Slc22a2 MGI Mouse Gene Detail - MGI:1335072 - solute carrier family 22 (organic cation transporter), member 2
J:47780 Koehler MR, et al., The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. ... J:236752 Sprowl JA, et al., A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16;7:10880 ... No significant defects in the renal secretion of a model organic cation are observed. ... 1 phenotype from 1 allele in 1 genetic background 1 phenotype from multigenic genotypes 9 phenotype references ...http://www.informatics.jax.org/marker/MGI:1335072
Third Row TMs for Treating Cancer | Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and...
This work with organic cation transporters led to our rediscovery and extension of the anti-cancer activity of cation ... 2006 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 66, 8847-8857. (doi:10.1158/0008- ... we investigated the role of the organic cation transporters in the mechanism of action of oxaliplatin . Greater expression ... we showed that cells overexpressing the organic cation transporters OCT1 and OCT2 were significantly more sensitive to ...http://rsta.royalsocietypublishing.org/content/373/2037/20140185
Kinetic and Selectivity Differences between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1) | Journal of...
1996) Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn- ... organic cation transporter. MPP+. 1-methyl-4-phenylpyridinium. TMA. tetramethylammonium. TEA. tetraethylammonium. TPrA. ... Organic cation transporters in the kidney and liver play an important role in the removal of potentially toxic drugs and their ... 1998) Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim Biophys Acta 1369:1-6. ...http://jpet.aspetjournals.org/content/292/3/1146
Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane | BMC Research...
... is a gene family that contains organic cation transporters (OCTs), zwitterions/cation transporters (OCTNs) and organic anion ... In Arabidopsis six genes group into the gene family of the organic cation transporters (OCTs). In animals the members of the ... Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane. ... an organic cation transporter gene, affects root development and carnitine-related responses in Arabidopsis. Plant J. 2007, 51 ...https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-1-43
JAIRO | Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on...
Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance ... in Triple-negative Breast CancerImpact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic ... Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer. ...http://jairo.nii.ac.jp/0006/00023872/en
organic cation transporters - Wholesale organic cation transporters
... buy latest organic cation transporters direct from 928 organic cation transporters Factories. ... organic cation transporters. All organic cation transporters wholesalers & organic cation transporters manufacturers come from ... We doesn't provide organic cation transporters products or service, please contact them directly and verify their companies ... cationic surfactants cationic surfactant cation exchange resin cation exchange exchange cation cationic starch ...http://www.nccecojustice.org/organic-cation-transporters-sell
TCDB » Human MTPs
This transporter is distinct from the previously cloned organic cation transporters (OCT1, OCT2, NKT, NLT, RST, and OCTN1). ... This potential-sensitive organic cation transporter, designated as OCT3, represents a new member of the OCT gene family. ... demonstrating the conservation of the close physical linkage of these three organic cation transporter genes in mouse and human ... identifiesa conserved cluster of three organic cation transporters on mouse chromosome 17and human 6q26-q27.Genomics. 1999 Jan ...http://tcdb.org/hgnc_explore.php?symbol=SLC22A3
Molecular Organization of Renal and Hepatic Organic Cation Transporters - Stephen Wright
... of all prescribed drugs are cationic at physiological pH and the multidrug Organic Cation Transporters, OCT1 and OCT2, are the ... Pelis, Ryan M; Wright, Stephen H (2014) SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular ... Molecular Organization of Renal and Hepatic Organic Cation Transporters Wright, Stephen H. Chang, Geoffrey A. University of ... 2016) Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards ...http://grantome.com/grant/NIH/R01-DK058251-13
Focus on Organic Anion Transporting Polypeptides and Organic Cation Transporter 1. Abstract. OBJECTIVE-The uptake of drugs into ... organic anion transporting polypeptides [OATPs]; gene symbol SLCO/SLC21) or organic cation transporters (OCTs; gene symbol ... OCT, organic cation transporter. Patients with type 2 diabetes are commonly treated with more than one drug. It is therefore ... Koepsell H, Lips K, Volk C: Polyspecific organic cation transporters: structure, function, physiological roles, and ...http://diabetes.diabetesjournals.org/content/57/6/1463
Human Metabolome Database: Showing Protein Solute carrier family 22 member 1 (HMDBP02574)
... organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 ... Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma ... Involved in ion transmembrane transporter activity. Specific Function. Translocates a broad array of organic cations with ... Saborowski M, Kullak-Ublick GA, Eloranta JJ: The human organic cation transporter-1 gene is transactivated by hepatocyte ...http://www.hmdb.ca/proteins/HMDBP02574
Anika Dzierlenga, PhD | College of Pharmacy - University of Arizona
"Differential Regulation of Hepatic Organic cation Transporter 1. Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export ... Columbia on lumphocyte contribution in the regulation of hepatic sinusoidal uptake and canalicular efflux transporters, 2013.. ... 1. Karagas, N.E.; Jones, C.N.; Osborn, D.J.; Dzierlenga, A.L.; Oyala, P.; Konkle, M.E.; Whitney, E.M.; Britt, D.R.; Hunsicker- ... 1. The Yuma Friends of Arizona Health Sciences Center Young Investigator Research Award, 2012-13.. 2. GPSC Showcase ACS Women ...http://www.pharmacy.arizona.edu/research-student/anika-dzierlenga-phd
DiVA - Søkeresultat
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions2011 ... Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport ... Thirty-six transporters were studied for gene expression and nine for protein expression. The antibodies were validated using ... Human cell lines used to transiently or stably express single transporters (HeLa, HEK293) and leukaemia cell lines used to ...http://www.diva-portal.org/smash/resultList.jsf?dswid=-666&searchType=SUBJECT&language=no&onlyFullText=false&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211651%22%7D%5D%5D
Cell proliferation, tumorogenicity, and apoptosis sub-cluster 69
Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): ... ... cells is dependent on human organic cation transporter 1 (hOCT1; SLC22A1), and that low hOCT1 expression is an important ... Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) ... ... MATERIALS AND METHODS: The effects of several transporter inhibitors on the initial and steady-state apical uptake of AZT by TR ...http://www.biomedsearch.com/cluster/2/Cell-proliferation-tumorogenicity-and-apoptosis/sub-69-p10.html
SLC22A4 - Solute carrier family 22 member 4 - Homo sapiens (Human) - SLC22A4 gene & protein
Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ... A key substrate of this transporter seems to be ergothioneine (ET). ... low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. ... Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated. ,p>UniProtKB Keywords constitute a ,a href="http ...http://www.uniprot.org/uniprot/Q9H015
Metformin Pharmacogenomics: Biomarkers to Mechanisms | Diabetes
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431 ... Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther 2008; ... Schematic representation of the cellular locations of SLC transporters that contribute to metformin pharmacokinetics. It has ... There have been successful pharmacogenomic studies of metformin transporter genes such as OCT1 (SLC22A1), MATE1 (SLC47A1), and ...http://diabetes.diabetesjournals.org/content/63/8/2609.full
Spermine modulates the expression of two probable polyamine transporter genes and determines growth responses to cadaverine in...
Roth M, Obaindat A, Hagenbuch B (2012) OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A ... Recently, other research group reported that Organic Cation Transporter 1 (OCT1) is a causal gene which determines the Cad ... Strohm A, Vaughn LM, Masson PH (2015) Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length ... Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2 and OCT3. Mol Pharm 10:1450-1458CrossRefPubMed ...https://link.springer.com/article/10.1007/s00299-016-1957-3
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431. ... Genetic variants of the organic cation transporter 2 influence the disposition of metformin. Clin Pharmacol Ther 2008;84:559- ... 3) in their investigation of common variants in SLC22A1, which encodes the liver-specific organic cation transporter 1 ... Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus ...http://diabetes.diabetesjournals.org/content/59/10/2672
11C]-Labeled Metformin Distribution in the Liver and Small Intestine Using Dynamic Positron Emission Tomography in Mice...
Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) ... A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A 2005;102 ... Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 2002;302: ... Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007;117:1422-1431 ...http://diabetes.diabetesjournals.org/content/65/6/1724
Metabolic Studies Using Rat as Model Organism sub-cluster 89
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory ... ... Although ET is the largest volume organic chemical worldwide, the EO burden in ET-exposed humans is still uncertain and only ... 1. Infusions of muscimol into the lateral septum do not reduce rats' defensive ... ... Full-length native rat amylin 1-37 has previously been widely shown to be unable to form fibrils and to lack the toxicity of ...http://www.biomedsearch.com/cluster/0/Metabolic-Studies-Using-Rat-as-Model-Organism/sub-89.html
SLC22A1 - Wikipedia
... serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in ... Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many ... "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". Pryor, R; Cabreiro, F; Haberland, G (16 ... Schinkel AH, Jonker JW (November 2002). "Polymorphisms affecting function of the human organic cation transporter hOCT1 ( ...https://en.wikipedia.org/wiki/SLC22A1
Andrej Sali, PhD | School of Pharmacy | UCSF
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. ... Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 Apr ... A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16; 7:10880. ... Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 02; ...https://pharmacy.ucsf.edu/andrej-sali
DiVA - Search result
Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1:: predictions of metformin interactions2011In ... Common genetic variants of the liver-specific human organic cation transporter 1 (OCT1; SLC22A1) have reduced transport ... Regional levels of drug transporters along the human intestinal tract: Co-expression of ABC and SLC transporters and comparison ... BACKGROUND: The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a ...http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A11552%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health...
Association of organic cation transporter 1 with intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes 2015;64 ... 9 10 It has been proposed that patients with less functional variants in the organic cation transport 1 (OCT-1) gene may also ... Alvin I Mushlin1. *. 1 Department of Healthcare Policy and Research, Weill Cornell Medical College, New York City, New York, ... A minority of patients, 44%, had recorded body mass index, median 32.5 kg/m2 (IQR 27.8 to 37.8) (table 1). When HbA1c was ...https://bmjopen.bmj.com/content/8/7/e021505
A Proteomics Approach to Study Soybean and Its Symbiont Bradyrhizobium japonicum -A Review | IntechOpen
66 - Ferro M, Seigneurin-Berny D, Rolland N, Chapel A, Salvi D, Garin J, Joyard J. Organic solvent extraction as a versatile ... In the Canadian prairies, the dominant salts of saline seeps include calcium (Ca), magnesium (Mg) and sodium (Na) cations, and ... Three homologues of plasma membrane transporter proteins H1-ATPase and calnexin were prominent . Similarly, 3-day-old ... Some of the noteworthy proteins belonged to the cytoplasmic flagellar component FliG, periplasmic ABC transporters, proteins ...https://www.intechopen.com/books/a-comprehensive-survey-of-international-soybean-research-genetics-physiology-agronomy-and-nitrogen-relationships/a-proteomics-approach-to-study-soybean-and-its-symbiont-bradyrhizobium-japonicum-a-review/
JoVE Search Results: Cyclosporin%7CBinding Protein
Kidney transplantation down-regulates expression of organic cation transporters, which translocate β-blockers and ... Organic letters. Switching from altro-alpha-cyclodextrin dimer to pseudorotaxane dimer through tumbling. Abstract ... The Journal of organic chemistry. Nanospheres with polymerization ability coated by polyrotaxane. Abstract ... Organic & biomolecular chemistry. Switching of polymerization activity of cinnamoyl-alpha-cyclodextrin. Abstract ...http://labindex.jove.com/group/Cyclosporin%7CBinding-Protein