Fusion" by people in UAMS Profiles by year, and whether "Oncogene Proteins, Fusion" was a major or minor topic of these ... "Oncogene Proteins, Fusion" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular ... Below are the most recent publications written about "Oncogene Proteins, Fusion" by people in Profiles over the past ten years. ...

Stenman G (July 2013). "Fusion oncogenes in salivary gland tumors: molecular and clinical consequences". Head and Neck ... ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) ... Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in ... Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH (February 2000). "The ETV6-NTRK3 gene fusion encodes a chimeric ...

involved_in Golgi vesicle fusion to target membrane IBA Inferred from Biological aspect of Ancestor. more info ... mel transforming oncogene (RAB8 homolog). mel transforming oncogene (derived from cell line NK14). mel transforming oncogene ( ... RAB8A RAB8A, member RAS oncogene family [Homo sapiens] RAB8A RAB8A, member RAS oncogene family [Homo sapiens]. Gene ID:4218 ... RAB8A, member RAS oncogene familyprovided by HGNC. Primary source. HGNC:HGNC:7007 See related. Ensembl:ENSG00000167461 MIM: ...

Rare-sarcomas; Cancers driven by a single oncogene; Fusion-genes and the mechanism of their activation as fusion proteins, ... Because cancer-driven by a single oncogene, such as leukemia driven by the BCR-ABL fusion gene, is amenable to treatment with ... EHE - Epithelial Hemangio-Endothelioma, cancer driven by fusions of YAP or TAZ oncogenes with genes that encode transcription ... Although two newly described oncogenes known as YAP and TAZ are not generally mutated in human cancers, there is one exception ...

While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions ... In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a ... We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. ... Functional investigation of 128 conserved MLL-fusion-interactors identifies a specific role for the lysine methyltransferase ...

... as well as the mechanisms by which oncogenes disrupt this process, remain poorly understood. A major limitation in approaching ... Oncogene Proteins * Oncogene Proteins, Fusion / analysis * Oncogene Proteins, Fusion / metabolism* * Phagocytosis * Point ... The molecular pathways of normal myeloid differentiation, as well as the mechanisms by which oncogenes disrupt this process, ... conditional immortalization of primary murine marrow progenitors with an estrogen-regulated E2a/Pbx1-estrogen receptor fusion ...

2006). The synovial-sarcoma-associated SS18-SSX2 fusion protein induces epigenetic gene (de)regulation. Cancer Res 66: 9474- ... Oncogene 9: 1367-1377. ... Supplementary Information accompanies the paper on the Oncogene ...

Proto-Oncogene Proteins / metabolism* * Proto-Oncogene Proteins c-bcl-2 * Recombinant Fusion Proteins / metabolism ...

Show Gene Fusions Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene ... YES1 (YES proto-oncogene 1, Src family tyrosine kinase). 2003-02-01 Affiliation ...

2018). FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. Oncogene 37(46):6096-6104. *Joint-first authors. ...

... chimeric oncogene. Tumor-specific recurrent chromosomal translocations and novel fusion oncogenes in aggressive head and neck ... chimeric oncogene. Tumor-specific recurrent chromosomal translocations and novel fusion oncogenes in aggressive head and neck ... chimeric oncogene. Tumor-specific recurrent chromosomal translocations and novel fusion oncogenes in aggressive head and neck ... chimeric oncogene. Tumor-specific recurrent chromosomal translocations and novel fusion oncogenes in aggressive head and neck ...

In this fusion gene, the part of CSF1 coding for the CSF1 protein (exons 1-8 in sequences with accession nos. NM_000757 and NM_ ... AnxA2 and SOX2 bind to proto-oncogenes, c-Myc and c-Src, and AnxA2 forms a functional heterotetramer with S100A10 to promote ... Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors.. Int J Oncol ... A novel CSF1-S100A10 fusion gene was found in a TSGCT that carried the translocation t(1;1)(q21;p11) as the sole karyotypic ...

... gene fusions. These NTRK gene fusions are oncogenic drivers found in most tumour types at a low frequency (,5%), and at a ... We provide a Canadian consensus on when and how to test for NTRK gene fusions and when to consider treatment with a TRK ... Based on the probability of the tumour harbouring an NTRK gene fusion, we also suggest a tumour-agnostic consensus for NTRK ... We recommend considering a TRK inhibitor in all patients with TRK fusion cancer with no other effective treatment options. ...

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model. Oncogene. 2005;24(51):7579-91. ...

Unveiling the Molecular Signature of Salivary Gland Neoplasms with Tumor-specific Fusion Oncogenes By: Roopa Rao, Thirumal Raj ...

AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene. 2001 Sep 10;20(40):5660-79. doi: 10.1038/sj. ... The RUNX1-ETO fusion protein forms CBF and attaches to DNA, but instead of turning on genes that stimulate the development of ... The fusion protein produced from the t(8;21) translocation, called RUNX1-ETO, retains some functions of the two individual ...

"Regulatory Mechanisms, Expression Levels and Proliferation Effects of the Fus-Ddit3 Fusion Oncogene in Liposarcoma." J Pathol ... Functional characterization of the liposarcoma-associated fusion oncogene FUS-DDIT3. 2005. Surpervisor: Pierre Åman. Lachmi ... SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.. Boström P, Andersson ... A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.. ...

Loss of tumorigenicity of Ewings sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene. 1995 Sep 21;11(6 ... Oncogene. 2010 Jun 14. [Epub ahead of print] Toretsky JA, Erkizan V, Levenson A, Abaan OD, Parvin JD, Cripe TP, Rice AM, Lee SB ... The EWS/FLI Fusion Protein. The Ewing sarcoma gene encodes protein of uncertain function, while the FLI product is a ... Joint fusions often result in dissatisfied patients because of the lack of joint motion. They are better tolerated for the ...

RET Fusion-Positive NSCLC. The publication highlights the first 105 consecutively enrolled RET fusion-positive metastatic NSCLC ... This dependency, often referred to as "oncogene addiction," renders such tumors highly susceptible to small molecule inhibitors ... RET fusion-positive cancers and RET-mutant MTC are primarily dependent on this single activated kinase for their proliferation ... NEJM published separate articles focusing on efficacy and safety data in the RET fusion-positive NSCLC and RET-altered thyroid ...

Nodal Metastases Associated with Fusion Oncogenes Are Age Dependent in Young Adult Patients with Thyroid Cancer. August 03, ...

... to generate fusion plasmids, and a pcDNA empty vector was used as the control. For miR-195-5p enrichment or inhibition, miR-195 ... EST1 is considered to be a pro-oncogene that regulates the pathophysiological progress of GC (45). It has been reported that ... Propofol suppresses gastric cancer tumorigenesis by modulating the circular RNA‑PVT1/miR‑195‑5p/E26 oncogene homolog 1 axis. * ... Circ-PVT1, circular RNA-PVT1; ETS1, E26 oncogene homolog; miR-195-5p, microRNA-195-5p; NC, negative control; anti-miR-195-5p, ...

ROS 1 oncogene fusion mutation. *ROS-1 mutation. *ROS 1 oncogene mutation ... The ROS1 mutation is a mutation occurring in the ROS1 oncogene on chromosome 6 resulting in a defective receptor tyrosine ...

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression Tzu-Po Chuang, Wei-Yun Lai, ...

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"Novel K6-K14 keratin fusion enhances cancer stemness and aggressiveness in oral squamous cell carcinoma." in: Oncogene, Vol. 38 ...

Background: EML4-ALK fusion oncogene has emerged as a novel molecular target in non-small cell lung cancer (NSCLC). Although ... Conclusions: Highly specific and sensitive detection of EML4-ALK fusion oncoprotein is possible by in situ PLA method ... Sensitive detection of EML4-ALK fusion oncoprotein of lung cancer by in situ proximity ligation assay. ... EML4-ALK oncogene and protein in lung cancer cells were confirmed by multiplex RT-PCR and Western blots. Results: We detected ...

Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow- ... Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non-Small Cell Lung Cancers on the LIBRETTO-001 Trial. Clin ... RET fusion mutation detected by re-biopsy 7 years after initial cytotoxic chemotherapy: A case report ... The Treatment Status of Patients in NSCLC With RET Fusion Under the Prelude of Selective RET-TKI Application in China: A ...

... we annotated the gene fusions using published databases for gene fusions in cancer. To relate the occurrence of gene fusions to ... These fusions were detected in all four studied cohorts, providing compelling evidence for the validity of these fusions and ... With the fusion calling software Arriba, we computationally predicted gene fusions. Following detection, ... Our gene fusion characterization workflow revealed two potential novel fusions specific for PCa. We found evidence that the ...

... usually involving former proto-oncogenes) and may therefore be successfully inhibited by substances directed against the fusion ... Synstable Fusion: A Network-Based Algorithm for Estimating Driver Genes in Fusion Structures.. Molecules. 2018; 23(8) [PubMed] ... In this paper, Synstable Fusion (SYN), an algorithm for computationally evaluating the fusion genes, is proposed. This ... different methods sometimes suffer different weaknesses when handling gene fusion data due to multiple issues such as fusion ...