Urine Concentrations of a Tobacco-Specific Nitrosamine Carcinogen in the U.S. Population from Secondhand Smoke Exposure |...
Urine Concentrations of a Tobacco-Specific Nitrosamine Carcinogen in the U.S. Population from Secondhand Smoke Exposure. John T ... Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 1998;11:559-603. ... However, these results might be altered if cigarettes with lower tobacco-specific nitrosamine contents, such as seen in Canada ... When a cigarette burns, the tobacco-specific nitrosamines partition into mainstream and sidestream smoke and can be measured in ...http://cebp.aacrjournals.org/content/19/11/2969.long
Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in...
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most abundant carcinogens ... Tobacco-specific nitrosamines in new tobacco products.. *Irina Stepanov. , Joni Jensen. , Dorothy Hatsukami. , Stephen S Hecht ... The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most abundant carcinogens ...https://www.semanticscholar.org/paper/Metabolism-of-the-tobacco-specific-carcinogen-4-me-Hecht-Carmella/c019375dc4e26c6e122e5dd853b8e56c6d355bb0
Moreover, nicotine-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is carcinogenic in lung cancer. ...http://cancerres.aacrjournals.org/content/68/9_Supplement/2238
Blowing smoke: the history of tobacco-specific nitrosamines in Canadian tobacco | Tobacco Control
Nitrosamines and TSNAs. Nitrosamines are a large group of carcinogens that cause a wide range of tumours in many species of ... The nitrosamine levels in tobacco from these barns was as low or lower than tobacco cured by the modern method of indirect ... Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014. Regul Toxicol Pharmacol 2016;76: ... Ten carcinogenic nitrosamines have been identified in tobacco smoke. Four of these are in the subclass of TSNAs, frequently ...http://tobaccocontrol.bmj.com/content/26/4/365
Toxins | Free Full-Text | Cloning and Characterization of a Hybridoma Secreting a 4-(Methylnitrosamino)-1-(3-pyridyl)-1...
... due in part to the presence of tobacco-specific nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone ( ... Schuller, H.M. Nitrosamines as nicotinic receptor ligands. Life Sci. 2007, 80, 2274-2280. [Google Scholar] [CrossRef] ... Figure 4. Relative affinity of mAb 4H2 for nicotine and other tobacco-specific nitrosamines (TSNAs). Competition Enzyme linked ... Figure 4. Relative affinity of mAb 4H2 for nicotine and other tobacco-specific nitrosamines (TSNAs). Competition Enzyme linked ...http://www.mdpi.com/2072-6651/5/3/568/htm
Incremental Lifetime Cancer Risks Computed for Benzo[a]pyrene and Two Tobacco-Specific N-nitrosamines in Mainstream Cigarette...
Cogliano V, Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F. Smokeless tobacco and tobacco-related nitrosamines. Lancet ... NNN and NNK are tobacco-specific nitrosamines that are also classified as human carcinogens by IARC (Cogliano et al., 2004) ... Incremental Lifetime Cancer Risks Computed for Benzo[a]pyrene and Two Tobacco-Specific N-nitrosamines in Mainstream Cigarette ... They found 19 carcinogens (e.g., carcinogenic polycyclic aromatic hydrocarbons, nitrosamines, and hydrazine) with chemical- ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2789685/
BS 7115-1 : Determination of Volatile Nitrosamines in Rubber Teats for Feeding Bottles and Babies Dummies Part 1:...
Determination of Volatile Nitrosamines in Rubber Teats for Feeding Bottles and Babies Dummies Part 1: Dichloromethane ... Nitrosamines are extracted by dichloromethane and after a clean-up process the solution is analysed using gas chromatography. ... Determination of Volatile Nitrosamines in Rubber Teats for Feeding Bottles and Babies Dummies Part 1: Dichloromethane ...https://global.ihs.com/doc_detail.cfm?document_name=BS%207115-1&item_s_key=00212940
Hamster exhibits major differences in organ-specific metabolism of the esophageal carcinogen N-nitrosodiethylamine
Nitrosamines are carcinogens that require metabolic activation by CYP enzymes in order to exert their carcinogenic effect. ... Nitrosamines, N-nitrosodiethylamine, Esophagus, CYP2A, Hamster National Category Pharmaceutical Sciences Identifiers. URN: urn: ... In order to find a mechanistic explanation for the resistance of hamster esophagus for nitrosamines, we have compared the ... suggesting that tissue-specific metabolic activation is involved in hamster esophageal resistance to nitrosamines. We have ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:338148
Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and Areca-derived N-Nitrosamines | Cancer...
Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and Areca-derived N-Nitrosamines Abraham ... The approximate total doses of the nitrosamines (mmol/kg of body weight) in these groups were: NNK, 0.073, 0.17, and 0.68; NNAL ... The observation of benign and malignant tumors of the lung and pancreas of rats treated with the tobacco-specific nitrosamines ... Induction of Lung and Exocrine Pancreas Tumors in F344 Rats by Tobacco-specific and Areca-derived N-Nitrosamines ...http://cancerres.aacrjournals.org/content/48/23/6912.long
"Immunological characterization of diethyl nitrosamine (den) induced mu" by R J. Jamasbi and E H. Perkins
Jamasbi, R J. and Perkins, E H., "Immunological characterization of diethyl nitrosamine (den) induced murine forestomach ... Immunological characterization of diethyl nitrosamine (den) induced murine forestomach squamous cell carcinomas. Abstr. ...https://mouseion.jax.org/ssbb1980/905/
Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry |...
Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry ... Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry ... Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry ...http://tobaccocontrol.bmj.com/content/early/2011/05/20/tc.2010.042192.share
Water quality-Determination of nitrosamine compounds -Gas chromatography
... Article type: Translated 2016-10-01 Font Size:[S M L ... This standard specifies the gas chromatography used to determine nitrosamine compounds in surface water, groundwater, ... and setting standards for the determination of nitrosamine compounds in waters. ...http://english.mep.gov.cn/Resources/standards/water_environment/method_standard2/201608/t20160816_362371.shtml
Nitrosamine - Wikipedia
Most nitrosamines are carcinogenic. Nitrosamines are used in the manufacture of some cosmetics, pesticides, and in most rubber ... Endogenous nitrosamine formation can be inhibited by ascorbic acid. In the case of formation of carcinogenic nitrosamines in ... Nitrosamines from condoms are not thought to be of toxicological significance. In foods, nitrosamines are produced from ... High temperatures, as in frying, can also enhance the formation of nitrosamines. The presence of nitrosamines may be identified ...https://en.wikipedia.org/wiki/Nitrosamine
Nitrosamine | chemical compound | Britannica.com
... nitrosamines): R2NH + HNO2 → R2N−NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a ... Tertiary amines give rise to nitrosamines more slowly; an alkyl… ... aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N−NO. Some nitrosamines are potent cancer-inducing substances ... Nitrosamines can be formed by the nitrosation of nitrite-cured, protein-rich food, such as nitrite-cured meat and fish, in the ...https://www.britannica.com/science/nitrosamine
Mechanism of Organ Specificity in Nitrosamine Carcinogenesis | SpringerLink
The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). The ... These nitrosamines induce high incidences of basal and squamous cell tumours, independent of the route of administration. ... Silinskas, K.C., Zucker, P.F. and Archer, M.C., 1985, Formation of 06-methylguanine in rat liver DNA by nitrosamines does not ... The nitrosamines exhibit remarkable species and tissue specificity in their carcinogenic action (Shank and Magee, 1981). The ...https://link.springer.com/chapter/10.1007/978-1-4684-5134-4_97
Nomination Summary for Tobacco-specific N-nitrosamines (N94322)
... Nomination Summary for Tobacco-specific N-nitrosamines (N94322 ...https://ntp.niehs.nih.gov/testing/noms/search/summary/nm-n94322.html
Methyl(butyroxymethyl)nitrosamine | C6H12N2O3 - PubChem
... nitrosamine , C6H12N2O3 , CID 49929 - structure, chemical names, physical and chemical properties, classification, patents, ...https://pubchem.ncbi.nlm.nih.gov/compound/49929
Blowing smoke: the history of tobacco-specific nitrosamines in Canadian tobacco | Tobacco Control
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center's RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...http://tobaccocontrol.bmj.com/content/26/4/365.info
Nitrosamines in Rubber Industry - Solubility
The first is a review of the published information about the formation of nitrosamines in vulcanisates and also legislative and ... However, the nitrosamine problem has refused to go away and the factors influencing nitrosamine formation remain obscure. ... Nitrosamines in Rubber Industry. Author: B.G. Willoughby and K. Scott ISBN 978-1-84735-246-40. Published: 1997 88 pages, ... In accepting that nitrosamines can be by-products of it's manufacturing chemistry, the rubber industry has already started to ...http://www.chemtec.org/proddetail.php?prod=978-1-84735-246-40&cat=88
Mechanisms of Nitrosamine Bioactivation and Carcinogenesis | Springer for Research & Development
The carcinogenicity of this compound and many other nitrosamines has since been tested by... ... Lu, S. H., Chui, S. X., Yang, W. X., Hu, X. N., Guo, L. P., and Li, F. M., 1991, Relevance of N-nitrosamines to esophageal ... Yang, C. S., Tu, Y. Y, Koop, D. R., and Coon, M. J. 1985, Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 ... Yang, C. S., Smith, T., Ishizaki, H., and Hong, J.-Y., 1991, Enzyme mechanisms in the metabolism of nitrosamines. In O'Neill, I ...https://rd.springer.com/chapter/10.1007/978-1-4757-9480-9_47
Nitrosamines: a review on their prevalence as emerging pollutants and potential remediation options
Whether this is a direct result of the exposure to nitrosamines or whether nitrosamines merely increase an individual's ... SHAPLEY D (1976) Nitrosamines: Scientists on the trail of prime suspect in urban cancer. Sci. 191 268-270. [ Links ]. ... and detecting previously unknown nitrosamines. There are several detection methods for nitrosamines that have been described ... POLO J and CHOW YL (1976) Efficient photolytic degradation of nitrosamines. J. Natl. Cancer Inst. 56 (5) 997-1001. [ Links ]. ...http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1816-79502009000500023&lng=pt&nrm=iso
Tobacco-specific nitrosamines - Wikipedia
Among the tobacco-specific nitrosamines, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most ... The tobacco-specific nitrosamines are present in cigarette smoke and to a lesser degree in "smokeless" tobacco products such as ... These nitrosamine carcinogens are formed from nicotine and related compounds by a nitrosation reaction that occurs during the ... Tobacco-specific nitrosamines (TSNAs) comprise one of the most important groups of carcinogens in tobacco products, ...https://en.wikipedia.org/wiki/Tobacco-specific_nitrosamines
Scandinavian Journal of Work, Environment & Health - N-nitrosamines in the southern Swedish rubber industries - exposure,...
Results The sum of N-nitrosamines ranged from less than the limit of detection to 36 µg/m3 and differed with the vulcanization ... Objectives The aim of this study was twofold: (i) to evaluate the air levels of N-nitrosamines in the Swedish rubber industry ... Conclusions High levels of N-nitrosamines were found and must be lowered considerably in order to decrease the risk of cancer. ... Methods Using adsorption tubes, we collected samples of N-nitrosamines in the breathing zone of 96 rubber workers and analyzed ...https://www.sjweh.fi/show_abstract.php?abstract_id=1323