*  Genome-Wide Prediction of Traits with Different Genetic Architecture Through Efficient Variable Selection | Genetics
2011 Different models of genetic variation and their effect on genomic evaluation. Genet. Sel. Evol. 43: 18. ... 2012 Comparison of whole-genome prediction models for traits with contrasting genetic architecture in a diversity panel of ... Most authors concluded that this might reflect an infinitesimal genetic model underlying the traits under study. However, the ... In the case of LASSO, model performance was even considerably derogated when model complexity and the level of ...
  http://www.genetics.org/content/195/2/573
*  Plus it
5 were not included in final summary estimates because no data were presented using the dominant genetic model (21, 22), there ... Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Int J Med Sci 2007;4:59- ... XRCC1 and XPD genetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study. Breast Cancer Res 2005;7: ... Genetic dissection methods: Designs used for tests of gene-environment interaction. Curr Opin Genet Dev 2004;14:241-5. ...
  http://cebp.aacrjournals.org/content/19/12/3055
*  One-Locus Two-Allele Models With Maternal (Parental) Selection | Genetics
Symmetric model for maternal selection. A standard approach for simplifying analysis of population genetic models is to ... 1984 Evolution by kin selection: a quantitative genetic model illustrated by maternal performance in mice. Evolution 38: 766- ... In contrast, in the model considered here cycling is brought about by genetic factors and maternal selection. ... If wij = wj for all i,j, that is, if the fitness of an individual depends only on the genotype of its mother, one has a model ...
  http://www.genetics.org/content/149/2/1147
*  Back to Biology: Confounding, Bias, and Dichotomous Traits | heavytailed
The first is the observation that genetic studies (typically) have differential power to find protective and risk variants, an ... for error covariates, and in modeling the distributions of read counts or genotyping errors. I have written about specific ... See here, and a related post on fixed and random effect models here. ... we review the impact of oversampling on a linear model. For binary outcomes, this amounts to inflating or deflating the rate of ...
  https://heavytailed.wordpress.com/2013/06/05/back-to-biology-confounding-bias-and-dichotomous-traits/
*  Non-genetic Inheritance and Evolution | Department of Biology
... or a cause of phenotypic variance that biases responses to selection as in many quantitative genetic models). We have suggested ... But such non-genetic inheritance has been conspicuously absent from discussions of how evolution works. Similarly to plasticity ... For example, we could ask how parental and offspring plasticity co-evolve and if this enables non-genetic transmission of ... But non-genetic inheritance is more than an adaptation to transfer information between generations ( ...
  https://www.biology.lu.se/research/research-groups/experimental-evolution-ecology-and-behaviour/research-projects/non-genetic-inheritance-and-evolution
*  Mouse genetic model for spongiform brain diseases
Some mice with a genetic mutation for mahogany-colored coats also develop spongiform degeneration of brain tissue, similar to ... Because of this oddity, the mice could be valuable animal models for human disorders, such as Parkinson's and Alzheimer's ... As an animal model, the mahoganoid mutant mice probably will not be useful to study spongiform encephalopathies like mad cow ... Cornell geneticist Teresa Gunn displays a mahoganoid mutant mouse, a possible animal model for brain disease in humans. ...
  http://www.innovations-report.com/html/reports/life-sciences/report-16142.html
*  Development of Porcine Genetic Models of Atherosclerosis | SBIR.gov
The ideal pig model would be of manageable size and manifest both metabolic syndrome and atherosclerosis at an early age. Like ... In this Phase 1 STTR we propose to generate a pig model of metabolic syndrome and rapid atherosclerosis by knocking out the low ... Indeed, a consensus report concerning FDA approval of the stents recommends the use of the pig model to assess these devices. ... However, a marked deficiency in current pig models is that they do not present with metabolic syndrome and significant ...
  https://www.sbir.gov/sbirsearch/detail/370162
*  ARL-TR-6354 - Modeling Genetic Regulatory Networks Using First-Order Probabilistic Logic | U.S. Army Research Laboratory
There is a need to model biological systems to aid in medication and drug delivery. Genetic Regulatory Networks (GRNs) ... GRNs can be modeled using statistical and logical techniques, more precisely using Bayesian networks. Bayesian networks are ... a learning algorithm was implemented to determine the structure and the parameters of Bayesian networks that model GRNs from ... Modeling Genetic Regulatory Networks Using First-Order Probabilistic Logic. Report No.. ARL-TR-6354. ...
  http://www.arl.army.mil/www/?technical_report=6697
*  Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations | Genetics
Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations Message Subject (Your Name) has ... Hudson, R. R., 2002 Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18: 337-338. ... Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations. Badri Padhukasahasram, Paul ... Exploring Population Genetic Models With Recombination Using Efficient Forward-Time Simulations. Badri Padhukasahasram, Paul ...
  http://www.genetics.org/content/178/4/2417
*  Fish eyes: modeling genetic mutations behind ocular disease - Department of Biological Sciences - Purdue University
Using zebrafish as a model, Dr Yuk Fai Leung studies the gene networks behind ocular diseases. Finding the genetic root of ... projects.croucher.org.hk/news/fish-eyes-modeling-genetic-mutations-behind-ocular-disease ...
  https://www.bio.purdue.edu/news/articles/2016/zebrafish-gene-networks.html
*  Genome-wide expression profiling data analysis to study autism genetic models | Autism Speaks
Autism SpeaksScienceGrant SearchResultsGenome-wide expression profiling data analysis to study autism genetic models ... This study aims to test that model in an attempt to explain possible risk factors of autism. Using gene expression data from ... It has been proposed that autism spectrum disorders are caused by combinations of multiple genetic variants, or mutations that ...
  https://www.autismspeaks.org/science/grants/genome-wide-expression-profiling-data-analysis-study-autism-genetic-models?destination=about-us%2Fgrant-search%2Fresults%2Ftaxonomy%3A9771%2C10861
*  Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs
... María Antonia Lizarbe,1 Jorge ... In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved. In addition ...
  https://www.hindawi.com/journals/bmri/2017/7354260/abs/
*  Genetic model of posterior subcapsular cataract formation | Disease Models & Mechanisms
Genetic model of posterior subcapsular cataract formation Message Subject (Your Name) has sent you a message from Disease ... Anatoly Samoylenko, Seppo Vainio and colleagues describe a novel model to assay the roles of co-regulated genes in kidney ... Your Name) thought you would like to see the Disease Models & Mechanisms web site. ... Thank you for your interest in spreading the word on Disease Models & Mechanisms. ...
  http://dmm.biologists.org/content/4/4/421.5
*  Modelling Genetic Regulatory Networks - ePrints - Newcastle University
Full text for this publication is not currently held within this repository. Alternative links are provided below where available. ...
  http://eprint.ncl.ac.uk/pub_details2.aspx?pub_id=167806
*  New genetic models of autism point to cellular roots of disease | UCSF Department of Psychiatry
New genetic models of autism point to cellular roots of disease. December 5, 2017 - 1:21pm. *Print ... Researchers at UC San Francisco have developed a new genetic model of autism, using neurons created in the lab from patients' ... "For something as behaviorally complex and hard to quantify as autism, when we look at all the different genetic models that ... 21, 2017, in Molecular Psychiatry developed a second novel genetic model of autism. The researchers again created neurons from ...
  http://psych.ucsf.edu/node/3486
*  Scripps Research Scientists Create New Genetic Model of Premature Aging Diseases - Healthcanal.com : Healthcanal.com
Home Geriatrics and Aging Scripps Research Scientists Create New Genetic Model of Premature Aging Diseases ... scientists from the Florida campus of The Scripps Research Institute have developed a new genetic model of premature aging ... to model two rare human genetic disorders: Hutchinson-Gilford Progeria Syndrome and laminopathies. ... "This model is ready now and can be used to screen and develop chemical compounds to treat these and other age-related diseases ...
  https://www.healthcanal.com/geriatrics-aging/16640-scripps-research-scientists-create-new-genetic-model-of-premature-aging-diseases.html
*  Immunity at the forefront of the brain: A new genetic model of FTD | Science Translational Medicine
Functional characterization of a genetic variant linked to frontotemporal dementia in a murine model reveals deficits in ... Functional characterization of a genetic variant linked to frontotemporal dementia in a murine model reveals deficits in ... Functional characterization of a genetic variant linked to frontotemporal dementia in a murine model reveals deficits in ... Immunity at the forefront of the brain: A new genetic model of FTD ...
  http://stm.sciencemag.org/content/9/394/eaan5227.full
*  Qualitative Modelling of genetic networks using high level Petri nets
Qualitative Modelling of genetic networks using high level Petri nets J.-P. Comet, H. Klaudel and S. Liauzu ... The second modelling is more compact since the unique place abstracts the cell in which each token represents a specific gene ... This formalism allows us to unify the modelling of both approaches, to take advantage of all results and tools in the field of ... biological system to the model. We revisit here the tremendous work of R. Thomas in term of high-level Petri nets. It has been ...
  http://www.i3s.unice.fr/~comet/publications/ConfIntl-sans-actes/confIPG2004.html
*  DIGITAL.CSIC: Genetic model for the inheritance of the parthenocarpy in the tomato line '75/59'
EN] A genetic model for the parthenocarpy in the strain 75/79 was proposed in 1986 by Nuez et al. This parthenocarpic strain ... Genetic model for the inheritance of the parthenocarpy in the tomato line '75/59'. ... ANALES_19_1-2.-Genetic model.pdf. 174,47 kB. Adobe PDF. Visualizar/Abrir ... In agreement with this model, 75/79 would be homozygous for the genes pat-3 and pat-4 wich are partially recessive and with ...
  https://digital.csic.es/handle/10261/12882
*  Abstract 4951: A Genetic Model of Vascular Inflammation: Switchable Expression of Hypoxia Inducible Factor1 Alpha (HIF1a)...
Abstract 4951: A Genetic Model of Vascular Inflammation: Switchable Expression of Hypoxia Inducible Factor1 Alpha (HIF1a) ... Abstract 4951: A Genetic Model of Vascular Inflammation: Switchable Expression of Hypoxia Inducible Factor1 Alpha (HIF1a) ... Abstract 4951: A Genetic Model of Vascular Inflammation: Switchable Expression of Hypoxia Inducible Factor1 Alpha (HIF1a) ... Abstract 4951: A Genetic Model of Vascular Inflammation: Switchable Expression of Hypoxia Inducible Factor1 Alpha (HIF1a) ...
  http://circ.ahajournals.org/content/120/Suppl_18/S1028.3
*  Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools | Genetics
Tetrahymena have the advantages of a "do-it-all" model system; this is especially true as a genetic model system. Tetrahymena ... Why Use Tetrahymena as a Genetic Model Organism?. Model systems are typically chosen based on their utility in identifying new ... GENETIC model systems have a long-standing history as important tools to discover novel genes and processes in cell and ... Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools. Marisa D. Ruehle, Eduardo Orias and Chad G. Pearson ...
  http://www.genetics.org/content/203/2/649
*  IDEALS @ Illinois: Optimizing Groundwater Remediation Designs Using Dynamic Meta-Models and Genetic Algorithms
Optimizing Groundwater Remediation Designs Using Dynamic Meta-Models and Genetic Algorithms. Welcome to the IDEALS Repository. ... Optimizing Groundwater Remediation Designs Using Dynamic Meta-Models and Genetic Algorithms. Yan, Shengquan ... As in AMGA, the meta-models in Noisy-AMGA are online updated but they are trained to predict the expected outputs. The method ... The last focus of the research is to extend the adaptive modeling technique in a stochastic optimization framework so that ...
  https://www.ideals.illinois.edu/handle/2142/83308
*  "Modelling genetic data using Bayesian hierarchical models" by Feng Guo
In another application of modelling genetic data, we propose a hierarchical Bayesian model to estimate the proportional ... Model comparison using several criteria, including DIC and LPML, reveals that CAR models are superior to alternative models for ... We apply the CAR models and the beta-hierarchical models to a high resolution SNP data from the HapMap project. ... We apply the hierarchical-beta models to a subset of single nucleotide polymorphism data from the HapMap project. With this ...
  http://opencommons.uconn.edu/dissertations/AAI3270962/
*  Modeling Human Liver Cancer Heterogeneity: Virally Induced Transgenic Models and Mouse Genetic Models of Chronic Liver...
Modeling Human Liver Cancer Heterogeneity: Virally Induced Transgenic Models and Mouse Genetic Models of Chronic Liver ... Keywords: mouse model; chronic liver inflammation; HCC; liver cancer; modeling human disease ... Mouse models of hepatocellular carcinoma. Semin. Liver Dis. 30:87‐98.. Freeman, A.J., Dore, G.J., Law, M.G., Thorpe, M., Von ... Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL‐6 and TNF expression. Cell 140:197‐208 ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-ph1431.html?quicktabs_cp=toc
*  Bayesian hierarchical models in genetic association studies :: University of Southern California Dissertations and Theses
i BAYESIAN HIERARCHICAL MODELS IN GENETIC ASSOCIATION STUDIES by Wei Liang A Dissertation Presented to the FACULTY OF THE USC ... i BAYESIAN HIERARCHICAL MODELS IN GENETIC ASSOCIATION STUDIES by Wei Liang A Dissertation Presented to the FACULTY OF THE USC ... Genetic association studies aim to find the genetic variations that are associated with phenotypes (traits). In the last decade ... The method works when the model size is relatively small, but fails when the model is over-parameterized. ❧ As mentioned above ...
  http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/344907/rec/8