*  MYXV treatment of normal and leukemic HSPCs in vitro(A) | Open-i
Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor ... Myxoma virus targets primary human leukemic stem and progenitor cells while sparing normal hematopoietic stem and progenitor ... of AML cells were infected with the virus, which was significantly higher in comparison to normal BM-derived MNCs (p,0.05; ... of AML cells were infected with the virus, which was significantly higher in comparison to normal BM-derived MNCs (p,0.05; ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3277946_nihms142036f1&req=4
*  Targeting Human Medulloblastoma: Oncolytic Virotherapy with Myxoma Virus Is Enhanced by Rapamycin | Cancer Research
I.t. administration of myxoma virus prolongs survival in Daoy tumor-bearing mice. To determine the efficacy of myxoma virus ... which may explain its ability to enhance myxoma virus oncolysis. These observations suggest that myxoma virus may be an ... Arrows, GFP virus expression. Bottom, immunohistochemical staining for myxoma virus protein M-T7. Arrow, brown staining. ... Viruses. Two derivatives of myxoma virus (strain Lausanne), created by intergenic insertion of a marker cassette, were used for ...
  http://cancerres.aacrjournals.org/content/67/18/8818
*  Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus | Cancer Research
Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus. Franz J. Zemp, Brienne A. ... Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus ... Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus ... Cellular Factors Promoting Resistance to Effective Treatment of Glioma with Oncolytic Myxoma Virus ...
  http://cancerres.aacrjournals.org/content/early/2014/12/05/0008-5472.CAN-14-0876
*  Myxoma virus - Wikipedia
The myxoma virus matures naturally by budding through the surface membrane of the host cell. The myxoma virus has multiple ... Myxoma virus is a virus that causes myxomatosis in rabbits and was used as a pest control in Australia. Virions are enveloped, ... Myxoma virus. In: ICTVdB-The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA. ... In addition, the myxoma virus utilizes the Serp-2 viral gene to inhibit a variety of other caspases. The Serp-2 gene is also ...
  https://en.wikipedia.org/wiki/Myxoma_virus
*  "Exploring Myxoma Virus Oncolytic Virotherapy in Combination with Carbo" by Milani Sivapragasam
In an in vitro model of EOC metastasis, we have recently demonstrated that Myxoma virus (MYXV) effectively kills adherent EOC ... Administration of different sequential regimens of carboplatin and virus does not enhance sensitivity to oncolysis of EOC cell ... In an in vitro model of EOC metastasis, we have recently demonstrated that Myxoma virus (MYXV) effectively kills adherent EOC ... Exploring Myxoma Virus Oncolytic Virotherapy in Combination with Carboplatin for the Treatment of Epithelial Ovarian Cancer ...
  https://ir.lib.uwo.ca/ungradawards_2014/10/
*  Serological response against myxoma virus and rabbit hemorrhagic disease virus in European wild rabbits using commercial...
Serological response against myxoma virus and rabbit hemorrhagic disease virus in European wild rabbits using commercial ... We carried out an experimental study to determine the serological response against myxoma virus (MV) and rabbit hemorrhagic ... disease virus (RHDV) in wild rabbits using commercial vaccines. Seroconversion against MV ranged between 72.7% and 97.2% in ...
  http://onlinelibrary.wiley.com/doi/10.1002/jwmg.207/abstract?globalMessage=0
*  AKC Canine Health Foundation
Since MYXV only grows in abnormal cells, virus replication in healthy tissue should not occur. The lab has tested several ... This project is designed to determine if the poxvirus, myxoma virus (MYXV), can be used to eliminate cancer cells and prevent ... Home > Research > Research Portfolio > Myxoma virus oncolytic therapy in mouse models of canine cancer ... 01502-A: Myxoma virus oncolytic therapy in mouse models of canine cancer. Grant Status: Closed ...
  http://www.akcchf.org/research/research-portfolio/1502.html
*  IJMS | Free Full-Text | The Role of F-Box Proteins during Viral Infection | HTML
This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions. ... Several discoveries have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete ... The Myxoma virus M150 [47] and the Cowpox virus CP77 [48] proteins, for example, interact with the NFκB subunit p65, inhibiting ... Variola virus: Cowpox virus, Monkeypox virus, and Ectromelia virus. G1R. Interacts with cullin and with p105 subunit of NFκB, ...
  http://www.mdpi.com/1422-0067/14/2/4030/htm
*  CSIRO PUBLISHING | Reproduction, Fertility and Development
R96067Progress towards using recombinant myxoma virus as a vector for fertility control in rabbits. A. J. Robinson, R. Jackson ... R96074Selection of antigens for use in a virus-vectored immunocontraceptive vaccine: PH-20 as a case study. Michael K. Holland ...
  http://www.publish.csiro.au/RD/issue/203/
*  Decade - 1950s
It is caused by the Myxoma virus. First observed in Uruguay in the late 1800s. It was introduced illegally to Egypt in 1842 and ...
  http://www.answers.com/Q/FAQ/5385
*  Viruses up their game in arms race with immune system | EurekAlert! Science News
This example of an evolutionary arms race highlights the potential for escalating virus virulence and host resistance to ... produce more dangerous viruses with implications for agriculture and human vaccination, where resistance to viruses is ... Myxoma virus -- introduced to control the rabbit population in Australia in 1950 -- has developed a deadly ability to suppress ... Myxoma virus stained with fluorescent dye in rabbit cells. In an evolutionary arms race with its host rabbits, the virus has ...
  https://www.eurekalert.org/pub_releases/2017-08/ps-vut080917.php
*  Plus it
Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors invivo. Mol Ther 2008;16:52. ... Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity. PLoS ... Myxoma virus: propagation, purification, quantification, and storage. Curr Protoc Microbiol 2010; Chapter 14, Unit 14A1. ... Role of the serine-threonine kinase PAK-1 in myxoma virus replication. J Virol 2003;77:5877. ...
  http://cancerres.aacrjournals.org/content/77/11/2952
*  Myxomatosis vaccination of pet rabbits | Australian Veterinary Association
Use of live virus vaccines have the potential to spread the attenuated myxoma virus into the wild rabbit population potentially ... Today, myxoma virus is widespread throughout Australia. It can be spread by direct contact with infected rabbits but it is most ... Because of the extent of the pest rabbit problem, the myxoma virus, a member of the Poxviridae, was released in December 1950, ... Adams MM, Van Leeuwen BH, McFadden G, Kerr P. Construction and testing of a novel host range defective myxoma virus vaccine ...
  http://www.ava.com.au/node/26820
*  Leporipoxvirus - Wikipedia
Hare fibroma virus Myxoma virus Rabbit fibroma virus Squirrel fibroma virus Viruses in Leporipoxvirus are enveloped, with brick ... There are currently four species in this genus including the type species Myxoma virus. Diseases associated with this genus ... The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another ... This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or ...
  https://en.wikipedia.org/wiki/Leporipoxvirus
*  Caring for Rabbits - Edgar's Mission Farm Sanctuary
Myxomatosis is a disease caused by the myxoma virus. It was introduced into Australia in the 1950's to control the population ... Calici Virus Vaccination. This is needed annually. It would be wise to have your veterinarian give your rabbit a complete check ... Myxomatosis is spread by mosquitos, who are not affected the disease themselves but carry the virus after feeding on an ...
  https://www.edgarsmission.org.au/caring-for-rabbits/
*  Immunocontraception - Wikipedia
... using myxoma virus-vectored immunocontraception". Wildl Res. 34 (7): 511-522. doi:10.1071/wr06167. Jackson, RJ; DJ Maguire; LA ... in Australia by engineering rabbit zona pellucida glycoproteins into a recombinant myxoma virus. This approach has induced ... "Immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3". Biol Reprod ... Research in these countries has therefore focused on genetically modifying viruses or microorganisms that infect the unwanted ...
  https://en.wikipedia.org/wiki/Immunocontraception
*  Genetically modified organism - Wikipedia
The same myxoma virus was genetically modified to lower fertility in the Australian rabbit population.[124] ... Virus. Main article: Genetically modified virus. In 2017 researchers genetically modified a virus to express spinach defensin ... In both cases, the genetically modified organism used was a myxoma virus, but for opposite purposes: to protect the endangered ... the myxoma virus was genetically modified to immunize the rabbits. The European wild rabbit population in Australia faces the ...
  https://en.wikipedia.org/wiki/Transgenic_animal
*  Rabbits 1, Virus 1: Evolution of viral virulence
Typically, viruses that rapidly kill their host have a very short history, as they rapidly run out of places to reproduce.' I'm ... Myxomavirus is the type specimen. It also fits with the observation that some of the most virulent virus infections we see are ... Myxomavirus was introduced there in the early 1950s as a biological control agent for the rabbit plague. At first, the virus ... While on the one hand the rabbits were obviously selected for resistance to myxomavirus,3 the virus also did in fact evolve to ...
  http://www.iayork.com/MysteryRays/2007/08/26/rabbits-1-virus-1-evolution-of-viral-virulence/
*  Macquarie Island: ecological progress with challenges ahead - The Science Show - ABC Radio National (Australian Broadcasting...
Rabbits, to an extent, were controlled by the myxoma virus but the effectiveness gradually declined. The population really ... in a way because I have seen Macquarie over the last 12 years or so go from quite good vegetation as a result of myxoma virus ...
  http://www.abc.net.au/radionational/programs/scienceshow/macquarie-island3a-ecological-progress-with-challenges-ahead/4203344
*  Myxomatosis - definition of myxomatosis by The Free Dictionary
myx·o·ma·to·ses 1. A highly infectious, usually fatal disease of rabbits that is caused by a pox virus and is characterized by ... Genome sequence of SG33 strain and recombination between wild-type and vaccine myxoma viruses ... usually fatal disease of rabbits that is caused by a pox virus and is characterized by many skin tumors similar to myxomas. ... 1. a condition characterized by the presence of many myxomas. 2. a highly infectious viral disease of rabbits, artificially ...
  https://www.thefreedictionary.com/myxomatosis
*  Virokine - Wikipedia
The first identified virokine was an epidermal growth factor-like protein found in myxoma viruses. Much of the early work on ... Virokines are proteins encoded by some large DNA viruses that are secreted by the host cell and serve to evade the host's ... Virokines in this family are thought to have been acquired from host genes and from other viruses through horizontal gene ... Similar observations have been made in the herpesvirus family; for example, Epstein-Barr virus encodes an interleukin protein ...
  https://en.wikipedia.org/wiki/Virokine
*  Biology-Online • View topic - The Fiber Disease
Myxoma virus Brush rabbit/Brazilian rabbit European rabbit 1950s [3] Ebola virus Unknown Humans 1977 [54] FPLV/CPV Cats Dogs ... Nipah virus Bats Pigs and humans 1999 [57] SARS coronavirus Palm civets Humans 2003 [58] Monkeypox virus Prairie dogs Humans ... Canine/Phocine distemper virus Canids Seals 1988 [56] Hendra virus Bats Horses and humans 1994 [57] Australian bat lyssavirus ... virus (VEEV) [25]. Table 1. Examples of pathogens considered to have emerged via a species jump Pathogen Original host New host ...
  http://www.biology-online.org/biology-forum/about1958.html?hilit=Hair%20preparations&start=2772
*  Viral TNF Inhibitors as Potential Therapeutics | SpringerLink
Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced ... Xu X, Nash P, McFadden G. Myxoma virus expresses a TNF receptor homolog with two distinct functions. Virus Genes 2000; 21(1-2): ... Hepatitis C virus NS5A protein protects against TNF-α mediated apoptotic cell death. Virus Res 2000; 67(2):173-178.CrossRef ... Schreiber M, Sedger L, McFadden G. Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, ...
  https://link.springer.com/chapter/10.1007/978-1-4419-1601-3_5
*  Myxomatosis - Wikipedia
Its active ingredient is a live myxoma-vectored RHD virus strain 009 and it offers a duration of immunity of 1 year against ... Myxomatosis (sometimes shortened to "myxo" or "myxy") is a disease that affects rabbits, caused by the myxoma virus. It was ... The myxomatosis virus does not replicate in these insect hosts, but can be physically carried by an insect's mouthparts, i.e. ... In Australia, the virus was first field-tested for population control in 1938. A full-scale release was performed in 1950. It ...
  https://en.wikipedia.org/wiki/Myxomatosis