Dopamine transporter genotype predicts behavioural and neural measures of response inhibition - PubMed
Converging evidence from pharmacology and cognitive neuroscience suggests that response inhibition is instantiated within ... Dopamine transporter genotype predicts behavioural and neural measures of response inhibition T D R Cummins 1 , Z Hawi, J ... Dopamine transporter genotype predicts behavioural and neural measures of response inhibition T D R Cummins et al. Mol ... Influence of DAT1 and COMT variants on neural activation during response inhibition in adolescents with attention-deficit/ ...
Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression - PubMed
... changes in cortical excitation/inhibition (E/I) following ketamine administratio … ... Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression Erik D Fagerholm 1 , ... Fine-tuning neural excitation/inhibition for tailored ketamine use in treatment-resistant depression Erik D Fagerholm et al. ... A We obtain measurements of neural activity in the primary somatosensory cortex-approximate location shown by the red region. B ...
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling. | StemBook
TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration | NIH Research Festival
TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration. Wednesday, September 13 ... Although Eph-ephrin signaling has been implicated in the migration of cranial neural crest (CNC) cells, it is still unclear how ... and inhibition of CNC migration. Our results indicate that TBC1d24 is a critical player in ephrinB2 control of CNC cell ... and mediates a signal affecting contact inhibition of locomotion (CIL) in CNC cells. Moreover, we found that in migrating CNC, ...
Inhibition and Excitation Shape Activity Selection: Effect of Oscillations in a Decision-Making Circuit | Neural Computation |...
We adopt an inhibition motif from neural network theory and propose a dynamical system characterized by nonlinear feedback, ... To gain more insight into neural computations underlying ongoing binary decision-making tasks, we consider a neural circuit ... the variation of inhibition strength and ratio of excitation and inhibition strengths in the decision circuit allows the animal ... Inhibition and Excitation Shape Activity Selection: Effect of Oscillations in a Decision-Making Circuit In Special Collection: ...
Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit...
First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in ... 22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.• ... RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural ... Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hype... ...
Serval - The Neural Bases of Behavioral Inhibition : A Structural Analysis of the Monkey Amygdala and Hippocampus
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers |...
Neural Plast 2016:. 6827135. , PMID: 27069693. , 10.1155/2016/6827135. . Crossref, Medline, Google Scholar ... Nonetheless, it has been argued by the COT that because OPEs appear less potent via AChE inhibition than OPPs, such as ... Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. * ... Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Res 1638(pt A):57-73 ...
Neural Correlates of Motor Vigour and Motor Urgency During Exercise | Sports Medicine
This article reviews the brain structures and neural circuitry underlying the motor system as it pertains to endurance exercise ... The pallidum has extensive inhibitory neural inputs into the motor cortex via the thalamus [30], thus inhibition of the ... This inhibition of the pallidum removes the GABAergic inhibition of the thalamus (2c), thereby releasing excitatory thalamo- ... Rauch, H.G.L., Schönbächler, G. & Noakes, T.D. Neural Correlates of Motor Vigour and Motor Urgency During Exercise. Sports Med ...
Epidural Steroid Injections: Overview, Mechanisms of Radicular Low Back Pain, Rationale for Use of Steroids in Back Pain
Inhibition of PLA2 and inflammation. * Inhibition of neural transmission in nociceptive C fibers ... The radicular LBP caused by spinal stenosis is probably related to the inhibition of normal nerve root vascular flow with ... Early ESIs also carry the theoretical benefit of controlling inflammation at the early stage and of preventing permanent neural ... Multidose vials of Depo-Medrol contain benzyl alcohol, which is potentially toxic when administered locally to neural tissue ...
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. | Cell;150(4...
Shunting inhibition - Wikipedia
Holt GR, Koch C (July 1997). "Shunting inhibition does not have a divisive effect on firing rates". Neural Computation. 9 (5): ... Shunting inhibition, also known as divisive inhibition, is a form of postsynaptic potential inhibition that can be represented ... Shunting inhibition was discovered by Fatt and Katz in 1953. Shunting inhibition is theorized to be a type of gain control ... whereas shunting inhibition can in some cases account for a divisive effect. Some evidence exists that shunting inhibition can ...
Epidural Steroid Injections: Overview, Mechanisms of Radicular Low Back Pain, Rationale for Use of Steroids in Back Pain
Inhibition of PLA2 and inflammation. * Inhibition of neural transmission in nociceptive C fibers ... The radicular LBP caused by spinal stenosis is probably related to the inhibition of normal nerve root vascular flow with ... Early ESIs also carry the theoretical benefit of controlling inflammation at the early stage and of preventing permanent neural ... Multidose vials of Depo-Medrol contain benzyl alcohol, which is potentially toxic when administered locally to neural tissue ...
Tool Uses Light to Inhibit Neural Activity in Mice - National Institute of Mental Health (NIMH)
Credit: Copits, B. et al., (2021). A photoswitchable G protein-coupled receptor-based opsin for presynaptic inhibition. Neuron ... Home , News & Events , Science News , Science News from 2022 , Tool Uses Light to Inhibit Neural Activity in Mice. ... to inhibit the activity of neurons represents a powerful tool that can be used to better understand the workings of neural ... and inhibit neurons is an exciting technological advance that can help researchers better understand the intricacies of neural ...
NIH VideoCast - Refinement of Inhibitory Circuits - New Lessons from the Auditory System
Apoptosis in neural development and disease | ADC Fetal & Neonatal Edition
1997) Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 ... Neural cell death has a pivotal role in both the development and pathophysiology of the nervous system. Two distinct modes of ... Following focal neural injury, apoptosis has been detected in sites distant from the initial damage. After acute spinal cord ... NEURAL CANCERS. An intimate connection between apoptosis and the cell cycle has been shown in carcinogenesis: proto-oncogenes ...
Transcallosal sensorimotor integration: effects of sensory input on cortical projections to the contralateral hand
The neural mechanisms by which the state of anesthesia arises and - Outlook on PI3K/AKT/mTOR inhibition
The neural mechanisms by which the state of anesthesia arises and. * Post author By gasyblog ... The neural mechanisms by which the state of anesthesia arises and dissipates remain unidentified. of induction from those of ... Inhibition of Orexinergic Signaling WILL NOT Alter Induction. We following looked into the functional effects of impaired ... We conclude that we now have important distinctions in the neural substrates mediating induction and introduction. These ...
Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition | Nature Neuroscience
These light-gated channels, named kalium channelrhodopsins, enable robust inhibition of mouse cortical neurons with ... Adesnik, H. & Abdeladim, L. Probing neural codes with two-photon holographic optogenetics. Nat. Neurosci. 24, 1356-1366 (2021). ... Xue, M., Atallah, B. V. & Scanziani, M. Equalizing excitation-inhibition ratios across visual cortical neurons. Nature 511, 596 ... Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation. Nat. Methods 9, 1171-1179 (2012). ...
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Early-phase trial demonstrates shrinkage in pediatric neural tumors | National Institutes of Health (NIH)
Experiments in mice with similar neurofibromas confirmed the inhibition of the MEK protein function in the tumors. Inhibition ... Early-phase trial demonstrates shrinkage in pediatric neural tumors. In an early-phase clinical trial of a new oral drug, ... This indicates that even limited MEK inhibition could cause tumor shrinkage in this disease. ...
Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour<...
Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour. ... Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour. / ... Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive behaviour. ... title = "Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: Implications for ingestive ...
Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability
PAR-22-170: Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical...
Measures relevant to impulsivity such as delay discounting, behavioral inhibition.. *Measures that tap into neural circuit ... However, these measures do not reflect specific neural processes or predict efficacy. Relationships between these measures in ... Include discussion of evidence indicating how the planned measures/manipulations are relevant to key neural circuits/processes ... Behavioral assays without inclusion of measures of associated brain processes and/or neural circuits. ...