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*  KAKEN - Research Projects | Generation of disease model mice by the alteration of transcription factors regulating immune...
Publications] Liu J.et al: 'Calcineurin dependent nuclear translocation of a murine transcription factor NFATc:molecular ... Publications] Liu,J: 'Calcineurin dependent nuclear translocation of a murine transcription factor NFATc:molecular clonning and ... Molecular cloning and functional characterization of murine cDNA encloning transcription factor NFATc.' Biochem.Biophys.Res. ... Molecular cloning and functional characterization of murine cDNA encloning transcription factor NFATc.' Biochem.Biophys.Res. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557024/
*  Cloning of a novel inhibitory adaptor, SLAP-2. (A) Huma | Open-i
NFATC Transcription Factors. *Phosphorylation. *Promoter Regions, Genetic. *Receptor Protein-Tyrosine Kinases/biosynthesis/ ... nuclear factor of activated T cells (NFAT) promoter activation and calcium influx. Signaling induced by phorbol myristate ... nuclear factor of activated T cells (NFAT) promoter activation and calcium influx. Signaling induced by phorbol myristate ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195979_010067f2b&req=4
*  KAKEN - Research Projects | Analyses of cytokine gene expression by helper T cell subsets : role of NFAT-mediated gene...
Publications] Liu,J.,et al.: 'Calcineurin dependent nuclear translocation of a murine transcription factor NFATc:molecular ... Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc.' Biochem.Biophys.Res. ... Extensive studies of this region lead to discovery of NFIL-5CLEO and NFIL-5C, and GATA-3 or related transcription factor was ... We have isolated human and murine genes of NFAT, a transcription factor that plays a critical role in transcriptional induction ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457103/
*  Laser-regulated gene expression in HeLa cells.(a). TNF- | Open-i
NFATC Transcription Factors/genetics/metabolism. *Time Factors. *Transcription Factors/genetics/metabolism. *Tumor Necrosis ... Intrinsic or exogenous genes can be activated by a Ca(2+)-sensitive transcription factor nuclear factor of activated T cells ( ... Intrinsic or exogenous genes can be activated by a Ca(2+)-sensitive transcription factor nuclear factor of activated T cells ( ... sensitive transcription factor nuclear factor of activated T cells (NFAT) driven by a short flash of femtosecond-laser ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4061554_srep05346-f2&req=4
*  Wnt-5a promoted β-catenin degradation through a mechan | Open-i
NFATC Transcription Factors. *Nuclear Proteins/metabolism. *Transcription Factors/metabolism. *Ubiquitin-Protein Ligases ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172823_200303158f2&req=4
*  Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) ELISA Kits
Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional ... Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that ... COUP transcription factor 3 , EAR-2 , avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2 , COUPg , V-erbA- ... Nuclear Transcription Factor Y, gamma ELISA Kits * Nuclear Transcription Factor, X-Box Binding 1 ELISA Kits ...
  http://www.antikoerper-online.de/nuclear-receptor-transcription-pathway-pathway-23/nr2f6-elisa-kit-9624/
*  Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular...
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392,182 -186. ... The transcription factor NF-ATc is essential for cardiac valve formation. Nature 392,186 -190. ... Primer - GATA transcription factors in development and disease. Mathieu Tremblay, Oraly Sanchez-Ferras and Maxime Bouchard ... The Ap2α transcription factor, which is expressed in neural crest and ectoderm, was detected with a mouse monoclonal anti-AP2α- ...
  http://dev.biologists.org/content/130/25/6361?ijkey=f490b5bc7c4f5edbe0106cd2cb753b1c16debba4&keytype2=tf_ipsecsha
*  Frontiers | NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses | Immunology
Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte ... Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte ... Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 392:182-6. doi:10.1038/ ... Nuclear factor of activated T cells (NFAT) was originally described as a transcription factor inducing the expression of ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00411/full
*  Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development |...
1998). The transcription factor NFAT-c is essential for cardiac valve formation. Nature 392, 186-190. doi:10.1038/32426. ... growth factors (Macgrogan et al., 2011) and various transcription factors. One such transcription factor is nuclear factor of ... 1998). Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186. doi:10.1038/ ... 2003). An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic ...
  http://dev.biologists.org/content/143/3/473
*  Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and...
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature. 1998;392:182-186. [PubMed] ... The transcription factor NFATc is implicated in semilunar valve formation,36, 37 whereas mice heterozygous for eNos mutation ... The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998;392:186-190. [PubMed] ... Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2916734/?lang=en-ca
*  Differential function of genes regulated by VEGF-NFATc1 signaling pathway in migration of pulmonary valve endothelial cells
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature. 1998;392:182-186. [PubMed] ... The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998;392:186-190. [PubMed] ... The nuclear factor of activated T cells (NFAT) family of transcription factors was first identified in immune cells (3). There ... nuclear factor in activated T cells. VEGF. vascular endothelial growth factor. TGF. transforming growth factor. EMT. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2810463/
*  "Integration of calcium and cyclic AMP signaling pathways by 14-3-3" by Chi-Wing Chow and Roger J. Davis
In contrast, NFAT phosphorylation caused by cAMP increased 14-3-3 binding and reduced NFAT transcription activity. The ... transcription activity at the interleukin-2 promoter is negatively regulated by cyclic AMP (cAMP). This effect of cAMP is ... Calcium-stimulated nuclear factor of activated T cells (NFAT) ... NFATC Transcription Factors; Nuclear Localization Signals; * ... Calcium-stimulated nuclear factor of activated T cells (NFAT) transcription activity at the interleukin-2 promoter is ...
  https://escholarship.umassmed.edu/oapubs/1440/
*  "3,4-Dichloropropionanilide (DCPA) inhibits T-cell activation by alteri" by Tricia L. Lewis, Kathleen M. Brundage et al.
This alteration in [Ca(2+)](i), when exposed to DCPA, significantly reduces nuclear levels of nuclear factor of activated T ... NFATC Transcription Factors; Protein Transport; Spectrometry, Fluorescence; T-Lymphocytes; Thapsigargin ... This alteration in [Ca(2+)](i), when exposed to DCPA, significantly reduces nuclear levels of nuclear factor of activated T ...
  https://escholarship.umassmed.edu/gsbs_sp/1454/
*  "Temporal regulation of nuclear factor one occupancy by calcineurin/NFA" by Baojin Ding, Wei Wang et al.
Conversely, inhibition of the CaN/NFATc pathway in CGNs maturing under physiological nondepolarizing conditions upregulated the ... Using microarrays, we have identified a nuclear factor I (NFI)-regulated temporal switch program linked to dendrite formation ... NFATc) pathway and promotion of late-gene occupancy by NFATc4, and these mechanisms inhibited dendritogenesis. ... blocked NFI temporal occupancy of late-expressed genes and the NFI switch program via activation of the CaN/nuclear factor of ...
  https://escholarship.umassmed.edu/faculty_pubs/185/
*  p38 Alternative activation is required for TCR-induced | Open-i
NFATC Transcription Factors/genetics/immunology/metabolism. *Psoriasis/immunology/metabolism/radiotherapy. *Reverse ... we show that alternatively but not MAPK cascade-activated p38 up-regulates the transcription factors NFATc1 and IRF4, which are ... we show that alternatively but not MAPK cascade-activated p38 up-regulates the transcription factors NFATc1 and IRF4, which are ... CsA inhibits the expression of the transcription factor IRF4, and Th17 development is blocked in IRF4 knockout mice (Cristillo ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4042639_JEM_20131917_Fig1&req=4
*  Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end | SpringerLink
A similar mechanism underlies the regulated expression of the transcription factor NF-ATc during T cell differentiation [27]. ... 1), transcription initiation, the kinetics of transcription itself as well as transcription termination can control PAS choice ... Martincic K, Alkan SA, Cheatle A, Borghesi L, Milcarek C (2009) Transcription elongation factor ELL2 directs immunoglobulin ... Conversely, splicing factors associating with the 3′ terminal intron interact with downstream polyadenylation factors to ...
  https://link.springer.com/article/10.1007%2Fs00424-016-1828-3
*  PPP3CA | definition of PPP3CA by Medical dictionary
Calcineurin activates T cells via transcription factor NFATc (Nuclear Factor of Activated T cell, cytoplasmic) by ... Activated NFATc is translocated into the nucleus, where it upregulates IL-2 expression, and, by extension, the T cell response ... A calcium-dependent serine-threonine phosphatase involved in T-cell signaling transcription; the reaction cascade in which it ... A calcium-dependent serine-threonine phosphatase involved in T-cell signaling transcription; the target of cyclosporine ...
  https://medical-dictionary.thefreedictionary.com/PPP3CA
*  Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered...
Animals; Cluster Analysis; Genetic Variation; Genotype; Humans; Lymphocryptovirus; NF-kappa B; NFATC Transcription Factors; ... In contrast, only 3 of 5 were able to activate NFAT (nuclear factor of activated T cells); chimpanzee and orangutan BILF1 ... receptors exhibited constitutive signaling activity via G protein Gαi and induced activation of the NF-κB transcription factor ...
  http://www.forskningsdatabasen.dk/en/catalog/2262599620
*  Plus it
1998 The transcription factor NF‐ATc is essential for cardiac valve formation. Nature; 392:186-190. ... 2008 Genetic factors in congenital heart malformation. Clin. Genet.; 73:516-527. ... 2004). Significant progress has been made over the past decade in elucidating genetic and environmental factors causing these ... 2000 Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development ...
  http://physreports.physiology.org/content/1/6/e00143
*  Superoxide Dismutase 1 In Vivo Ameliorates Maternal Diabetes Mellitus-Induced Apoptosis and Heart Defects Through Restoration...
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature. 1998;392:182-186. ... interacts with the T-cell-specific factor/lymphoid enhancer-binding factor transcription factor to induce the transcription of ... is associated with transcription factors such as activator protein 1 and myocyte enhancer factor 2 to induce gene transcription ... Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 ...
  http://circgenetics.ahajournals.org/content/8/5/665
*  Genome-Wide Microarray Analyses Identify the Protein C Receptor as a Novel Calcineurin/Nuclear Factor of Activated T Cells...
To our knowledge, NFATc is the first transcription factor that has been validated to transcriptionally regulate PROCR in any ... Objective-Calcineurin (Cn) and the nuclear factor of activated T cells (NFAT) family of transcription factors are critical in ... Although the NFAT transcription factor was originally described in T cells, NFAT signaling has been shown to exist in almost ... 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem. 2000;43:2975-2981. ...
  http://atvb.ahajournals.org/content/31/11/2665
*  a) Activated Ras or Raf are sufficient for Elk-1 activ | Open-i
NFATC Transcription Factors. *Polymerase Chain Reaction. *Protein-Serine-Threonine Kinases/metabolism. *Proto-Oncogene Proteins ... The transcription factors Elk-1, an immediate early gene regulator and the nuclear factor of activated T cells (NFAT), in the ... The transcription factors Elk-1, an immediate early gene regulator and the nuclear factor of activated T cells (NFAT), in the ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2196099_JEM.turner2bc&req=4
*  "Biochemical interactions integrating Itk with the T cell receptor-init" by Stephen C. Bunnell, Maximilian Diehn et al.
NFATC Transcription Factors; *Nuclear Proteins; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Conformation; ... Time Factors; Transcription Factors; Type C Phospholipases; src Homology Domains ...
  https://escholarship.umassmed.edu/oapubs/762/
*  miR-185 negatively regulates the activity of CaMKIIδ i | Open-i
The activity of Nuclear Factor of Activated T-cell (NFAT) and calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) ... The activity of Nuclear Factor of Activated T-cell (NFAT) and calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4358957_pone.0122509.g005&req=4
*  Untersuchung der molekularen Mechanismen einer EGFR-Blockade induzierten Wachstumshemmung im Pankreaskarzinom
NFATC transcription factors [MeSH]. Pancreatic neoplasms [MeSH]. Receptor, epidermal growth factor [MeSH] ... The transcription factor NFATc2 could be identified as a major regulator of cell cycle progression and proliferation in ...
  https://oparu.uni-ulm.de/xmlui/handle/123456789/2087