*  Difference between revisions of "Lee:Publications" - OpenWetWare
Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and ... Factors influencing the protein binding of YH-439 using an equilibrium dialysis technique. A new hepatoprotective agent. ... Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and ... Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and ...
  https://openwetware.org/wiki/?title=Lee:Publications&diff=673215&oldid=479697
*  Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric...
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl ... Multidrug resistance protein Mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. Am J ... In this study, we show that the apical organic anion transporter MRP4 mediates ATP-dependent urate transport in isolated ... Here, we show that the renal apical organic anion efflux transporter human multidrug resistance protein 4 (MRP4), but not ...
  http://ajprenal.physiology.org/content/288/2/F327
*  Difference between revisions of "Lee:Publications" - OpenWetWare
Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and ... Factors influencing the protein binding of YH-439 using an equilibrium dialysis technique. A new hepatoprotective agent. ... Lockhart AC, Harris E, LaFleur BJ, Merchant NB, Washington MK, Resnick MB, Yeatman TJ, Lee W. Organic anion transporting ... A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) ...
  https://openwetware.org/wiki/?title=Lee:Publications&diff=756013&oldid=718767
*  REGULATION OF HUMAN ORGANIC ANION TRANSPORTER 3 BY PEPTIDE HORMONE BRADYKININ | Journal of Pharmacology and Experimental...
Protein kinase. *Regulation. *transport activity. Footnotes. **Received January 2, 2010.. *Revision received March 16, 2010. ... Human organic anion transporter 3 (hOAT3) belongs to a family of organic anion transporters that play critical roles in the ... REGULATION OF HUMAN ORGANIC ANION TRANSPORTER 3 BY PEPTIDE HORMONE BRADYKININ. Shanshan Li, Peng Duan and Guofeng You ... REGULATION OF HUMAN ORGANIC ANION TRANSPORTER 3 BY PEPTIDE HORMONE BRADYKININ. Shanshan Li, Peng Duan and Guofeng You ...
  http://jpet.aspetjournals.org/content/early/2010/03/18/jpet.110.165472
*  OST Family - Wikipedia
Organic cation transport proteins Organic anion-transporting polypeptide Solute carrier family Osmoregulation Organic anion ... The generalized transport reaction catalyzed by OSTα/OSTβ is: organic anion (out) ⇌ organic anion (in) Each transport system ... Roth B., M; Obaidat, A; Hagenbuch, B (March 2012). "OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO ... Substrates for OST transporters include a variety of organic compounds, most being anionic. Transport of estrone sulfate by the ...
  https://en.wikipedia.org/wiki/OST_Family
*  The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane, The...
... in transport of fluorescent anions across the human erythrocyte membrane, The Journal of Membrane Biology" on DeepDyve, the ... Transport of organic anions by multidrug resistanceassociated protein in the erythrocyte. Rychlik, B.; Pulaski, L.; Sokal, A.; ... Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs ... Inhibitor profiles of CF and BCECF transport are typical for substrates of organic anion transporters. BCECF is transported ...
  https://www.deepdyve.com/lp/springer_journal/the-role-of-multidrug-resistance-protein-1-mrp1-in-transport-of-CSW2cCJq2X
*  Push-Catch System for Effective Detoxification (FebMarch 2018) Townsend Letter, Alternative Medicine Magazine
... organic anion transport proteins (OATP), and P-glycoprotein (P-gp).16 These proteins also regulate the movement of molecules ... The primary proteins that play a role in Phase III are multidrug resistance protein (MRP) 1, 2, 3, and 4, ... Figure 2: Oxidative stress causes Nrf2 to dissociate from binding protein (Keap1) in the cytosol and translocate to the nucleus ... Phase III involves the process of transport and elimination of toxic substances through cellular membranes. ...
  http://townsendletter.com/FebMarch2018/pushcatch0218.html
*  Index by author - January 01, 2001, 296 (1) | Journal of Pharmacology and Experimental Therapeutics
Hepatic Uptake of Synthetic Chlorogenic Acid Derivatives by the Organic Anion Transport Proteins Dietmar Schwab, Andreas W. ... Hepatic Uptake of Synthetic Chlorogenic Acid Derivatives by the Organic Anion Transport Proteins Dietmar Schwab, Andreas W. ... Hepatic Uptake of Synthetic Chlorogenic Acid Derivatives by the Organic Anion Transport Proteins Dietmar Schwab, Andreas W. ... Hepatic Uptake of Synthetic Chlorogenic Acid Derivatives by the Organic Anion Transport Proteins Dietmar Schwab, Andreas W. ...
  http://jpet.aspetjournals.org/content/296/1.index-by-author
*  Folotyn (Pralatrexate Solution for Intravenous Injection): Side Effects, Interactions, Warning, Dosage & Uses
... organic anion transport protein 1B1 (OATP1B1), organic cation transporter 2 (OCT2), organic anion transporter 1 (OAT1), and ... multidrug resistance-associated protein 3 (MRP3), and organic anion transport protein 1B3 (OATP1B3) transporter systems at ... organic anion transporter 3 (OAT3) transporter systems.. In vitro, pralatrexate inhibits MRP2 and MRP3 transporter systems ([I ... In vitro, pralatrexate is a substrate for the breast cancer resistance protein (BCRP), MRP2, ...
  https://www.rxlist.com/folotyn-drug.htm
*  SLCO1B1 - Wikipedia
"The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695-9 ... "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion ... Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. ... Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of ...
  https://en.wikipedia.org/wiki/SLCO1B1
*  1 - Think forex webtrader
Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. 8 A; 5. ... Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. ... rhodopsin is a derivative of 11-cis-retinal with the protein opsin). Discuss how such a form of inheritance could be introduced ... tTG may generate novel antigenic epitopes by cross-linking gliadin peptides with self-proteins and may potentially initiate an ...
  http://forextradinggs.com/think-forex-webtrader.html
*  Human Metabolome Database: Showing metabocard for Etoposide (HMDB0014911)
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione ... multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab ... mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. [PubMed:9188796 ] ... multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab ...
  http://www.hmdb.ca/metabolites/HMDB14911
*  Organic anion transporter 1 - Wikipedia
OAT1 functions as organic anion exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an ... It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in ... and OATP4C1 transport small organic anions from the plasma into the S2 cells. MDR1, MRP2, MRP4 and URAT1 then transports these ... 2003). "Transport of cimetidine by flounder and human renal organic anion transporter 1". Am. J. Physiol. Renal Physiol. 284 (3 ...
  https://en.wikipedia.org/wiki/Organic_anion_transporter_1
*  Functional Expression of the Multidrug Resistance Protein 1 in Microglia | Journal of Pharmacology and Experimental Therapeutics
... and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother 46: 3456-3462. ... Loe DW, Almquist KC, Deeley RG, and Cole SPC (1996) Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and ... The MRP family of efflux transport proteins is known to confer multidrug resistance to a variety of structurally unrelated ... Seetharaman S, Barrand MA, Maskell L, and Scheper RJ (1998) Multidrug resistance-related transport proteins in isolated human ...
  http://jpet.aspetjournals.org/content/307/1/282
*  Human MRP1 Vesicles - Thermo Fisher Scientific
... multidrug resistance-associated protein 1, ABCC1). Our Human MRP1 Vesicles can be used to evaluate test compounds and drug ... Human MRP1 Vesicles are insect derived purified plasma membranes with inserted MRP1 transport protein ( ... MRP1 is an ATP-binding cassette (ABC) transporter that carries organic anions.. Use Human MRP1 Vesicles to:. • Investigate the ... Human MRP1 Vesicles are insect derived purified plasma membranes with inserted MRP1 transport protein (multidrug resistance- ...
  https://www.thermofisher.com/order/catalog/product/GM0010
*  Multidrug resistance-associated protein 2 - Wikipedia
These organic anions are transported from the blood into the endothelial cells of the renal proximal tubules by the OAT1 ... Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ... "Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions". Mol. Pharmacol. 57 (4): 760-8. PMID ... ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct ...
  https://en.wikipedia.org/wiki/Multidrug_resistance-associated_protein_2
*  Relistor - FDA prescribing information, side effects and uses
Breast Cancer Resistance Protein (BCRP), Multidrug Resistance Protein 2 (MRP2), Organic Anion-Transporting Polypeptide (OATP) ... Organic Anion Transporter (OAT)1, OAT3, Multidrug and Toxic Extrusion Transporter (MATE)1 and MATE2-K at the recommended dosage ... The fraction of methylnaltrexone bound to human plasma proteins is 11% to 15%, as determined by equilibrium dialysis. ... carbohydrate and protein, respectively) resulted in a decrease in the Cmax of methylnaltrexone by 60%, the AUC by 43% and ...
  https://www.drugs.com/pro/relistor.html
*  Isavuconazonium Sulfate Monograph for Professionals - Drugs.com
Plasma Protein Binding. ,99% (mainly albumin).1 10. Elimination. Metabolism. In vivo studies indicate isavuconazole is ... Weak inhibitor of P-glycoprotein (P-gp) and organic cation transporter (OCT) 2.1 Also inhibits breast cancer resistance protein ... Aspergillus: Active in vitro and in clinical infections against A. flavus,1 14 19 20 21 A. fumigatus,1 14 19 20 21 and A. niger ... Decreased bupropion exposure1. Use concomitantly with caution;1 increased bupropion dosage may be needed (do not exceed maximum ...
  https://www.drugs.com/monograph/isavuconazonium-sulfate.html
*  Carboxylate transporter - Wikipedia
A carboxylate transporter is a membrane transport protein that transports carboxylate. They are responsible for the ... cotransporter 3Na-dicarboxylate cotransporter 3Na-tricarboxylate cotransporter H-monocarboxylate cotransporter organic anion- ...
  https://en.wikipedia.org/wiki/Carboxylate_transporter
*  Plus it
... multidrug resistance protein 2, and organic anion transporting polypeptide 2]. Attenuated activation of PXR target genes, such ... multidrug resistance protein 2, and organic anion transporting polypeptide 2) involved in the metabolism and elimination of ... and protein concentrations were determined. Equal amounts of protein (40 µg/lane) were separated on 10% SDS-PAGE and ... monocyte chemotactic protein-1. MDR1. multidrug resistance 1. MPO. myeloperoxidase. MW. molecular weight. NF-κB. nuclear ...
  http://jpet.aspetjournals.org/content/345/3/473
*  DailyMed - RELISTOR- methylnaltrexone bromide tablet RELISTOR- methylnaltrexone bromide injection, solution
Breast Cancer Resistance Protein (BCRP), Multidrug Resistance Protein 2 (MRP2), Organic Anion-Transporting Polypeptide (OATP) ... Organic Anion Transporter (OAT)1, OAT3, Multidrug and Toxic Extrusion Transporter (MATE)1 and MATE2-K at the recommended dosage ... The fraction of methylnaltrexone bound to human plasma proteins is 11% to 15%, as determined by equilibrium dialysis. ... carbohydrate and protein, respectively) resulted in a decrease in the Cmax of methylnaltrexone by 60%, the AUC by 43% and ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c488fb7c-0a5b-487c-b452-996809d1cb99
*  SLCO4A1 polyclonal antibody - (PAB22760) - Products - Abnova
Recombinant protein corresponding to amino acids of human SLCO4A1. (PAB22760) - Products - Abnova ... organic anion transporting polypeptide E,sodium-independent organic anion transporter E,solute carrier family 21 (organic anion ... OTTHUMP00000031493,colon organic anion transporter,organic anion transporter polypeptide-related protein 1, ... Immunohistochemistry (1:20-1:50). The optimal working dilution should be determined by the end user. ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB22760
*  Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters | Journal of...
multidrug resistance protein 2. NPT1. human type I sodium-dependent inorganic phosphate transporter. S1. S2, S3, the first, ... organic anion transporter. hOAT. human organic anion transporter. OAT-K1. OAT-K2, renal organic anion transporter 1 and 2. ... Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters. Michio Takeda, ... Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters. Michio Takeda, ...
  http://jpet.aspetjournals.org/content/302/2/666
*  Kidneys sans glomeruli | Renal Physiology
Takeda M, Sekine T, and Endou H. Regulation by protein kinase C of organic anion transport driven by rat organic anion ... has recently discovered voltage-dependent organic anion transport that is mediated by the transport protein OATv1 located in ... Na-dependent transport of small organic anions such as PAH and fluorescein, 2) Na-independent transport of large organic acids ... transepithelial organic anion transport by stimulating the Na/K pump. PKC inhibits (-) uptake of organic anions directly via ...
  http://ajprenal.physiology.org/content/286/5/F811.full
*  Grapefruit-drug interactions - Wikipedia
For medications that interact due to inhibition of OATP (organic anion-transporting polypeptides), a relative short period of ... Another mechanism of interaction is possibly through the MDR1 (multidrug resistance protein 1) that is localized in the apical ... Andrade, Chittaranjan (24 November 2014). "Fruit Juice, Organic Anion Transporting Polypeptides, and Drug Interactions in ... organic anion transporting polypeptides), either increasing or decreasing the bioavailability of a number of drugs. Drugs that ...
  https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions