Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo | Nature Communications
How the cardiac myocyte epigenome is rearranged during development, postnatal maturation and disease is not well understood. ... Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. We find ... Here, the authors investigate the human cardiac myocyte epigenome during development and chronic heart failure and identify ... Notably, cis-regulatory regions in cardiac myocytes are significantly enriched for cardiovascular disease-associated variants. ...
Systematic analysis of different pluripotent stem cell-derived cardiac myocytes as potential testing model for...
Systematic analysis of different pluripotent stem cell-derived cardiac myocytes as potential testing model for ... Introduction: Stem cell-derived cardiac myocytes are potential sources for testing cardiocytoprotective molecules against ... Results: After analysis of full embryoid bodies (EBs) and cardiac marker (VCAM and cardiac troponin I) positive cells of three ... line-derived cardiac myocytes at two different developmental stages. Cell viability in simulated ischemia/reperfusion (SI/R)- ...
A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures
This is the first demonstration that the combination of the current hypercholesterolemic medium and SI/R in cardiac myocytes ... HiChol rat cardiac myocytes showed reduction of cell viability and increased oxidative stress, which were further aggravated by ... Methods: Cardiac myocytes isolated from neonatal or adult rat hearts were cultured in control or in three different ... Results: Neonatal cardiac myocytes took up cholesterol from the different hiChol media at a concentration-dependent manner. In ...
Primary Culture Cardiac Myocytes from Chicken Embryo | www.multichannelsystems.com
This application note describes solutions for studying conduction velocity, rhythmic/arrhythmic behavior, and QT-prolongation in acute heart preparations.. ...
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation....
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. ... Sudden cardiac death due to abnormal heart rhythm kills 400,000-460,000 Americans each year. To identify genes that regulate ... The mutant mice have cardiac arrhythmias and die prematurely. We also found that a common variant of AKAP10 in humans (646V, 40 ... In both heterozygous and homozygous mutant mice derived from these mESCs, the same Akap10 disruption increases the cardiac ...
Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes | Molecular Pharmacology
Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes. Stéphanie C. M. Choisy, Jules C. Hancox, ... Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes. Stéphanie C. M. Choisy, Jules C. Hancox, ... Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes. Stéphanie C. M. Choisy, Jules C. Hancox, ... Evidence for a Novel K+ Channel Modulated by α1A-Adrenoceptors in Cardiac Myocytes ...
Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes - Open...
Canard analysis reveals why a large Ca<sup>2+</sup> window current promotes early afterdepolarizations in cardiac...
Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes. In: PLoS ... Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes. / Kimrey, ... Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes. ... title = "Canard analysis reveals why a large Ca2+ window current promotes early afterdepolarizations in cardiac myocytes", ...
Nuclear Calcium in Cardiac Myocytes
Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes | Journal of...
The bulk of evidence for Ins(1,4,5)P3 causing Ca2+ release in cardiac myocytes has derived from studies of atrial myocytes, ... Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes Andrew Proven, ... Several laboratories have demonstrated the expression of Ins(1,4,5)P3R mRNA and functional protein in cardiac myocytes from ... ET-1 is secreted by endocardial endothelial cells, as well as being released by cardiac myocytes themselves. Both ET-1 receptor ...
Small Amounts of α-Myosin Heavy Chain Isoform Expression Significantly Increase Power Output of Rat Cardiac Myocyte Fragments
To this end, power output was measured in rat cardiac myocyte fragments that expressed {approx}12% {alpha}-MyHC and in myocyte ... Small Amounts of α-Myosin Heavy Chain Isoform Expression Significantly Increase Power Output of Rat Cardiac Myocyte Fragments. ... Myocyte fragments expressing {approx}12% {alpha}-MyHC developed {approx}52% greater peak normalized power output than myocyte ... These results indicate that small amounts of {alpha}-MyHC expression significantly augment myocyte power output. ...
DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes - Galaxy Community Hub
Remarkably, dynamic CpG and non-CpG methylation in cardiac myocytes is confined to A compartments. Furthermore, genetic ... Hein group for their new paper entiteled DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes ... ablation or reduction of DNA methylation in embryonic stem cells or cardiac myocytes, respectively, does not alter genome-wide ... of A/B compartments precedes and defines DNA methylation signatures during differentiation and maturation of cardiac myocytes. ...
Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass<...
Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass. Adam K. McDiarmid, Peter P. Swoboda, Bara ... Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass. / McDiarmid, Adam K.; Swoboda, Peter P.; ... Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass. Circulation: Cardiovascular Imaging. 2016 Apr 1 ... Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass. In: Circulation: Cardiovascular Imaging. 2016 ...
Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. - CentAUR
Clerk, A. and Sugden, P. H. (2004) Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. ... The extracellular signal-regulated kinases 1/2 (ERK1/2) are particularly implicated in the growth response of cardiac myocytes ... Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. ... to the nucleus and the regulation of transcription factor activity associated with ERK1/2 activation in cardiac myocytes are ...
Other Pharmacology
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TNF-mediated apoptosis in cardiac myocytes - TNF inhibitors
B) CVAK104-kinase-domain-YFP was transiently expressed in HeLa cells. GUID:?0547BAF1-0F6D-4FDF-9666-90D5FE4915DD Video S1: CVAK104-GFP expressed in HeLa cells (12). tra0008-0893_8_7cfig2.mov (3.5M) GUID:?F93FFB18-D162-45B3-A752-0D2E1FEB1993 Video S2: CVAK104-GFP expressed in HeLa cells depleted of clathrin heavy chain (12). tra0008-0893_8_7cfig3.mov (3.5M) GUID:?D873B89E-F14E-48EA-8874-AD771D5B8631 Video S3: CVAK104-kinase-domain-YFP expressed in HeLa cells (12). tra0008-0893_8_7cfig4.mov (2.1M) GUID:?BDB348E6-DC24-4ACD-98C9-7BD67F793C21 Video S4: CVAK104-kinase-domain-YFP expressed in HeLa cells depleted…. Read More "B) CVAK104-kinase-domain-YFP was transiently expressed in HeLa cells" ». ...
Cardiac Myocyte Medium-sf | ScienCell Research Laboratories
Quantification of Myocyte Disarray in Human Cardiac Tissue - RepairHeart
2018 Edition
Talk 1 (11:30-12:30): The ins and outs of cardiac myocytes. ... Sudden cardiac death (SCD) from arrhythmias is a leading cause ... Conversely, during one cardiac cycle, the artery wall is subjected to blood pressure, in the range 80 − 120 mmHg (mean at 100 ... Cardiac arrhythmias, such as focal atrial tachycardia or reentrant tachycardias are commonly treated by radio frequency ... Here we present a novel non-invasive personalized approach to assess SCD risk in post-infarction patients based on cardiac ...
Quantitation and distribution of β-tubulin in human cardiac myocytes<...
... myocyte function, and the coupling of myocytes to the extracellular matrix during cardiac hypertrophy and failure. Data from ... myocyte function, and the coupling of myocytes to the extracellular matrix during cardiac hypertrophy and failure. Data from ... myocyte function, and the coupling of myocytes to the extracellular matrix during cardiac hypertrophy and failure. Data from ... myocyte function, and the coupling of myocytes to the extracellular matrix during cardiac hypertrophy and failure. Data from ...
In-Vitro Assessment of Calcium Activated Force Production in Skinned Cardiac Myocytes - Aurora Scientific
Stress or damage to the cells - for example following ischemia - has profound effects on cardiac muscle cells, which can be ... In-Vitro Assessment of Calcium Activated Force Production in Skinned Cardiac Myocytes. aursc20dev2021-11-24T15:18:14-05:00 ... 803B permeabilized myocyte apparatus along with the 406A force transducer to assess force production in the cardiac myocytes. ... In-Vitro Assessment of Calcium Activated Force Production in Skinned Cardiac Myocytes ...
G:BOX Chemi XRQ used to study mechanisms of cardiac myocyte function
BOX Chemi XRQ used to study mechanisms of cardiac myocyte function ... G:BOX Chemi XRQ used to study mechanisms of cardiac myocyte function. September 22, 2015 By Euroscicon Off ... You are here: Home / Industry Updates / G:BOX Chemi XRQ used to study mechanisms of cardiac myocyte function ... the effects that genetic modification have on how stem cells differentiate into cardiac myocytes and integrate into cardiac ...
Interferon-gamma Causes Cardiac Myocyte Atrophy via Selective Degradation of Myosin Heavy Chain in a Model of Chronic...
Cardiac muscle - Wikipedia
Cardiac muscle cells also called cardiomyocytes are the contractile myocytes of the cardiac muscle. The cells are surrounded by ... The individual myocytes that make up the myocardium also differ between cardiac chambers. Ventricular cardiomyocytes are longer ... "Cardiovascular Physiology= Cardiac muscle Concept". "Cells Alive: Pumping Myocytes". Bergmann O, Bhardwaj RD, Bernard S, et al ... The ease of ion movement along cardiac muscle fibers axes is such that action potentials are able to travel from one cardiac ...
AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. - SCNi
Compound C prevented the effect of AICAR on myocyte function. These results suggest that AMPK activation increases myocyte ... CONCLUSIONS: We conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function. ... Mutations affecting the regulatory γ2 subunit have been shown to cause an essentially cardiac-restricted phenotype of ... A yeast 2-hybrid screen of a human heart cDNA library using the N-terminal 273 residues of γ2 as bait identified cardiac ...
Heart repair by reprogramming non-myocytes with cardiac transcription factors<...
... can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. Forced ... can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. Forced ... can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. Forced ... can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro. Forced ...
Research | Communications of the ACM
Altmetric - Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth
Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth. Overview of attention for ... Deletion of HP1γ in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth ... Cardiac myocytes (CMs) accumulate heterochromatin during differentiation and demethylation of H3K9me3 inhibits cell cycle gene ... Analysis of cardiac size and function by echo revealed no significant differences between HP1γ KO and control (WT, Cre, fl/fl) ...
α-Adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes - Fingerprint -...
α-Adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes. ... α-Adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes. Together they form a ...