*  Diseases | Free Full-Text | Pathological Mutations of the Mitochondrial Human Genome: the Instrumental Role of the Yeast S....
In particular; pathological mutations of tRNA, cytb, and ATPase genes have been successfully modeled. It is essential to stress ... However, in the case of mutations within the mitochondrial genome, yeast is a major model because it is a facultative aerobe ... In this short review, I will describe how these properties can be exploited to mimic mitochondrial pathogenic mutations, as ... can be due to mutations either in the nuclear or mitochondrial genomes. Several model organisms or cell lines are usually ...
  http://www.mdpi.com/2079-9721/2/1/24/htm
*  PLOS Medicine: Minority HIV-1 Drug Resistance Mutations Are Present in Antiretroviral Treatment-Naïve Populations and Associate...
Jeffrey Johnson and colleagues investigate prevalence and clinical implications of minority transmitted mutations. ... Using real-time PCR to detect HIV resistance mutations present at low levels, ...
  http://journals.plos.org/plosmedicine/article/authors?id=10.1371/journal.pmed.0050158&imageURI=info:doi/10.1371/journal.pmed.0050158.t005
*  Z53 Therapeutics, A New Oncology Start-Up, Launches to Combat Cancer-Associated Mutation - Z53 Therapeutics
Z53 Therapeutics aims to develop novel anti-cancer drugs that target tumors with p53 mutations. ... The gene encoding p53 is the most commonly mutated gene in human cancer with a large number of mutations resulting in a defect ... Z53 Therapeutics, A New Oncology Start-Up, Launches to Combat Cancer-Associated Mutation Courtney Kishbaugh ... Z53 Therapeutics aims to develop novel anti-cancer drugs that target tumors with p53 mutations. ...
  http://z53therapeutics.com/news/z53therapeuticsformation
*  Warburg's Lens: A Mathematical oncology pre-print discussion forum: The effects of mutational process and selection on driver...
Here we have used public cancer sequencing data to infer the independent effects of mutation and selection on driver mutation ... However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained ... The effects of mutational process and selection on driver mutations across cancer types. View ORCID ProfileDaniel Temko, Ian ... These results show that while mutational processes play a large role in determining which driver mutations are present in a ...
  http://mathematicaloncology.blogspot.co.uk/2017/07/the-effects-of-mutational-process-and.html
*  ZFIN Publication: Kane et al., 1996
Mutations in speed bump, ogre, zombie, specter, poltergeist and troll were tested for cell lethality by transplanting mutant ...
  http://zfin.org/ZDB-PUB-970210-5
*  A novel strategy for point mutation biomarker discovery in the colorectal cancer genome with massively parallel resequencing |...
For example, mutations in APC, KRAS and TP53 are critical to the development of colorectal cancer. Mutations in genes like EGFR ... Undoubtedly, there are other critical gene mutations to be discovered and comprehensive mutation discovery from individual ... This mutation profile may provide prognostic and predictive genetic biomarkers. However, current technologies are severely ... As a solution, we describe the development and application of a novel resequencing strategy for point mutation discovery on a ...
  http://cancerres.aacrjournals.org/content/67/9_Supplement/3799
*  Association of increased spontaneous mutation rates with high levels of transcription in yeast | Science
Here the effect of transcription on the rate of spontaneous mutation in the yeast Saccharomyces cerevisiae was examined. With ... Association of increased spontaneous mutation rates with high levels of transcription in yeast ... Thus, transcriptionally active DNA and enhanced spontaneous mutation rates are associated in yeast. ... Association of increased spontaneous mutation rates with high levels of transcription in yeast ...
  http://science.sciencemag.org/content/268/5217/1616
*  Somatic mutation identification and verification - QIAGEN
Cancer-causing mutations have been identified and cataloged in databases such as COSMIC. Within these databases are mutations ... qBiomarker Somatic Mutation PCR Arrays are panels of mutation-specific real-time PCR assays for simultaneously profiling ... For example, users could profile the most common 84 mutations in breast cancer or the 44 most common mutations in APC. The ... Read on to find out more about QIAGEN's somatic mutation detection solutions.. QIAGEN has developed a robust somatic mutation ...
  https://www.qiagen.com/ca/landing-pages/som-qpcr/
*  Rare Genetic Disorder: Genotype - Phenotype correlation in ABCA12 Mutations
... most mutations are truncation mutations including nonsense mutations, frameshift mutations (deletion/ insertion mutations), and ... Other mutations reported in HI families are missense mutations, exon deletions, and single amino acid deletions.. ... Thus far, in HI patients, at least one mutation on each allele must be a truncation or deletion mutation within a conserved ... Complete loss of ABCA12 function due to homozygous or compound heterozygous truncation mutations always results in the HI ...
  http://raregeneticdisorder.blogspot.com/2012/06/genotype-phenotype-correlation-in.html
*  Identification and Human Mutation Screen of the rd3 Gene | IOVS | ARVO Journals
Identification and Human Mutation Screen of the rd3 Gene J.S. Friedman; B. Chang; H.P. Singh; S. Jalali; N.L. Hawes; C. ... The mutation was present in all rd3 lines tested (RBF/DnJ, RBJ/Dn, 4bnr and IN-30) but not in the control lines (C57BL/6J, A/J ... Results: : The rd3 mutation is a homozygous C to T transition, leading to a stop codon, which is predicted to result in a ... Identification and Human Mutation Screen of the rd3 Gene You will receive an email whenever this article is corrected, updated ...
  http://iovs.arvojournals.org/article.aspx?articleid=2392154
*  The Evolution of Mutator Genes in Bacterial Populations: The Roles of Environmental Change and Timing | Genetics
1999b Beneficial mutations, hitchhiking and the evolution of mutation rates in sexual populations. Genetics 151: 1621-1631. ... In the case of the nonmutators, the per-cell mutation rate per generation is μn, so the number of mutations approximates a ... First, the mutator need not be the first to generate the benefical mutation. It just has to acquire that mutation before its ... 1999a The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation rates. Proc. ...
  http://www.genetics.org/content/164/3/843.long
*  Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
We show that the frequencies obtained by passenger mutations depend strongly on the ratio of death and birth rates of cancer ... We estimate the size of the cancer cell population that was present when a specific mutation first emerged. Our theory informs ... mathematical modeling to shed light on the evolutionary dynamics of cancer by studying the accumulation of passenger mutations ...
  http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004731
*  Drug Resistance
Screening patients for mutations at tumour recurrence identifies these new mutations which were not present (at detectable ... Only those mutations reported as associated with resistance are annotated as primary resistance mutations. ... COSMIC has started to annotate mutations identified in the literature as resistance mutations, including those conferring ... are annotated as acquired resistance mutations and not incidental passenger mutations detected in a recurrent tumour. ...
  http://cancer.sanger.ac.uk/cosmic/drug_resistance
*  Presence of gene mutation helps guide thyroid cancer... ( A specific gene mutation may be usef...)
The mutation called BRAF V600E is a genetic alteration in the BRAF o...Past studies have shown that the mutation frequently ... occurs in the mos...The findings come at an important time as both the incidence of thyroi...,Presence,of,gene,mutation,helps, ... A specific gene mutation may be useful in predicting the level of aggr... ... Bioelectronic 'signatures?hold key to DNA mutations. 8. Sugar beet virus mutation requires Texas touch. 9. Mutation in clams ...
  http://www.bio-medicine.org/biology-news-1/Presence-of-gene-mutation-helps-guide-thyroid-cancer-treatment-266-1/
*  Single gene mutation induces endometrial cancer | EurekAlert! Science News
A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers at UT ... Single gene mutation induces endometrial cancer. UT Southwestern Medical Center. Journal. Disease Models & Mechanisms. Funder. ... 10, 2010 - A mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy, researchers ... Mutations in Lkb1 disrupt its "braking" action on cancer and contribute to the disease in lungs, skin and other tissues. ...
  https://www.eurekalert.org/pub_releases/2010-02/usmc-sgm020910.php
*  Institute of Cancer Research Repository - The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia
flt3 mutations gene model rearrangements identification murine. Research teams:. ICR divisions , Molecular Pathology , Biology ... enhancing the acquisition of additional key mutations. To gain insight into the genomic landscape of infant MLL-AF4 pro-B ALL ... demonstrating that only a very small number of mutations are necessary to generate infant MLL-leukemia. (c) 2013 Wiley ...
  http://publications.icr.ac.uk/12706/
*  mutation - Wiktionary
"mutation" in le Trésor de la langue française informatisé (The Digitized Treasury of the French Language). ... Names for a group: A flute or mutation of thrushes.. *2013, Jason Sacher, A Compendium of Collective Nouns: From an Armory of ... A Mutation of Thrushes. The authors of the books of venery were not predicting Darwin with this term, but taking a cue from a ... These rarities may be new mutations, or they can be existing ones that are neutral-or are even selected against-in a wild ...
  https://en.wiktionary.org/wiki/mutation
*  Suppressor mutation - Wikipedia
A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of an already existing mutation in ... suppression relieves the effects of a mutation in one gene by a mutation somewhere else within the genome. The second mutation ... Intragenic suppression results from suppressor mutations that occur in the same gene as the original mutation. In a classic ... Genetic suppression therefore restores the phenotype seen prior to the original background mutation.[1] Suppressor mutations ...
  https://en.wikipedia.org/wiki/Suppressor_mutation
*  Mutation
Change in the genetic structure (DNA); it may occur spontaneously or be induced (e.g., by radiation, drugs, or certain mutagenic chemicals ...
  https://labtestsonline.org/glossary/mutation
*  mutation analysis
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK +44 (0)1223 49 44 44. Copyright © EMBL-EBI 2013 , EBI is an outstation of the European Molecular Biology Laboratory , Privacy , Cookies , Terms of use. ...
  https://www.ebi.ac.uk/ols/ontologies/mi/terms?obo_id=MI%3A0074
*  I-mutation
... (also known as 'i-umlaut') is the raising and fronting of a root vowel in anticipation of 'i' or 'y' s ... I-Mutation. I-MUTATION (also known as 'i-umlaut') is the raising and fronting of a root vowel in anticipation of 'i' or 'y' ... 6. I-mutation turns up in an adjective formed from a noun by adding -ish in at least one important case: English (Old English ... I-mutation is caused by the very human habit of laziness: taking the shortest distance between two points. The plural of man in ...
  https://www.etymonline.com/columns/post/imutate
*  mutation
... Chesley Huskins huskincg at brevard.edu Wed Dec 1 13:51:55 EST 1999 *Previous message: mutation ... I have recently seen a news story that suggests a genetic mutation in females may be responsible in causing them to be more ...
  http://www.bio.net/bionet/mm/biochrom/1999-December/002197.html
*  JAK2 Mutation
... gene mutations are associated with bone marrow disorders called myeloproliferative neoplasms (MPNs) caused by the production of ... The JAK2 mutation test may be used, along with other tests such as CALR mutation and MPL mutation testing, to help diagnose ... have a JAK2 mutation, most for the JAK2 V617F mutation. Additionally, the mutation is also rarely found in people with chronic ... The primary JAK2 test is JAK2 V617F, named for a mutation at a specific location in the JAK2 gene. JAK2 V617F mutation is ...
  https://labtestsonline.org/tests/jak2-mutation
*  mutation | genetics | Britannica.com
mutation: An alteration in the genetic material (the genome) of a cell of a living organism or of a virus that is more or less ... Mutations in egg or sperm cells (germinal mutations) may result in an individual offspring all of whose cells carry the ... Mutations are of several types. Changes within genes are called point mutations. The simplest kinds are changes to single base ... mutation - Children's Encyclopedia (Ages 8-11). A mutation is a mistake or a change in a living thing's DNA. DNA, or ...
  https://www.britannica.com/science/mutation-genetics
*  Evolution - A-Z - Mutation
Mutation. A mutation is any change occurring in the message that a gene carries. Mutations mainly arise as copy errors when DNA ... Mutations can occur at single base level or at chromosomal level. The effects of mutation can occasionally be very dramatic: ... Darwinian evolution requires a constant supply of variation: much of it is supplied by mutation, and a mutation-selection ... The first major geneticist to study mutation was H.J. Muller, who demonstrated it can be induced by X-rays. He also recognized ...
  http://www.blackwellpublishing.com/ridley/a-z/Mutation.asp