of positive antiphospholipid antibodies and neuropsychiatric symptoms but without thromboembolism composed the case group; patients without antiphospholipid antibody served as the control group. Subjects with autoantibodies to extractable nuclear antigens were excluded from this study. All patients underwent Tc-99m ECD SPECT and were classified by the number of positive antiphospholipid antibodies they carried. The heterogeneity of brain perfusion was defined as the coefficient of variation. Analysis of variance (ANOVA) was used to evaluate the differences between groups. ...http://lupus.bmj.com/content/4/Suppl_1/A8.3
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Cognitive-nigrostriatal relationships in de novo, drug-naïve Parkinson's disease patients: a [I-123]FP-CIT SPECT study. -...
To unveil cognitive-nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug-naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I-123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys-executive (NPS-EX), a visuospatial (NPS-VS), a verbal memory (NPS-VM), and a 'mixed' (NPD-MIX) factor. In PD group, there were inverse correlations between UPDRS-III score and both NPS-VS (P | 0.01) and mSPECT (P | 0.05), and a direct correlation between mSPECT and NPS-EX (P | 0.05). Posthttps://www.semanticscholar.org/paper/Cognitive-nigrostriatal-relationships-in-de-novo-d-Nobili-Campus/4cc56b91c12e10a937cac1aa0c10dc790e611cdb
OSA | Method for reducing background artifacts from images in single-photon emission computed tomography with a uniformly...
Uniformly redundant array coded apertures have proven to be useful in the design of collimators for x-ray astronomy. They were initially expected to be equally successful in single-photon emission computed tomography (SPECT). Unfortunately, the SPECT images produced by this collimator contain artifacts, which mask the true picture and can lead to false diagnosis. Monte Carlo simulation has shown that the formation of a composite image will significantly reduce these artifacts. A simulation of a tumor in a compressed breast phantom has produced a composite image, which clearly indicates the presence of a 5 mm × 5 mm × 5 mm tumor with a 6:1 intensity ratio relative to the background tissue.. © 2002 Optical Society of America. Full Article , PDF Article ...https://www.osapublishing.org/ao/abstract.cfm?URI=ao-41-7-1454
Chest Pain Can Be Identified By New Tracer Chemical 30 Hours After Pain Relief ( Nuclear medicine combines computers de...)
Health,Nuclear medicine combines computers detectors and radioactive substan...Ever since the introduction of nuclear medicine in diagnosis it has...It has now been demonstrated for the first time that an experiment...The heart normally uses fatty acid as its primary fuel source for ...The new tracer test keys in on this metabolic disturbance and seemin...,Chest,Pain,Can,Be,Identified,By,New,Tracer,Chemical,30,Hours,After,Pain,Relief,,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine newshttp://www.bio-medicine.org/medicine-news/Chest-Pain-Can-Be-Identified-By-New-Tracer-Chemical-30-Hours-After-Pain-Relief--5031-1/
A star whose spectrum reveals the presence of the element technetium. The first such stars were discovered in 1952 and provided the first direct evidence for stellar nucleosynthesis - the manufacture of heavier elements from lighter ones in stellar interiors. Because the most stable isotopes of technetium have half-lives of only a few million years, the only way this element could be present inside stars is if it had made there in the relatively recent past. Technetium is observed in some M stars, MS stars, MC stars, S stars, and C stars ...http://www.daviddarling.info/encyclopedia/T/technetium_star.html
Follow-up study of depression in the elderly. Clinical and SPECT data. - Department of Psychiatry
BACKGROUND: Imaging studies in depression of the elderly are often small and highly selective. AIMS: To investigate a large group of elderly depressed patients in order to assess changes in clinical, imaging and neuropsychological variables at follow-up. METHOD: Patients (n = 175, age range 65-91 years) with clinical depression were identified from consecutive local referrals. Clinical interviews, neuropsychological tests and SPECT scans were carried out at referral and at two-year follow-up. RESULTS: Of 84 re-examined patients, 46.5% were well, 9.5% were ill, 33% partially recovered and 11% had developed dementia. Duration of illness before index assessment was the only factor to predict outcome. Thirty-nine patients could be scanned and followed up. There were no differences between patients with good or poor depressive outcome on SPECT. Ten clinically improved patients could be re-examined with SPECT. There were relative increases in right cingulate gyrus and right cerebellum at follow-up.https://www.psych.ox.ac.uk/publications/583014
Can omega-3 help prevent Alzheimer's disease? Brain SPECT imaging shows possible link | EurekAlert! Science News
The incidence of Alzheimer's disease (AD) is expected to triple in the coming decades and no cure has been found. Recently, interest in dietary approaches for prevention of cognitive decline has increased. In particular, the omega-3 fatty acids have shown anti-amyloid, anti-tau and anti-inflammatory actions in the brains of animals.https://www.eurekalert.org/pub_releases/2017-05/ip-coh051917.php
A Study of 123I-CMICE-013 Radiopharmaceutical in Healthy Volunteers - Full Text View - ClinicalTrials.gov
Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an established, cost effective tool for the risk stratification and management of patients suspected or known to have coronary artery disease (CAD)Myocardial perfusion imaging is significantly affected by interruptions in the supply of 99mMo, the parent isotope of 99mTc used for the majority of MPI. An alternative radiotracer, I123-CMICE-013,developed at the Canadian Molecular Imaging Center of Excellence (C-MICE) at the University of Ottawa Heart Institute, has completed pre-clinical trial testing and is ready for Phase 1 human trials.. This Phase I study will be a single centre, open label study. Subjects will receive 2 doses of study drug. One rest dose and one stress dose will be administered on separate days, one week apart. Subjects will undergo a standard clinical exercise stress protocol for the stress dose. Gamma camera imaging following each administration will be done over 2 ...https://clinicaltrials.gov/ct2/show/NCT01558362
SPECT Spots Sentinel Nodes in Melanoma | Medpage Today
The preoperative use of a new hybrid imaging single-photon emission CT modality improved the detection of metastatic lymph nodes and increased disease-free survival in patients with cutaneous melanomahttps://www.medpagetoday.com/radiology/diagnosticradiology/34757
Safety of Cardiolite (Technetium Tc99m Sestamibi) - Heart Disease - MedHelp
I was slated to take a 'nuclear stress test' with cardiolite (Technetium Tc99m Sestamibi) but grew concerned when they recommened not holding a small child for 24 hours. I wonder (a) whether this subs...http://www.medhelp.org/posts/Heart-Disease/Safety-of-Cardiolite-Technetium-Tc99m-Sestamibi/show/252883
PBMC (Peripheral Blood Mononuclear Cells) /Lymphocyte SPECT (Single Photon Emission Computerized Tomography) Imaging in Crohn...
This study is based on the established technology of scintigraphic 'white cell scanning', in which the leukocytes in a limited volume of patient's blood are radiolabeled with indium-111 or technetium-99m, re-introduced into the circulation, and their subsequent trafficking and accumulation in areas of active inflammation is visualised by scintigraphic imaging. This methodology is routinely used for diagnosis of inflammatory conditions and pharmacodynamic changes have been documented in the literature. As it is intended that this technology could be used in future drug intervention studies.. However, because this sub-population labelling methodology remains exploratory, this study will investigate the utility of such techniques for use in future clinical trials in Crohn's patients.. Two parallel exploratory approaches will be investigated to enrich for lymphocyte populations expressing leukocyte trafficking inhibitors. In the first, whole blood will be fractionated on a ficoll gradient to purify ...https://clinicaltrials.gov/ct2/show/NCT01051622
Specialty Clinical - AAMS
Pre-hospital and critical care transport medicine are rapidly advancing fields with implementation of new technology and research based care. In effort to improve patient outcomes, we continually look for diagnostic measures to confirm clinical impressions. Ultrasound (US) technology is becoming more readily available outside of the hospital and can be used to guide definitive interventions. This presentation discusses the benefits of ultrasound use in the settings of ACS (Acute Coronary Syndromes) and even Cardiac Arrest. US imagery is used to show valve dysfunction, areas of compromised cardiac muscle as well as pericardial effusion/tamponade. Materials covered are basics of image interpretation, optimal probe placement and actual case presentations. These cases demonstrate ways in which US was used to confirm extent of myocardial injury in ACS/STEMI and even myocardial activity in the presence of apparent cardiac arrest. The most interesting case and inspiration for this presentation was a ...http://aams.org/education-meetings/specialty-clinical-sessions/
Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging -...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...https://clinicaltrials.gov/ct2/show/results/NCT00864591
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Heart-Encyclopedia - adenosine
A SPECT scan of the heart is a noninvasive nuclear imaging test. It uses radioactive tracers that are injected into the blood to produce pictures of your heart. Doctors use SPECT to diagnose coronary artery disease and find out if a heart attack has occurred. SPECT can show how well blood is flowing to the heart and how well the heart is working.. ...http://www.heart.org/HEARTORG/Encyclopedia/Heart-Encyclopedia_UCM_445084_Encyclopedia.jsp?title=adenosine
Myocardial Perfusion Imaging | Grand Strand Health
Learn more about Myocardial Perfusion Imaging at Grand Strand Medical Center DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...http://grandstrandmed.com/hl/?/2010815751/Myocardial-Perfusion-Imaging&com.dotmarketing.htmlpage.language=1
US Contrast Agent and Radiopharmaceutical Market Saw a 15 Percent Decline between 2010 and 2012 | Business Wire
Procedural growth in the US contrast agent and radiopharmaceutical market will be limited by reimbursement cuts and insurer restriction.http://www.businesswire.com/news/home/20121220005837/en/Contrast-Agent-Radiopharmaceutical-Market-15-Percent-Decline
Novel Ether Containing Ligand Complexes: Cardiac Imaging | SBIR.gov
DESCRIPTION (provided by applicant): There remains a clinical need for myocardial perfusion tracers that more accurately reflect cardiac blood flow over a wide range of flow rates while simultaneously demonstrating a reduced accumulation and/or rapi ...https://www.sbir.gov/sbirsearch/detail/238836
Simultaneous and intercontinental tests show synchronism between the local gravimetric tide and the ultra-weak photon emission...
In order to corroborate the hypothesis that variations in the rate of spontaneous ultra-weak photon emission (UPE) from germinating seedlings are related to local variations of the lunisolar tidal forhttps://link.springer.com/article/10.1007%2Fs00709-016-0947-1
University of Notre Dame Selects Albira PET/SPECT/CT Preclinical Imaging System from Carestream Molecular Imaging
Woodbridge, CT (PRWEB) March 3, 2011 -- The University of Notre Dame has added Carestream's Albira system to its In Vivo Imaging Core, part of the Notre Damehttp://www.prweb.com/releases/2011/03/prweb5118404.htm