*  The role of smooth muscle PPAR gamma in neointima formation - Seth Furgeson
Along with neointima size, we will measure production of chemokines (IL-6, MCP-1, SDF-11, and KC), recruitment of bone marrow- ... The role of smooth muscle PPAR gamma in neointima formation Furgeson, Seth Bernat University of Colorado Denver, Aurora, CO, ... At multiple time points, neointima size will again be measured. All mice used in Aim 3B will have the R26R reporter allele in ... The role of smooth muscle PPAR gamma in neointima formation. Furgeson, Seth Bernat / University of Colorado Denver. $130,446. ...
  http://grantome.com/grant/NIH/K08-HL103774-02
*  Abstract 1150: Angiotensin II Type1 Receptor Blocker Inhibits Neointima Formation by Inhibiting Both Smooth Muscle Cell...
Circulating MNCs, transforming to SM-like cells, contributed to the neointima formation in wire injured arteries. The neointima ... These findings suggest that circulating BM derived SM-like progenitor cells play an important role in the neointima formation, ... It has been shown that angiotensinII receptor blocker (ARB) has an inhibitory effect on neointima formation. Bone marrow- ... AngII increased while CV-11974 decreased neointima formation compared to control none treatment mice(Intima/ Media ratio: 1.5± ...
  http://circ.ahajournals.org/content/114/Suppl_18/II_214.4
*  CaMKII-δ Isoform Regulation of Neointima Formation After Vascular Injury | Arteriosclerosis, Thrombosis, and Vascular Biology
CaMKIIδ2 Silencing Attenuates Neointima Formation. To assess the effects of siRNA-mediated CaMKIIδ2 suppression on neointima ... neointima. Vascular smooth muscle (VSM) cell phenotype modulation and proliferation is a hallmark of disease or injury-induced ... Graph quantifies neointima/medial cross-sectional areas (I/M). D, 14-day adventitial layer cross-sectional areas. Values are ... CaMKII-δ Isoform Regulation of Neointima Formation After Vascular Injury. Suzanne J. House, Harold A. Singer ...
  http://atvb.ahajournals.org/content/28/3/441
*  Neointima - Wikipedia
Neointima can form as a result of vascular surgery such as angioplasty or stent placement. It is actually due to proliferation ... Neointima typically refers to scar tissue that forms within tubular anatomical structures such as blood vessels, as the intima ...
  https://en.wikipedia.org/wiki/Neointima
*  Neointima dictionary definition | neointima defined
neointima definition: Noun (plural neointimas or neointimae) 1. (anatomy) A new layer of arterial intima, especially that ... neointima. Noun (plural neointimas or neointimae). *(anatomy) A new layer of arterial intima, especially that formed on a ... How would you define neointima? Add your definition here.. Please enable JavaScript to view the comments powered by Disqus.. ...
  http://www.yourdictionary.com/neointima
*  Abstract 14668: Epac1 Deficiency Inhibit Neointima Formation After Vascular Injuryin vivo | Circulation
Abstract 14668: Epac1 Deficiency Inhibit Neointima Formation After Vascular Injuryin vivo. Yuko Kato, Utako Yokoyama, Satoshi ... Conclusion:These results suggest that Epac1 deficiency inhibit neointima formation after vascular injury in vivo. ... Abstract 14668: Epac1 Deficiency Inhibit Neointima Formation After Vascular Injuryin vivo ... Abstract 14668: Epac1 Deficiency Inhibit Neointima Formation After Vascular Injuryin vivo ...
  http://circ.ahajournals.org/content/124/Suppl_21/A14668
*  Abstract 20944: Perivascular Progenitor Cells Contribute To Neointima Formation After Wire-induced Injury | Circulation
Abstract 20944: Perivascular Progenitor Cells Contribute To Neointima Formation After Wire-induced Injury. Jan-Marcus Daniel, ... In conclusion, we provide evidence that BMPCs within the neointima rarely co-express markers for vascular cells and do not ... Most of the accumulating EGFP+-cells were identified as inflammatory cells (CD45, CD68), and their number in the neointima ... Abstract 20944: Perivascular Progenitor Cells Contribute To Neointima Formation After Wire-induced Injury ...
  http://circ.ahajournals.org/content/122/Suppl_21/A20944
*  Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury | Circulation
Diet-Induced Hyperhomocysteinemia Exacerbates Neointima Formation in Rat Carotid Arteries After Balloon Injury. Hiroyuki Morita ... Methods and Results-We prepared diet-induced hyperhomocysteinemic rats in which neointima formation after balloon injury to the ... Oral administration of folate, which had a homocysteine-lowering effect, diminished neointima formation induced by moderate ... Conclusions-Diet-induced hyperhomocysteinemia, even mild to moderate, exacerbates neointima formation after denuding injury, ...
  http://circ.ahajournals.org/content/103/1/133
*  Tranilast Suppresses Vascular Chymase Expression and Neointima Formation in Balloon-Injured Dog Carotid Artery | Circulation
The balloon injury elicited remarkable neointima formation (Figure 1A⇓). Tranilast markedly prevented this neointima formation ... A indicates adventitia; M, media; N, neointima. Immunohistochemical labeling for PCNA in neointima of injured common carotid ... adventitial myofibroblasts migrated across the EEL toward the intima and contributed to neointima formation.27 Neointima ... In addition to neointima formation, adventitial thickening occurred in the injured arteries. PCNA-positive cells were found ...
  http://circ.ahajournals.org/content/99/8/1084
*  Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries | Arteriosclerosis, Thrombosis, and Vascular Biology
Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ... Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ... Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ...
  http://atvb.ahajournals.org/content/early/2009/01/22/ATVBAHA.108.183392
*  Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries | Arteriosclerosis, Thrombosis, and Vascular Biology
Animals treated with empty gel exhibited a significant and concentric neointima. In contrast, a markedly diminished neointima ... Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ... Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ... Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries. Kelly J. Peyton, Diana Ensenat, Mohammed A. Azam, Amit N ...
  http://atvb.ahajournals.org/content/29/4/488
*  β3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice | Circulation
β3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice. Eric T. Choi, M. Faisal Khan ... β3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice ... β3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice ... β3-Integrin Mediates Smooth Muscle Cell Accumulation in Neointima After Carotid Ligation in Mice ...
  http://circ.ahajournals.org/content/early/2004/03/08/01.CIR.0000121733.68724.FF
*  Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta...
Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta ... Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta ... Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta ... Adenovirus-Mediated Extracellular Superoxide Dismutase Gene Therapy Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta ...
  http://circ.ahajournals.org/content/early/2002/09/16/01.CIR.0000031331.05368.9D
*  Deficiency of the NR4A Neuron-Derived Orphan Receptor-1 Attenuates Neointima Formation After Vascular Injury | Circulation
Figure 2. Neointima formation is decreased in NOR1-deficient mice. Endothelial denudation injury was performed in NOR1+/+ (n=9 ... In the vascular system, NOR1 is expressed in atherosclerotic lesions and in the neointima after vascular injury.7-9 At the ... As depicted in Figure 1A, all 3 members of the NR4A subfamily were expressed in the neointima of NOR1+/+ mice. In contrast, ... NOR1 Deficiency Attenuates Neointima Formation After Vascular Injury. The profound increase in NOR1 expression during vascular ...
  http://circ.ahajournals.org/content/119/4/577
*  BuMA OCT Study(A Comparative Evaluation of the Extent of Neointima Formation at 3 Months After Implantation Using OCT) - Full...
BuMA OCT Study(A Comparative Evaluation of the Extent of Neointima Formation at 3 Months After Implantation Using OCT). The ... The objective of this study is a comparative evaluation of BuMA stent and of EXCEL stent in terms of the extent of neointima ... BuMA OCT Study(A Comparative Evaluation of BuMA Stent and of EXCEL Stent in Terms of the Extent of Neointima Formation at 3 ... Neointima. Cardiovascular Diseases. Pathologic Processes. Chest Pain. Pain. Neurologic Manifestations. Nervous System Diseases ...
  https://clinicaltrials.gov/ct2/show/NCT01752582?recr=Open&cond=%22Angina+Pectoris%22&rank=8
*  Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured...
Finally, neointima formation in a model of rat carotid artery balloon injury was significantly attenuated after treatment with ... These data demonstrate that LXR ligands inhibit VSMC proliferation and neointima formation after balloon injury and suggest ... Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured ...
  https://www.ncbi.nlm.nih.gov/pubmed/15539633
*  Kallikrein Gene Delivery Inhibits Vascular Smooth Muscle Cell Growth and Neointima Formation in the Rat Artery After Balloon...
Role of kinins and nitric oxide in the effects of ACE inhibition on neointima formation. Circ Res. 1993;72:1202-1210. ... Inhibition of neointima formation in rat carotid artery after adenovirus-mediated kallikrein gene delivery. A through D show ... Smooth-muscle-cell proliferation and differentiation in neointima formation and vascular restenosis. Clin Sci. 1994;87:467-479. ... The lumen, neointima, media areas were measured by use of the NIH Image 1.60 software package. ...
  http://hyper.ahajournals.org/content/34/2/164
*  Effect of Selective or Combined Inhibition of Integrins αIIbβ3 and αvβ3 on Thrombosis and Neointima After Oversized Porcine...
... processes thought to be central to neointima formation,4 and antagonists of these mitogens reduce neointima formation.5 6 The ... αvβ3 antagonism has been shown to reduce neointima in other studies,13 14 15 17 although agent specificity has varied, and ... The reduction in neointima with αIIbβ3 antagonists appears to be related to a reduction in thrombus formation at the site of ... αvβ3 also has effects on proliferation25 and apoptosis.17 27 Inhibition of these processes may affect the amount of neointima ...
  http://circ.ahajournals.org/content/103/8/1135
*  Regional Expression of Natriuretic Peptide Receptors During the Formation of Arterial Neointima in the Rabbit | Circulation...
Neointima. Specific binding of [125I-Tyr0]CNP-(1-22) occurred throughout the neointima but tended to be most concentrated near ... Development of Neointima. The neointima developed as originally described27 for this preparation. Control arteries had no cells ... occurred in 7-day neointima, and 34±10/mm2 were present in neointima at 20 days (Fig 1⇓). ... NPR-C-like receptors also occur on the neointima. These findings are important because both NPR-B6 7 8 and NPR-C-like receptors ...
  http://circres.ahajournals.org/content/77/5/906
*  Curcumin Inhibits Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Function and Injury-Induced Neointima...
Neointima-induced vessel stenosis after percutaneous angioplasty is a major clinical complication, occurring in 30% to 50% of ... Carotid artery neointima formation was significantly attenuated by perivascular curcumin compared with vehicle controls 14 days ... Curcumin Inhibits Neointima Formation. Representative photomicrographs of balloon-injured, perfusion-fixed left carotid artery ... Curcumin significantly attenuated neointima formation, cell proliferation, collagen synthesis, and the overexpression of PDGF ...
  http://atvb.ahajournals.org/content/26/1/85
*  Increased Neointima Formation in Cysteine-Rich Protein 2-Deficient Mice in Response to Vascular Injury | Circulation Research
Characterization of the neointima revealed that WT (n=8) and Csrp2−/− (n=8) neointima had similar cell densities (19.6±0.5 and ... Increased Neointima Formation in Cysteine-Rich Protein 2-Deficient Mice in Response to Vascular Injury. Jiao Wei, Terri E. ... In Csrp2−/− mice (n=9) (Figure 6F), we observed 7.1±2.7% of BrdUrd incorporation in the neointima (P=0.63 versus WT) and 6.0± ... The cells observed in the neointima at the 4-day time point might reflect migrated rather than proliferating cells.6,7 En face ...
  http://circres.ahajournals.org/content/97/12/1323
*  B-Myb Represses Vascular Smooth Muscle Cell Collagen Gene Expression and Inhibits Neointima Formation After Arterial Injury |...
Figure 3. Neointima formation is inhibited in B-myb transgenic mice. Four weeks after endothelial denudation or sham surgery of ... As shown previously,29 the typical lesion of a WT mouse displayed a large neointima rich in matrix (blue-green color) and SMCs ... Figure 4. The formation of a neointima and luminal narrowing are reduced in B-myb transgenic mice. Averages of the ratio of the ... B-Myb Represses Vascular Smooth Muscle Cell Collagen Gene Expression and Inhibits Neointima Formation After Arterial Injury. ...
  http://atvb.ahajournals.org/content/24/9/1608
*  Involvement of the CD1d-Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury | Circulation Research
Involvement of the CD1d-Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury. Åsa Ström, Maria Wigren, ... Involvement of the CD1d-Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury ... Involvement of the CD1d-Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury ... Involvement of the CD1d-Natural Killer T Cell Pathway in Neointima Formation After Vascular Injury ...
  http://circres.ahajournals.org/content/early/2007/09/20/CIRCRESAHA.107.160705