Produktübersicht anti-MCL1 Antikörper
bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein Mcl-1 homolog ... Mouse (Murine) Myeloid Cell Leukemia Sequence 1 (MCL1) Interaktionspartner * The findings support a model in which survival is ... anti-Myeloid Cell Leukemia Sequence 1 (MCL1) Antikörper. ovarian BAD-interacting protein\; may inhibit apoptosis [RGD, Feb 2006 ... anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 Antikörper * anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax ...https://www.antikoerper-online.de/abstract/Myeloid+Cell+Leukemia+Sequence+1+
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
... cell survival through elaborating factors. We demonstrate herein that IL-6 and TNF family cytokines, TNFα, BAFF and APRIL, but ... Bone marrow stromal cells (BMSCs) and osteoclasts (OCs) confer multiple myeloma (MM) ... 0/STAT3 protein, human; 0/myeloid cell leukemia sequence 1 protein; 154447-36-6/2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- ... 0/Adaptor Proteins, Signal Transducing; 0/Apoptosis Regulatory Proteins; 0/Chromones; 0/EIF4EBP1 protein, human; 0/IL6 protein ...http://www.biomedsearch.com/nih/kinase-Pim-2-novel-anti/21475253.html
Browse our MCL1 ELISA Kits
Protein level used designations for MCL1 bcl-2-related protein EAT/mcl1 , induced myeloid leukemia cell differentiation protein ... Mouse (Murine) Myeloid Cell Leukemia Sequence 1 (MCL1) interaction partners * These results identify MCL-1 as a critical ... Myeloid Cell Leukemia Sequence 1 (MCL1) ELISA Kits. ovarian BAD-interacting protein\; may inhibit apoptosis [RGD, Feb 2006].. ... Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 ELISA Kits * Myeloid/lymphoid Or Mixed-Lineage Leukemia 5 (Trithorax Homolog, ...http://www.antibodies-online.com/abstract/Myeloid+Cell+Leukemia+Sequence+1+
Effect of miR-26a on apoptosis in breast cancer cells.F | Open-i
Effect of miR-26a on apoptosis in breast cancer cells.FACS analysis of MDA-MB-231 and MCF-7 cells transfected with miR-26a for ... Myeloid Cell Leukemia Sequence 1 Protein/genetics*. Minor. *Adult. *Animals. *Apoptosis/drug effects/genetics ... 4). The cells in the lower right quadrant of the square chart represent the percentage of early apoptotic cells and in the ... 4). The cells in the lower right quadrant of the square chart represent the percentage of early apoptotic cells and in the ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3672200_pone.0065138.g004&req=4
Burkholderia ambifaria Putative membrane protein|gentaur.com
Burkholderia ambifaria Putative membrane protein insertion efficiency factor BamMC406_3100 - Gentaur.com - Product info ... Human Myeloid Cell Leukemia Sequence 1 Bcl2 Related MCL1 ELISA Kit 96 well plate ... hypothetical protein BamMC406_3100; Putative membrane protein insertion efficiency factor; hypothetical protein; ... GEN1161344.Mammalian Cell , Burkholderia ambifaria Putative membrane protein insertion efficiency factor (BamMC406_3100)100ug ...https://gentaur.com/prod/burkholderia-ambifaria-putative-membrane-protein-insertion-efficiency-factor-bammc406_3100/mbs-recombinant/3498930472
HUWE1 gene - Genetics Home Reference
... myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and ... The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 ( ... This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ... E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates ...https://ghr.nlm.nih.gov/gene/HUWE1
Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in...
Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein ... IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells. J Hematol Oncol ... Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat ... Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response. Trends Immunol 2004;25:17-24. ...http://cebp.aacrjournals.org/content/26/10/1531
Molecular mechanism underlying differential apoptosis between human melanoma cell lines UACC903 and UACC903(+6) revealed by...
... protein phosphatase 2 catalytic subunit alpha isoform (PPP2CA, Hs00427259_m1); and myeloid cell leukemia sequence 1 (MCL1, ... Cells were harvested at indicated time points. Protein concentration of cell lysate was determined by using DC Protein Assay ... Cells were incubated for 22 h after addition of FASLG and viable cells were measured by MTS cell proliferation assay. The time- ... Bar graph of the TUNEL-positive apoptotic cells and G2/M phase cells before and after UV irradiation. TUNEL-positive cells: ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2470374/?lang=en-ca
Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog...
... myeloid cell leukemia sequence [Mcl] 1, and A1) and proapoptotic members that are further subdivided in multidomain (Bax, Bak, ... The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008;9:47-59pmid:18097445. ... The BH3-only proteins induce apoptosis in a cell type- and stimulus-dependent fashion. These proteins are essential initiators ... F: FoxO3a and AKT protein phosphorylation and TRB3 protein expression in INS-1E cells transfected with negative (N) or TRB3 (T ...http://diabetes.diabetesjournals.org/content/61/11/2763
Martine Raes - Fingerprint - the Research Portal - University of Namur
Myeloid Cell Leukemia Sequence 1 Protein Chemical Compounds. Proteins Chemical activation Proteomics ...https://researchportal.unamur.be/en/persons/martine-raes/fingerprints/
Roscovitine inhibits proliferation in neutrophil progen | Open-i
Left panel gives the numbers of Bcl-2-transgenic progenitor cells in control cultures and ... Roscovitine inhibits proliferation in neutrophil progenitor cells.(A) ... Membrane Proteins/metabolism. *Mice. *Myeloid Cell Leukemia Sequence 1 Protein/metabolism. *Proto-Oncogene Proteins/metabolism ... In addition, roscovitine strongly inhibited proliferation in progenitor cells, associated with an accumulation of cells in G2/M ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3815126_pone.0079352.g007&req=4
Dinaciclib and Epirubicin Hydrochloride in Treating Patients With Metastatic Triple-Negative Breast Cancer - Full Text View -...
I. To determine the predictive value of myeloid cell leukemia sequence 1 protein (MCL-1), low molecular weight cyclin E (LMW-E ... Epirubicin is designed to block the way cancer cells grow and divide and may slow or stop cancer cells from spreading ... Dinaciclib is designed to stop cancer cells from dividing into new cancer cells. ... Patients must be disease free of prior malignancy for ,= 5 years with the exception of curatively treated squamous cell ...https://clinicaltrials.gov/ct2/show/NCT01624441?recr=Open&cond=%22Breast+Neoplasms%2C+Male%22&rank=18
Patent US4458686 - Cutaneous methods of measuring body substances - Google Patents
siRNA targeting myeloid cell leukemia sequence 1. US20080188387 *. 19 May 2006. 7 Aug 2008. Peter Horsewood. Direct Assay of ... In view of these observations, a preferred technique is to not let the enzymes escape and to not let immune proteins or ... Proteolytic enzymes may destroy the enzyme or it may be picked up by Kupffer cells. If the immune system of the body including ... The overall arrangement of the circuit and polarographic cell may be obtained with reference to my above mentioned patents. ...http://www.google.com.au/patents/US4458686
A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer | Clinical Cancer Research
... in several human cancer cell lines by down-regulating the levels of antiapoptotic protein myeloid cell leukemia sequence 1 (Mcl ... In cells for which PSA was to be analyzed at the 48th hour, treatment was repeated at the 24th hour; in cells for which PSA was ... A, cumulative PSA (normalized to cell count) over 72 h. B, cell count-normalized PSA in successive 24-h duration after ... Sorafenib inhibits pERK and induces cancer cell death. A, survival of HT-29 cells following 3 d of sorafenib (Bay) treatment ...http://clincancerres.aacrjournals.org/content/14/1/209.long
Exposure to S. aureus triggers Mcl-1 production in vivo | Open-i
a) Immunoblot reveals increase in Mcl-1 expression in inflamed joints derived from three individual S. ... Myeloid Cell Leukemia Sequence 1 Protein. *NF-kappa B/metabolism. *Reverse Transcriptase Polymerase Chain Reaction ... but also prolonged the stability of this antiapoptotic protein. Consistent with this, we proved a crucial role of Mcl-1 in S. ... This process occurs through the upregulation of crucial antiapoptotic genes, in particular, myeloid cell leukemia-1 (MCL-1). ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569898_MI2013-427021.003&req=4
PASS2 :: Superfamily Details for 56854
Myeloid cell leukemia sequence 1). Mouse (Mus musculus) [TaxId: 10090]. d3bl2a1. Bcl-2 homolog V-bcl-2. Murid herpesvirus 4 [ ... Early antigen protein R. Epstein-Barr virus [TaxId: 10376]. d2jm6b1. EAT/MCL-1 ( ... 1 ) gsmdcevnngsslrdecitnllvfgFlqSCsdnsfrreldalghel d2jm6b1 ( 147 ) gplgseddlyrqSleiiSrYlrEqAtg------------- d3bl2a1 ( 6 ) sgty ... 10 20 30 40 50 d1f16a- ( 1 ) mdgsgeqprgggptsseqimktGalllqgFiqdragrmg----------- d1ohua- ( 71 ) ndweeprLdIegFVVDYFthrirqng--- ...http://caps.ncbs.res.in/pass2.4/superfamily/superfamilydetail.php?superfamilyId=56854
JCI - Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
Here, we showed that myeloid cell leukemia sequence 1 (Mcl-1) acts as a functional switch in selecting between HR and NHEJ ... and cyclin F in total cell lysates were analyzed by Western blot. As, asynchronous cells. (. C. and D. ) Relative protein and ... H1299 cells were synchronized by double-thymidine block. After thymidine was washed off, cells were released to normal medium ... Mitochondrial and nuclear fractions were isolated from cells at various time points during cell cycle progression. Mcl-1 was ...https://jci.org/articles/view/92742/figure/1
JCI - Usage information: Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia...
Execution of cell death, but not induction of autophagy, was strictly dependent on expression of receptor-interacting protein ( ... Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome ... Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome ... is a strong predictor of poor outcome in children with acute lymphoblastic leukemia (ALL). Modulation of cell death regulators ...https://www.jci.org/articles/view/39987/usage
Volume 11.20 | May 31 - Cell Therapy News
ATF5, in turn, promotes survival by stimulating transcription of myeloid cell leukemia sequence-1 (MCL1), an antiapoptotic B ... The results reveal an essential survival pathway in malignant glioma, whereby activation of a RAS-mitogen-activated protein ... B-Lymphoid Cells with Attributes of Dendritic Cells Regulate T Cells via Indoleamine 2,3-Dioxygenase. Researchers show that ... Senior Scientist - Magnetic Cell Separation (STEMCELL Technologies). Business Development Manager Europe - Cell Therapy ...https://www.celltherapynews.com/issue/volume-11-20-may-31/
BCL2 - What does BCL2 stand for? The Free Dictionary
B-cell CLL/lymphoma 2) and MCL1 [myeloid cell leukemia sequence 1 (BCL2-related)].. MicroRNA analysis: is it ready for prime ... Prognostic significance of Bc1-2 and p53 protein expressions and Ki67 proliferative index in diffuse large B-cell lymphoma / ... BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma.. ... Masir N, Campbell LJ, Jones M, Mason DY: Pseudonegative BCL2 protein expression in a t(14;18) translocation positive lymphoma ...https://acronyms.thefreedictionary.com/BCL2
Phospho-MCL-1 (Ser159), APC, clone: RBCERNR, eBioscience™ 100 Tests; APC Phospho-MCL-1 (Ser159), APC, clone: RBCERNR,...
Phospho-MCL-1 (Ser159), APC, clone: RBCERNR, eBioscience™ 100 Tests; APC Phospho-MCL-1 (Ser159), APC, clone: RBCERNR, ... Description: This RBCERNR monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1) when ... Use of Protocol A: Two-step protocol: intracellular (cytoplasmic) proteins allows for the greatest flexibility for detection of ... Cell Culture & Analysis Cell Culture & Analysis * Cell Culture Dishes, Plates and Flasks ...https://www.fishersci.co.uk/shop/products/phospho-mcl-1-s159-mouse-anti-human-mouse-apc-clone-rbcernr-ebioscience-2/15578226
Protocols and Video Articles Authored by Victoria Del Gaizo Moore (Translated to Italian)
... cells. BH3 profiling also accurately distinguishes myeloid cell leukemia sequence 1 (MCL1) from BCL2 dependence in myeloma cell ... Jan, 2007 , Pubmed ID: 17200714 Antiapoptotic B cell leukemia/lymphoma 2 (BCL2) family proteins are expressed in many cancers, ... Furthermore, the BH3 profiling and protein analysis predicted that ALL cell lines and primary cells would be sensitive to ABT- ... Fusion proteins constructed with TAT rapidly enter and exit cells and have been shown to cross intracellular membranes as well ...https://www.jove.com/author/Victoria_Del+Gaizo+Moore?language=Italian
Mechanism of Action
... myeloid cell leukemia sequence 1). Triptolide appears unique among anti-cancer agents in that it reduces the signals ... Key among them are Bcl-2 (B-cell lymphoma-2), XIAP (X-linked inhibitor of apoptosis protein) and Mcl-1 ( ... 2. Cell signaling pathways- Proliferation of leukemic and other cancer cells is due to an overabundance of growth signals and a ... The activity appears quite broad in that triptolide is capable of blocking proliferation of all of the cells in the NCI 60 cell ...http://myelorx.com/Mechanism_of_Action.html
IMP: Integrative Multi-species Prediction
Mdm2 p53 binding protein homolog (mouse). 0.508. NBN. nibrin. 0.456. MCL1. myeloid cell leukemia sequence 1 (BCL2-related). ... The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution ... protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1. 0.050. ... A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. ...http://imp.princeton.edu/predictions/process/human-context-global/4115/?gene=6962
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. - PubMed - NCBI
Cancer Cell. 2012 Apr 17;21(4):547-62. doi: 10.1016/j.ccr.2012.02.028. Research Support, N.I.H., Intramural; Research Support, ... BAK1 protein, human. *Mcl1 protein, mouse. *Myeloid Cell Leukemia Sequence 1 Protein ... Data were measured from 17 breast cancer cell lines.. F-I. Effects of MCL1 shRNAs (G, I) or BCL-xL shRNAs (F, H) on cell ... H1437 and H23 cells had longer exposure time than HCC15 and SKLU1 cells for Western blots to show the shRNA effects.. E. ...https://www.ncbi.nlm.nih.gov/pubmed/22516262