Organic Anion Transport Protein 1 | Colorado PROFILES
Organic Anion Transporters, Sodium-Independent [D12.776.157.530.450.074.500.781]. *Organic Anion Transport Protein 1 [D12.776. ... Organic Anion Transporters, Sodium-Independent [D12.776.543.585.450.074.500.875]. *Organic Anion Transport Protein 1 [D12.776. ... "Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... This graph shows the total number of publications written about "Organic Anion Transport Protein 1" by people in this website ...
Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1
rlst-1 is a counterpart of human LST-1 and is one of the important transporters in rat liver for the clearance of bile acid. ... The expression of rlst-1 may be under feedback regulation of cholestasis by biliary obstruction and/or sepsis. ... Anion Transport Proteins * Blotting, Northern * Carrier Proteins / genetics* * Cecum * Cholestasis / etiology * Cholestasis / ... Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 ...
Solute carrier organic anion transporter family member 1B1 - Wikipedia
"The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695-9 ... "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion ... Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. ... Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of ...
MeSH Browser
Anion Transport Proteins [D12.776.157.530.450.074] * Organic Anion Transporters [D12.776.157.530.450.074.500] * Organic Anion ... Anion Transport Proteins [D12.776.543.585.450.074] * Organic Anion Transporters [D12.776.543.585.450.074.500] * Organic Anion ... Norepinephrine Plasma Membrane Transport Proteins [D12.776.157.530.937.600] * Organic Anion Transport Protein 1 [D12.776. ... Proteins [D12.776] * Carrier Proteins [D12.776.157] * Membrane Transport Proteins [D12.776.157.530] * Solute Carrier Proteins [ ...
ATP-DEPENDENT TRANSPORT OF ROSUVASTATIN IN MEMBRANE VESICLES EXPRESSING BREAST CANCER RESISTANCE PROTEIN | Drug Metabolism &...
... mitoxantrone resistance protein; Papp, apparent permeability; Pgp, P-glycoprotein; OATP, organic anion-transporting polypeptide ... ATP-DEPENDENT TRANSPORT OF ROSUVASTATIN IN MEMBRANE VESICLES EXPRESSING BREAST CANCER RESISTANCE PROTEIN. Liyue Huang, Yi Wang ... ATP-DEPENDENT TRANSPORT OF ROSUVASTATIN IN MEMBRANE VESICLES EXPRESSING BREAST CANCER RESISTANCE PROTEIN. Liyue Huang, Yi Wang ... ATP-DEPENDENT TRANSPORT OF ROSUVASTATIN IN MEMBRANE VESICLES EXPRESSING BREAST CANCER RESISTANCE PROTEIN. Liyue Huang, Yi Wang ...
Profile | University of Otago
Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization ... Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. ... Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). Journal of Biological Chemistry, 276(49 ... Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Biochemical & Biophysical ...
DailyMed - VIZIMPRO- dacomitinib tablet, film coated
... organic anion transporting polypeptide (OATP)1B1, and OATP1B3. ... Dacomitinib is a substrate for the membrane transport protein P ... P-gp) and Breast Cancer Resistance Protein (BCRP). Dacomitinib inhibits P-gp, BCRP, and organic cation transporter (OCT)1. ... Dacomitinib does not inhibit organic anion transporters (OAT)1 and OAT3, OCT2, ... In vitro binding of dacomitinib to human plasma proteins is approximately 98% and is independent of drug concentrations from ...
Drug Interactions with Antiretroviral Therapy (ART): Overview, Drug Interactions by Antiretroviral Class
15] , organic anion transporter, breast cancer resistance protein [16] , and organic anion transporting polypeptide (OATP) ... Kovacsics D, Patik I, Özvegy-Laczka C. The role of organic anion transporting polypeptides in drug absorption, distribution, ... Several other drug transport proteins have been discovered, and families of these proteins include multidrug and toxin ... Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update. AAPS J. 2015 Jan. 17 (1):65-82. [QxMD ...
Experts at Lehigh Valley Health Network - SelectedWorks
Prepared organic compounds in an organic synthesis laboratory. Overall goal was to isolate an anion transport protein found in ... Prepared organic compounds in an organic synthesis laboratory. Overall goal was to isolate an anion transport protein found in ... Thesis Objectives: To investigate molecular mechanisms mediating desensitization of the G protein coupled A1-Adenosine receptor ... Thesis Objectives: To investigate molecular mechanisms mediating desensitization of the G protein coupled A1-Adenosine receptor ...
Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction...
Based on the ECCCS class assignment (4 classes), the mechanistic interplay of metabolic and transport processes, resulting in ... represents a powerful tool to anticipate the DDI potential of victim drugs based on in vitro drug metabolism and transport data ... Methods: We applied a recently developed in vitro-in vivo extrapolation method, including hepatic metabolism and transport ... of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting ...
Isentress 600 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc)
... breast cancer resistance protein (BCRP), organic anion-transporting polypeptides (OATP) 1B1, OATP1B3, organic cation ... In vitro, raltegravir is a weak inhibitor of organic anion transporter (OAT) 1 (IC50 of 109 µM) and OAT3 (IC50 of 18.8 µM). ... Raltegravir is approximately 83 % bound to human plasma protein over the concentration range of 2 to 10 µM. ... or multidrug and toxin extrusion proteins (MATE)1 and MATE2-K. Based on these data, raltegravir is not expected to affect the ...
Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration...
... and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and ... Duran, I., Carles, J., Bulat, I. et al. Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in ... Pharmacokinetic Drug-Drug Interaction of Apalutamide, Part 1: Clinical Studies in Healthy Men and Patients with Castration- ...
Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance...
... and sulfate-conjugated organic anions. In addition, the transport of certain MRP1 substrates is stimulated by the presence of ... multidrug resistance protein 1. E1SO4. estrone 3-sulfate. NNAL. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Abu. ... In addition, this tripeptide was shown to be a competitive inhibitor of apigenin-stimulated GSH transport (Ki value of 14 μM), ... Transport Is Not Rate-Limiting in Morphine Glucuronidation in the Single-Pass Perfused Rat Liver Preparation ...
The Fish Gill: A Sensitive Target for Waterborne Pollutants
The inhibition of influx is due in large part to the binding of metal ions to sulphydryl groups on transport proteins (ATPases ... The role of metallothionein or other metal-binding proteins in acclimation is equivocal. Inorganic anions also appear to affect ... The gills play a role in the excretion of some organic compounds (log P < 3). There are many reports of pesticides inhibiting ... There is little information on the effects of organometallics or organics on the gills, when exposed to environmentally ...
Plus it
multidrug resistance associated protein 2. Mrp3. multidrug resistance associated protein 3. Oatp. organic anion transporting ... 1B). BOPTA and MEB are transported by organic anion transporting polypeptides (Oatps), multidrug resistance associated protein ... 1999) Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver. Gastroenterology 117:688-695. ... 2019) Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic ...
DailyMed - ATORVASTATIN CALCIUM tablet, film coated
... breast cancer resistant protein [BCRP], organic anion-transporting polypeptide [OATP1B1/OATP1B3] and P-glycoprotein [P-gp]), ... Atorvastatin calcium is ≥98% bound to plasma proteins. A blood/plasma ratio of approximately 0.25 indicates poor drug ... Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin calcium ... 1 INDICATIONS AND USAGE 1.1 Prevention of Cardiovascular Disease in Adults 1.2 Hyperlipidemia 1.3 Limitations of Use 2 DOSAGE ...
WikiGenes - ABCC3 - ATP-binding cassette, sub-family C...
MRP3, an organic anion transporter able to transport anti-cancer drugs. Kool, M., van der Linden, M., de Haas, M., Scheffer, G. ... Transport of amphipathic anions by human multidrug resistance protein 3. Zeng, H., Liu, G., Rea, P.A., Kruh, G.D. Cancer Res. ( ... Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells ... Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile ...
Figure 9.1 Overview of bilirubin metabolism and transport. OATP, organic anion transporter- UDP-GT, uridine diphosphoglucuronyl...
Personalized therapeutics for levofloxacin: a focus on pharmacokinetic | TCRM
Transporters such as organic anion-transporting polypeptide 1A2, P-glycoprotein, human organic cation transporter 1, and ... multidrug and toxin extrusion protein 1 are involved in the pharmacokinetics of LVX.Conclusion: Personalized LVX therapeutics ... New findings regarding individual dosing of LVX in special patient populations and active transport mechanisms in vivo are ... 1 Lu-Shan Yu,2 Su Zeng,2 Yu-Wen Huang,1 Quan Zhou11Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, ...
Tissue expression of SOX8 - Summary - The Human Protein Atlas
Solute carrier organic anion transporter family member 1A2. 0.9860. 9. ERMN. Ermin. 0.9860. 9. ... Sodium/potassium transporting ATPase interacting 2. 0.9860. 9. SHTN1. Shootin 1. 0.9860. 9. ... RNA AND PROTEIN EXPRESSION SUMMARYi Below is an overview of RNA and protein expression data generated in the Human Protein ... Protein evidencei Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence ( ...
Anatomy & Structural Biology - Publications - Albert Einstein College of Medicine
Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation ... moxMaple3: a Photoswitchable Fluorescent Protein for PALM and Protein Highlighting in Oxidizing Cellular Environments. ... Simultaneous detection of mRNA and protein in S. cerevisiae by single-molecule FISH and immunofluorescence. Tutucci, E. & ... Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice. Selvanesan, B. C., Chandra ...
USF1 | Cancer Genetics Web
Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells ... transporters involved in organic anion transport using liquid chromatography-tandem mass spectroscopy, immunocytochemistry, and ... protein binding - protein dimerization activity - protein heterodimerization activity - protein homodimerization activity - ... However, their relevance for investigations of drug-drug and drug-organic anion (e.g., bile acid, steroid hormone) interactions ...
The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter...
organic anion transporting polypeptide. OR-2. oocyte Ringers 2. PAH. p-aminohippurate. PBS-M. phosphate-buffered saline/5% dry ... protein kinase A. PKC. protein kinase C. PMEG. 9-(2-phosphonylmethoxyethyl)guanine. PMEDAP. 9-(2-phosphonylmethoxyethyl) ... 1976) Transport of organic cations and anions by choroid plexus. J Pharmacol Exp Ther 196:771-777. ... The renal organic anion transport system, because of its sensitivity to probenecid and broad substrate specificity, is a ...
Frontiers | A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC...
... and organic anion transporter (OAT)1 as SLC transporters and multidrug resistance-associated protein (MRP)1 and MRP2 as ABC ... and organic anion transporter (OAT)1 as solute carrier transporters and multidrug resistance-associated protein (MRP)1 and MRP2 ... We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, ... We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, ...
Long-term Safety of Oral Anti-virals for Chronic HBV
Modified from Rodriguez-Novoa et al19). MRP4, multidrug resistance protein 4, NtA, nucleotide analogues, OAT, organic anion ... they are excreted by multidrug resistance protein (MRP)-4. NtA is actively transported by MRP-4 to the proximal tubule; when ... Modified from Rodriguez-Novoa et al19). MRP4, multidrug resistance protein 4, NtA, nucleotide analogues, OAT, organic anion ... Adefovir and tenofovir are substrates of organic anion transporter (OAT)-1 and OAT-3; they are excreted by multidrug resistance ...
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
OATP-B, OATP-C, and OATP8 account for the major part of sodium-independent bile salt, organic anion, and drug clearance of ... Carrier Proteins / genetics* * Carrier Proteins / immunology * Carrier Proteins / metabolism* * Coloring Agents / ... Background & aims: Hepatic uptake of cholephilic organic compounds is mediated by members of the organic anion-transporting ... Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver ...
Richard J. Reimer, MD's Profile | Stanford Profiles
... a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their ... While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by ... it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ... and are part of a family of structurally related proteins that mediate organic anion transport. Standard computer-based ...
PD Dr. Martin Fraunholz - Lehrstuhl für Mikrobiologie
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated ... The chloroplast division protein FtsZ is encoded by a nucleomorph gene in cryptomonads. Mol Gen Genet. 1998 Nov 260(2-3):207-11 ... Wagner F, Kunz TC, Chowdhury SR, Thiede B, Fraunholz M, Eger D, Kozjak-Pavlovic V. Armadillo repeat-containing protein 1 is a ... Zauner S, Fraunholz M, Wastl J, Penny S, Beaton M, Cavalier-Smith T, Maier UG, Douglas S. Chloroplast protein and centrosomal ...