Su, SS; Modrich, P (July 1986). "Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs". Proceedings of the ... He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to ... He is known for his research on DNA mismatch repair. Modrich received the Nobel Prize in Chemistry 2015, jointly with Aziz ... They later searched for proteins associated with mismatch repair in humans. Honors and awards received by Modrich include: 1983 ...

MutS DNA Mismatch-Binding Protein. *Gene Expression Regulation, Bacterial. *Escherichia coli Proteins ... In Escherichia coli, a DNA mismatch repair (MMR) pathway corrects errors that occur during DNA replication by coordinating the ... Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches.. Publication , Journal ... Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches. Nucleic Acids Research ...

The crystal structure of DNA mismatch repair protein MutS binding to a G:T mismatch. Lamers MH, Perrakis A, Enzlin JH. ... Dissimilar mispair recognition spectra of Arabidopsis DNA-mismatch repair proteins MSH2·MSH6 (MutSα) and MSH2·MSH7 (MutSγ). Wu ... Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch ... Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode ...

Scientists detail how DNA proofreader proteins discover replication errors and tag the problem for the bodys repair mechanism. ... it changes shape in a way that allows MutL to bind with it, holding it in place at the site of the mismatch. MutL then changes ... However a system exists for detecting and repairing these mismatches, i.e., a pair of proteins known as MutS and MutL. MutS ... "MutL traps MutS at a DNA mismatch") in PNAS describing the research. "For example, when the DNA is repaired, it only happens on ...

Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel ... Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins.. Biochemistry. 47(16):4583-96.* ... PHH1, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial ... Arabidopsis thaliana AtPOLK encodes a DinB-like DNA polymerase that extends mispaired primer termini and is highly expressed in ...

Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel ... Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins.. Biochemistry. 47(16):4583-96.* ... PHH1, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial ... Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis.. Genes Dev. 18(21): ...

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature 407:711-717 ...

PCNA sliding clamps increase the polymerase processivity during DNA replication and are important at several stages of mismatch ... Mismatch repair corrects errors that have escaped polymerase proofreading enhancing replication fidelity by at least two orders ... Both MutS and MutL, the two proteins that initiate the mismatch repair response, interact with β. Binding of MutS to β is ... interaction between the two proteins. Mutation of this conserved motif correlates with defects in mismatch repair, ...

Matrix Attachment Region Binding Proteins. *Methyl-CpG-Binding Protein 2. *MutS DNA Mismatch-Binding Protein ... Immunoglobulin J Recombination Signal Sequence-Binding Protein*Immunoglobulin J Recombination Signal Sequence-Binding Protein ... Below are MeSH descriptors whose meaning is more general than "Immunoglobulin J Recombination Signal Sequence-Binding Protein". ... Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin J Recombination Signal Sequence-Binding Protein ...

... a DNA mismatch repair homolog of human MutS protein in yeast, plays a role in binding double-stranded DNA and in four-way ... Mismatch repair proteins are a highly diverse group of proteins that interact with numerous DNA structures during DNA repair ... An example that five different types of DNA binding proteins are involved in biological processes meiotic mismatch repair and ... "DNA binding", "meiotic mismatch repair" and "chiasma assembly". The genes and concepts that connect "DNA binding", "meiotic ...

Escherichia coli Proteins / physiology; Motion; MutS DNA Mismatch-Binding Protein / metabolism; MutS DNA Mismatch-Binding ... DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ... DNA / chemistry; DNA / metabolism; DNA Methylation; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; ... DNA Repair / genetics; DNA Repair / physiology; DNA Replication / physiology; DNA-Binding Proteins / chemistry; DNA-Binding ...

DNA-(Apurinic or Apyrimidinic Site) Lyase. *MutS DNA Mismatch-Binding Protein. *MutS Homolog 2 Protein ... Enzymes that are involved in the reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule, ... Discordant Mismatch Repair Protein Immunoreactivity in Lynch Syndrome-Associated Neoplasms: ?A Recommendation for Screening ... "DNA Repair Enzymes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...

... primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA. ... primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.. ... MutL Proteins - Preferred Concept UI. M000612744. Scope note. DNA repair proteins that include the bacterial MutL protein and ... DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal ...

MUTS C-TERMINAL DOMAIN FUSED TO MALTOSE BINDING PROTEIN , DNA REPAIR, MISMATCH REPAIR, TETRAMERIZATION, SUGAR BINDING PROTEIN ... BINDING COOPERATIVITY, MALTOSE BINDING PROTEIN, MBP, SUGAR BINDING, DNA BINDING PROTEIN 4ozq:B (ASP-161) to (LYS-73) CRYSTAL ... ION BINDING PROTEIN H9Q MUTANT FORM , IRON-BINDING PROTEIN, EDTA-FE-PROTEIN COMPLEX, METAL BINDING PROTEIN 2b3b:A (SER223) to ( ... A FERRIC ION-BINDING PROTEIN FROM THERMUS THERMOPHILUS HB8 , A FERRIC BINDING PROTEIN, FERRIC ION, METAL BINDING PROTEIN 3wae:B ...

MutS DNA Mismatch-Binding Protein. *NADP Transhydrogenase, B-Specific. *Penicillin-Binding Proteins ... They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria. ...

MutS DNA Mismatch-Binding Protein. *MutS Homolog 2 Protein. *N-Ethylmaleimide-Sensitive Proteins ...

MutS DNA Mismatch-Binding Protein. *NADP Transhydrogenase, B-Specific. *Penicillin-Binding Proteins ... Probing the structural role of an alpha beta loop of maltose-binding protein by mutagenesis: heat-shock induction by loop ... New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH. Mol Microbiol. ... "Periplasmic Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...

MutS DNA Mismatch-Binding Protein. *NADP Transhydrogenase, B-Specific. *Penicillin-Binding Proteins ... Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is ...

Methyl-CpG-Binding Protein 2. *Minichromosome Maintenance 1 Protein. *MutS DNA Mismatch-Binding Protein ... A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. The protein ... This graph shows the total number of publications written about "Factor For Inversion Stimulation Protein" by people in this ... Below are the most recent publications written about "Factor For Inversion Stimulation Protein" by people in Profiles. ...

... including MutS, MutL, and MutH. Among them, MutS is responsible for recognizing and binding to mismatched or ... DNA mismatch repair system (MMR) is mainly composed of three proteins, ... DNA mismatch repair system (MMR) is mainly composed of three proteins, including MutS, MutL, and MutH. Among them, MutS is ... DNA mismatch repair system (MMR) is mainly composed of three proteins, including MutS, MutL, and MutH. Among them, MutS is ...

MutS DNA Mismatch-Binding Protein [D12.776.097.537] MutS DNA Mismatch-Binding Protein ... bact & plant proteins; /drug eff /ultrastruct permitted. Allowable Qualifiers:. AD administration & dosage. AE adverse effects ... Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in ... Iron-containing proteins that transfer electrons, usually at a low potential, to flavoproteins; the iron is not present as in ...

Once bound to mismatches, MutSα and MutSβ complexes interact with another heterodimeric complex, MutLα, which is composed of ... Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing ... Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα.. J. Biol. Chem. ... This complex is able to bind to base-base mismatches and to loops of one or a few nucleotides. A second, less abundant MutS- ...

DNA repair enzymes are highly conserved from bacteria to yeast to mammals. In yeast the proteins are called MutS homolog 2 ( ... It is thought that after MSH2 binds to a mismatched DNA duplex, it is joined by a heterodimer of MLH1 and PMS1 which together ... DNA repair enzymes are highly conserved from bacteria to yeast to mammals. In yeast the proteins are called MutS homolog 2 ( ... It is thought that after MSH2 binds to a mismatched DNA duplex, it is joined by a heterodimer of MLH1 and PMS1 which together ...

Methyl-CpG-Binding Protein 2. *Minichromosome Maintenance 1 Protein. *MutS DNA Mismatch-Binding Protein ... A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. It regulates GENETIC TRANSCRIPTION involved ... "Leucine-Responsive Regulatory Protein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... This graph shows the total number of publications written about "Leucine-Responsive Regulatory Protein" by people in this ...

mutS homolog 6. Description. This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein ... CHEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding ... Hub Proteins Protein-Protein Interactions interacting hub proteins for MSH6 from the curated Hub Proteins Protein-Protein ... Virus MINT Protein-Viral Protein Interactions interacting viral proteins for MSH6 from the Virus MINT Protein-Viral Protein ...

... primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.. Terms. ... primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.. Entry ... Amino Acids, Peptides, and Proteins [D12] * Proteins [D12.776] * DNA-Binding Proteins [D12.776.260] * Adenovirus E2 Proteins [ ... DNA-(Apurinic or Apyrimidinic Site) Lyase [D08.811.074.750] * MutL Proteins [D08.811.074.766] * Mismatch Repair Endonuclease ...

... provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. ... The DNA mismatch repair protein MutS recognizes mispaired bases in DNA and initiates repair in an ATP-dependent manner. ... Mismatched DNA regulates the asymmetry in the ATPase sites; we observe a stable DNA-bound state containing a single AMP.PNP ... native mass spectrometry to detect simultaneous DNA mismatch binding and asymmetric nucleotide binding to Escherichia coli MutS ...

... interaction between YB-1 and PCNA as well as YB-1-mediated inhibition of the MutSα/PCNA interaction and MutSα mismatch binding ... proteins to a target protein, plays key roles in the modulation of protein functions. In this study, our results revealed that ... indicating a functional role of YB-1 sumoylation in inducing DNA mismatch repair (MMR) deficiency and spontaneous mutations. ... Numerous reports indicate that enhanced expression of Y-box binding protein-1 (YB-1) in tumor cells is strongly associated with ...

Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. ... This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous ... The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are ... High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different ...