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*  Mustafa Khokha, MD > Genetics | Yale School of...
Embryo, Nonmammalian; Germ Layers; Notochord; Organizers, Embryonic; Neural Plate Research Organizations. Pediatrics: Pediatric ... Reza N, Khokha MK, Del Viso F: Nucleoporin gene expression in Xenopus tropicalis embryonic development. Int J Dev Biol. 2016. ... van Veenendaal NR, Ulmer B, Boskovski MT, Fang X, Khokha MK, Wendler CC, Blum M, Rivkees SA: Embryonic exposure to ... My laboratory is interested in the problem of birth defects that occur when embryonic patterning fails to occur properly. A ...
  http://medicine.yale.edu/genetics/people/mustafa_khokha-2.profile
*  Formation of neural tissue is influenced by blastocoel | Open-i
The Spemann organizer meets the anterior-most neuroectoderm at the equator of early gastrulae in amphibian species. ... The Spemann organizer meets the anterior-most neuroectoderm at the equator of early gastrulae in amphibian species. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4402005_dgd0057-0218-f5&req=4
*  ZFIN Publication: Solnica-Krezel et al., 2001
Organizers, Embryonic; Proto-Oncogene Proteins/physiology; Signal Transduction; Wnt Proteins; Zebrafish/embryology*; Zebrafish/ ... boz cooperates with the Nodal-related secreted factors, Cyclops and Squint, in organizer formation. The incomplete organizer in ... Bozozok itself acts as a transcriptional repressor, and promotes organizer formation by directly inhibiting expression of the ... is required during blastula stages for the formation of a complete Spemann-Mangold gastrula organizer and subsequent ...
  https://zfin.org/ZDB-PUB-010410-2
*  ZFIN Publication: Saude et al., 2000
Danio rerio; zebrafish; organizer; embryonic shield; regeneration; goosecoid; floating head; secondary axis; notochord; ... Previous studies have demonstrated that the zebrafish embryonic shield possesses classically defined dorsal organizer activity ... Organizers, Embryonic/physiology*; Proteins/genetics; Regeneration; Repressor Proteins*; T-Box Domain Proteins/genetics; Trans- ... suggesting that the morphological shield does not comprise the entire organizer region. Complete removal of the embryonic ...
  http://zfin.org/ZDB-PUB-000824-13
*  ZFIN Publication: Kenyon et al., 2015
Organizers, Embryonic/embryology*; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology*; Zebrafish/ ... By contrast MO disruption of other zebrafish rab5 genes shows little or no effect on expression of markers of dorsal organiser ... We conclude that rab5ab is essential for nodal signalling and organizer specification in the developing zebrafish embryo. ...
  http://zfin.org/ZDB-PUB-141206-3
*  Lipid Metabolism sub-cluster 33
Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic ... ... Both Tbx1 and retinoic acid (RA) are key players in embryonic pharyngeal development; loss of Tbx1 produces DiGeorge syndrome- ... Segmentation of the presomitic mesoderm must therefore be tightly coordinated along the left and right embryonic sides. We show ... BACKGROUND: Retinoids are vital for embryonic development; both excesses and deficiencies of vitamin A are known to give ...
  http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-33-p7.html
*  The slipper snail, Crepidula: an Emerging lophotrochozoan model system[dagger]. - Free Online Library
MAPK signaling by the D quadrant embryonic organizer of the mollusc Ilyanassa obsoleta. Development 128: 45-56. Lambert J.D., ... Therefore, as 4d serves as the organizer in C. fornicata (Henry et al., 2006), ERK1/2, MAPK is not required for 4d organizer ... These experiments indicate that, unlike the case seen in other spiralians where 3D serves as the organizer, the key organizer ... it has recently been suggested that 4d might serve as the organizer in annelids and that the organizer activity of 3D might be ...
  https://www.thefreelibrary.com/The+slipper+snail%2C+Crepidula%3A+an+Emerging+lophotrochozoan+model+...-a0232076667
*  A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway | Disease Models & Mechanisms
2005). Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels. Dev. Biol. 279, ... 2005). Reversal of ethanol toxicity in embryonic neurons with growth factors and estrogen. Brain Res. Bull. 67, 459-465. ... 1992). Cognitive and behavioral deficits in nonhuman primates associated with very early embryonic binge exposures to ethanol. ...
  http://dmm.biologists.org/content/4/3/335
*  Situs inversus and ciliary abnormalities: 20 years later, what is the connection? | Cilia | Full Text
It was now widely accepted that laterality is initiated at the embryonic LR-organizer, where motile cilia generate leftward ... Special type of cilia at the embryonic organizer. Although the ultrastructural defect causing ciliary immotility and ... Situs inversus CiliaLeft-right organizerNode Nodal Nodal flowTwo cilia modelPlanar cell polarityMotile ciliaSensory cilia ... Types of cilia found at the left-right-organizer of vertebrates. In mouse, two types of ciliated cells at the node have been ...
  https://ciliajournal.biomedcentral.com/articles/10.1186/s13630-014-0010-9
*  Analysis and Classification of Cerebellar Malformations | American Journal of Neuroradiology
A potent embryonic organizer within the neuroepithelium controls the early patterning of the prospective midbrain and anterior ... The Development of Mossy Fibres and Climbing Fibres: Embryonic and Postnatal Features. New York: Alan R Liss,;1987 :57-88. ... Chiari malformations are considered to be the result of a lack of expansion of the embryonic fourth ventricle, with consequent ... O'Rahilly R, Muller F. The Embryonic Human Brain: An Atlas of Developmental Stages. New York: Wiley-Liss; 1994. ...
  http://www.ajnr.org/content/23/7/1074.full
*  Cilia in left-right asymmetry | Philosophical Transactions of the Royal Society B: Biological Sciences
Signalling molecules were first found to be asymmetrically expressed around a transient embryonic organizer structure called ... which include creating transient leftward fluid flows in an embryonic 'left-right organizer'. These flows direct asymmetric ... 2001 Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates. Genes Cells 6, 923-930. (doi:10.1046/j.1365- ... 2011 Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev. Biol. 354, 208-220. (doi: ...
  http://rstb.royalsocietypublishing.org/content/371/1710/20150410
*  Nobel Prize in Medicine: 1901-Present
1935: Hans Spemann, 'for his discovery of the organizer effect in embryonic development.' ... for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells.' ... for their discoveries concerning the genetic control of early embryonic development.' ...
  https://www.livescience.com/16342-nobel-prize-medicine-history-list.html
*  Anteriore Musterbildung im Wirbeltierembryo - Die Induktion von Vorderhirn und Herz - ...
... the embryonic organizer. Secreted factors emanating from the organizer and from its derivatives lay down the identity of ... Keywords: embryonic organizer; prechordal plate; expression screen; mouse embryo; chick embryo; neural induction; pattern ... The first part of this thesis examined the role of the murine gastrula organizer as a source of anterior neural plate inducing ... Based on the observation that the prechordal plate, a derivative of the gastrula organizer, is a source for signals with an ...
  https://ediss.uni-goettingen.de/handle/11858/00-1735-0000-0006-AB98-6
*  Nobel Prize in Physiology or Medicine - RF Cafe
"for his discovery of the organizer effect in embryonic development". 1934. George H. Whipple, George R. Minot, and William P. ... "for their discoveries concerning the genetic control of early embryonic development". 1994. Alfred G. Gilman and Martin Rodbell ... "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells". ...
  http://www.rfcafe.com/references/general/nobel-prize-medicine.htm
*  EMBO Gold Medal - Wikipedia
Niehrs, C. (2001). "MEDAL REVIEW: The Spemann organizer and embryonic head induction". The EMBO Journal. 20 (4): 631-637. doi: ...
  https://en.wikipedia.org/wiki/EMBO_Gold_Medal
*  Frontiers | Diffuse intrinsic pontine glioma: poised for progress | Oncology
... "differential reprogramming of embryonic signaling organizers." They demonstrated involvement of two distinct oncogenic pathways ...
  https://www.frontiersin.org/articles/10.3389/fonc.2012.00205/full
*  Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis | PNAS
2009) Spemann's organizer and the self-regulation of embryonic fields. Mech Dev 126:925-941. ... 1924) Induction of embryonic primordia by implantation of organizers from a different species. Roux's Arch Entwicklungsmech Org ... Extensive screens of a region with embryonic induction activity, called Spemann organizer, have revealed a large number of ... 1993) Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic ...
  http://www.pnas.org/content/early/2018/09/11/1812117115
*  Nobel Medicine - AccessScience from McGraw-Hill Education
Awarded to: Hans Spermann for his discovery of the organizer effect in embryonic development.. See related AccessScience ... for their discoveries concerning the genetic control of early embryonic development.. See related AccessScience content:. ... Oliver Smithies for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic ...
  http://www.accessscience.com/pages/nobel-medicine
*  Interactive Fly, Drosophila
Additionally, ectopic expression of Wnt1 is observed in the embryonic roofplate organizer region and dorsal telencephalon. To ... Xemx genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Nor are they ... Targeted disruption of the mouse Sonic hedgehog gene shows that Shh plays a critical role in patterning of embryonic tussues, ... The earliest detectable defect occurs in the future forbrain region at embryonic day 9.5. In Shh mutants, the midline is ...
  http://www.sdbonline.org/sites/fly/segment/emptysp2.htm
*  Transcriptional Control of Left-Right Patterning in Cardiac Development | SpringerLink
Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and ... Shawlot W, Behringer RR (1995) Requirement for Lim1 in head-organizer function. Nature 374:425-430CrossRefPubMedGoogle Scholar ... Slough J, Cooney L, Brueckner M (2008) Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac ...
  https://link.springer.com/article/10.1007%2Fs00246-009-9610-3
*  Smed-Evi/Wntless is required for β-catenin-dependent and -independent processes during planarian regeneration | Development
Wnts are secreted glycoproteins that behave as major organizers during embryonic development in various metazoan organisms ( ... Slusarski, D. C., Yang-Snyder, J., Busa, W. B. and Moon, R. T. (1997). Modulation of embryonic intracellular Ca2+ signaling by ... TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. Kuisheng Liu, Yan Zhang, ... Anisotropic shear stress patterns predict the orientation of convergent tissue movements in the embryonic heart ...
  http://dev.biologists.org/content/136/6/905
*  JCI - The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression
CHD7 is essential for the maintenance of rhombomere 1 identity and Fgf8 expression in the embryonic isthmus organizer, with ... of Chd7 after the establishment of this embryonic organizer had little effect on the expression of genes linked to organizer ... As deregulated Fgf8 expression and signaling from this embryonic organizer selectively disrupt the formation of the cerebellar ... Chd7 deletion from embryonic neural progenitors causes cerebellar hypoplasia and foliation abnormalities. (A-D) In situ ...
  https://jci.org/articles/view/83408
*  Primitive knot - Wikipedia
Overview at nature.com Overview at Northwestern University Embryonic Organizers at the US National Library of Medicine Medical ... The primitive knot (or primitive node) is the organizer for gastrulation in the vertebrate embryo. In birds, it is known as " ... Posterior to the node is the primitive pit, where the cells of the epiblast (the upper layer of embryonic cells) initially ... In amphibians, it is known as "Spemann's organizer", and is named after Hans Spemann (who, with Mangold, first identified the ...
  https://en.wikipedia.org/wiki/Primitive_knot
*  Felio - definition and meaning
He won a 1935 Nobel Prize for his discovery of the organizer effect in embryonic development. ... He won a 1935 Nobel Prize for his discovery of the organizer effect in embryonic development. ...
  https://www.wordnik.com/words/Felio
*  De novo mutations in histone-modifying genes in congenital heart disease. - PubMed - NCBI
There are also two de novo mutations in SMAD2, which regulates H3K27 methylation in the embryonic left-right organizer. The ...
  https://www.ncbi.nlm.nih.gov/pubmed/23665959?access_num=23665959&link_type=MED&dopt=Abstract