... a single MyoD protein is typically found. MyoD is one of the earliest markers of myogenic commitment. MyoD is expressed at ... MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle ... Maleki SJ, Royer CA, Hurlburt BK (June 1997). "MyoD-E12 heterodimers and MyoD-MyoD homodimers are equally stable". Biochemistry ... of the murine MyoD protein in a different cell lines (fibroblast and adipoblast) and found MyoD converted them to myogenic ...

MyoD Protein / genetics * MyoD Protein / metabolism * Myocardium / cytology* * NADPH Oxidases / genetics * NADPH Oxidases / ... as well as myoD, and neurogenin 1 for skeletal myogenesis and neurogenesis, respectively. Conversely, REAC treatment elicited a ...

... the immunoglobin Fc-binding site of the Z domain and the DNA-binding motif of MyoD bHLH, into a novel stable protein. ... In this work, we generated and optimized a new synthetic fusion protein using an evolutionary approach. The optimization was ... Computational design of novel proteins with well-defined functions is an ongoing topic in computational biology. ... Protein Z and MyoD. Protein Z is derived from staphylococcal protein A and holds an IgG Fc-binding domain. It consists of a ...

Sequence analysis revealed that, like its human homolog, Akt2 encodes a protein-serine/threonine kinase containing a pleckstrin ... MyoD Protein / genetics * Oncogene Proteins / analysis * Oncogene Proteins / genetics* * Oncogenes* * Protein Serine-Threonine ... Expression levels of mouse Akt2 mRNA and Akt2 protein varied among tissues, with the highest levels in skeletal muscle. Akt2 ... Sequence analysis revealed that, like its human homolog, Akt2 encodes a protein-serine/threonine kinase containing a pleckstrin ...

smart00520 (PSSM ID: 128794): Conserved Protein Domain Family BASIC,

Zhou，Zijing,et al."MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels".Science (New York, N.Y.) ... MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels[J]. Science (New York, N.Y.),2023,381(6659):799-804 ... In this work, we found that MyoD (myoblast determination)-family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting ... Zhou，Zijing.,Ma，Xiaonuo.,Lin，Yiechang.,Cheng，Delfine.,Bavi，Navid.,...&Cox，Charles D..(2023).MyoD-family inhibitor proteins act ...

MyoD Protein. 2. 2021. 159. 0.920. Why? Muscle Development. 2. 2021. 289. 0.810. Why? ...

Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and ... Protein-interactions e.g. with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and ... via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. This review summarizes our current ... via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. This review summarizes our current ...

Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. The FASEB Journal, v. 18, n ... VASHISHT GOPAL, Y. N.; ARORA, T. S; VAN DYKE, M. W. Tumour necrosis factor-alpha depletes histone deacetylase 1 protein through ... ROSE, A. J.; KIENS, B.; RICHTER, E. A. Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle ... J. O.; SEMENKOVICH, C. F. Exercise induces lipoprotein lipase and glut-4 protein in muscle independent of adrenergic-receptor ...

Representative images of myofiber-associated cells after immunostaining for Pax7 (red) and MyoD (green) protein. Nuclei were ... Pax7+/MyoD-), proliferating (Pax7+/MyoD+), and differentiating (Pax7-/MyoD+) satellite cells per myofiber in Ern1cKO cultures ... Average number of (F) cellular clusters per myofiber, (G) cells per cluster, (H) Pax7+/MyoD- cells per cluster, (I) Pax7-/MyoD+ ... and synthesis of an entirely new set of contractile proteins, cytoskeletal proteins, membrane proteins and machinery for ...

By combining transient expression of a protein called MyoD and treatment with three small molecules, we converted mouse skin ... Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells. Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang ... Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells. Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang ... Our team reported that HIV turns on a cell survival program governed by a protein called BIRC5. We also found that compounds ...

CD56, desmin, α-smooth muscle actin (SMA), MyoD-1, AE1/AE3, and tumor protein 53 (P53) ... While the sarcomatous component with rhabdoid differentiation was positive for MyoD-1 and desmin and negative for h-caldesmon, ... and desmin and focal positivity for α-SMA and MyoD-1 [Figure 3a-d]. In the malignant epithelial components, AE1/AE3 and P53 ... MyoD-1 (×40). (e) The carcinomatous component stained positive for P53 (×10). ...

When satellite cells are activated, the myogenic regulatory factors (MRFs) including myoblast determination protein 1 (MYOD), ... Protein deposition occurs when protein synthesis rate is greater than the protein degradation rate, which contributes to the ... Expressions of PAX7 (a), MYOD (b), MYF5 (c), MYOG (d), MSTN (e) and PPARGC1A (f) were analyzed in MLD of glutamine (GLN) or ... but it was co-expressed with MYOD when they were activated23, 41. Furthermore, MYF5 and MYOD are involved in satellite cell ...

Muscle, Apoptosis, MyoD, Myf5, Stem cell, Manduca, Zebrafish, Myogenesis MeSH Terms *Animals ... Acheron (Achn), a phylogenetically-conserved member of the Lupus antigen family of RNA binding proteins, was initially ... Achn expression is induced in myoblasts that form myotubes and acts upstream of the muscle specific transcription factor MyoD. ...

Functional antagonism between c-Jun and MyoD proteins: a direct physical association ... Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins ... Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix- loop-helix proteins ... Moreover, in mammalian cell cultures bHLH proteins can interact with b-leucine-zipper proteins (Bengal et al., 1992). This ...

Western immunoblot analysis revealed increased eNOS, MyoD, and myogenin protein levels 48- hours post-strain injury, but a ... Transcript levels for neuronal (n) NOS, endothelial (e) NOS, inducible (i) NOS, MyoD and myogenin were assessed using reverse ... Muscle biopsy samples were evaluated 48- hours after strain injury for the presence of nitric oxide synthase, MyoD, and ... MyoD and myogenin. METHODS: Using female Sprague Dawley rats, muscle strains were produced by manually stretching (50 ...

HDAC may also complex with retinoblastoma protein (pRb) leading to the interruption of myogenic differentiation 1 (MyoD(1))- ... The most important signaling pathway for muscle protein synthesis is the phosphoinositide 3-kinase/serine-threonine protein ... or by binding to certain proteins. Exosomes are EVs of 30-100 nm that effectively transfer molecules such as proteins, RNA, DNA ... leads to skeletal muscle wasting through the reduction of protein synthesis and an increase of ubiquitin-mediated protein ...

Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Osborn, D. P. S., Li, K., ... Polycomb repressor complex protein EZH2 regulation of muscle stem cell migration and differentiation. Knight, R. & Wardle, F. ...

Blackwell TK, Weintraub H: Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed ... TFBS matches of the MyoD dataset. The matches from TRANSFAC to the 2nd motif output by GALF-G on the MyoD dataset. The red ... In-depth investigation on the MyoD dataset. The MyoD dataset seems to be an exceptional case among the 8 real datasets tested ... except for the MyoD dataset. The exceptional case of MyoD will be investigated separately and shown containing multiple motifs ...

Here we identify Heterochromatin Protein 1β (HP1β) as an essential protein for proper differentiation, and, unexpectedly, for ... Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role ... epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. ... of the major heterochromatin proteins in pluripotency is unknown. ...

91% increase in MyoD (a protein that plays a major role in regulating muscle differentiation). ... Protein Hydrolysate Matrix Yielding 22% Glutamine Peptide, 21% BCAA Peptide, & 41% EAAs ... myofibrillar protein content, and stimulating increases in myogenic markers indicative of satellite cell activation." ...

Skeletal muscle holds significant regenerative potential but is incapable of restoring tissue loss caused by severe injury, congenital defects or tumour ablation. Consequently, skeletal muscle models are being developed to study human pathophysiology and regeneration. Their physiological accuracy, however, is hampered by the lack of an easily accessible human cell source that is readily expandable and capable of efficient differentiation. MYOD1, a master gene regulator, induces transdifferentiation of a variety of cell types into skeletal muscle, although inefficiently in human cells. Here we used MYOD1 to establish its capacity to induce skeletal muscle transdifferentiation of human dermal fibroblasts under baseline conditions. We found significant transdifferentiation improvement via transforming growth factor-β/activin signalling inhibition, canonical WNT signalling activation, receptor tyrosine kinase binding and collagen type I utilization. Mechanistically, manipulation of individual ...

MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient Journal Article ... Muscle Proteins - Myogenic Regulatory Factors PubMed MeSh Term *Overview. Overview. subject area of * Cardiomyopathy in ... Muscle Proteins - MyoD Protein PubMed MeSh Term * Muscle Proteins - Myogenic Regulatory Factor 5 PubMed MeSh Term ... Muscle Proteins - MEF2 Transcription Factors PubMed MeSh Term * ... Muscle Proteins PubMed MeSh Term narrower concept * ...

Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Osborn, Daniel P S; Li, Kuoyu ...

Cells are usually positive for intermediate filaments and other proteins typical of differentiated muscle cells, such as desmin ... vimentin, myoglobin, actin, and transcription factor myoD.. An image depicting rhabdomyosarcoma can be seen below. ... metastatic disease of the liver may affect values of these proteins ...

First, a new screening method was used to identify Hey1-binding proteins from protein expression filters hybridised with ... MyoD and c-hairy1 was found. Furthermore, it could be shown that Hey1 and Hey2 can form homodimers as well as Hey1/Hey2 ... With direct yeast-two hybrid and GST-pulldown assays of candidate proteins an interaction of Hey1 and Hey2 with the bHLH ... Electrophoretic mobility shift assays revealed that Hey1 and Hey2 proteins are able to bind an E(spl)-specific E-box DNA ...

Идентификация MyoD интерактомные Использование Тандем Аффинная очистка В… * Определение белок-белковых взаимодействие вы по ...

A protein-protein interaction (PPI) network was also constructed. Of 766 initially identified records through database ... myoblast determination protein 1 (MYOD) and myogenin (MYOG) [47]. ... A protein-protein interaction (PPI) network was also ... to determine the interactions between the proteins regulated by the miRNAs, a protein-protein interaction (PPI) network is ... Finally, ten hub proteins of the PPI network were identified most of which are well-known proteins involved in regulating cell ...

... and activity of MyoD proteins that include and do not include the polyserine region. ... have retained both MyoD paralogues. Here we reveal the expression patterns of the two MyoD genes in Oreochromis (Alcolapia) ... We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica, along with some ... while a second MyoD gene (MyoD2) was subsequently lost from the genomes of some lineages (including zebrafish), many fish ...