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*  organic cation transporters - Wholesale organic cation transporters
... buy latest organic cation transporters direct from 928 organic cation transporters Factories. ... organic cation transporters. All organic cation transporters wholesalers & organic cation transporters manufacturers come from ... We doesn't provide organic cation transporters products or service, please contact them directly and verify their companies ... cationic surfactants cationic surfactant cation exchange resin cation exchange exchange cation cationic starch ...
  http://www.nccecojustice.org/organic-cation-transporters-sell
*  OriGene - SLC22A4 (NM 003059) Human ORF cDNA Clone
... organic cation/ergothioneine transporter), member 4 (SLC22A4) available for purchase from OriGene - Your Gene Company. ... Slc22a4 (Myc-DDK-tagged) - Mouse solute carrier family 22 (organic cation transporter), member 4 (Slc22a4). $680. Next day. ... Slc22a4 (untagged) - Mouse solute carrier family 22 (organic cation transporter), member 4 (Slc22a4), (10ug). $190. Next day. ... organic cation/ergothioneine transporter), member 4 (SLC22A4). pCMV6-AC-GFP. pLenti-C-Myc-DDK. pLenti-C-mGFP. $610. In Stock. ...
  http://www.origene.com/orf_clone/trueclone/NM_003059/RC206575/SLC22A4.aspx
*  Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220
In the present study, we reported that the BIM also blocks activity of the solute carrier organic cation transporter (OCT) 1, ... In addition to activity of OCT1, Ro 31-8220 inhibited those of other organic cation transporters such as multidrug and toxin ... these data extend the nature of cellular off-targets of the BIM Ro 31-8220 to OCT1 and other organic cation transporters, which ... including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein. ...
  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144667
*  Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib | Drug...
Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib. Waleed ... Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib ...
  http://dmd.aspetjournals.org/content/early/2017/10/31/dmd.117.076554/tab-figures-data
*  Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer | Molecular...
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer. Thorsten ... Organic cation transporters OCT1 (SLC22A1) and OCT2 (SLC22A2) are critically involved in absorption and excretion of diverse ...
  http://molpharm.aspetjournals.org/content/early/2018/11/08/mol.118.113498
*  JAIRO | Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on...
Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance ... in Triple-negative Breast CancerImpact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic ... Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer. ...
  http://jairo.nii.ac.jp/0006/00023872/en
*  Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2...
Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 ... Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 ... which is hypothesized to be the result of genetic variations in its transport by organic cation transporters (OCTs). This ...
  http://scholar.sun.ac.za/handle/10019.1/104204
*  Plus it
Focus on Organic Anion Transporting Polypeptides and Organic Cation Transporter 1. Abstract. OBJECTIVE-The uptake of drugs into ... organic anion transporting polypeptides [OATPs]; gene symbol SLCO/SLC21) or organic cation transporters (OCTs; gene symbol ... OCT, organic cation transporter. Patients with type 2 diabetes are commonly treated with more than one drug. It is therefore ... Koepsell H, Lips K, Volk C: Polyspecific organic cation transporters: structure, function, physiological roles, and ...
  http://diabetes.diabetesjournals.org/content/57/6/1463
*  SLC22A1 - Solute carrier family 22 member 1 - Homo sapiens (Human) - SLC22A1 gene & protein
Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma ... The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine ... Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- ... methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N- ...
  https://www.uniprot.org/uniprot/O15245
*  Human Metabolome Database: Showing Protein Solute carrier family 22 member 1 (HMDBP02574)
... organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 ... Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma ... Involved in ion transmembrane transporter activity. Specific Function. Translocates a broad array of organic cations with ... Saborowski M, Kullak-Ublick GA, Eloranta JJ: The human organic cation transporter-1 gene is transactivated by hepatocyte ...
  http://www.hmdb.ca/proteins/HMDBP02574
*  Third Row TMs for Treating Cancer | Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and...
This work with organic cation transporters led to our rediscovery and extension of the anti-cancer activity of cation ... 2006 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 66, 8847-8857. (doi:10.1158/0008- ... we investigated the role of the organic cation transporters in the mechanism of action of oxaliplatin [8]. Greater expression ... we showed that cells overexpressing the organic cation transporters OCT1 and OCT2 were significantly more sensitive to ...
  http://rsta.royalsocietypublishing.org/content/373/2037/20140185
*  Effect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study | Diabetes...
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 2002;302: ... Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS Study. Diabetes 2015;64 ... Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Mol ... Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes. Diabet ...
  http://care.diabetesjournals.org/content/39/11/1896?ijkey=dbc45465828f1501447a0f66d9fbf3f4a82cb09c&keytype2=tf_ipsecsha
*  Anika Dzierlenga, PhD | College of Pharmacy - University of Arizona
"Differential Regulation of Hepatic Organic cation Transporter 1. Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export ... Columbia on lumphocyte contribution in the regulation of hepatic sinusoidal uptake and canalicular efflux transporters, 2013.. ... 1. Karagas, N.E.; Jones, C.N.; Osborn, D.J.; Dzierlenga, A.L.; Oyala, P.; Konkle, M.E.; Whitney, E.M.; Britt, D.R.; Hunsicker- ... 1. The Yuma Friends of Arizona Health Sciences Center Young Investigator Research Award, 2012-13.. 2. GPSC Showcase ACS Women ...
  http://www.pharmacy.arizona.edu/research-student/anika-dzierlenga-phd
*  DiVA - S√łkeresultat
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions2011 ... Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport ... Thirty-six transporters were studied for gene expression and nine for protein expression. The antibodies were validated using ... Human cell lines used to transiently or stably express single transporters (HeLa, HEK293) and leukaemia cell lines used to ...
  http://www.diva-portal.org/smash/resultList.jsf?dswid=-666&searchType=SUBJECT&language=no&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211651%22%7D%5D%5D
*  Cell proliferation, tumorogenicity, and apoptosis sub-cluster 69
Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): ... ... cells is dependent on human organic cation transporter 1 (hOCT1; SLC22A1), and that low hOCT1 expression is an important ... Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) ... ... MATERIALS AND METHODS: The effects of several transporter inhibitors on the initial and steady-state apical uptake of AZT by TR ...
  http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-69-p10.html
*  SLC22A4 - Solute carrier family 22 member 4 - Homo sapiens (Human) - SLC22A4 gene & protein
Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ... A key substrate of this transporter seems to be ergothioneine (ET). ... low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. ... Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated. ,p>UniProtKB Keywords constitute a ,a href="http ...
  http://www.uniprot.org/uniprot/Q9H015
*  Metformin Pharmacogenomics: Biomarkers to Mechanisms | Diabetes
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431 ... Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther 2008; ... Schematic representation of the cellular locations of SLC transporters that contribute to metformin pharmacokinetics. It has ... There have been successful pharmacogenomic studies of metformin transporter genes such as OCT1 (SLC22A1), MATE1 (SLC47A1), and ...
  http://diabetes.diabetesjournals.org/content/63/8/2609.full
*  Spermine modulates the expression of two probable polyamine transporter genes and determines growth responses to cadaverine in...
Roth M, Obaindat A, Hagenbuch B (2012) OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A ... Recently, other research group reported that Organic Cation Transporter 1 (OCT1) is a causal gene which determines the Cad ... Strohm A, Vaughn LM, Masson PH (2015) Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length ... Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2 and OCT3. Mol Pharm 10:1450-1458CrossRefPubMed ...
  https://link.springer.com/article/10.1007/s00299-016-1957-3
*  Plus it
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431. ... Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 2008;84:559- ... 3) in their investigation of common variants in SLC22A1, which encodes the liver-specific organic cation transporter 1 ... Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus ...
  http://diabetes.diabetesjournals.org/content/59/10/2672
*  11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice...
Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) ... A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A 2005;102 ... Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 2002;302: ... Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431 ...
  http://diabetes.diabetesjournals.org/content/65/6/1724
*  Metabolic Studies Using Rat as Model Organism sub-cluster 89
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory ... ... Although ET is the largest volume organic chemical worldwide, the EO burden in ET-exposed humans is still uncertain and only ... 1. Infusions of muscimol into the lateral septum do not reduce rats' defensive ... ... Full-length native rat amylin 1-37 has previously been widely shown to be unable to form fibrils and to lack the toxicity of ...
  http://www.biomedsearch.com/cluster/0/Metabolic-Studies-Using-Rat-as-Model-Organism/sub-89.html
*  SLC22A1 Fragment MS Protein Standard - Creative Proteomics
Organic cation transporter 1. Uniprot ID. O15245. Protein Name. Solute carrier family 22 member 1. ... 45-1 Ramsey Road, Shirley, NY 11967, USA. Tel: 1-631-275-3058. Fax: 1-631-614-7828. Email: info@creative-proteomics.com. ...
  https://www.creative-proteomics.com/product/detail-cpilf20928_9662.htm
*  Andrej Sali, PhD | School of Pharmacy | UCSF
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. ... Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 Apr ... A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16; 7:10880. ... Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 02; ...
  https://pharmacy.ucsf.edu/andrej-sali
*  DiVA - Search result
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions2011In ... Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport ... Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison ... BACKGROUND: The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a ...
  http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A11552%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
*  Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health...
Association of organic cation transporter 1 with intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes 2015;64 ... 9 10 It has been proposed that patients with less functional variants in the organic cation transport 1 (OCT-1) gene may also ... Alvin I Mushlin1. *. 1 Department of Healthcare Policy and Research, Weill Cornell Medical College, New York City, New York, ... A minority of patients, 44%, had recorded body mass index, median 32.5 kg/m2 (IQR 27.8 to 37.8) (table 1). When HbA1c was ...
  https://bmjopen.bmj.com/content/8/7/e021505